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The map label for this gene is guaB [H]

Identifier: 16125864

GI number: 16125864

Start: 1789976

End: 1791439

Strand: Direct

Name: guaB [H]

Synonym: CC_1617

Alternate gene names: 16125864

Gene position: 1789976-1791439 (Clockwise)

Preceding gene: 16125863

Following gene: 16125865

Centisome position: 44.56

GC content: 67.08

Gene sequence:

>1464_bases
ATGGAGATTCGCGAAGGGCTCACCTTCGACGACGTTTTGCTCGAACCCGCAGCGTCCGACGTCATGCCCACCCAGGTGAC
GACCGAGACCCGGTTCACGCGTGAAATCAGTCTGAACATTCCGCTCGTGTCCGCCGCCATGGACACGGTGACCGAAAGCC
GCCTCGCCATCGCCATGGCCCAGGCCGGCGGCATGGGCGTCCTGCACCGCAACCTCTCCAACGAGGAGCAGGCCGACCAG
GTGCGCGAGGTCAAGCGCTACGAAAGCGGCATGGTCATCAATCCGCTGACTATCCACCCCGACACGACCCTGGCCGAGAT
CCGTGAGATCAAGGCCCGCCGCAAGATCTCGGGCTTCCCGGTGGTCGAGCGTGGTTCGGGCAAGCTGGTCGGGATTCTGA
CCAATCGCGACATGCGGTTCGAGGGTGACGACAAGGTCCCGGCCTCTCAGCTGATGACCCGCGACAACCTGATCACCGTC
TCGGAAGGCGTGGATCACCGCGAGGCGCGTGAGCTGCTGCGCAGGCACAAGATCGAGCGCCTGATCGTCGTCGACGAGGC
CTATCGCGCCGTCGGCCTGATCACGGTCAAGGACATCGAGAAGGCCCAGGCCCATCCGCTGGCCGCCAAGGACGACAAGG
GTCGCCTGCTGGTCGGCGCCGCCTCGACCGTCGGCGACGCGGGCTTCGAGCGCTCGATGGCGCTGGTGGACGCCGGCGTC
GACGTCGTCGTGATCGACACGGCCCATGGCCATTCCAGCCAGGTCGCAGCCGCCGTGACCCGTCTGAAGCGTGAAGCCAA
TCGCGTCCAGATCGTCGCCGGCAACATCGCCACCTACGACGCCGCGCGCGCGCTGATCGACGCCGGCGCCGATGCGGTGA
AGGTCGGAATTGGTCCCGGCTCGATCTGCACCACCCGCATCGTCGCGGGCGTGGGCGTGCCGCAGCTGACCGCGATCATG
GAAGCGGTTCGCGCCGCCAAGGAAAGCAACACGCCGGTCATCGCCGACGGCGGCATCAAGTATTCGGGCGACCTGGCCAA
GGCCATCGCCGCCGGGGCCTCGACCGCCATGATGGGTTCGATGTTCGCCGGCACCGAAGAGGCGCCGGGCGAGGTGTTCC
TGTACCAAGGGCGCTCGTACAAGAGCTATCGCGGCATGGGCTCGGTGGGCGCCATGGCGCGCGGCTCGGCCGATCGCTAC
TTCCAGAAGGAAGTCACCGACAACTTCAAGCTGGTGCCGGAAGGCATCGAGGGCCAGACGCCCTTCAAGGGCCCCATCTC
GCCGGTGCTGCACCAGCTGGTCGGCGGCCTGCGCGCGGCCATGGGCTATCTCGGCGCGCCGACGATCCCTGAGCTACAAA
AGCGCGCCAGGTTCGTGCGCATCACGGGCGCGGGCCTGCGGGAAAGCCACGTCCACGACGTGATGATCACGCGCGAGGCG
CCCAACTATCCGAGCGCGGTCTAA

Upstream 100 bases:

>100_bases
CCGACTGACGCCGGGGAAGATTCATCTCCAAATCGGCGACGTGGCGGGTCGACAACGGTCGACCTCGCGGCTATATCCGC
GCCGCAAAATGGAGACTCCG

Downstream 100 bases:

