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The map label for this gene is adk

Identifier: 16125518

GI number: 16125518

Start: 1416607

End: 1417182

Strand: Direct

Name: adk

Synonym: CC_1269

Alternate gene names: 16125518

Gene position: 1416607-1417182 (Clockwise)

Preceding gene: 16125517

Following gene: 16125519

Centisome position: 35.27

GC content: 67.01

Gene sequence:

>576_bases
ATGAATCTGATCCTGTTCGGCCCGCCGGCGGCGGGGAAGGGGACCCAGGCCAAGCGACTGGTCACGGAGCGGGGCATGGT
CCAGCTCTCGACCGGCGACATGCTGCGCGCGGCCATCGCCTCAGGCTCGGAGCTCGGCCAGCGCGTCAAGGGCGTGCTGG
ACCGTGGCGAGCTGGTGACCGACGAGATCGTCATCGCCCTGATCGAAGACCGCCTGCCCGAAGCCGAAGCCGCCGGCGGC
GCGATCTTCGACGGTTTCCCGCGGACGGTCGCCCAGGCCGAGGCTCTGGATAAAATGCTCGCCGCGCGCGGTCAGAAGAT
CGACGTCGTTCTCCGACTCAAGGTAGACGAGCCCGCCCTGATCGAGCGGATCAAGAAGCGGTTCGAAGAGCAGGGACGGC
CCGACGACAATCCGGAAGTCTTCGTGACTCGCCTGGCCGCGTACAACGCTCAGACCGCGCCGCTGCTGCCCTACTATGAA
GGGCAGGGCAAGTTGACGGAACTGGATGGCATGGGGACCGTCGAAGCGGTCGCCGCGTCGATCGACAGCGCACTGGAGCC
CGTCGCTGCAGGATGA

Upstream 100 bases:

>100_bases
CGGTTTGTCACAAAACCGGCTTCCGTTTTTATTGCCGGGGCTCTAGGTCTGCTCCGGGAGACAGCCGGGCGCAGACTCGG
CGACGCGCGAAGGGGCTTTT

Downstream 100 bases:

>100_bases
TTATCCCGCAGCGATAGACGGACTCCATCTTCAAGGAGAGCGTGACTTTGGTCGCGCGAGCCTCGTCGATTAAGAAAGCC
CGAATTCGGGGGATGTCTCC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MNLILFGPPAAGKGTQAKRLVTERGMVQLSTGDMLRAAIASGSELGQRVKGVLDRGELVTDEIVIALIEDRLPEAEAAGG
AIFDGFPRTVAQAEALDKMLAARGQKIDVVLRLKVDEPALIERIKKRFEEQGRPDDNPEVFVTRLAAYNAQTAPLLPYYE
GQGKLTELDGMGTVEAVAASIDSALEPVAAG

Sequences:

>Translated_191_residues
MNLILFGPPAAGKGTQAKRLVTERGMVQLSTGDMLRAAIASGSELGQRVKGVLDRGELVTDEIVIALIEDRLPEAEAAGG
AIFDGFPRTVAQAEALDKMLAARGQKIDVVLRLKVDEPALIERIKKRFEEQGRPDDNPEVFVTRLAAYNAQTAPLLPYYE
GQGKLTELDGMGTVEAVAASIDSALEPVAAG
>Mature_191_residues
MNLILFGPPAAGKGTQAKRLVTERGMVQLSTGDMLRAAIASGSELGQRVKGVLDRGELVTDEIVIALIEDRLPEAEAAGG
AIFDGFPRTVAQAEALDKMLAARGQKIDVVLRLKVDEPALIERIKKRFEEQGRPDDNPEVFVTRLAAYNAQTAPLLPYYE
GQGKLTELDGMGTVEAVAASIDSALEPVAAG

