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The map label for this gene is tetA [H]

Identifier: 16125530

GI number: 16125530

Start: 1426585

End: 1428345

Strand: Direct

Name: tetA [H]

Synonym: CC_1281

Alternate gene names: 16125530

Gene position: 1426585-1428345 (Clockwise)

Preceding gene: 16125529

Following gene: 16125531

Centisome position: 35.51

GC content: 66.61

Gene sequence:

>1761_bases
ATGTGGAGAGCAAGGCGCGGTGAACTCTCGAATTGTTGTGTCTCTTCGCATCGCCGCCTCGCCCGAGGTCGTGTTCGACG
CCTTCGTCGACGACATCGCCGTTTGGTGGCGGCCCAATGGGCTGTTCGCCTTCACGCCGCGCTCGCCGGGCGTGATGGCC
TTCGAGGATGGCCGGCTGGTGGAGCGTTTGCCCAATGGCAAGGTGTTCGAGGTCGGCGTCGTCAGCGTCTGGGAGCGCGG
CGCGCGACTGGTGTTCGGCTGGCGTCAGGCCGCCTTCACCCCGGACATGAACACCGAGGTCGAGGTCCGTTTCGAAGCGG
TGGGCGAGGGGACCCGCGTCACGGTCGAGCATCGCGGCTGGGACAGCGTGCCTGCGCCGCACGTGGCGCGTCATGGCTTT
CCCAATGCGGCTTTCCTGGCCCGACATGGGGAATGGTGGCGCAACCTTCTGGCCGGGCTTGCGGCGCGGGCCAACAGCGT
CCACCTAGGGGCGGGCGACGAGGGGCTGTCATGAACACGACGATCACGGGCGGACGGCGTCAGGCCGCCCTGGGCTTCAT
CTTCGTCACCGCCATCCTGGATGTGCTGTCGCTCGGCGTGATGATCCCGGTGCTGCCGAACCTGGTGAAGGCGTTCGGCG
GCGGCGATACGGCCGCGGCGGCCGACTGGAACGTGCTGTTCGCCACCACCTGGGGCGTGATGCAGTTCATCTGCTCGCCG
ATCCTGGGCTTGCTGTCCGACCGCTTCGGCCGACGGCCGGTGATCCTGACCTCGATCTTTGGTCTCGGCATCGACTTCCT
GTTTATGGCCTTTGCGCCGAACCTCTGGTGGCTGTTCATCGGCCGGATCTTCAACGGCATGACGGCGGCCAGTTTCTCGA
CCGCCAGCGCCTATGTGGCCGATGTCACCACGCCGGAGAACCGGGCCAAGGGCTTTGGTCTGATGGGCGCGGCGTTCGGG
ATCGGCTTCACCTTCGGCCCGGCGCTGGGCGGGTGGCTGTGGGAGTTCGACCACCGCGCGCCGTTCCTGGTCTGCGCAGC
CCTGGCCCTCACCAACTGGCTTTACGGCTTCTTCGTGCTGCCGGAGTCGCTGCCGCCCGAGCGTCGCCAGCCGCGCTTCG
ACTGGAAGAAGGCCAATCCGATCGGCTCGCTGCAACTGCTGCGTCACCATCCGGGCCTGATGGGTCTGGCGGGCGTGGGC
TTCCTGTTCCAGCTGGCGCACAATGTGCTGCCCAGCGTCTTCGTGCTGTACATGGGCTTCCGCTATGGCTGGAGCCCTCA
GACGATCGGCCTGACCCTGATGGCCAGCGGGATCGCCAGCATCCTGATCCAGGCGTTCGTTGTCGGCCCTGCGGTGAAGC
GGTTGGGTGAGCGCGGCGTGCTGCTGATCGGGCTGTTTGCAGGCTTCCTGGGCTTTTCGATCTACGCCTTGGCGCCGACG
AGCTTGCTGTACCTGGCCGGTCTGCCGATCTTCGCTTTCTCCGGTTTGATCCAGCCCGGCCTCCAGGGGCTGATGACACG
CCGGGTCGGTCCGAACGAGCAGGGCCAGCTGCAAGGCGCCAATGCGGCGATGATGGGCATCGCCTCGATCATCGGTCCGC
CGCTGTTCCTGATCCCGTTCGCCTTCGCGGTCCGTCATGACGCGACGCTGCACCTTCCGGGTCTGCCGATCCTGATCGCA
GCGGTCTTGATGCTAGCGGCGACCCTCCTAGCTTATGCCAAGGCCAAGCCCGCCCCAGCGCCGGAACCCCAGCCGGCTTG
A

Upstream 100 bases:

