Click here to switch to the map view.

The map label for this gene is accB [H]

Identifier: 16126126

GI number: 16126126

Start: 2078374

End: 2078886

Strand: Direct

Name: accB [H]

Synonym: CC_1883

Alternate gene names: 16126126

Gene position: 2078374-2078886 (Clockwise)

Preceding gene: 16126125

Following gene: 16126127

Centisome position: 51.74

GC content: 71.73

Gene sequence:

>513_bases
ATGTCGAACCCCAAGGCCCCCGCCGATCCGGTCGAAGCTCCCGCGATCGACGCCCGTCTGGTCCGCAAGCTCGCGGACAT
CCTGAAGGACACGGGTCTGTCCGAGATCGAAGTCGAGCATGCCGGCCTGAAGATCCGCGTCGCGCGTGAACTGACCGCCG
CGCCCGTCAACTACGTCCAGGCCGCCGCGCCGGCCTACGCGCCGGCCCCGGCCGCCGCCTCGGCCCCGGTCGCCGCCGCG
CCGGCCCCCGCCGTCGAGGCCGCTCCGGCCGCCGTTCGTGGTGACGCCGTGAAGTCGCCGATGGTCGGCACCGCCTATCT
CTCGCCCCAGCCGGGCGCCGACGCCTTCGTGAAGGTGGGCGACACCGTCGCGGCGGGCCAGACCCTGCTGATCGTCGAAG
CCATGAAGACCATGAACCCGATCGCCGCCCCGAAGGCCGGCAAGATCGTCGAGATCCTGGTCGAGGACGCCCAGCCCGTC
GAGTTCGGCGAGCCGCTCGTCGTCATCGAGTAA

Upstream 100 bases:

>100_bases
ACTGGCGATCGAGGCCGCTTTCGGCCTGATCCGCGCATAGCAACGATAACGCCCGGCGTTTTCCGCCGCCCGGCGCATCA
GAAGAACAAGGTAAGCTTCC

Downstream 100 bases:

>100_bases
CGCTCATGTTCGACAAGATCCTCATTGCGAACCGGGGCGAGATCGCGCTCCGGGTTCACCGCGCCTGTAAGGAAATGGGC
ATCGCCACGGTGGCGGTCCA

Product: acetyl-CoA carboxylase, biotin carboxyl carrier protein

Products: Malonyl-CoA; malonyl-CoA; phosphate; ADP [C]

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MSNPKAPADPVEAPAIDARLVRKLADILKDTGLSEIEVEHAGLKIRVARELTAAPVNYVQAAAPAYAPAPAAASAPVAAA
PAPAVEAAPAAVRGDAVKSPMVGTAYLSPQPGADAFVKVGDTVAAGQTLLIVEAMKTMNPIAAPKAGKIVEILVEDAQPV
EFGEPLVVIE

Sequences:

>Translated_170_residues
MSNPKAPADPVEAPAIDARLVRKLADILKDTGLSEIEVEHAGLKIRVARELTAAPVNYVQAAAPAYAPAPAAASAPVAAA
PAPAVEAAPAAVRGDAVKSPMVGTAYLSPQPGADAFVKVGDTVAAGQTLLIVEAMKTMNPIAAPKAGKIVEILVEDAQPV
EFGEPLVVIE
>Mature_169_residues
SNPKAPADPVEAPAIDARLVRKLADILKDTGLSEIEVEHAGLKIRVARELTAAPVNYVQAAAPAYAPAPAAASAPVAAAP
APAVEAAPAAVRGDAVKSPMVGTAYLSPQPGADAFVKVGDTVAAGQTLLIVEAMKTMNPIAAPKAGKIVEILVEDAQPVE
FGEPLVVIE

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789653, Length=159, Percent_Identity=46.5408805031447, Blast_Score=125, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001249
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: NA

Molecular weight: Translated: 17213; Mature: 17082

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPKAPADPVEAPAIDARLVRKLADILKDTGLSEIEVEHAGLKIRVARELTAAPVNYVQ
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECHHHHCCHHHHH
AAAPAYAPAPAAASAPVAAAPAPAVEAAPAAVRGDAVKSPMVGTAYLSPQPGADAFVKVG
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCEEEEECCCCCCCCEEEEC
DTVAAGQTLLIVEAMKTMNPIAAPKAGKIVEILVEDAQPVEFGEPLVVIE
CCHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEC
>Mature Secondary Structure 
SNPKAPADPVEAPAIDARLVRKLADILKDTGLSEIEVEHAGLKIRVARELTAAPVNYVQ
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECHHHHCCHHHHH
AAAPAYAPAPAAASAPVAAAPAPAVEAAPAAVRGDAVKSPMVGTAYLSPQPGADAFVKVG
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCEEEEECCCCCCCCEEEEC
DTVAAGQTLLIVEAMKTMNPIAAPKAGKIVEILVEDAQPVEFGEPLVVIE
CCHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; HCO3-; Proton; acetyl-CoA; ATP [C]

Specific reaction: acetyl-CoA = malonyl-CoA HCO3- + Proton + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds; acetyl-CoA carboxylase Reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]