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=209, Percent_Identity=40.6698564593301, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI7524346, Length=209, Percent_Identity=40.6698564593301, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI4502011, Length=185, Percent_Identity=31.8918918918919, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI19923437, Length=197, Percent_Identity=31.9796954314721, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI28144897, Length=194, Percent_Identity=30.9278350515464, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI28144899, Length=194, Percent_Identity=30.9278350515464, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI310110345, Length=197, Percent_Identity=29.4416243654822, Blast_Score=94, Evalue=5e-20,
Organism=Homo sapiens, GI53832003, Length=197, Percent_Identity=29.4416243654822, Blast_Score=94, Evalue=5e-20,
Organism=Homo sapiens, GI8051579, Length=197, Percent_Identity=29.4416243654822, Blast_Score=94, Evalue=5e-20,
Organism=Homo sapiens, GI53832001, Length=197, Percent_Identity=29.4416243654822, Blast_Score=94, Evalue=5e-20,
Organism=Homo sapiens, GI7706497, Length=180, Percent_Identity=30.5555555555556, Blast_Score=94, Evalue=7e-20,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=37.7880184331797, Blast_Score=135, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17552384, Length=209, Percent_Identity=36.3636363636364, Blast_Score=134, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17567503, Length=186, Percent_Identity=33.3333333333333, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17533833, Length=185, Percent_Identity=31.8918918918919, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17550688, Length=168, Percent_Identity=33.9285714285714, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17537943, Length=210, Percent_Identity=29.0476190476191, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320432, Length=213, Percent_Identity=37.0892018779343, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6322828, Length=186, Percent_Identity=30.6451612903226, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321018, Length=188, Percent_Identity=32.9787234042553, Blast_Score=95, Evalue=6e-21,
Organism=Drosophila melanogaster, GI22026816, Length=213, Percent_Identity=38.9671361502347, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI17737899, Length=199, Percent_Identity=34.1708542713568, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24645822, Length=199, Percent_Identity=34.1708542713568, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24663208, Length=161, Percent_Identity=32.2981366459627, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17647141, Length=161, Percent_Identity=32.2981366459627, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221459597, Length=195, Percent_Identity=29.7435897435897, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21356893, Length=195, Percent_Identity=29.7435897435897, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_CAUCN (B8H4F5)

Other databases:

- EMBL:   CP001340
- RefSeq:   YP_002516700.1
- ProteinModelPortal:   B8H4F5
- SMR:   B8H4F5
- GeneID:   7333059
- GenomeReviews:   CP001340_GR
- KEGG:   ccs:CCNA_01327
- OMA:   CGEGYHD
- ProtClustDB:   PRK14532
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 20342; Mature: 20342

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLILFGPPAAGKGTQAKRLVTERGMVQLSTGDMLRAAIASGSELGQRVKGVLDRGELVT
CCEEEECCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHHCCHHHHHHHHHHHHCCCHHH
DEIVIALIEDRLPEAEAAGGAIFDGFPRTVAQAEALDKMLAARGQKIDVVLRLKVDEPAL
HHHHHHHHHHCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHH
IERIKKRFEEQGRPDDNPEVFVTRLAAYNAQTAPLLPYYEGQGKLTELDGMGTVEAVAAS
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCEECCCCCEEECCCCCHHHHHHHH
IDSALEPVAAG
HHHHHHHHCCC
>Mature Secondary Structure
MNLILFGPPAAGKGTQAKRLVTERGMVQLSTGDMLRAAIASGSELGQRVKGVLDRGELVT
CCEEEECCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHHCCHHHHHHHHHHHHCCCHHH
DEIVIALIEDRLPEAEAAGGAIFDGFPRTVAQAEALDKMLAARGQKIDVVLRLKVDEPAL
HHHHHHHHHHCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHH
IERIKKRFEEQGRPDDNPEVFVTRLAAYNAQTAPLLPYYEGQGKLTELDGMGTVEAVAAS
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCEECCCCCEEECCCCCHHHHHHHH
IDSALEPVAAG
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA