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The map label for this gene is napA [H]

Identifier: 16125747

GI number: 16125747

Start: 1658750

End: 1660195

Strand: Direct

Name: napA [H]

Synonym: CC_1500

Alternate gene names: 16125747

Gene position: 1658750-1660195 (Clockwise)

Preceding gene: 16125746

Following gene: 16125748

Centisome position: 41.29

GC content: 66.11

Gene sequence:

>1446_bases
GTGGGTTGCGTCCGCGACTTGACTCAGCGCGGCATGCGGCAAGGCGCAAAGCCAGTACGATATTTTGGGGAGCGTACAGA
CGTGTCAGACCTGCTCGCGCACACACTGCAGACCGTGGCCGACATCCTTGGGCCGCACGGCCCGGCGACCAAGGCGGCCG
AGCACAGCTATACGCCGAACGATTACTCAATCCATTTCTTCCTGCAGCTGGCGGTGATCCTGCTGGCCTGCCGCGTGACG
GGCTGGTTCGGGAAGAAGTTCCTGGCCCAGCCGCAGGTGGTGGGCGAGATGATCGCGGGCGTCGTCCTGGGCCCGTCGCT
GCTTGGGCTGCTGTTCCCCGACTTCCAACTCTCGCTGTTCCCCAAGGAGACGCGGAACATCCTCTATGTCGGCGCCCAGC
TGGGCGTGGGCCTCTACATGTTCCTGGTCGGGGCCAGCTTTCAGGCGGGGCACTTCAAGACCAAGGCCAGGAGCGCCATG
AGCGTGTCGTTCGCCGGCATCGCCGCCCCGTTCGCCATCGCCGTCATCATCACGCCGTTCCTGCTGAAGGTTCCCGGGCT
CTTTGCGCCGACCATCACGCCGGGGGCGGCGACGCTGTTCATGGGGGCCTGTATCGCCCTGACCGCCTTCCCGATGCTGG
CGCGGATCATCAATGAGCGCGGTCTGCAGAAGACCTCGCTGGGCACCCTGTCCCTGACCGCCGGCGCCTTCGATGACGCG
GTGTCCTGGTGCGTTCTGGCCGTCGTGCTGGCGATGTTCGGCGGCGGACCCGGCGTGGCGGTTCTGGCGATCGGCGGCGG
CCTGCTGTGGGTGCTGTTCGTGCTGACCCTGGGTCCGAAGATCCTGGCGCCGCTGGGCCGCATGGTCGAGCGCGAGGGGG
AGCTCAGCGCCCACGCCCTGGCCCTGGTCATCCTGGCCTTCTGCGTCTCGGCCTTCCTGATGGACGCGGTCGGGATTCAC
GCCATCTTCGGCGGCTTCATCATGGGTGTGGTCATGCCGCGCGGCCTGTTGACCCAGGAGCTGAAGAAGAAGGTCGAGCC
GCTGGTCGTGGTGCTGCTGCTGCCGATGTTCTTCACCTATTCGGGCCTGAACACCCGGCTGGACATGGTCAACTCGCTGG
ATCTGCTGCTGATCGCGCTGGGGATCCTGGCCTGCTCCATCCTGGCCAAGTGGGGCGCCTGCTATGTGGCCGCCCGCGCC
ACCGGCGAGGATCACGCCACGGCCATGGGCATCGGCGCCCTGATGAACTCGCGCGGCCTGATGGAGCTGATCATCATCAA
CATCGGCCTGCAGAAGGGCATTATCGGCCCGACCCTGTTCGCCATGCTGGTGCTTATGGCGATCGTCACCACGATGATGG
CCAGCCCGCTGTTCGAGATCGTCTACGGCAAGAAGGCCCGCGAGCGCGGCGAACTGGACGCCGTTCCGGACGCTAAGCGG
GCTTAG

Upstream 100 bases:

>100_bases
ATCATGGACGGCTTGCCCAGGCTGTAGTCGTCTACTCGGCCATCGGGGGTCTCGGCGCCGGGAATTCGTCGGGTGACAAG
GCTGTCAAATTGAGCGATCG

Downstream 100 bases:

>100_bases
AGGTCAGGCGGGGGCTCGCTTCGGCGGGTCCCTGTCCGTCTCCCGGGTAAATTTCTGCGCCGCGCCTCCAAAGCGCCCCG
CCAAGGCCTCTAACAGACAG

Product: hypothetical protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MGCVRDLTQRGMRQGAKPVRYFGERTDVSDLLAHTLQTVADILGPHGPATKAAEHSYTPNDYSIHFFLQLAVILLACRVT
GWFGKKFLAQPQVVGEMIAGVVLGPSLLGLLFPDFQLSLFPKETRNILYVGAQLGVGLYMFLVGASFQAGHFKTKARSAM
SVSFAGIAAPFAIAVIITPFLLKVPGLFAPTITPGAATLFMGACIALTAFPMLARIINERGLQKTSLGTLSLTAGAFDDA
VSWCVLAVVLAMFGGGPGVAVLAIGGGLLWVLFVLTLGPKILAPLGRMVEREGELSAHALALVILAFCVSAFLMDAVGIH
AIFGGFIMGVVMPRGLLTQELKKKVEPLVVVLLLPMFFTYSGLNTRLDMVNSLDLLLIALGILACSILAKWGACYVAARA
TGEDHATAMGIGALMNSRGLMELIIINIGLQKGIIGPTLFAMLVLMAIVTTMMASPLFEIVYGKKARERGELDAVPDAKR
A