>100_bases
CGGGTGTATCGCCTGCGGCCCGGGCCGATGGCCGAGCTTAAGGCCTGGCTGGAGGCCGCCGAGGAGCACTGGGTCGATCA
GCTTTCGGCGCTGAAGGCGC

Downstream 100 bases:

>100_bases
CGGTTTTGGGCATGGCCAAACCTCGACCTTTCGTCGCCTTAGACTCGCCCGAAAGCTGGGCTGAGGTTTCGGCGAACCGC
TAGGAGTCCTTCGTGACCAA

Product: tetracycline resistance protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: TetA(C) [H]

Number of amino acids: Translated: 586; Mature: 586

Protein sequence:

>586_residues
MWRARRGELSNCCVSSHRRLARGRVRRLRRRHRRLVAAQWAVRLHAALAGRDGLRGWPAGGAFAQWQGVRGRRRQRLGAR
RATGVRLASGRLHPGHEHRGRGPFRSGGRGDPRHGRASRLGQRACAARGASWLSQCGFPGPTWGMVAQPSGRACGAGQQR
PPRGGRRGAVMNTTITGGRRQAALGFIFVTAILDVLSLGVMIPVLPNLVKAFGGGDTAAAADWNVLFATTWGVMQFICSP
ILGLLSDRFGRRPVILTSIFGLGIDFLFMAFAPNLWWLFIGRIFNGMTAASFSTASAYVADVTTPENRAKGFGLMGAAFG
IGFTFGPALGGWLWEFDHRAPFLVCAALALTNWLYGFFVLPESLPPERRQPRFDWKKANPIGSLQLLRHHPGLMGLAGVG
FLFQLAHNVLPSVFVLYMGFRYGWSPQTIGLTLMASGIASILIQAFVVGPAVKRLGERGVLLIGLFAGFLGFSIYALAPT
SLLYLAGLPIFAFSGLIQPGLQGLMTRRVGPNEQGQLQGANAAMMGIASIIGPPLFLIPFAFAVRHDATLHLPGLPILIA
AVLMLAATLLAYAKAKPAPAPEPQPA

Sequences:

>Translated_586_residues
MWRARRGELSNCCVSSHRRLARGRVRRLRRRHRRLVAAQWAVRLHAALAGRDGLRGWPAGGAFAQWQGVRGRRRQRLGAR
RATGVRLASGRLHPGHEHRGRGPFRSGGRGDPRHGRASRLGQRACAARGASWLSQCGFPGPTWGMVAQPSGRACGAGQQR
PPRGGRRGAVMNTTITGGRRQAALGFIFVTAILDVLSLGVMIPVLPNLVKAFGGGDTAAAADWNVLFATTWGVMQFICSP
ILGLLSDRFGRRPVILTSIFGLGIDFLFMAFAPNLWWLFIGRIFNGMTAASFSTASAYVADVTTPENRAKGFGLMGAAFG
IGFTFGPALGGWLWEFDHRAPFLVCAALALTNWLYGFFVLPESLPPERRQPRFDWKKANPIGSLQLLRHHPGLMGLAGVG
FLFQLAHNVLPSVFVLYMGFRYGWSPQTIGLTLMASGIASILIQAFVVGPAVKRLGERGVLLIGLFAGFLGFSIYALAPT
SLLYLAGLPIFAFSGLIQPGLQGLMTRRVGPNEQGQLQGANAAMMGIASIIGPPLFLIPFAFAVRHDATLHLPGLPILIA
AVLMLAATLLAYAKAKPAPAPEPQPA
>Mature_586_residues
MWRARRGELSNCCVSSHRRLARGRVRRLRRRHRRLVAAQWAVRLHAALAGRDGLRGWPAGGAFAQWQGVRGRRRQRLGAR
RATGVRLASGRLHPGHEHRGRGPFRSGGRGDPRHGRASRLGQRACAARGASWLSQCGFPGPTWGMVAQPSGRACGAGQQR
PPRGGRRGAVMNTTITGGRRQAALGFIFVTAILDVLSLGVMIPVLPNLVKAFGGGDTAAAADWNVLFATTWGVMQFICSP
ILGLLSDRFGRRPVILTSIFGLGIDFLFMAFAPNLWWLFIGRIFNGMTAASFSTASAYVADVTTPENRAKGFGLMGAAFG
IGFTFGPALGGWLWEFDHRAPFLVCAALALTNWLYGFFVLPESLPPERRQPRFDWKKANPIGSLQLLRHHPGLMGLAGVG
FLFQLAHNVLPSVFVLYMGFRYGWSPQTIGLTLMASGIASILIQAFVVGPAVKRLGERGVLLIGLFAGFLGFSIYALAPT
SLLYLAGLPIFAFSGLIQPGLQGLMTRRVGPNEQGQLQGANAAMMGIASIIGPPLFLIPFAFAVRHDATLHLPGLPILIA
AVLMLAATLLAYAKAKPAPAPEPQPA

