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The map label for this gene is pyrG

Identifier: 16125964

GI number: 16125964

Start: 1891911

End: 1893563

Strand: Direct

Name: pyrG

Synonym: CC_1720

Alternate gene names: 16125964

Gene position: 1891911-1893563 (Clockwise)

Preceding gene: 16125963

Following gene: 16125965

Centisome position: 47.1

GC content: 65.7

Gene sequence:

>1653_bases
ATGACGCGGTACATCTTCATCACCGGCGGCGTGGTTTCCTCGCTTGGCAAAGGTCTGGCCTCGGCGGCGCTCGGCGCGCT
GCTGCAAGCGCGCGGCTACAAGGTCCGCCTTCGTAAGCTCGACCCCTATCTCAACGTCGATCCGGGCACGATGAGCCCGT
ATCAGCACGGCGAGGTCTTCGTGACCGACGACGGGGCCGAAACCGACCTGGACCTGGGCCACTACGAGCGCTTCACCGGC
GTGTCGGCGACCAAGGCCGACAACATCACCACCGGCCAGATCTACAAGACGATCATCGAGAAGGAGCGCCGCGGCGACTA
TCTGGGCGCGACCGTCCAGGTGATCCCGCACGTGACCAACGAGATCAAGGACTTCGTCCTGTCGCCGGCCATGGACGAGA
CGGGCGAGAAGGCCGTCGACTTCGTGCTGGTCGAGATCGGCGGCACGGTCGGCGACATCGAGGGCCTGCCGTTCTTCGAG
GCCATCCGCCAGCTGCGCCAGGACCTGCCGCGCGGCCAGAGCTGCTATGTGCACCTGACCCTGCTGCCGTTCATCAAGAC
GGCCGGCGAGATGAAGACCAAGCCGACCCAGCACTCGGTCAAGGAGCTGCGCTCGATCGGCATCCAGCCGGACATCCTGC
TGTGCCGCTGCGAGCAGGAGATCCCGCCGGAGGAAAAGCGCAAGATCGCCCAGTTCTGCAACGTGCGGCCCAGCGCGGTG
ATCCAGGCGATGGACTCATCGTCCATCTACGCCGTGCCGATCGACTATCACGAGCAGGGCCTGGACGCCGAAGTGCTGGA
CGTGTTCGGCATGCGCGATGCGCCGGCTCCGGACCTGACGCGCTGGAAGACCATCGACGACACCGTCCAGCATCCGGACG
GCGAGGTCACCATCGCCGTCGTGGGCAAGTACACGGTGCTGAAGGACGCCTACAAGTCGCTGATCGAGGCTCTGCACCAC
GGGGGCCTGGCCAACAAGGTCAAGGTCAACCTCGACTGGGTCGAGAGCGAGACCTTCGAGGGCGACGAGGGGGCGGCTGC
GGCCCGTCTTGAGAACGCCCACGCCATCATGGTGCCCGGCGGCTTCGGCGAGCGGGGCGCGGAGGGCAAGATCCGCGCGG
CCCAGTTCGCCCGGGAGCGGAAGGTGCCGTATTTCGGCATCTGCTTTGGCATGCAGATGGCGGTCATCGAGACCCTGCGG
AACGTCGCGGGCATCAAGGACGCCAGCTCCAGCGAATTCGGGCCCACCGAGCGTCCGGTCGTCGGCATCATGACCGAGTG
GATCAAGGGCAATGAGACCGTCCAGCGCCGCGCCAATGACGATCTGGGCGGTACGATGCGTCTGGGGGCCTATGACGCGG
TCCTGACGGCCGGTTCGAAGATCGCCGAGATCTATGGGGCCACCGAGATCAGCGAGCGCCACCGCCACCGCTACGAGGTC
AATATCGGCTACGTCCACCTGATGGAGGACGCCGGCCTGAAACTGACCGGTCGATCGCCCAACGGCGTGCTGCCCGAAAT
CGTCGAGCGGGACGACCATCCGTGGTTCATCGGCGTGCAGTATCACCCCGAACTGAAGAGCCGTCCGTTCGCTCCGCACC
CGCTTTTCGCCAGCTTTATCGCGGCGGCGAAGGAGCATGGACGCCTCGTCTGA

Upstream 100 bases:

>100_bases
CTTTCACCGACCCCCGAGGGCGACCTCGGGGGTTTAATCTTGTTGATGAACGCGGGTCTTTGCTCCCCGCGTCCACGAAT
CACGAGTAATCTGATCGCCC

Downstream 100 bases:

>100_bases
TCACGAGGTTGCATCTTCCCACAGATTCGGGCATAAGCCCGCCCTCACGCGGCGGCTCGGGCGCTCCCAAGCCGCCGCTC
TCGATTTTCACGCTCAGCGA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 550; Mature: 549

Protein sequence:

>550_residues
MTRYIFITGGVVSSLGKGLASAALGALLQARGYKVRLRKLDPYLNVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFTG
VSATKADNITTGQIYKTIIEKERRGDYLGATVQVIPHVTNEIKDFVLSPAMDETGEKAVDFVLVEIGGTVGDIEGLPFFE
AIRQLRQDLPRGQSCYVHLTLLPFIKTAGEMKTKPTQHSVKELRSIGIQPDILLCRCEQEIPPEEKRKIAQFCNVRPSAV
IQAMDSSSIYAVPIDYHEQGLDAEVLDVFGMRDAPAPDLTRWKTIDDTVQHPDGEVTIAVVGKYTVLKDAYKSLIEALHH
GGLANKVKVNLDWVESETFEGDEGAAAARLENAHAIMVPGGFGERGAEGKIRAAQFARERKVPYFGICFGMQMAVIETLR
NVAGIKDASSSEFGPTERPVVGIMTEWIKGNETVQRRANDDLGGTMRLGAYDAVLTAGSKIAEIYGATEISERHRHRYEV
NIGYVHLMEDAGLKLTGRSPNGVLPEIVERDDHPWFIGVQYHPELKSRPFAPHPLFASFIAAAKEHGRLV

Sequences:

>Translated_550_residues
MTRYIFITGGVVSSLGKGLASAALGALLQARGYKVRLRKLDPYLNVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFTG
VSATKADNITTGQIYKTIIEKERRGDYLGATVQVIPHVTNEIKDFVLSPAMDETGEKAVDFVLVEIGGTVGDIEGLPFFE
AIRQLRQDLPRGQSCYVHLTLLPFIKTAGEMKTKPTQHSVKELRSIGIQPDILLCRCEQEIPPEEKRKIAQFCNVRPSAV
IQAMDSSSIYAVPIDYHEQGLDAEVLDVFGMRDAPAPDLTRWKTIDDTVQHPDGEVTIAVVGKYTVLKDAYKSLIEALHH
GGLANKVKVNLDWVESETFEGDEGAAAARLENAHAIMVPGGFGERGAEGKIRAAQFARERKVPYFGICFGMQMAVIETLR
NVAGIKDASSSEFGPTERPVVGIMTEWIKGNETVQRRANDDLGGTMRLGAYDAVLTAGSKIAEIYGATEISERHRHRYEV
NIGYVHLMEDAGLKLTGRSPNGVLPEIVERDDHPWFIGVQYHPELKSRPFAPHPLFASFIAAAKEHGRLV
>Mature_549_residues
TRYIFITGGVVSSLGKGLASAALGALLQARGYKVRLRKLDPYLNVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFTGV
SATKADNITTGQIYKTIIEKERRGDYLGATVQVIPHVTNEIKDFVLSPAMDETGEKAVDFVLVEIGGTVGDIEGLPFFEA
IRQLRQDLPRGQSCYVHLTLLPFIKTAGEMKTKPTQHSVKELRSIGIQPDILLCRCEQEIPPEEKRKIAQFCNVRPSAVI
QAMDSSSIYAVPIDYHEQGLDAEVLDVFGMRDAPAPDLTRWKTIDDTVQHPDGEVTIAVVGKYTVLKDAYKSLIEALHHG
GLANKVKVNLDWVESETFEGDEGAAAARLENAHAIMVPGGFGERGAEGKIRAAQFARERKVPYFGICFGMQMAVIETLRN
VAGIKDASSSEFGPTERPVVGIMTEWIKGNETVQRRANDDLGGTMRLGAYDAVLTAGSKIAEIYGATEISERHRHRYEVN
IGYVHLMEDAGLKLTGRSPNGVLPEIVERDDHPWFIGVQYHPELKSRPFAPHPLFASFIAAAKEHGRLV

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=566, Percent_Identity=45.0530035335689, Blast_Score=484, Evalue=1e-136,
Organism=Homo sapiens, GI28559085, Length=561, Percent_Identity=43.3155080213904, Blast_Score=461, Evalue=1e-130,
Organism=Homo sapiens, GI28559083, Length=561, Percent_Identity=43.3155080213904, Blast_Score=461, Evalue=1e-130,
Organism=Homo sapiens, GI221316689, Length=561, Percent_Identity=43.3155080213904, Blast_Score=461, Evalue=1e-130,
Organism=Escherichia coli, GI1789142, Length=546, Percent_Identity=54.9450549450549, Blast_Score=575, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI25148299, Length=606, Percent_Identity=38.2838283828383, Blast_Score=403, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6322563, Length=574, Percent_Identity=42.6829268292683, Blast_Score=443, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6319432, Length=568, Percent_Identity=42.0774647887324, Blast_Score=439, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24664469, Length=560, Percent_Identity=45.5357142857143, Blast_Score=473, Evalue=1e-133,
Organism=Drosophila melanogaster, GI21357815, Length=506, Percent_Identity=44.8616600790514, Blast_Score=409, Evalue=1e-114,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_CAUCN (B8GW64)

Other databases:

- EMBL:   CP001340
- RefSeq:   YP_002517164.1
- ProteinModelPortal:   B8GW64
- SMR:   B8GW64
- GeneID:   7331257
- GenomeReviews:   CP001340_GR
- KEGG:   ccs:CCNA_01791
- OMA:   RVTMQKL
- ProtClustDB:   PRK05380
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 60543; Mature: 60411

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 388-388 ACT_SITE 522-522 ACT_SITE 524-524

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRYIFITGGVVSSLGKGLASAALGALLQARGYKVRLRKLDPYLNVDPGTMSPYQHGEVF
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFTGVSATKADNITTGQIYKTIIEKERRGDYLGATVQVIPHVTN
EECCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
EIKDFVLSPAMDETGEKAVDFVLVEIGGTVGDIEGLPFFEAIRQLRQDLPRGQSCYVHLT
HHHHHHHCCCCCCCCCHHHEEEEEEECCCEECCCCCCHHHHHHHHHHHCCCCCCEEEEEE
LLPFIKTAGEMKTKPTQHSVKELRSIGIQPDILLCRCEQEIPPEEKRKIAQFCNVRPSAV
EHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCHHHH
IQAMDSSSIYAVPIDYHEQGLDAEVLDVFGMRDAPAPDLTRWKTIDDTVQHPDGEVTIAV
HHCCCCCCEEEEECCHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCEEEEE
VGKYTVLKDAYKSLIEALHHGGLANKVKVNLDWVESETFEGDEGAAAARLENAHAIMVPG
ECCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCHHHEECCCCEEEECC
GFGERGAEGKIRAAQFARERKVPYFGICFGMQMAVIETLRNVAGIKDASSSEFGPTERPV
CCCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VGIMTEWIKGNETVQRRANDDLGGTMRLGAYDAVLTAGSKIAEIYGATEISERHRHRYEV
HHHHHHHHCCCHHHHHHCCCCCCCEEEECCHHHHHHCCCHHHHHHCCHHHHHHHCCEEEE
NIGYVHLMEDAGLKLTGRSPNGVLPEIVERDDHPWFIGVQYHPELKSRPFAPHPLFASFI
EEEEEEEEECCCEEEECCCCCCCCHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHH
AAAKEHGRLV
HHHHHCCCCC
>Mature Secondary Structure 
TRYIFITGGVVSSLGKGLASAALGALLQARGYKVRLRKLDPYLNVDPGTMSPYQHGEVF
CEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFTGVSATKADNITTGQIYKTIIEKERRGDYLGATVQVIPHVTN
EECCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
EIKDFVLSPAMDETGEKAVDFVLVEIGGTVGDIEGLPFFEAIRQLRQDLPRGQSCYVHLT
HHHHHHHCCCCCCCCCHHHEEEEEEECCCEECCCCCCHHHHHHHHHHHCCCCCCEEEEEE
LLPFIKTAGEMKTKPTQHSVKELRSIGIQPDILLCRCEQEIPPEEKRKIAQFCNVRPSAV
EHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCHHHH
IQAMDSSSIYAVPIDYHEQGLDAEVLDVFGMRDAPAPDLTRWKTIDDTVQHPDGEVTIAV
HHCCCCCCEEEEECCHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCEEEEE
VGKYTVLKDAYKSLIEALHHGGLANKVKVNLDWVESETFEGDEGAAAARLENAHAIMVPG
ECCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCHHHEECCCCEEEECC
GFGERGAEGKIRAAQFARERKVPYFGICFGMQMAVIETLRNVAGIKDASSSEFGPTERPV
CCCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VGIMTEWIKGNETVQRRANDDLGGTMRLGAYDAVLTAGSKIAEIYGATEISERHRHRYEV
HHHHHHHHCCCHHHHHHCCCCCCCEEEECCHHHHHHCCCHHHHHHCCHHHHHHHCCEEEE
NIGYVHLMEDAGLKLTGRSPNGVLPEIVERDDHPWFIGVQYHPELKSRPFAPHPLFASFI
EEEEEEEEECCCEEEECCCCCCCCHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHH
AAAKEHGRLV
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA