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The map label for this gene is tyrS

Identifier: 16126113

GI number: 16126113

Start: 2062305

End: 2063564

Strand: Direct

Name: tyrS

Synonym: CC_1870

Alternate gene names: 16126113

Gene position: 2062305-2063564 (Clockwise)

Preceding gene: 16126110

Following gene: 16126114

Centisome position: 51.34

GC content: 66.11

Gene sequence:

>1260_bases
ATGTCCGCCGCCTCGTCCTTCAAGTCAGAGTTCCTGCGAACCCTGGAGGCGCGCGGCTATATCCACCAGATCACCCATGC
GGACGAACTGGACACGGCGGCGCAAGGCGGCCCGATCGTCGCCTACATTGGCTTCGACGCCACCGCGCCCAGCCTGCACG
TCGGCTCTCTGATCCAGATCATGCTGCTGCGCCGTCTGCAGCAGGCCGGCCACAAGCCGATCGTCCTGATGGGCGGCGGC
ACGACCAAGGTCGGCGATCCCACGGGCAAGGACGAAAGCCGCAAGCTGCTGAGCGACGCCGACATCCAGGCCAATATCGC
GGGCATCAAGACGGTGTTCTCGAAGTTCCTGACCTTCGGCGACGGGCCCACCGACGCGATCATGGTCGATAACGACGTCT
GGCTGTCGAAGTTCGGCTACGTCCAGTTCCTGCGCGAATACGGCGTGCACTTCACGGTCAACCGCATGCTGGCGTTCGAC
TCGGTCAAGCTGCGCCTCGAGCGCGAGCAGCCGATGACGTTCCTCGAGTTCAACTACATGCTGATGCAGGCGGTGGACTT
CCTGGAGCTGAACCGCGCCCACGGCTGCGTGCTGCAGATGGGCGGCTCGGACCAGTGGGGCAACATCCTCAACGGCGTCG
AGCTGACCCGCCGCGTCGATCAGAAGAGCGCCTTTGGCCTGACGACGCCGCTCCTGGCCACCGCCTCGGGCGCCAAGATG
GGCAAGACGGCGGCTGGCGCAGTGTGGCTGAACGCCGAGCAGCTGAGCCCGTACGACTACTGGCAGTTCTGGAGGAACAC
CGAGGACGCGGACGTTGGCCGTTTCCTGAAGCTGTTCACCGACCTGCCGCTGGATCGCATCGCCGAACTGGAGGCCCTGG
AAGGCGCCCAGATCAACGAGGCCAAGAAGGTGCTGGCCGATGAGGCCACCCGCATGGCCCACGGCGAGGAAGAGGCTCGC
AAGGCTCGCGACGCCGCTGAAAAGGCGTTCGAGCAAGGCGCGCTGTCAGCTGACCTGCCGACCTACGAGATCGCGGCGGC
GGACCTGGACGCCGGCGTCGTTCTGGCGGCCCTGTTCGCGGACGCGGGTCTGGCGGGATCGCGCGGCGAGGCGCGTCGTC
TGGCCCAAGGCGGCGGCCTCAAGGTCAACGACAAGGCCGAAGCCGACGCCAACCGCCTGATCACCGCCGCCGATCTCGTC
GAGGGCGTGGTCAAGCTGGCGGCCGGCAAGAAGAAGATCGTGTTGGTGAAGCCTGTTTAG

Upstream 100 bases:

>100_bases
ATCATGCGCTCCGGCCGCTCACCCGGAGTCTGAAATGAACCCCTCACACACCGACCAAGCCGTGCTAGACGGCCCGCCAC
GTCAGATAGAGAGTCGATCC

Downstream 100 bases:

>100_bases
TTATGAGTTGATTGTCATCCCGGCCCTGGCGTAGCCAAGGCGGGACTGGTTAGACTCATGCCATTGGCGATCCCGGCTCA
GCGCGCTTCGCGCTGGGTCG

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MSAASSFKSEFLRTLEARGYIHQITHADELDTAAQGGPIVAYIGFDATAPSLHVGSLIQIMLLRRLQQAGHKPIVLMGGG
TTKVGDPTGKDESRKLLSDADIQANIAGIKTVFSKFLTFGDGPTDAIMVDNDVWLSKFGYVQFLREYGVHFTVNRMLAFD
SVKLRLEREQPMTFLEFNYMLMQAVDFLELNRAHGCVLQMGGSDQWGNILNGVELTRRVDQKSAFGLTTPLLATASGAKM
GKTAAGAVWLNAEQLSPYDYWQFWRNTEDADVGRFLKLFTDLPLDRIAELEALEGAQINEAKKVLADEATRMAHGEEEAR
KARDAAEKAFEQGALSADLPTYEIAAADLDAGVVLAALFADAGLAGSRGEARRLAQGGGLKVNDKAEADANRLITAADLV
EGVVKLAAGKKKIVLVKPV

Sequences:

