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The map label for this gene is degP [C]

Identifier: 16125531

GI number: 16125531

Start: 1428438

End: 1429856

Strand: Direct

Name: degP [C]

Synonym: CC_1282

Alternate gene names: 16125531

Gene position: 1428438-1429856 (Clockwise)

Preceding gene: 16125530

Following gene: 16125532

Centisome position: 35.56

GC content: 68.08

Gene sequence:

>1419_bases
GTGACCAACATGCGCAAGCTTCGCGCCCTGCTGCCCGTCTTCGTCCTGCTGACCGCCTGCTCGAACCCGGCCGGCCCGTC
GAACGCCCAGTCGATCCCGGACATGCCTCAGCCCACGCGCCAGGTTCCGGCCGACGCGGCCTCGATGAAGCAGTCGTTCT
CGCCCGTCGTGAAGAAGGCTGCGCCGGCCGTGGTCAATGTCGCCAGCCGCCGCCTGGTCCAGCGTCGCGTCGATCCGTTC
TGGGACTTCTTCATGGGCGGCGGGCAGGGCGGCTCGCAGGTGCAAAGCTCGCTGGGATCCGGCGCGATCGTCCGCGCCGA
CGGCGTGATCATCACCAATCACCACAATATCAACGGGATGAGCGACATCACCATCCAGTTGGCCGACCGGCGTGAGTTCC
CGGCGGTGGTGCTGCTGGATGACCCGCGCGCCGACCTCGCCGTGCTGAAGATCGACACCAAGGGCGAGAAGCTGCCGGTC
ATGGCCATCGACGACCAGGAGCAGCTGGAGGTCGGCGATCTGGTGCTGGCCATGGGCAATCCGTTCGGCGTGGGTCAGAC
CGTCACCAACGGCATCGTCTCAGCCCTGGCGCGGACCGATGTCGGCGCGGCCGACTTCGGCAGCTACATCCAGACCGATG
CGGCGATCAATCCGGGCAATTCCGGCGGTCCGCTGGTCGACATGGACGGCGATCTGGTCGGCATCAACACCTTCATCATT
TCGCGTTCGGGTTCGTCGTCGGGCGTCGGCTTCGCCATTCCGGCGCGCGTCGTGCGTCAGGTGGTCAACGCCGCGCTGGG
CGGCGGGCATAGCATTGTCCGGCCCTGGCTGGGCGTGAAGGGCCAGGCCGTCACGGGCGACATCGCCAAGAGCCTGGGCA
TGACCGCCCCGCGCGGCGTGCTTGTGGCCCAGATCTATCCGGGCTCTTCGGCCGAGCGCGCTGGTCTGAAGGAAGGCGAC
GTGATCCTGTCGATCGACGGCCAGCCGGTGAACGACGAAGGCGGCGGCGCCTTTGCGATTGGAACCCACAAGGTCGGCGA
CCGCGTGCCGATGCAAATCCGTCGCGGCGACCGCGAGCTGACCATCACGGTCCGCGCCGACGCCGCGCCGGAAACCCCGG
CCCGCGACGAGCGCACCCTCAGCGGCAATAACCCGTTCAACGGCGCGACGGTGATGAACCTGTCGCCGGCCGTCGCGCAG
GACCTGGGCGTGGATCCGTTCGCCGGGCGCGGCGCGCTGGTGACCAAGATCGGACCCGGCTATGCGGGCAACTGGATGCG
TCCTGGCGACTTCGTGCGCAGCGTCAATGGTCGCCAGATCAACACGGTGGCTGACCTCGCCTCGGCCATCGCCGGTCGGT
CTGGCCGTTGGAGCGTCACCATCGAGCGTGGCGGCCAGTTGATCCAGGCGCAGTTCTAG

Upstream 100 bases:

>100_bases
CGGCTTGACGGTTTTGGGCATGGCCAAACCTCGACCTTTCGTCGCCTTAGACTCGCCCGAAAGCTGGGCTGAGGTTTCGG
CGAACCGCTAGGAGTCCTTC

Downstream 100 bases:

>100_bases
GTTTGGAGCCGCCCCCGGCGGCTTGCCGTTCCTCTATTGATGAACGGCCCCCTTTCTTGGAGCGTGGCGGGCGGCGAAAC
CGCTCACACTTTCGCCTGCC

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MTNMRKLRALLPVFVLLTACSNPAGPSNAQSIPDMPQPTRQVPADAASMKQSFSPVVKKAAPAVVNVASRRLVQRRVDPF
WDFFMGGGQGGSQVQSSLGSGAIVRADGVIITNHHNINGMSDITIQLADRREFPAVVLLDDPRADLAVLKIDTKGEKLPV
MAIDDQEQLEVGDLVLAMGNPFGVGQTVTNGIVSALARTDVGAADFGSYIQTDAAINPGNSGGPLVDMDGDLVGINTFII
SRSGSSSGVGFAIPARVVRQVVNAALGGGHSIVRPWLGVKGQAVTGDIAKSLGMTAPRGVLVAQIYPGSSAERAGLKEGD
VILSIDGQPVNDEGGGAFAIGTHKVGDRVPMQIRRGDRELTITVRADAAPETPARDERTLSGNNPFNGATVMNLSPAVAQ
DLGVDPFAGRGALVTKIGPGYAGNWMRPGDFVRSVNGRQINTVADLASAIAGRSGRWSVTIERGGQLIQAQF

Sequences:

>Translated_472_residues
MTNMRKLRALLPVFVLLTACSNPAGPSNAQSIPDMPQPTRQVPADAASMKQSFSPVVKKAAPAVVNVASRRLVQRRVDPF
WDFFMGGGQGGSQVQSSLGSGAIVRADGVIITNHHNINGMSDITIQLADRREFPAVVLLDDPRADLAVLKIDTKGEKLPV
MAIDDQEQLEVGDLVLAMGNPFGVGQTVTNGIVSALARTDVGAADFGSYIQTDAAINPGNSGGPLVDMDGDLVGINTFII
SRSGSSSGVGFAIPARVVRQVVNAALGGGHSIVRPWLGVKGQAVTGDIAKSLGMTAPRGVLVAQIYPGSSAERAGLKEGD
VILSIDGQPVNDEGGGAFAIGTHKVGDRVPMQIRRGDRELTITVRADAAPETPARDERTLSGNNPFNGATVMNLSPAVAQ
DLGVDPFAGRGALVTKIGPGYAGNWMRPGDFVRSVNGRQINTVADLASAIAGRSGRWSVTIERGGQLIQAQF
>Mature_471_residues
TNMRKLRALLPVFVLLTACSNPAGPSNAQSIPDMPQPTRQVPADAASMKQSFSPVVKKAAPAVVNVASRRLVQRRVDPFW
DFFMGGGQGGSQVQSSLGSGAIVRADGVIITNHHNINGMSDITIQLADRREFPAVVLLDDPRADLAVLKIDTKGEKLPVM
AIDDQEQLEVGDLVLAMGNPFGVGQTVTNGIVSALARTDVGAADFGSYIQTDAAINPGNSGGPLVDMDGDLVGINTFIIS
RSGSSSGVGFAIPARVVRQVVNAALGGGHSIVRPWLGVKGQAVTGDIAKSLGMTAPRGVLVAQIYPGSSAERAGLKEGDV
ILSIDGQPVNDEGGGAFAIGTHKVGDRVPMQIRRGDRELTITVRADAAPETPARDERTLSGNNPFNGATVMNLSPAVAQD
LGVDPFAGRGALVTKIGPGYAGNWMRPGDFVRSVNGRQINTVADLASAIAGRSGRWSVTIERGGQLIQAQF

