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The map label for this gene is mmsB [H]

Identifier: 16125603

GI number: 16125603

Start: 1507740

End: 1508636

Strand: Direct

Name: mmsB [H]

Synonym: CC_1354

Alternate gene names: 16125603

Gene position: 1507740-1508636 (Clockwise)

Preceding gene: 16125602

Following gene: 16125604

Centisome position: 37.53

GC content: 68.12

Gene sequence:

>897_bases
ATGACGCGTATCGCCTTTATCGGCCTTGGCAACATGGGCGGCGGCATGGCCGCCAATCAGGCGAAGGCCCAGCATCAGGT
CCGCGCCTTCGACCTTTCAGCCGCCGCAGTGGAGCGTGCTGTCGCAGCAGGTTGTCTGGCGGCCGCCTCGGTCGCTGAAG
CCGTCGCCGAAGCCGAGATCGTCATCACCATGCTGCCGGCAGGGCCGCATGTGCGCGCGGTCTACGCCGAGCAGATCCTC
CCGAATGCGCCCAAATCCGCGCTGTTGATCGATTGTTCGACCATCGACGTGGACAGCGCCCGCGTCGTGGCCAGGCAGGC
CGCTGAGGCCGGCTTCCGGTTCGCTGACGCGCCGGTGTCCGGCGGGATCATGGCTGCAGAGGCGGGAACCCTGGCCTTCA
TGGTCGGCTGCGAGGCGAGCGACTTTGCCGCCGTGGAGGCCGCCTTGGCGCCGATGTCGCGCGTGACCATCCACGCCGGC
GACCATGGGGCGGGGCAGGCGGCCAAGATCTGCAACAACATGCTGCTGGGCGTCTCGATGCTGGGGACCTGCGAGGCCTT
CGCCCTGGCCGAGAAGCTGGGTCTGGCGGCCGACCGCTTCTTCGAGATCGCCAGCAAATCATCGGGCCAGTGCTGGTCGA
TCACCTCGTACTGCCCGGTGCCGGGCGTGGGGCCGCAGACGCCCGCAGATCGCGGCTACGAGGGCGGCTTCGCCTCGGCG
ATGATGCTGAAGGATCTCAAGCTGGCTCAGGAAGCCGCCGCCAAGGCCGGCGCCTCGACGCCGATGGGGGCGCAGGCCGA
GGCGCTTTACGCGCTGTTCGACGCCAACGGCTTTGGCGGCAAGGACTTCTCGGCCGTCATCGAGTTACTGCGCGGAAGGG
TGGCCGATCTGCATTGA

Upstream 100 bases:

>100_bases
TCTACAAGTTCCGCAAGCCGGCGCGCTAAGAAAGCTGATTAAAATCAACGATAAGAGCCGCGCCCATGAGGCGCGGTTCG
CTTTTGCAGGGAGTTCTTCG

Downstream 100 bases:

>100_bases
ATCGGCCAAGAGATGACGGTTCGGGGCGTGTATCGAGAAACTCGATCAAGGCCATCAGGCCTTTCGATTTGCTAGGTAAA
CGCCCTTAGATGGACACTGC

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MTRIAFIGLGNMGGGMAANQAKAQHQVRAFDLSAAAVERAVAAGCLAAASVAEAVAEAEIVITMLPAGPHVRAVYAEQIL
PNAPKSALLIDCSTIDVDSARVVARQAAEAGFRFADAPVSGGIMAAEAGTLAFMVGCEASDFAAVEAALAPMSRVTIHAG
DHGAGQAAKICNNMLLGVSMLGTCEAFALAEKLGLAADRFFEIASKSSGQCWSITSYCPVPGVGPQTPADRGYEGGFASA
MMLKDLKLAQEAAAKAGASTPMGAQAEALYALFDANGFGGKDFSAVIELLRGRVADLH

Sequences:

>Translated_298_residues
MTRIAFIGLGNMGGGMAANQAKAQHQVRAFDLSAAAVERAVAAGCLAAASVAEAVAEAEIVITMLPAGPHVRAVYAEQIL
PNAPKSALLIDCSTIDVDSARVVARQAAEAGFRFADAPVSGGIMAAEAGTLAFMVGCEASDFAAVEAALAPMSRVTIHAG
DHGAGQAAKICNNMLLGVSMLGTCEAFALAEKLGLAADRFFEIASKSSGQCWSITSYCPVPGVGPQTPADRGYEGGFASA
MMLKDLKLAQEAAAKAGASTPMGAQAEALYALFDANGFGGKDFSAVIELLRGRVADLH
>Mature_297_residues
TRIAFIGLGNMGGGMAANQAKAQHQVRAFDLSAAAVERAVAAGCLAAASVAEAVAEAEIVITMLPAGPHVRAVYAEQILP
NAPKSALLIDCSTIDVDSARVVARQAAEAGFRFADAPVSGGIMAAEAGTLAFMVGCEASDFAAVEAALAPMSRVTIHAGD
HGAGQAAKICNNMLLGVSMLGTCEAFALAEKLGLAADRFFEIASKSSGQCWSITSYCPVPGVGPQTPADRGYEGGFASAM
MLKDLKLAQEAAAKAGASTPMGAQAEALYALFDANGFGGKDFSAVIELLRGRVADLH

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=292, Percent_Identity=42.1232876712329, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI40556376, Length=288, Percent_Identity=24.6527777777778, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI145693186, Length=287, Percent_Identity=32.0557491289199, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1790315, Length=299, Percent_Identity=33.7792642140468, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786719, Length=291, Percent_Identity=28.8659793814433, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1789092, Length=304, Percent_Identity=25.9868421052632, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17557316, Length=295, Percent_Identity=41.6949152542373, Blast_Score=211, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24655230, Length=289, Percent_Identity=43.598615916955, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI19922568, Length=289, Percent_Identity=43.598615916955, Blast_Score=243, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 30297; Mature: 30166

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRIAFIGLGNMGGGMAANQAKAQHQVRAFDLSAAAVERAVAAGCLAAASVAEAVAEAEI
CCEEEEEEECCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
VITMLPAGPHVRAVYAEQILPNAPKSALLIDCSTIDVDSARVVARQAAEAGFRFADAPVS
EEEEECCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEECCCCC
GGIMAAEAGTLAFMVGCEASDFAAVEAALAPMSRVTIHAGDHGAGQAAKICNNMLLGVSM
CCEEEECCCCEEEEEECCCCHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHH
LGTCEAFALAEKLGLAADRFFEIASKSSGQCWSITSYCPVPGVGPQTPADRGYEGGFASA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHH
MMLKDLKLAQEAAAKAGASTPMGAQAEALYALFDANGFGGKDFSAVIELLRGRVADLH
HHHHHHHHHHHHHHHCCCCCCCCCCHHHEEEEEECCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TRIAFIGLGNMGGGMAANQAKAQHQVRAFDLSAAAVERAVAAGCLAAASVAEAVAEAEI
CEEEEEEECCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
VITMLPAGPHVRAVYAEQILPNAPKSALLIDCSTIDVDSARVVARQAAEAGFRFADAPVS
EEEEECCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEECCCCC
GGIMAAEAGTLAFMVGCEASDFAAVEAALAPMSRVTIHAGDHGAGQAAKICNNMLLGVSM
CCEEEECCCCEEEEEECCCCHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHH
LGTCEAFALAEKLGLAADRFFEIASKSSGQCWSITSYCPVPGVGPQTPADRGYEGGFASA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHH
MMLKDLKLAQEAAAKAGASTPMGAQAEALYALFDANGFGGKDFSAVIELLRGRVADLH
HHHHHHHHHHHHHHHCCCCCCCCCCHHHEEEEEECCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1339433; 10984043 [H]