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The map label for this gene is pip [H]

Identifier: 16125746

GI number: 16125746

Start: 1657591

End: 1658676

Strand: Direct

Name: pip [H]

Synonym: CC_1499

Alternate gene names: 16125746

Gene position: 1657591-1658676 (Clockwise)

Preceding gene: 16125744

Following gene: 16125747

Centisome position: 41.26

GC content: 67.59

Gene sequence:

>1086_bases
ATGGATTTCTCCAAGCTTCGCACCACCAGCAAGGTCACCACCGAGTGGAGCTATCCGCAAGGGCAGCCCCTGCGCACGGG
CTGGCTGCGGGTCGACACCGCGCCGGACCATGAGCTCTACTGGGAGGAATACGGCCGCGCCGACGGCGAGCCGGTGATGT
TCCTGCACGGCGGTCCCGGCGGGGCCTGCGCGCCGGTGATGTCGCGCTTCTTCGATCCGGACCGCTATCGGGTGATCCTG
TTCGACCAGCGTGGCTGCGGCAAGAGCCGCCCGACCGTGGCGGCCGATGGCCCGGACAAGGCCCTAGCCAACAACACCAC
CGACCATCTGGTCTCCGACATCAACGCCCTGCGCGAGGCGCTGGGGATCAGCGGCAAGATGCATGTGTTCGGCGGCAGCT
GGGGCAGCACCCTGGCCCTCGTCTATGCCATCCGTCATCCGGAGAAGGTCGCCTCGCTGATCCTGCGCGGCATCTTCCTG
GGGCGGAAGGAGGACCTGCTCTACATGTATCAGGGCAACGCCGCGACCTATCAGGCCCAGCCCTACGCCCTGACCGCGCC
GGGCGCCTACATCACCTATCCGGACGAATGGAAGGCCTTTGTCGAGGTGATCGCGCCCGAGCAGCGCGGCGACATGATGG
CCGCCTATAAGGCGATCTTCGACACGGTTCCGACCACCGACACCGAGCGCGCGGCGCAGCTGAAGGCGGCCCTGGCCTGG
TCGGTGTGGGAAGGCACGATCTCGAACATGATCCCGGCCGCCGAGGACGCGGGCAAGTTCGGCGAGGCCGAATTCGCGCT
GAGCTTCGCCCAGATCGAGGCCCACTTCTTCGCCCACGACCTGTTCCTGAAAGAGGACGAGATCACCGACGGCGTGGCGG
CGCTCACGGGCGTGCCGGTCCATATCGTGCATGGTCGTTTCGACCAGGTCTGCCCGCTGACCCAGGGCTCGCGGCTGGTC
CAGGCCCTGGAGGCGGCGGGGCTGCCGCCGGCGACCTATGTCATCACCGACGCCGGCCACAGCGCCATGGAGGCCCAGAC
GGTGATCGCCCTGACCGCGATCATGGACGGCTTGCCCAGGCTGTAG

Upstream 100 bases:

>100_bases
CCCGGGATGACGAGAGAAATTGATAGCCCATAGAGCGAGGGCCTGGAGGTGGGCCTCGTTCAGCGCGAGAGTGCCCAACC
CCTTTCGGCAGGATTCGACC

Downstream 100 bases:

>100_bases
TCGTCTACTCGGCCATCGGGGGTCTCGGCGCCGGGAATTCGTCGGGTGACAAGGCTGTCAAATTGAGCGATCGGTGGGTT
GCGTCCGCGACTTGACTCAG

Product: proline iminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MDFSKLRTTSKVTTEWSYPQGQPLRTGWLRVDTAPDHELYWEEYGRADGEPVMFLHGGPGGACAPVMSRFFDPDRYRVIL
FDQRGCGKSRPTVAADGPDKALANNTTDHLVSDINALREALGISGKMHVFGGSWGSTLALVYAIRHPEKVASLILRGIFL
GRKEDLLYMYQGNAATYQAQPYALTAPGAYITYPDEWKAFVEVIAPEQRGDMMAAYKAIFDTVPTTDTERAAQLKAALAW
SVWEGTISNMIPAAEDAGKFGEAEFALSFAQIEAHFFAHDLFLKEDEITDGVAALTGVPVHIVHGRFDQVCPLTQGSRLV
QALEAAGLPPATYVITDAGHSAMEAQTVIALTAIMDGLPRL

