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The map label for this gene is folK [H]

Identifier: 16125798

GI number: 16125798

Start: 1715049

End: 1715582

Strand: Direct

Name: folK [H]

Synonym: CC_1551

Alternate gene names: 16125798

Gene position: 1715049-1715582 (Clockwise)

Preceding gene: 16125795

Following gene: 16125799

Centisome position: 42.7

GC content: 69.48

Gene sequence:

>534_bases
TTGAAAAATCAGGTCGCTCGAAATGACTTGGACGAGGCCGTGATCGTGGCGCTCGGCTGCAATCTGCCCGGAGCCTATAC
GAGTCGCGAGGCCTTGTTGGAAGCCGCCGTGGCGGCGCTGCCGCAGGTCGGGCTGGAGGTGGTGACGCGGTCGGGCTGGT
GGACCTCCGCCGCTTGGCCTGACCCGGCGGGGCCCGCGTATCTGAACGGCGTGGCGGTCGTGCGGACGACGCTCTCGCCG
CGTCAGGTCCTGGACGCGCTGCATTCACTGGAGGCGCGGTTCGGGCGGGCGAGGGGAGAGGCCAATGCGCCGCGCACTCT
GGACCTGGATCTCATCGCCCATGGCCGCACGGTGTTGGACGATGGCCTGGTGGTGCCGCATCCGCGCGCCCACCAGCGGC
TGTTTGTGATGGGGCCGCTTTCGGAGCTGTATTCTGGCTGGATTCACCCTGTCACCGGCGAGCCGGCCTTTCGCCTGGCG
GCGACCGCGACGGTCGGCCGCGATGCGCGACCAATGGCGGCGCCGACGGCCTAG

Upstream 100 bases:

>100_bases
GTCGATGTCAAAGCCCAGCGCCTTGGCGGCGGAATAGAGGTTGGCCCCGTCAATGAACAGGGCAAGCCGGTCGGTCGGAT
AGAAGGTCACGTTAAATCCC

Downstream 100 bases:

>100_bases
AGGGTGGACATCGCACCCCGAAGCGGGCATAAGCGCCCGCTCGCGAAAGCAGGATGCTCGTGCGCGGCGTTGCGTGTCGC
GGCACAGAAGCCTATTTTGC

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 177; Mature: 177

Protein sequence:

>177_residues
MKNQVARNDLDEAVIVALGCNLPGAYTSREALLEAAVAALPQVGLEVVTRSGWWTSAAWPDPAGPAYLNGVAVVRTTLSP
RQVLDALHSLEARFGRARGEANAPRTLDLDLIAHGRTVLDDGLVVPHPRAHQRLFVMGPLSELYSGWIHPVTGEPAFRLA
ATATVGRDARPMAAPTA

Sequences:

>Translated_177_residues
MKNQVARNDLDEAVIVALGCNLPGAYTSREALLEAAVAALPQVGLEVVTRSGWWTSAAWPDPAGPAYLNGVAVVRTTLSP
RQVLDALHSLEARFGRARGEANAPRTLDLDLIAHGRTVLDDGLVVPHPRAHQRLFVMGPLSELYSGWIHPVTGEPAFRLA
ATATVGRDARPMAAPTA
>Mature_177_residues
MKNQVARNDLDEAVIVALGCNLPGAYTSREALLEAAVAALPQVGLEVVTRSGWWTSAAWPDPAGPAYLNGVAVVRTTLSP
RQVLDALHSLEARFGRARGEANAPRTLDLDLIAHGRTVLDDGLVVPHPRAHQRLFVMGPLSELYSGWIHPVTGEPAFRLA
ATATVGRDARPMAAPTA

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=137, Percent_Identity=30.6569343065693, Blast_Score=61, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18842; Mature: 18842

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNQVARNDLDEAVIVALGCNLPGAYTSREALLEAAVAALPQVGLEVVTRSGWWTSAAWP
CCCCCCCCCHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCC
DPAGPAYLNGVAVVRTTLSPRQVLDALHSLEARFGRARGEANAPRTLDLDLIAHGRTVLD
CCCCCHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCEECC
DGLVVPHPRAHQRLFVMGPLSELYSGWIHPVTGEPAFRLAATATVGRDARPMAAPTA
CCEECCCCCCCCEEEEECCHHHHHCCCCCCCCCCCCEEEEEHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MKNQVARNDLDEAVIVALGCNLPGAYTSREALLEAAVAALPQVGLEVVTRSGWWTSAAWP
CCCCCCCCCHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCC
DPAGPAYLNGVAVVRTTLSPRQVLDALHSLEARFGRARGEANAPRTLDLDLIAHGRTVLD
CCCCCHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCEECC
DGLVVPHPRAHQRLFVMGPLSELYSGWIHPVTGEPAFRLAATATVGRDARPMAAPTA
CCEECCCCCCCCEEEEECCHHHHHCCCCCCCCCCCCEEEEEHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]