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The map label for this gene is hemN [H]

Identifier: 16125660

GI number: 16125660

Start: 1558261

End: 1559625

Strand: Direct

Name: hemN [H]

Synonym: CC_1411

Alternate gene names: 16125660

Gene position: 1558261-1559625 (Clockwise)

Preceding gene: 16125659

Following gene: 16125662

Centisome position: 38.79

GC content: 66.59

Gene sequence:

>1365_bases
ATGATGACCCAGACCGTTCTTTCGTCCGTCCAACGGGCGCACGCCGAGCGCAACCTGCCGCGCTATACCAGCTATCCTAC
GGCCGTCGCCTTCGACGCCGCGCAAGTGACGCAGGCGCCGGACTGGTTCGCCAAGACGCGGTCGGAGGATCACCTGTCGG
TCTATGTCCACGTGCCGTTTTGCCGTCGGCTTTGCTGGTATTGCGGCTGCCACACCTCGATCGCCCATACCTATGAACGG
GTCGGGACCTACGCCGATGTTCTGGCGCGCGAGATCGATCTGACGGCCCGGCGGCTGGGAGAACACGACGGGCTGGCGCA
TCTCCACTTCGGCGGCGGCAGCCCGAACGCCCTCAGTCCCTCGGACTTCAAGCGCCTGGTGGCCCAGCTGAAGACGGCGT
TCCGAGTTCGACCCGGTGCGGAGATCGCCGCCGAGCTTGACCCCGGGATGCTCTCAGACACGTTTGTCGACGCGACCGGC
GAGGCGGGTGTCACCCGCGTGAGCCTCGGCGTGCAAACCTTCGACCCGACCGTCCAGGCGCTGGTCAACCGCGTTCAGCC
GTTCGAGCAGGTTGCTGCGGCTGTCGAGCGTCTCCGCGCTGTCGGGGTTGGCGGCTTGAACTTCGACCTGATGTACGGAC
TGCCGGGGCAGACCGTCGAGAATGTCTATGCTTCGGCGAAAACAGCCGTCGCGTTGCGCCCGGATCGGATCGCCGTCTTC
GGCTACGCCCACGTGCCGTGGATGAAGAAGCACCAGACGATGATCCAGGAGACGGATCTGGCCGATATCGACGGCCGGTG
GGCGCAGGCGGACGCGGCGGATGCGGCTTTGACCGAGGCGGGCTATGTCCGGATCGGCCTCGATCACTATGCCTTGCCCG
ATGACTCCCTCAGCCGAGCCGCGGCGGAAGGGCGGCTGCGGCGCAACTTCCAAGGCTACACCGATGATCCTGCGCCAGTG
CTGGTTCCCATCGGCCCGTCCTCAATCGGCCAGTTCCGTGAGGGCTTTGTCCAGAACCTGACCCCGACCGACGCTTGGGC
GGCGAGGATCGCCCGAGATGAGTTGCCGCTGGGGCGCGCCCTGGCGTTCAGTGATGAGGACCGTCTGCGCGCGGCCGTGA
TCGAGCGACTGATGTGCGACATGACGGTCGATGTTGCAGCCATCTGCGAGGCGCATGGCTTCTCGACCGACCATCTGGCG
GGAAGTCTCGCCAGTCTGGCGGCGATCGAGGTGGCCGGCCTCTGCGTGCTTGACGGCGCCGTCGTCACCATCCCTGAAGA
CGCGCGTCGCCTGATGCGCGTGGTCGCGGCCGCGTTCGACGACCGTCTGCCCGCCACGGTCACCCGCCACGCCAAGGCTG
TCTAA

Upstream 100 bases:

>100_bases
GCCAGGCTGAGCGCGAGCGGCGCCGTGGCGGCCGCACCGCCATCGCAGCGCACTAGCATCGACGCCCCGGACCACAATCG
CCCGCAGAGCAGCCCGCCAG

Downstream 100 bases:

>100_bases
AGCTCCCCGCCGATCCGCTCGACCTCCTGGGCCAGCGCGTCCATGTCGAGGACATGAAGCGAGCGGCCGGTTTGGCGGAC
GATCCTGAGGCCCGCCAGGC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MMTQTVLSSVQRAHAERNLPRYTSYPTAVAFDAAQVTQAPDWFAKTRSEDHLSVYVHVPFCRRLCWYCGCHTSIAHTYER
VGTYADVLAREIDLTARRLGEHDGLAHLHFGGGSPNALSPSDFKRLVAQLKTAFRVRPGAEIAAELDPGMLSDTFVDATG
EAGVTRVSLGVQTFDPTVQALVNRVQPFEQVAAAVERLRAVGVGGLNFDLMYGLPGQTVENVYASAKTAVALRPDRIAVF
GYAHVPWMKKHQTMIQETDLADIDGRWAQADAADAALTEAGYVRIGLDHYALPDDSLSRAAAEGRLRRNFQGYTDDPAPV
LVPIGPSSIGQFREGFVQNLTPTDAWAARIARDELPLGRALAFSDEDRLRAAVIERLMCDMTVDVAAICEAHGFSTDHLA
GSLASLAAIEVAGLCVLDGAVVTIPEDARRLMRVVAAAFDDRLPATVTRHAKAV

Sequences:

>Translated_454_residues
MMTQTVLSSVQRAHAERNLPRYTSYPTAVAFDAAQVTQAPDWFAKTRSEDHLSVYVHVPFCRRLCWYCGCHTSIAHTYER
VGTYADVLAREIDLTARRLGEHDGLAHLHFGGGSPNALSPSDFKRLVAQLKTAFRVRPGAEIAAELDPGMLSDTFVDATG
EAGVTRVSLGVQTFDPTVQALVNRVQPFEQVAAAVERLRAVGVGGLNFDLMYGLPGQTVENVYASAKTAVALRPDRIAVF
GYAHVPWMKKHQTMIQETDLADIDGRWAQADAADAALTEAGYVRIGLDHYALPDDSLSRAAAEGRLRRNFQGYTDDPAPV
LVPIGPSSIGQFREGFVQNLTPTDAWAARIARDELPLGRALAFSDEDRLRAAVIERLMCDMTVDVAAICEAHGFSTDHLA
GSLASLAAIEVAGLCVLDGAVVTIPEDARRLMRVVAAAFDDRLPATVTRHAKAV
>Mature_454_residues
MMTQTVLSSVQRAHAERNLPRYTSYPTAVAFDAAQVTQAPDWFAKTRSEDHLSVYVHVPFCRRLCWYCGCHTSIAHTYER
VGTYADVLAREIDLTARRLGEHDGLAHLHFGGGSPNALSPSDFKRLVAQLKTAFRVRPGAEIAAELDPGMLSDTFVDATG
EAGVTRVSLGVQTFDPTVQALVNRVQPFEQVAAAVERLRAVGVGGLNFDLMYGLPGQTVENVYASAKTAVALRPDRIAVF
GYAHVPWMKKHQTMIQETDLADIDGRWAQADAADAALTEAGYVRIGLDHYALPDDSLSRAAAEGRLRRNFQGYTDDPAPV
LVPIGPSSIGQFREGFVQNLTPTDAWAARIARDELPLGRALAFSDEDRLRAAVIERLMCDMTVDVAAICEAHGFSTDHLA
GSLASLAAIEVAGLCVLDGAVVTIPEDARRLMRVVAAAFDDRLPATVTRHAKAV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=167, Percent_Identity=27.5449101796407, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI87082341, Length=426, Percent_Identity=35.6807511737089, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1789325, Length=251, Percent_Identity=27.4900398406374, Blast_Score=93, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 49252; Mature: 49252

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTQTVLSSVQRAHAERNLPRYTSYPTAVAFDAAQVTQAPDWFAKTRSEDHLSVYVHVPF
CCHHHHHHHHHHHHHHCCCCCCCCCCCCEEECHHHHCCCCHHHHHCCCCCCEEEEEECHH
CRRLCWYCGCHTSIAHTYERVGTYADVLAREIDLTARRLGEHDGLAHLHFGGGSPNALSP
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCH
SDFKRLVAQLKTAFRVRPGAEIAAELDPGMLSDTFVDATGEAGVTRVSLGVQTFDPTVQA
HHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCHHHCCCCCCCCCEEEEECCHHCCHHHHH
LVNRVQPFEQVAAAVERLRAVGVGGLNFDLMYGLPGQTVENVYASAKTAVALRPDRIAVF
HHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHEEEEECCCEEEEE
GYAHVPWMKKHQTMIQETDLADIDGRWAQADAADAALTEAGYVRIGLDHYALPDDSLSRA
EEECCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCEEEECCCCCCCCCHHHHHH
AAEGRLRRNFQGYTDDPAPVLVPIGPSSIGQFREGFVQNLTPTDAWAARIARDELPLGRA
HHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCE
LAFSDEDRLRAAVIERLMCDMTVDVAAICEAHGFSTDHLAGSLASLAAIEVAGLCVLDGA
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCEEEECCE
VVTIPEDARRLMRVVAAAFDDRLPATVTRHAKAV
EEECCHHHHHHHHHHHHHHHCCCCHHHHHHHCCC
>Mature Secondary Structure
MMTQTVLSSVQRAHAERNLPRYTSYPTAVAFDAAQVTQAPDWFAKTRSEDHLSVYVHVPF
CCHHHHHHHHHHHHHHCCCCCCCCCCCCEEECHHHHCCCCHHHHHCCCCCCEEEEEECHH
CRRLCWYCGCHTSIAHTYERVGTYADVLAREIDLTARRLGEHDGLAHLHFGGGSPNALSP
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCH
SDFKRLVAQLKTAFRVRPGAEIAAELDPGMLSDTFVDATGEAGVTRVSLGVQTFDPTVQA
HHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCHHHCCCCCCCCCEEEEECCHHCCHHHHH
LVNRVQPFEQVAAAVERLRAVGVGGLNFDLMYGLPGQTVENVYASAKTAVALRPDRIAVF
HHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHEEEEECCCEEEEE
GYAHVPWMKKHQTMIQETDLADIDGRWAQADAADAALTEAGYVRIGLDHYALPDDSLSRA
EEECCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCEEEECCCCCCCCCHHHHHH
AAEGRLRRNFQGYTDDPAPVLVPIGPSSIGQFREGFVQNLTPTDAWAARIARDELPLGRA
HHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCE
LAFSDEDRLRAAVIERLMCDMTVDVAAICEAHGFSTDHLAGSLASLAAIEVAGLCVLDGA
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCEEEECCE
VVTIPEDARRLMRVVAAAFDDRLPATVTRHAKAV
EEECCHHHHHHHHHHHHHHHCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11157943; 12597275 [H]