Sequences:

>Translated_481_residues
MGCVRDLTQRGMRQGAKPVRYFGERTDVSDLLAHTLQTVADILGPHGPATKAAEHSYTPNDYSIHFFLQLAVILLACRVT
GWFGKKFLAQPQVVGEMIAGVVLGPSLLGLLFPDFQLSLFPKETRNILYVGAQLGVGLYMFLVGASFQAGHFKTKARSAM
SVSFAGIAAPFAIAVIITPFLLKVPGLFAPTITPGAATLFMGACIALTAFPMLARIINERGLQKTSLGTLSLTAGAFDDA
VSWCVLAVVLAMFGGGPGVAVLAIGGGLLWVLFVLTLGPKILAPLGRMVEREGELSAHALALVILAFCVSAFLMDAVGIH
AIFGGFIMGVVMPRGLLTQELKKKVEPLVVVLLLPMFFTYSGLNTRLDMVNSLDLLLIALGILACSILAKWGACYVAARA
TGEDHATAMGIGALMNSRGLMELIIINIGLQKGIIGPTLFAMLVLMAIVTTMMASPLFEIVYGKKARERGELDAVPDAKR
A
>Mature_480_residues
GCVRDLTQRGMRQGAKPVRYFGERTDVSDLLAHTLQTVADILGPHGPATKAAEHSYTPNDYSIHFFLQLAVILLACRVTG
WFGKKFLAQPQVVGEMIAGVVLGPSLLGLLFPDFQLSLFPKETRNILYVGAQLGVGLYMFLVGASFQAGHFKTKARSAMS
VSFAGIAAPFAIAVIITPFLLKVPGLFAPTITPGAATLFMGACIALTAFPMLARIINERGLQKTSLGTLSLTAGAFDDAV
SWCVLAVVLAMFGGGPGVAVLAIGGGLLWVLFVLTLGPKILAPLGRMVEREGELSAHALALVILAFCVSAFLMDAVGIHA
IFGGFIMGVVMPRGLLTQELKKKVEPLVVVLLLPMFFTYSGLNTRLDMVNSLDLLLIALGILACSILAKWGACYVAARAT
GEDHATAMGIGALMNSRGLMELIIINIGLQKGIIGPTLFAMLVLMAIVTTMMASPLFEIVYGKKARERGELDAVPDAKRA

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322367, Length=417, Percent_Identity=29.9760191846523, Blast_Score=172, Evalue=7e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 51051; Mature: 50920

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGCVRDLTQRGMRQGAKPVRYFGERTDVSDLLAHTLQTVADILGPHGPATKAAEHSYTPN
CCHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
DYSIHFFLQLAVILLACRVTGWFGKKFLAQPQVVGEMIAGVVLGPSLLGLLFPDFQLSLF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEC
PKETRNILYVGAQLGVGLYMFLVGASFQAGHFKTKARSAMSVSFAGIAAPFAIAVIITPF
CCCCCCEEEECHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLKVPGLFAPTITPGAATLFMGACIALTAFPMLARIINERGLQKTSLGTLSLTAGAFDDA
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCEEEEECCCHHHH
VSWCVLAVVLAMFGGGPGVAVLAIGGGLLWVLFVLTLGPKILAPLGRMVEREGELSAHAL
HHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHH
ALVILAFCVSAFLMDAVGIHAIFGGFIMGVVMPRGLLTQELKKKVEPLVVVLLLPMFFTY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLNTRLDMVNSLDLLLIALGILACSILAKWGACYVAARATGEDHATAMGIGALMNSRGL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHCCCCH
MELIIINIGLQKGIIGPTLFAMLVLMAIVTTMMASPLFEIVYGKKARERGELDAVPDAKR
HHHHHHHHCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCC
A
C
>Mature Secondary Structure 
GCVRDLTQRGMRQGAKPVRYFGERTDVSDLLAHTLQTVADILGPHGPATKAAEHSYTPN
CHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
DYSIHFFLQLAVILLACRVTGWFGKKFLAQPQVVGEMIAGVVLGPSLLGLLFPDFQLSLF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEC
PKETRNILYVGAQLGVGLYMFLVGASFQAGHFKTKARSAMSVSFAGIAAPFAIAVIITPF
CCCCCCEEEECHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLKVPGLFAPTITPGAATLFMGACIALTAFPMLARIINERGLQKTSLGTLSLTAGAFDDA
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCEEEEECCCHHHH
VSWCVLAVVLAMFGGGPGVAVLAIGGGLLWVLFVLTLGPKILAPLGRMVEREGELSAHAL
HHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHH
ALVILAFCVSAFLMDAVGIHAIFGGFIMGVVMPRGLLTQELKKKVEPLVVVLLLPMFFTY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLNTRLDMVNSLDLLLIALGILACSILAKWGACYVAARATGEDHATAMGIGALMNSRGL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHCCCCH
MELIIINIGLQKGIIGPTLFAMLVLMAIVTTMMASPLFEIVYGKKARERGELDAVPDAKR
HHHHHHHHCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]