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The map label for this gene is crt [H]

Identifier: 16125601

GI number: 16125601

Start: 1505760

End: 1506812

Strand: Direct

Name: crt [H]

Synonym: CC_1352

Alternate gene names: 16125601

Gene position: 1505760-1506812 (Clockwise)

Preceding gene: 16125600

Following gene: 16125602

Centisome position: 37.49

GC content: 66.38

Gene sequence:

>1053_bases
ATGACCGACGACCCTGAAGTCCTGATCCGCGTCGAGAAGAACGTCGGCCGCATCACGCTGAACCGGCCCAAGGCGCTGCA
TGCCCTGACGCTTGGCATGTGCGAGACCATGATCGGCGCGCTGCTGGACTGGCAGGATGACCCCGAGGTCTACATGGTCC
TGATCGACCATACGGGCGAGCGCGGCTTCTGCGCCGGCGGCGATATCCGCATGCTGGCCGACAGCGGCGCCAAGGACGGC
GTCGAGGCGCGCCGGTTCTTCCACACCGAGTACCAGCTGAACCACCTGCTGTTCACCTACGAGACTCCGGTCGTCGCGGT
GATGGACGGGATCGTGATGGGCGGTGGTGTCGGGATCTCGATGCCGGCCCACATCCGGATCGCTACCGAGCGCACCACCT
TCGCCATGCCGGAGACGGGCATCGGCCTGTTCCCGGACGTCGGGGGTGGCTGGTACCTGCCGCGCCTGCCGGGCAAGGCC
GGGCTGTGGCTGGCGCTGACGGGCGCCCGGATCAAGGGCGCGGACTGCATGCGCCTGGGCATCGCCACCCACTTCGTCGA
GTTCGGCGCCGTGGAGGGCCTGAAGAAGGCGATCATCGCAGATCCGCGTCGCATCGAGGAGACGCTGCGCAAGTACCGCG
CCGACGCCGGCAAGGCCTCGCTCCTGGGCTTCGAACAGGATCTGAACCGGTTGTTCGTCGGCGAAAGCGTCGAGGAGATC
TTCGAGTTCCTGACCCTCGACTCCAGCGACTGGGGCAAGGCGCAGCTGGAGGTCATGAAGACCAAGTCGCCCCAGACCCT
CAAGGTGGCTTTCGAGCAGCTGAAACGCGGTGCGGCGATGGAGGACTTCGCCGACAACATGGCCATGGAGTACCGGATCG
GCTCGCGCGTGGTGATGAAGCATGACTTCATCGAGGGCGTGCGGGCCGTGATCGTCGACAAGGACAACGCGCCCCGCTGG
TCGCCGGCGCGGGTCGAGGATGTCACGGACGCCGCACTGGCCGAGATTTTTGCACCTCTTCCGCCGGGCGAAGAGTGGAC
ACCGCTGACGTAG

Upstream 100 bases:

>100_bases
TGCGGCTCGATATCCCTCAGGACGCCATCTATCGCCTCGCCAACGGCCAGATCGACCGCTTCGACTGCGCGCCGATCGAC
GAACCCGCATAGGACTTGCC

Downstream 100 bases:

>100_bases
CGGACGTCGTGCGCTAACGTGTCCGGAAACAAGAACACGTCGGTTCGGAAGGATTGCCATGCGTAAGCCGCTGCTAAGTC
TCGTCGCTGTGCTGGGTTTG

Product: enoyl-CoA hydratase/isomerase family protein

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MTDDPEVLIRVEKNVGRITLNRPKALHALTLGMCETMIGALLDWQDDPEVYMVLIDHTGERGFCAGGDIRMLADSGAKDG
VEARRFFHTEYQLNHLLFTYETPVVAVMDGIVMGGGVGISMPAHIRIATERTTFAMPETGIGLFPDVGGGWYLPRLPGKA
GLWLALTGARIKGADCMRLGIATHFVEFGAVEGLKKAIIADPRRIEETLRKYRADAGKASLLGFEQDLNRLFVGESVEEI
FEFLTLDSSDWGKAQLEVMKTKSPQTLKVAFEQLKRGAAMEDFADNMAMEYRIGSRVVMKHDFIEGVRAVIVDKDNAPRW
SPARVEDVTDAALAEIFAPLPPGEEWTPLT

Sequences:

>Translated_350_residues
MTDDPEVLIRVEKNVGRITLNRPKALHALTLGMCETMIGALLDWQDDPEVYMVLIDHTGERGFCAGGDIRMLADSGAKDG
VEARRFFHTEYQLNHLLFTYETPVVAVMDGIVMGGGVGISMPAHIRIATERTTFAMPETGIGLFPDVGGGWYLPRLPGKA
GLWLALTGARIKGADCMRLGIATHFVEFGAVEGLKKAIIADPRRIEETLRKYRADAGKASLLGFEQDLNRLFVGESVEEI
FEFLTLDSSDWGKAQLEVMKTKSPQTLKVAFEQLKRGAAMEDFADNMAMEYRIGSRVVMKHDFIEGVRAVIVDKDNAPRW
SPARVEDVTDAALAEIFAPLPPGEEWTPLT
>Mature_349_residues
TDDPEVLIRVEKNVGRITLNRPKALHALTLGMCETMIGALLDWQDDPEVYMVLIDHTGERGFCAGGDIRMLADSGAKDGV
EARRFFHTEYQLNHLLFTYETPVVAVMDGIVMGGGVGISMPAHIRIATERTTFAMPETGIGLFPDVGGGWYLPRLPGKAG
LWLALTGARIKGADCMRLGIATHFVEFGAVEGLKKAIIADPRRIEETLRKYRADAGKASLLGFEQDLNRLFVGESVEEIF
EFLTLDSSDWGKAQLEVMKTKSPQTLKVAFEQLKRGAAMEDFADNMAMEYRIGSRVVMKHDFIEGVRAVIVDKDNAPRWS
PARVEDVTDAALAEIFAPLPPGEEWTPLT

Specific function: Catalyzes The Reversible Dehydration Of L-Carnitinyl-CoA To Crotobetainyl-CoA. [C]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI37594471, Length=344, Percent_Identity=43.3139534883721, Blast_Score=280, Evalue=1e-75,
Organism=Homo sapiens, GI37594469, Length=299, Percent_Identity=42.809364548495, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI194097323, Length=240, Percent_Identity=30, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI68989263, Length=169, Percent_Identity=33.7278106508876, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI221142681, Length=170, Percent_Identity=31.1764705882353, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788682, Length=177, Percent_Identity=26.5536723163842, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787660, Length=186, Percent_Identity=32.258064516129, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788597, Length=155, Percent_Identity=29.6774193548387, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787659, Length=180, Percent_Identity=27.7777777777778, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI25144157, Length=352, Percent_Identity=40.3409090909091, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI25144160, Length=352, Percent_Identity=40.3409090909091, Blast_Score=268, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI25145438, Length=174, Percent_Identity=31.0344827586207, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17554946, Length=186, Percent_Identity=31.7204301075269, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17540714, Length=198, Percent_Identity=26.2626262626263, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17558304, Length=184, Percent_Identity=30.4347826086957, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17508951, Length=190, Percent_Identity=28.9473684210526, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25144276, Length=190, Percent_Identity=28.9473684210526, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17508953, Length=190, Percent_Identity=28.9473684210526, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320241, Length=379, Percent_Identity=31.9261213720317, Blast_Score=171, Evalue=2e-43,
Organism=Drosophila melanogaster, GI28571730, Length=342, Percent_Identity=43.859649122807, Blast_Score=285, Evalue=3e-77,
Organism=Drosophila melanogaster, GI28571729, Length=342, Percent_Identity=43.859649122807, Blast_Score=285, Evalue=3e-77,
Organism=Drosophila melanogaster, GI20129971, Length=175, Percent_Identity=30.8571428571429, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24653477, Length=175, Percent_Identity=30.8571428571429, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24653139, Length=193, Percent_Identity=29.5336787564767, Blast_Score=78, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 38642; Mature: 38511

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDDPEVLIRVEKNVGRITLNRPKALHALTLGMCETMIGALLDWQDDPEVYMVLIDHTGE
CCCCCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCC
RGFCAGGDIRMLADSGAKDGVEARRFFHTEYQLNHLLFTYETPVVAVMDGIVMGGGVGIS
CCEECCCCEEEEECCCCCCCHHHHHHHHHHEEEEEEEEEECCCHHHHHCCEEECCCCCCC
MPAHIRIATERTTFAMPETGIGLFPDVGGGWYLPRLPGKAGLWLALTGARIKGADCMRLG
CCCEEEEEECCEEEECCCCCCCCCCCCCCCEECCCCCCCCCEEEEEECCEECCCCHHHHH
IATHFVEFGAVEGLKKAIIADPRRIEETLRKYRADAGKASLLGFEQDLNRLFVGESVEEI
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHEECHHHHHHHHHCCCCHHHH
FEFLTLDSSDWGKAQLEVMKTKSPQTLKVAFEQLKRGAAMEDFADNMAMEYRIGSRVVMK
HHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHCCEEEEECCCEEEEH
HDFIEGVRAVIVDKDNAPRWSPARVEDVTDAALAEIFAPLPPGEEWTPLT
HHHHHCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TDDPEVLIRVEKNVGRITLNRPKALHALTLGMCETMIGALLDWQDDPEVYMVLIDHTGE
CCCCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCC
RGFCAGGDIRMLADSGAKDGVEARRFFHTEYQLNHLLFTYETPVVAVMDGIVMGGGVGIS
CCEECCCCEEEEECCCCCCCHHHHHHHHHHEEEEEEEEEECCCHHHHHCCEEECCCCCCC
MPAHIRIATERTTFAMPETGIGLFPDVGGGWYLPRLPGKAGLWLALTGARIKGADCMRLG
CCCEEEEEECCEEEECCCCCCCCCCCCCCCEECCCCCCCCCEEEEEECCEECCCCHHHHH
IATHFVEFGAVEGLKKAIIADPRRIEETLRKYRADAGKASLLGFEQDLNRLFVGESVEEI
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHEECHHHHHHHHHCCCCHHHH
FEFLTLDSSDWGKAQLEVMKTKSPQTLKVAFEQLKRGAAMEDFADNMAMEYRIGSRVVMK
HHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHCCEEEEECCCEEEEH
HDFIEGVRAVIVDKDNAPRWSPARVEDVTDAALAEIFAPLPPGEEWTPLT
HHHHHCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]