>100_bases
CCGATGCGGATGGCCTTCGAGCTGCAGATGATCGCCGTGGCGGTCGCCATCGGGATCTTGAACCTGCTCTGGGCGTCGGC
CGCCGCCCAGCCGCAGCGTG

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MEIREGLTFDDVLLEPAASDVMPTQVTTETRFTREISLNIPLVSAAMDTVTESRLAIAMAQAGGMGVLHRNLSNEEQADQ
VREVKRYESGMVINPLTIHPDTTLAEIREIKARRKISGFPVVERGSGKLVGILTNRDMRFEGDDKVPASQLMTRDNLITV
SEGVDHREARELLRRHKIERLIVVDEAYRAVGLITVKDIEKAQAHPLAAKDDKGRLLVGAASTVGDAGFERSMALVDAGV
DVVVIDTAHGHSSQVAAAVTRLKREANRVQIVAGNIATYDAARALIDAGADAVKVGIGPGSICTTRIVAGVGVPQLTAIM
EAVRAAKESNTPVIADGGIKYSGDLAKAIAAGASTAMMGSMFAGTEEAPGEVFLYQGRSYKSYRGMGSVGAMARGSADRY
FQKEVTDNFKLVPEGIEGQTPFKGPISPVLHQLVGGLRAAMGYLGAPTIPELQKRARFVRITGAGLRESHVHDVMITREA
PNYPSAV

Sequences:

>Translated_487_residues
MEIREGLTFDDVLLEPAASDVMPTQVTTETRFTREISLNIPLVSAAMDTVTESRLAIAMAQAGGMGVLHRNLSNEEQADQ
VREVKRYESGMVINPLTIHPDTTLAEIREIKARRKISGFPVVERGSGKLVGILTNRDMRFEGDDKVPASQLMTRDNLITV
SEGVDHREARELLRRHKIERLIVVDEAYRAVGLITVKDIEKAQAHPLAAKDDKGRLLVGAASTVGDAGFERSMALVDAGV
DVVVIDTAHGHSSQVAAAVTRLKREANRVQIVAGNIATYDAARALIDAGADAVKVGIGPGSICTTRIVAGVGVPQLTAIM
EAVRAAKESNTPVIADGGIKYSGDLAKAIAAGASTAMMGSMFAGTEEAPGEVFLYQGRSYKSYRGMGSVGAMARGSADRY
FQKEVTDNFKLVPEGIEGQTPFKGPISPVLHQLVGGLRAAMGYLGAPTIPELQKRARFVRITGAGLRESHVHDVMITREA
PNYPSAV
>Mature_487_residues
MEIREGLTFDDVLLEPAASDVMPTQVTTETRFTREISLNIPLVSAAMDTVTESRLAIAMAQAGGMGVLHRNLSNEEQADQ
VREVKRYESGMVINPLTIHPDTTLAEIREIKARRKISGFPVVERGSGKLVGILTNRDMRFEGDDKVPASQLMTRDNLITV
SEGVDHREARELLRRHKIERLIVVDEAYRAVGLITVKDIEKAQAHPLAAKDDKGRLLVGAASTVGDAGFERSMALVDAGV
DVVVIDTAHGHSSQVAAAVTRLKREANRVQIVAGNIATYDAARALIDAGADAVKVGIGPGSICTTRIVAGVGVPQLTAIM
EAVRAAKESNTPVIADGGIKYSGDLAKAIAAGASTAMMGSMFAGTEEAPGEVFLYQGRSYKSYRGMGSVGAMARGSADRY
FQKEVTDNFKLVPEGIEGQTPFKGPISPVLHQLVGGLRAAMGYLGAPTIPELQKRARFVRITGAGLRESHVHDVMITREA
PNYPSAV

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=456, Percent_Identity=40.3508771929825, Blast_Score=326, Evalue=3e-89,
Organism=Homo sapiens, GI34328930, Length=456, Percent_Identity=40.3508771929825, Blast_Score=325, Evalue=7e-89,
Organism=Homo sapiens, GI34328928, Length=456, Percent_Identity=40.3508771929825, Blast_Score=325, Evalue=7e-89,
Organism=Homo sapiens, GI156616279, Length=456, Percent_Identity=40.3508771929825, Blast_Score=325, Evalue=8e-89,
Organism=Homo sapiens, GI66933016, Length=482, Percent_Identity=39.0041493775934, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI217035152, Length=450, Percent_Identity=40.2222222222222, Blast_Score=316, Evalue=3e-86,
Organism=Homo sapiens, GI217035148, Length=456, Percent_Identity=39.4736842105263, Blast_Score=312, Evalue=5e-85,
Organism=Homo sapiens, GI217035150, Length=456, Percent_Identity=37.719298245614, Blast_Score=286, Evalue=2e-77,
Organism=Homo sapiens, GI50541954, Length=264, Percent_Identity=35.9848484848485, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI50541952, Length=264, Percent_Identity=35.9848484848485, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI50541948, Length=264, Percent_Identity=35.9848484848485, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI50541956, Length=270, Percent_Identity=35.5555555555556, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI156104880, Length=265, Percent_Identity=35.8490566037736, Blast_Score=161, Evalue=1e-39,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=56.4681724845996, Blast_Score=494, Evalue=1e-141,
Organism=Escherichia coli, GI1786293, Length=240, Percent_Identity=37.9166666666667, Blast_Score=160, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71994385, Length=504, Percent_Identity=34.5238095238095, Blast_Score=271, Evalue=6e-73,
Organism=Caenorhabditis elegans, GI71994389, Length=430, Percent_Identity=37.2093023255814, Blast_Score=263, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17560440, Length=245, Percent_Identity=37.1428571428571, Blast_Score=164, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6322012, Length=487, Percent_Identity=39.6303901437372, Blast_Score=345, Evalue=1e-95,
Organism=Saccharomyces cerevisiae, GI6323585, Length=485, Percent_Identity=38.7628865979381, Blast_Score=337, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6323464, Length=487, Percent_Identity=40.041067761807, Blast_Score=334, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=40.9356725146199, Blast_Score=265, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6319353, Length=141, Percent_Identity=34.0425531914894, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24641071, Length=484, Percent_Identity=38.8429752066116, Blast_Score=324, Evalue=7e-89,
Organism=Drosophila melanogaster, GI24641073, Length=484, Percent_Identity=38.8429752066116, Blast_Score=324, Evalue=7e-89,
Organism=Drosophila melanogaster, GI28571163, Length=442, Percent_Identity=39.1402714932127, Blast_Score=293, Evalue=1e-79,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52104; Mature: 52104

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIREGLTFDDVLLEPAASDVMPTQVTTETRFTREISLNIPLVSAAMDTVTESRLAIAMA
CCCCCCCCHHHHHHCCCCCCCCCCEEECCCEEEEEEEECCCHHHHHHHHHHHHHHEEEEC
QAGGMGVLHRNLSNEEQADQVREVKRYESGMVINPLTIHPDTTLAEIREIKARRKISGFP
CCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEECCEEECCCCHHHHHHHHHHHHHCCCCC
VVERGSGKLVGILTNRDMRFEGDDKVPASQLMTRDNLITVSEGVDHREARELLRRHKIER
EEECCCCCEEEEEECCCEEECCCCCCCHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHE
LIVVDEAYRAVGLITVKDIEKAQAHPLAAKDDKGRLLVGAASTVGDAGFERSMALVDAGV
EEEEECHHHHEEEEEEECCHHHHCCCCCCCCCCCCEEEEECCHHCCCCHHHHHHEEECCC
DVVVIDTAHGHSSQVAAAVTRLKREANRVQIVAGNIATYDAARALIDAGADAVKVGIGPG
CEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCC
SICTTRIVAGVGVPQLTAIMEAVRAAKESNTPVIADGGIKYSGDLAKAIAAGASTAMMGS
CHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEECCCEEECCHHHHHHHCCCHHHHHHH
MFAGTEEAPGEVFLYQGRSYKSYRGMGSVGAMARGSADRYFQKEVTDNFKLVPEGIEGQT
HHCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHCCCHHHHHHHHHCCCCEEEECCCCCCC
PFKGPISPVLHQLVGGLRAAMGYLGAPTIPELQKRARFVRITGAGLRESHVHDVMITREA
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCEEEEEECCCCCCCCCCEEEEEECC
PNYPSAV
CCCCCCC
>Mature Secondary Structure
MEIREGLTFDDVLLEPAASDVMPTQVTTETRFTREISLNIPLVSAAMDTVTESRLAIAMA
CCCCCCCCHHHHHHCCCCCCCCCCEEECCCEEEEEEEECCCHHHHHHHHHHHHHHEEEEC
QAGGMGVLHRNLSNEEQADQVREVKRYESGMVINPLTIHPDTTLAEIREIKARRKISGFP
CCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEECCEEECCCCHHHHHHHHHHHHHCCCCC
VVERGSGKLVGILTNRDMRFEGDDKVPASQLMTRDNLITVSEGVDHREARELLRRHKIER
EEECCCCCEEEEEECCCEEECCCCCCCHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHE
LIVVDEAYRAVGLITVKDIEKAQAHPLAAKDDKGRLLVGAASTVGDAGFERSMALVDAGV
EEEEECHHHHEEEEEEECCHHHHCCCCCCCCCCCCEEEEECCHHCCCCHHHHHHEEECCC
DVVVIDTAHGHSSQVAAAVTRLKREANRVQIVAGNIATYDAARALIDAGADAVKVGIGPG
CEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCC
SICTTRIVAGVGVPQLTAIMEAVRAAKESNTPVIADGGIKYSGDLAKAIAAGASTAMMGS
CHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEECCCEEECCHHHHHHHCCCHHHHHHH
MFAGTEEAPGEVFLYQGRSYKSYRGMGSVGAMARGSADRYFQKEVTDNFKLVPEGIEGQT
HHCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHCCCHHHHHHHHHCCCCEEEECCCCCCC
PFKGPISPVLHQLVGGLRAAMGYLGAPTIPELQKRARFVRITGAGLRESHVHDVMITREA
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCEEEEEECCCCCCCCCCEEEEEECC
PNYPSAV
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA