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The map label for this gene is pdhA [H]

Identifier: 16125970

GI number: 16125970

Start: 1897981

End: 1899012

Strand: Direct

Name: pdhA [H]

Synonym: CC_1726

Alternate gene names: 16125970

Gene position: 1897981-1899012 (Clockwise)

Preceding gene: 16125969

Following gene: 16125971

Centisome position: 47.25

GC content: 65.12

Gene sequence:

>1032_bases
ATGGCGCGCACGCGCAAGGCTGAAGCCTCCGAGGGGAAGGCGCCGGAAACCGGTGTCAACGCCTTCGTCGGCAAGGACGA
ACTCCTGAAATTCTATCAGGACATGCTGCTCATCCGCCGCTTCGAGGAGCGGGCGGGTCAGCTGTACGGCATGGGCCTGA
TCGGCGGCTTCTGCCACCTGTACATCGGTCAGGAAGCCATCGCGGTCGGCATGCAGTCGATCTCGCAGAAGGGCGACCAG
ATCATCACGGGCTATCGTGACCACGGCCACATGCTGGCGGCGGGCATGGATCCCCGCGAGGTGATGGCTGAACTGACCGG
CCGTGCCGGCGGCTCGTCCAAGGGCAAGGGCGGGTCGATGCACATGTTCGACATCGCCACCGGCTTCTACGGCGGTCACG
GCATCGTCGGCGCCCAGGTCGCGCTCGGCACCGGTCTGGCCTTGGCCAACAGCTACCGCAACAACGGCAACGTCTCCTAC
GCCTATATGGGCGATGGCGCGGCCAACCAGGGTCAGGTCTACGAGAGCTTCAACATGGCCCAGCTGTGGAAGCTGCCGGT
CGTGTACGTGATCGAGAACAACCAGTACGCCATGGGCACCGCCGTCGAGCGCGCCGCCTCGGAAACCGCGTTCCACAAGC
GCGGCGTCTCGTTCCGCATTCCGGGCGAGGAAGTCGACGGCATGGACGTCATCGCCGTCCGCGAAGCCGGCGCTCGCGCC
ACCGAACACGCCCGTAGCGGCCAAGGTCCCTACATCCTCGAGATGAAGACCTACCGCTATCGCGGTCACTCGATGTCGGA
TCCGGCCAAGTACCGCACCAAGGAAGAGGTCGACGAGGTCAAGACGACCCGCGATCCCATCGATCACATCAAGGAACGCC
TGGCCAAGGCCGGCGTGACCGAAGACGACCTGAAGGGCGTCGACGCCGAAGTGAAGCGCATTGTCGCCGAGGCCGCCGAA
TTCGCCCGCACGAGCCCCGAGCCCGATCCCTCGGAACTGTATACCGACGTCTACCTGGAGGCCGCCGAGTGA

Upstream 100 bases:

>100_bases
GAGTGAACATCAGGGCGTTACCTTCGCGGAACCGACGAATTTTCGGCGGGAAGCGCTCATCGGATGAAGGCCGCGATGAA
GATTGGCCAGGGAGATTTGA

Downstream 100 bases:

>100_bases
CGGACATCCTGATGCCCGCGCTTTCCCCGACGATGGAGGAAGGCACCCTGGCCAAGTGGCTGGTGAAGGAAGGCGACACC
ATCAAGGCCGGCGACGTGAT

Product: pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MARTRKAEASEGKAPETGVNAFVGKDELLKFYQDMLLIRRFEERAGQLYGMGLIGGFCHLYIGQEAIAVGMQSISQKGDQ
IITGYRDHGHMLAAGMDPREVMAELTGRAGGSSKGKGGSMHMFDIATGFYGGHGIVGAQVALGTGLALANSYRNNGNVSY
AYMGDGAANQGQVYESFNMAQLWKLPVVYVIENNQYAMGTAVERAASETAFHKRGVSFRIPGEEVDGMDVIAVREAGARA
TEHARSGQGPYILEMKTYRYRGHSMSDPAKYRTKEEVDEVKTTRDPIDHIKERLAKAGVTEDDLKGVDAEVKRIVAEAAE
FARTSPEPDPSELYTDVYLEAAE

Sequences:

>Translated_343_residues
MARTRKAEASEGKAPETGVNAFVGKDELLKFYQDMLLIRRFEERAGQLYGMGLIGGFCHLYIGQEAIAVGMQSISQKGDQ
IITGYRDHGHMLAAGMDPREVMAELTGRAGGSSKGKGGSMHMFDIATGFYGGHGIVGAQVALGTGLALANSYRNNGNVSY
AYMGDGAANQGQVYESFNMAQLWKLPVVYVIENNQYAMGTAVERAASETAFHKRGVSFRIPGEEVDGMDVIAVREAGARA
TEHARSGQGPYILEMKTYRYRGHSMSDPAKYRTKEEVDEVKTTRDPIDHIKERLAKAGVTEDDLKGVDAEVKRIVAEAAE
FARTSPEPDPSELYTDVYLEAAE
>Mature_342_residues
ARTRKAEASEGKAPETGVNAFVGKDELLKFYQDMLLIRRFEERAGQLYGMGLIGGFCHLYIGQEAIAVGMQSISQKGDQI
ITGYRDHGHMLAAGMDPREVMAELTGRAGGSSKGKGGSMHMFDIATGFYGGHGIVGAQVALGTGLALANSYRNNGNVSYA
YMGDGAANQGQVYESFNMAQLWKLPVVYVIENNQYAMGTAVERAASETAFHKRGVSFRIPGEEVDGMDVIAVREAGARAT
EHARSGQGPYILEMKTYRYRGHSMSDPAKYRTKEEVDEVKTTRDPIDHIKERLAKAGVTEDDLKGVDAEVKRIVAEAAEF
ARTSPEPDPSELYTDVYLEAAE

