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The map label for this gene is hemA [H]

Identifier: 16125604

GI number: 16125604

Start: 1508812

End: 1510038

Strand: Direct

Name: hemA [H]

Synonym: CC_1355

Alternate gene names: 16125604

Gene position: 1508812-1510038 (Clockwise)

Preceding gene: 16125603

Following gene: 16125606

Centisome position: 37.56

GC content: 64.87

Gene sequence:

>1227_bases
ATGGACTACAAAGCCGCGTTCCGCAGCGCCGTTGAGCAGATCCGCGAAGAGGGTCGCTACCGGGTGTTCGCCGACCTGAA
GCGTCAGCGCGGCCAGTTTCCGCGCGCGACCTGGACGCGCCAGGACGGTTCGGAACATGAAGTCGTTGTCTGGTGCAGCA
ACGACTATCTCGGACAAGGCCAGAATCCGGTGGTTCTGGAGGCCATGAAGGCCGCCGTTGACGAGCACGGTTCGGGTTCC
GGCGGTACGCGCAACATTTCGGGCACCAACCATGACCACGTCCTGCTGGAGCAGGAACTGGCGGATCTGCACGGCAAGGA
AGCCGGCCTGCTGTTCACCTCGGGCTATGTCTCGAACGAGGCGACGCTCTCGGTGGTCCAGAAGATTCTGCCCGGCCTGA
TCATCTTCTCGGACGAACTGAACCACGCCTCGATGATCGCTGGCATCCGCAACGGCGGTGGTCCGCGCAAGATCTTCAAG
CACAACGACCTGGCGCATCTCGAGCAACTGCTGGCCGAAGCGCCGGCTGACGCGCCCAAGCTGATCGCCTTCGAAAGCGT
CTACTCGATGGACGGCGACATCGCCGACCTCGCCGGCACCGTGGCCCTGGCCAAGAAGTACGGCGCGATGACCTATCTCG
ACGAGGTTCACGCGGTCGGCATGTATGGCCCGCGCGGCGGCGGTGTCGCCGAGCGCGATGGCCTGATGGGCGAGATCGAC
ATCATCGAAGGCACGTTGGGCAAGGCGTTCGGCGTGATGGGCGGCTACATCACCGGCGACGCCGAGGTGATCGACGCCAT
TCGCCTGATGGCTTCGGGCTTCATTTTCACGACGTCTCTGCCGCCGGCCCTGACGGCCGGTGCGCTGGCCAGCGTCCGCT
GGCTCAAGCAGCACCCCGAGGTTCGCGAGATCCACCAGGAGCGCGCGGCGACCCTGAAGGCCATGTTCAAGGCGGCGGGC
CTGCCGGTCATGGACAGCGTCAGCCACATCGTTCCGGTGCTGGTCGGCGATCCGGTCCACTGCAAGATGATCAGCGATAT
GCTGCTGGCCGATTTCGGCGTCTATGTGCAGCCGATCAACTATCCGACCGTGCCGCGTGGCACCGAGCGCCTGCGCTTCA
CCCCGACGCCGTTCCATACCGACGACATGATGCGCAAGCTGGTCGCGGCGATGGAGAAGCTTTGGGCCCACTGCAACGTC
GCGCGGATGGGCGGCTACGCGGCCTAG

Upstream 100 bases:

>100_bases
GTAAACGCCCTTAGATGGACACTGCGGGCCACAGGTGCGAAAAGCCGGGCCTGGACTTAGGGGATCGTCGACCCGATGGG
GCGGCGGTTTAGAGATCGAA

Downstream 100 bases:

>100_bases
AAGGAAGACGCGCACCTTCAGCTTCGGACGCCCGCAACGCACTGGAAACGAAAAACGCCGCCGGAAACCGGCGGCGTTTG
TGCGCCTGGATGATGGCTCA

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MDYKAAFRSAVEQIREEGRYRVFADLKRQRGQFPRATWTRQDGSEHEVVVWCSNDYLGQGQNPVVLEAMKAAVDEHGSGS
GGTRNISGTNHDHVLLEQELADLHGKEAGLLFTSGYVSNEATLSVVQKILPGLIIFSDELNHASMIAGIRNGGGPRKIFK
HNDLAHLEQLLAEAPADAPKLIAFESVYSMDGDIADLAGTVALAKKYGAMTYLDEVHAVGMYGPRGGGVAERDGLMGEID
IIEGTLGKAFGVMGGYITGDAEVIDAIRLMASGFIFTTSLPPALTAGALASVRWLKQHPEVREIHQERAATLKAMFKAAG
LPVMDSVSHIVPVLVGDPVHCKMISDMLLADFGVYVQPINYPTVPRGTERLRFTPTPFHTDDMMRKLVAAMEKLWAHCNV
ARMGGYAA

Sequences:

>Translated_408_residues
MDYKAAFRSAVEQIREEGRYRVFADLKRQRGQFPRATWTRQDGSEHEVVVWCSNDYLGQGQNPVVLEAMKAAVDEHGSGS
GGTRNISGTNHDHVLLEQELADLHGKEAGLLFTSGYVSNEATLSVVQKILPGLIIFSDELNHASMIAGIRNGGGPRKIFK
HNDLAHLEQLLAEAPADAPKLIAFESVYSMDGDIADLAGTVALAKKYGAMTYLDEVHAVGMYGPRGGGVAERDGLMGEID
IIEGTLGKAFGVMGGYITGDAEVIDAIRLMASGFIFTTSLPPALTAGALASVRWLKQHPEVREIHQERAATLKAMFKAAG
LPVMDSVSHIVPVLVGDPVHCKMISDMLLADFGVYVQPINYPTVPRGTERLRFTPTPFHTDDMMRKLVAAMEKLWAHCNV
ARMGGYAA
>Mature_408_residues
MDYKAAFRSAVEQIREEGRYRVFADLKRQRGQFPRATWTRQDGSEHEVVVWCSNDYLGQGQNPVVLEAMKAAVDEHGSGS
GGTRNISGTNHDHVLLEQELADLHGKEAGLLFTSGYVSNEATLSVVQKILPGLIIFSDELNHASMIAGIRNGGGPRKIFK
HNDLAHLEQLLAEAPADAPKLIAFESVYSMDGDIADLAGTVALAKKYGAMTYLDEVHAVGMYGPRGGGVAERDGLMGEID
IIEGTLGKAFGVMGGYITGDAEVIDAIRLMASGFIFTTSLPPALTAGALASVRWLKQHPEVREIHQERAATLKAMFKAAG
LPVMDSVSHIVPVLVGDPVHCKMISDMLLADFGVYVQPINYPTVPRGTERLRFTPTPFHTDDMMRKLVAAMEKLWAHCNV
ARMGGYAA

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=417, Percent_Identity=46.7625899280576, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI83977440, Length=417, Percent_Identity=46.7625899280576, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI83977444, Length=417, Percent_Identity=46.7625899280576, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI4502025, Length=417, Percent_Identity=47.4820143884892, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI40316939, Length=417, Percent_Identity=47.4820143884892, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI7657118, Length=354, Percent_Identity=35.0282485875706, Blast_Score=215, Evalue=7e-56,
Organism=Homo sapiens, GI284448556, Length=346, Percent_Identity=34.971098265896, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI4758668, Length=351, Percent_Identity=33.048433048433, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI119220554, Length=347, Percent_Identity=30.5475504322767, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI5454084, Length=290, Percent_Identity=30.6896551724138, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1790046, Length=387, Percent_Identity=34.8837209302326, Blast_Score=211, Evalue=5e-56,
Organism=Escherichia coli, GI1786993, Length=339, Percent_Identity=32.7433628318584, Blast_Score=150, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71994529, Length=401, Percent_Identity=33.1670822942643, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI32566772, Length=378, Percent_Identity=31.7460317460317, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17560914, Length=378, Percent_Identity=30.1587301587302, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17560912, Length=378, Percent_Identity=30.1587301587302, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71982617, Length=241, Percent_Identity=29.045643153527, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71982625, Length=241, Percent_Identity=29.045643153527, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320438, Length=425, Percent_Identity=46.3529411764706, Blast_Score=388, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6320267, Length=350, Percent_Identity=30.8571428571429, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6323954, Length=272, Percent_Identity=26.8382352941176, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI17137420, Length=397, Percent_Identity=49.8740554156171, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24662918, Length=358, Percent_Identity=36.5921787709497, Blast_Score=241, Evalue=8e-64,
Organism=Drosophila melanogaster, GI17136286, Length=384, Percent_Identity=28.6458333333333, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24653280, Length=282, Percent_Identity=29.7872340425532, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24653276, Length=282, Percent_Identity=29.7872340425532, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24653278, Length=282, Percent_Identity=29.7872340425532, Blast_Score=122, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 44274; Mature: 44274

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKAAFRSAVEQIREEGRYRVFADLKRQRGQFPRATWTRQDGSEHEVVVWCSNDYLGQG
CCHHHHHHHHHHHHHHCCCEEEHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCC
QNPVVLEAMKAAVDEHGSGSGGTRNISGTNHDHVLLEQELADLHGKEAGLLFTSGYVSNE
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEHHHHHHHHCCCCCCEEEECCCCCCH
ATLSVVQKILPGLIIFSDELNHASMIAGIRNGGGPRKIFKHNDLAHLEQLLAEAPADAPK
HHHHHHHHHHCCEEEEECCCCHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHCCCCCCH
LIAFESVYSMDGDIADLAGTVALAKKYGAMTYLDEVHAVGMYGPRGGGVAERDGLMGEID
HEEHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEE
IIEGTLGKAFGVMGGYITGDAEVIDAIRLMASGFIFTTSLPPALTAGALASVRWLKQHPE
EECCHHHHHHHHCCCEECCCHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHCCH
VREIHQERAATLKAMFKAAGLPVMDSVSHIVPVLVGDPVHCKMISDMLLADFGVYVQPIN
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECC
YPTVPRGTERLRFTPTPFHTDDMMRKLVAAMEKLWAHCNVARMGGYAA
CCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCC
>Mature Secondary Structure
MDYKAAFRSAVEQIREEGRYRVFADLKRQRGQFPRATWTRQDGSEHEVVVWCSNDYLGQG
CCHHHHHHHHHHHHHHCCCEEEHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCC
QNPVVLEAMKAAVDEHGSGSGGTRNISGTNHDHVLLEQELADLHGKEAGLLFTSGYVSNE
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEHHHHHHHHCCCCCCEEEECCCCCCH
ATLSVVQKILPGLIIFSDELNHASMIAGIRNGGGPRKIFKHNDLAHLEQLLAEAPADAPK
HHHHHHHHHHCCEEEEECCCCHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHCCCCCCH
LIAFESVYSMDGDIADLAGTVALAKKYGAMTYLDEVHAVGMYGPRGGGVAERDGLMGEID
HEEHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEE
IIEGTLGKAFGVMGGYITGDAEVIDAIRLMASGFIFTTSLPPALTAGALASVRWLKQHPE
EECCHHHHHHHHCCCEECCCHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHCCH
VREIHQERAATLKAMFKAAGLPVMDSVSHIVPVLVGDPVHCKMISDMLLADFGVYVQPIN
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECC
YPTVPRGTERLRFTPTPFHTDDMMRKLVAAMEKLWAHCNVARMGGYAA
CCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034217 [H]