Sequences:

>Translated_361_residues
MDFSKLRTTSKVTTEWSYPQGQPLRTGWLRVDTAPDHELYWEEYGRADGEPVMFLHGGPGGACAPVMSRFFDPDRYRVIL
FDQRGCGKSRPTVAADGPDKALANNTTDHLVSDINALREALGISGKMHVFGGSWGSTLALVYAIRHPEKVASLILRGIFL
GRKEDLLYMYQGNAATYQAQPYALTAPGAYITYPDEWKAFVEVIAPEQRGDMMAAYKAIFDTVPTTDTERAAQLKAALAW
SVWEGTISNMIPAAEDAGKFGEAEFALSFAQIEAHFFAHDLFLKEDEITDGVAALTGVPVHIVHGRFDQVCPLTQGSRLV
QALEAAGLPPATYVITDAGHSAMEAQTVIALTAIMDGLPRL
>Mature_361_residues
MDFSKLRTTSKVTTEWSYPQGQPLRTGWLRVDTAPDHELYWEEYGRADGEPVMFLHGGPGGACAPVMSRFFDPDRYRVIL
FDQRGCGKSRPTVAADGPDKALANNTTDHLVSDINALREALGISGKMHVFGGSWGSTLALVYAIRHPEKVASLILRGIFL
GRKEDLLYMYQGNAATYQAQPYALTAPGAYITYPDEWKAFVEVIAPEQRGDMMAAYKAIFDTVPTTDTERAAQLKAALAW
SVWEGTISNMIPAAEDAGKFGEAEFALSFAQIEAHFFAHDLFLKEDEITDGVAALTGVPVHIVHGRFDQVCPLTQGSRLV
QALEAAGLPPATYVITDAGHSAMEAQTVIALTAIMDGLPRL

Specific function: Specifically catalyzes the removal of N-terminal proline residues from peptides [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005944
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 39401; Mature: 39401

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFSKLRTTSKVTTEWSYPQGQPLRTGWLRVDTAPDHELYWEEYGRADGEPVMFLHGGPG
CCHHHHCCCCCEEEECCCCCCCCCCCCEEEECCCCCCHHHHHHHCCCCCCEEEEEECCCC
GACAPVMSRFFDPDRYRVILFDQRGCGKSRPTVAADGPDKALANNTTDHLVSDINALREA
CHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEECCCCCHHHCCCCHHHHHHHHHHHHHH
LGISGKMHVFGGSWGSTLALVYAIRHPEKVASLILRGIFLGRKEDLLYMYQGNAATYQAQ
HCCCCEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEECC
PYALTAPGAYITYPDEWKAFVEVIAPEQRGDMMAAYKAIFDTVPTTDTERAAQLKAALAW
CEEEECCCCEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
SVWEGTISNMIPAAEDAGKFGEAEFALSFAQIEAHFFAHDLFLKEDEITDGVAALTGVPV
HHHHHHHHHCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHCCCCE
HIVHGRFDQVCPLTQGSRLVQALEAAGLPPATYVITDAGHSAMEAQTVIALTAIMDGLPR
EEECCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCC
L
C
>Mature Secondary Structure
MDFSKLRTTSKVTTEWSYPQGQPLRTGWLRVDTAPDHELYWEEYGRADGEPVMFLHGGPG
CCHHHHCCCCCEEEECCCCCCCCCCCCEEEECCCCCCHHHHHHHCCCCCCEEEEEECCCC
GACAPVMSRFFDPDRYRVILFDQRGCGKSRPTVAADGPDKALANNTTDHLVSDINALREA
CHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEECCCCCHHHCCCCHHHHHHHHHHHHHH
LGISGKMHVFGGSWGSTLALVYAIRHPEKVASLILRGIFLGRKEDLLYMYQGNAATYQAQ
HCCCCEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEECC
PYALTAPGAYITYPDEWKAFVEVIAPEQRGDMMAAYKAIFDTVPTTDTERAAQLKAALAW
CEEEECCCCEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
SVWEGTISNMIPAAEDAGKFGEAEFALSFAQIEAHFFAHDLFLKEDEITDGVAALTGVPV
HHHHHHHHHCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHCCCCE
HIVHGRFDQVCPLTQGSRLVQALEAAGLPPATYVITDAGHSAMEAQTVIALTAIMDGLPR
EEECCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9348090; 11011150; 10467172 [H]