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=322, Percent_Identity=51.2422360248447, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI291084742, Length=322, Percent_Identity=50.6211180124224, Blast_Score=310, Evalue=8e-85,
Organism=Homo sapiens, GI4505685, Length=322, Percent_Identity=50.6211180124224, Blast_Score=310, Evalue=1e-84,
Organism=Homo sapiens, GI291084744, Length=329, Percent_Identity=49.5440729483283, Blast_Score=303, Evalue=1e-82,
Organism=Homo sapiens, GI291084757, Length=322, Percent_Identity=45.6521739130435, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI11386135, Length=332, Percent_Identity=27.710843373494, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI258645172, Length=332, Percent_Identity=27.710843373494, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI32564172, Length=326, Percent_Identity=51.5337423312883, Blast_Score=329, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI17536047, Length=326, Percent_Identity=51.5337423312883, Blast_Score=328, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI86563357, Length=283, Percent_Identity=27.9151943462898, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI86563355, Length=283, Percent_Identity=27.9151943462898, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321026, Length=323, Percent_Identity=49.8452012383901, Blast_Score=310, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24639744, Length=330, Percent_Identity=51.8181818181818, Blast_Score=327, Evalue=6e-90,
Organism=Drosophila melanogaster, GI28571106, Length=330, Percent_Identity=51.8181818181818, Blast_Score=327, Evalue=6e-90,
Organism=Drosophila melanogaster, GI24639740, Length=330, Percent_Identity=51.8181818181818, Blast_Score=327, Evalue=8e-90,
Organism=Drosophila melanogaster, GI24639746, Length=306, Percent_Identity=52.9411764705882, Blast_Score=314, Evalue=7e-86,
Organism=Drosophila melanogaster, GI24639748, Length=318, Percent_Identity=49.3710691823899, Blast_Score=295, Evalue=3e-80,
Organism=Drosophila melanogaster, GI21355903, Length=322, Percent_Identity=24.5341614906832, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 37357; Mature: 37225

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARTRKAEASEGKAPETGVNAFVGKDELLKFYQDMLLIRRFEERAGQLYGMGLIGGFCHL
CCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCEECHHHHHHHHHH
YIGQEAIAVGMQSISQKGDQIITGYRDHGHMLAAGMDPREVMAELTGRAGGSSKGKGGSM
HHCHHHHHHHHHHHHCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCCCE
HMFDIATGFYGGHGIVGAQVALGTGLALANSYRNNGNVSYAYMGDGAANQGQVYESFNMA
EEEEEHHCCCCCCCCCHHHHHHHCCHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHCCHH
QLWKLPVVYVIENNQYAMGTAVERAASETAFHKRGVSFRIPGEEVDGMDVIAVREAGARA
HHHCCCEEEEEECCCEEHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEECCCCHH
TEHARSGQGPYILEMKTYRYRGHSMSDPAKYRTKEEVDEVKTTRDPIDHIKERLAKAGVT
HHHHHCCCCCEEEEEEEEEECCCCCCCCHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCC
EDDLKGVDAEVKRIVAEAAEFARTSPEPDPSELYTDVYLEAAE
HHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHEEHEEEECC
>Mature Secondary Structure 
ARTRKAEASEGKAPETGVNAFVGKDELLKFYQDMLLIRRFEERAGQLYGMGLIGGFCHL
CCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCEECHHHHHHHHHH
YIGQEAIAVGMQSISQKGDQIITGYRDHGHMLAAGMDPREVMAELTGRAGGSSKGKGGSM
HHCHHHHHHHHHHHHCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCCCE
HMFDIATGFYGGHGIVGAQVALGTGLALANSYRNNGNVSYAYMGDGAANQGQVYESFNMA
EEEEEHHCCCCCCCCCHHHHHHHCCHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHCCHH
QLWKLPVVYVIENNQYAMGTAVERAASETAFHKRGVSFRIPGEEVDGMDVIAVREAGARA
HHHCCCEEEEEECCCEEHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEECCCCHH
TEHARSGQGPYILEMKTYRYRGHSMSDPAKYRTKEEVDEVKTTRDPIDHIKERLAKAGVT
HHHHHCCCCCEEEEEEEEEECCCCCCCCHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCC
EDDLKGVDAEVKRIVAEAAEFARTSPEPDPSELYTDVYLEAAE
HHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHEEHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]