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=339, Percent_Identity=33.9233038348083, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI7019477, Length=326, Percent_Identity=36.8098159509202, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI24308541, Length=330, Percent_Identity=34.2424242424242, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI22129776, Length=332, Percent_Identity=32.2289156626506, Blast_Score=153, Evalue=3e-37,
Organism=Escherichia coli, GI1786356, Length=455, Percent_Identity=32.967032967033, Blast_Score=225, Evalue=6e-60,
Organism=Escherichia coli, GI1789629, Length=473, Percent_Identity=35.0951374207188, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI1789630, Length=325, Percent_Identity=34.7692307692308, Blast_Score=177, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24646839, Length=317, Percent_Identity=30.2839116719243, Blast_Score=128, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 49207; Mature: 49075

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNMRKLRALLPVFVLLTACSNPAGPSNAQSIPDMPQPTRQVPADAASMKQSFSPVVKKA
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHH
APAVVNVASRRLVQRRVDPFWDFFMGGGQGGSQVQSSLGSGAIVRADGVIITNHHNINGM
CCHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHCCCCEEEEECCEEEECCCCCCCC
SDITIQLADRREFPAVVLLDDPRADLAVLKIDTKGEKLPVMAIDDQEQLEVGDLVLAMGN
CEEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCEEEEEEECCHHHHECCEEEEECCC
PFGVGQTVTNGIVSALARTDVGAADFGSYIQTDAAINPGNSGGPLVDMDGDLVGINTFII
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCEEECCCCEEEEEEEEE
SRSGSSSGVGFAIPARVVRQVVNAALGGGHSIVRPWLGVKGQAVTGDIAKSLGMTAPRGV
ECCCCCCCCCEECHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEECHHHHHHHCCCCCCCE
LVAQIYPGSSAERAGLKEGDVILSIDGQPVNDEGGGAFAIGTHKVGDRVPMQIRRGDREL
EEEEECCCCCHHHCCCCCCCEEEEECCEECCCCCCEEEEEECCCCCCCCCHHEECCCEEE
TITVRADAAPETPARDERTLSGNNPFNGATVMNLSPAVAQDLGVDPFAGRGALVTKIGPG
EEEEEECCCCCCCCCCCCEECCCCCCCCEEEEECCHHHHHHCCCCCCCCCCEEEEECCCC
YAGNWMRPGDFVRSVNGRQINTVADLASAIAGRSGRWSVTIERGGQLIQAQF
CCCCCCCCHHHHHCCCCCEEHHHHHHHHHHCCCCCCEEEEEECCCCEEEECC
>Mature Secondary Structure 
TNMRKLRALLPVFVLLTACSNPAGPSNAQSIPDMPQPTRQVPADAASMKQSFSPVVKKA
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHH
APAVVNVASRRLVQRRVDPFWDFFMGGGQGGSQVQSSLGSGAIVRADGVIITNHHNINGM
CCHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHCCCCEEEEECCEEEECCCCCCCC
SDITIQLADRREFPAVVLLDDPRADLAVLKIDTKGEKLPVMAIDDQEQLEVGDLVLAMGN
CEEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCEEEEEEECCHHHHECCEEEEECCC
PFGVGQTVTNGIVSALARTDVGAADFGSYIQTDAAINPGNSGGPLVDMDGDLVGINTFII
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCEEECCCCEEEEEEEEE
SRSGSSSGVGFAIPARVVRQVVNAALGGGHSIVRPWLGVKGQAVTGDIAKSLGMTAPRGV
ECCCCCCCCCEECHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEECHHHHHHHCCCCCCCE
LVAQIYPGSSAERAGLKEGDVILSIDGQPVNDEGGGAFAIGTHKVGDRVPMQIRRGDREL
EEEEECCCCCHHHCCCCCCCEEEEECCEECCCCCCEEEEEECCCCCCCCCHHEECCCEEE
TITVRADAAPETPARDERTLSGNNPFNGATVMNLSPAVAQDLGVDPFAGRGALVTKIGPG
EEEEEECCCCCCCCCCCCEECCCCCCCCEEEEECCHHHHHHCCCCCCCCCCEEEEECCCC
YAGNWMRPGDFVRSVNGRQINTVADLASAIAGRSGRWSVTIERGGQLIQAQF
CCCCCCCCHHHHHCCCCCEEHHHHHHHHHHCCCCCCEEEEEECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]