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI39753965, Length=327, Percent_Identity=27.82874617737, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI94721311, Length=370, Percent_Identity=27.5675675675676, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI225703104, Length=166, Percent_Identity=33.7349397590361, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI225703102, Length=166, Percent_Identity=33.7349397590361, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI217416366, Length=435, Percent_Identity=23.6781609195402, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI31543204, Length=366, Percent_Identity=26.775956284153, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71996331, Length=367, Percent_Identity=24.2506811989101, Blast_Score=128, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17551570, Length=320, Percent_Identity=26.25, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24656463, Length=365, Percent_Identity=25.2054794520548, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24656468, Length=365, Percent_Identity=25.2054794520548, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI161080926, Length=365, Percent_Identity=25.2054794520548, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI161080924, Length=365, Percent_Identity=25.2054794520548, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI221513297, Length=385, Percent_Identity=27.2727272727273, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI21357569, Length=365, Percent_Identity=25.2054794520548, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI17738085, Length=342, Percent_Identity=25.4385964912281, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24667557, Length=155, Percent_Identity=32.258064516129, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24667561, Length=161, Percent_Identity=30.4347826086957, Blast_Score=94, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 63093; Mature: 63093

Theoretical pI: Translated: 12.33; Mature: 12.33

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWRARRGELSNCCVSSHRRLARGRVRRLRRRHRRLVAAQWAVRLHAALAGRDGLRGWPAG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GAFAQWQGVRGRRRQRLGARRATGVRLASGRLHPGHEHRGRGPFRSGGRGDPRHGRASRL
CCHHHHHCHHHHHHHHHCCHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
GQRACAARGASWLSQCGFPGPTWGMVAQPSGRACGAGQQRPPRGGRRGAVMNTTITGGRR
HHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCH
QAALGFIFVTAILDVLSLGVMIPVLPNLVKAFGGGDTAAAADWNVLFATTWGVMQFICSP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHH
ILGLLSDRFGRRPVILTSIFGLGIDFLFMAFAPNLWWLFIGRIFNGMTAASFSTASAYVA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHCCCCCHHEEE
DVTTPENRAKGFGLMGAAFGIGFTFGPALGGWLWEFDHRAPFLVCAALALTNWLYGFFVL
ECCCCCHHHCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
PESLPPERRQPRFDWKKANPIGSLQLLRHHPGLMGLAGVGFLFQLAHNVLPSVFVLYMGF
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RYGWSPQTIGLTLMASGIASILIQAFVVGPAVKRLGERGVLLIGLFAGFLGFSIYALAPT
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
SLLYLAGLPIFAFSGLIQPGLQGLMTRRVGPNEQGQLQGANAAMMGIASIIGPPLFLIPF
HHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHH
AFAVRHDATLHLPGLPILIAAVLMLAATLLAYAKAKPAPAPEPQPA
HHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MWRARRGELSNCCVSSHRRLARGRVRRLRRRHRRLVAAQWAVRLHAALAGRDGLRGWPAG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GAFAQWQGVRGRRRQRLGARRATGVRLASGRLHPGHEHRGRGPFRSGGRGDPRHGRASRL
CCHHHHHCHHHHHHHHHCCHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
GQRACAARGASWLSQCGFPGPTWGMVAQPSGRACGAGQQRPPRGGRRGAVMNTTITGGRR
HHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCH
QAALGFIFVTAILDVLSLGVMIPVLPNLVKAFGGGDTAAAADWNVLFATTWGVMQFICSP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHH
ILGLLSDRFGRRPVILTSIFGLGIDFLFMAFAPNLWWLFIGRIFNGMTAASFSTASAYVA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHCCCCCHHEEE
DVTTPENRAKGFGLMGAAFGIGFTFGPALGGWLWEFDHRAPFLVCAALALTNWLYGFFVL
ECCCCCHHHCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
PESLPPERRQPRFDWKKANPIGSLQLLRHHPGLMGLAGVGFLFQLAHNVLPSVFVLYMGF
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RYGWSPQTIGLTLMASGIASILIQAFVVGPAVKRLGERGVLLIGLFAGFLGFSIYALAPT
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
SLLYLAGLPIFAFSGLIQPGLQGLMTRRVGPNEQGQLQGANAAMMGIASIIGPPLFLIPF
HHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHH
AFAVRHDATLHLPGLPILIAAVLMLAATLLAYAKAKPAPAPEPQPA
HHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 383387; 6337373; 6307828; 1517220 [H]