>Translated_419_residues
MSAASSFKSEFLRTLEARGYIHQITHADELDTAAQGGPIVAYIGFDATAPSLHVGSLIQIMLLRRLQQAGHKPIVLMGGG
TTKVGDPTGKDESRKLLSDADIQANIAGIKTVFSKFLTFGDGPTDAIMVDNDVWLSKFGYVQFLREYGVHFTVNRMLAFD
SVKLRLEREQPMTFLEFNYMLMQAVDFLELNRAHGCVLQMGGSDQWGNILNGVELTRRVDQKSAFGLTTPLLATASGAKM
GKTAAGAVWLNAEQLSPYDYWQFWRNTEDADVGRFLKLFTDLPLDRIAELEALEGAQINEAKKVLADEATRMAHGEEEAR
KARDAAEKAFEQGALSADLPTYEIAAADLDAGVVLAALFADAGLAGSRGEARRLAQGGGLKVNDKAEADANRLITAADLV
EGVVKLAAGKKKIVLVKPV
>Mature_418_residues
SAASSFKSEFLRTLEARGYIHQITHADELDTAAQGGPIVAYIGFDATAPSLHVGSLIQIMLLRRLQQAGHKPIVLMGGGT
TKVGDPTGKDESRKLLSDADIQANIAGIKTVFSKFLTFGDGPTDAIMVDNDVWLSKFGYVQFLREYGVHFTVNRMLAFDS
VKLRLEREQPMTFLEFNYMLMQAVDFLELNRAHGCVLQMGGSDQWGNILNGVELTRRVDQKSAFGLTTPLLATASGAKMG
KTAAGAVWLNAEQLSPYDYWQFWRNTEDADVGRFLKLFTDLPLDRIAELEALEGAQINEAKKVLADEATRMAHGEEEARK
ARDAAEKAFEQGALSADLPTYEIAAADLDAGVVLAALFADAGLAGSRGEARRLAQGGGLKVNDKAEADANRLITAADLVE
GVVKLAAGKKKIVLVKPV

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain

Homologues:

Organism=Homo sapiens, GI94681057, Length=424, Percent_Identity=32.5471698113208, Blast_Score=210, Evalue=2e-54,
Organism=Escherichia coli, GI1787925, Length=419, Percent_Identity=40.5727923627685, Blast_Score=316, Evalue=2e-87,
Organism=Caenorhabditis elegans, GI25145802, Length=394, Percent_Identity=32.741116751269, Blast_Score=177, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI25145805, Length=270, Percent_Identity=32.2222222222222, Blast_Score=121, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6325160, Length=444, Percent_Identity=31.981981981982, Blast_Score=204, Evalue=2e-53,
Organism=Drosophila melanogaster, GI20130383, Length=435, Percent_Identity=34.9425287356322, Blast_Score=234, Evalue=1e-61,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYY_CAUCN (B8GWL9)

Other databases:

- EMBL:   CP001340
- ProteinModelPortal:   B8GWL9
- SMR:   B8GWL9
- GenomeReviews:   CP001340_GR
- KEGG:   ccs:CCNA_01946
- OMA:   WINQDDR
- ProtClustDB:   PRK13354
- GO:   GO:0005737
- HAMAP:   MF_02006
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11766
- PRINTS:   PR01040
- SMART:   SM00363
- TIGRFAMs:   TIGR00234

Pfam domain/function: PF00579 tRNA-synt_1b

EC number: =6.1.1.1

Molecular weight: Translated: 45407; Mature: 45276

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00178 AA_TRNA_LIGASE_I; PS50889 S4

Important sites: BINDING 42-42 BINDING 179-179 BINDING 183-183 BINDING 242-242

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAASSFKSEFLRTLEARGYIHQITHADELDTAAQGGPIVAYIGFDATAPSLHVGSLIQI
CCCHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHH
MLLRRLQQAGHKPIVLMGGGTTKVGDPTGKDESRKLLSDADIQANIAGIKTVFSKFLTFG
HHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
DGPTDAIMVDNDVWLSKFGYVQFLREYGVHFTVNRMLAFDSVKLRLEREQPMTFLEFNYM
CCCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHEEEEECCCCCCHHHHHHH
LMQAVDFLELNRAHGCVLQMGGSDQWGNILNGVELTRRVDQKSAFGLTTPLLATASGAKM
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCC
GKTAAGAVWLNAEQLSPYDYWQFWRNTEDADVGRFLKLFTDLPLDRIAELEALEGAQINE
CCCCCCEEEEEHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCHHH
AKKVLADEATRMAHGEEEARKARDAAEKAFEQGALSADLPTYEIAAADLDAGVVLAALFA
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHH
DAGLAGSRGEARRLAQGGGLKVNDKAEADANRLITAADLVEGVVKLAAGKKKIVLVKPV
HCCCCCCCCHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
>Mature Secondary Structure 
SAASSFKSEFLRTLEARGYIHQITHADELDTAAQGGPIVAYIGFDATAPSLHVGSLIQI
CCHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHH
MLLRRLQQAGHKPIVLMGGGTTKVGDPTGKDESRKLLSDADIQANIAGIKTVFSKFLTFG
HHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
DGPTDAIMVDNDVWLSKFGYVQFLREYGVHFTVNRMLAFDSVKLRLEREQPMTFLEFNYM
CCCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHEEEEECCCCCCHHHHHHH
LMQAVDFLELNRAHGCVLQMGGSDQWGNILNGVELTRRVDQKSAFGLTTPLLATASGAKM
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCC
GKTAAGAVWLNAEQLSPYDYWQFWRNTEDADVGRFLKLFTDLPLDRIAELEALEGAQINE
CCCCCCEEEEEHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCHHH
AKKVLADEATRMAHGEEEARKARDAAEKAFEQGALSADLPTYEIAAADLDAGVVLAALFA
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHH
DAGLAGSRGEARRLAQGGGLKVNDKAEADANRLITAADLVEGVVKLAAGKKKIVLVKPV
HCCCCCCCCHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA