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The map label for this gene is aceE [H]

Identifier: 16125456

GI number: 16125456

Start: 1366304

End: 1368658

Strand: Direct

Name: aceE [H]

Synonym: CC_1205

Alternate gene names: 16125456

Gene position: 1366304-1368658 (Clockwise)

Preceding gene: 16125455

Following gene: 16125461

Centisome position: 34.01

GC content: 69.55

Gene sequence:

>2355_bases
ATGCCTGACGGCGCTCTGACGGCCAAGCGGCAGGAAATCGCGCTGCTGCGGCGGCTCGAGGAACGGATTCTCTGGTTGGC
GGCGTGGACTATCCACAACGCCAACCATCTCCGCGAAAGCCGGGACGGCTTGAAGGTCGGCGGCCACCAGGCGTCCAGCG
CCTCGCTGACCACGATCATGACCGCGCTCTACATGAAGGCGTTGCGTCCGCAGGACCGGGTCGCGGTCAAGCCGCACGCC
AGCCCGGTCTTCCACGCCATCCAGCACCTGTTCGGGCGCCAGAGCCTGGATAATCTCAAGCGCTTCCGGGCCTTGGGCGG
CGCGCAGTCCTATCCGTCGCGCACCAAGGACGTCGACGACGTCGATTTCTCGACCGGCTCGGTGGGCCTGGGCGTGGCCA
TGACCGCCTTCGCCTCGCTGACCCAGGACTATCTGGCCGCGCGCGGCGCGGTGAAGCCCGAGAAGATGGGCCGGATGATC
TCGCTGCTGGGCGACGCCGAGCTGGACGAGGGCAATATCTACGAAGCCCTGATCGAGGCCTGCAAGCACGACATCCGCAA
CACCTGGTGGATCGTCGACTACAACCGCCAAAGCCTGGACGCGACCACCCAGGACCGGATGTTCACCCGCTATGGCGAGA
TCTTCGAGGCCGCCGGCTGGGCGGTCGAGACGCTGAAGTGGTCCAGGCGTCAGCGCGAGGCCTTCGCCCGGCCGGGCGGC
GACAAGCTGCAGGCCTGGATCGAGACCGCCCCCAACGACCTGTTCTCGGCCCTGACCTATCAGGGCGGCGCGGCGTGGCG
CGAGCGGCTCACCGCCGATCTGGCCGATAGCCCCGAGGCCTTGGCCCTGATCGCCGCCTACAAGGACGTCGACCTCGCCG
AACTTATGACCGAGCTGGGCGGGCACTGCCTGGAGACGCTGCTGGAGGCCTTCGAGAAGGCCAGCCAGGATGATCGCCCG
CGCTTCTTCATCGCCTACACCGTCAAGGGCCTGCGGCTGCCGTTCCAGGGCCACAAGGACAATCACGCGGGCCTGATGAC
CCCGGCCCAGATCGCCGAACTGCGGGCGCGTCTTGGCGTGGTCGAGGGCGAGGAATGGGACCCTCTGTCGGGCCTGTCGG
CCGCCGAGCGCACCGCGATCAAGGGCCTGGTCGCGCGCGCGCCGTTCGCCGCCGAGGTCGAGCGCAATCACCTAGCGCCG
CAGATTCCGACGCCCAGCGCCAGCGAGCTGCTGGCCGCTGTCGCTGGCGGCGGTGATCAATCCACCCAGGCCGCGTTCGG
CAAGGTGATGTTCGAGATCGCGGCGCGAAAGGACGAGTTCGCCGGCCGGGTGGTCACGACCTCGCCAGACGTGACGGTGT
CGACCAACCTGGGCGGTTTCGTGAATCGTCGTGGCGTGTTCCAGCGGCGCGCTCATGACGATGTCTTCAAGCGTCGCCGC
ATCCCCTCGGCCCAGGTTTGGTCCAAGGCCGAGACGGGCCAGCACGTGGAGCTGGGCATCGCGGAGAACAACCTGTTCAT
CGCCCTGGCGGCGCTGGGCCTGACCGCGCCGCTGTTTGGCGAGCGGTTGTTTCCGGTCGGCACGCTCTACGATCCGTTCA
TCGCCCGGGGTCTCGATGCGCTGAACTACGCCTGCTACCAGGACGCTCGGTTCCTGCTGGTGGCGACCCCGTCCGGCCTG
ACGCTGGCGCCCGAAGGCGGGGCGCACCAGTCGATCAATGCGCCGGTGATCGGCATGGCGCAGCCGGGCCTTGATACCTA
CGAGCCTGCGTTTGCGGACGAGACGGCGGTGCTGATGGCGCACGCTTTCGAGCGCATCCAGGCCAAGGACGGCGCCTCGA
CCTATCTGCGCCTGTCGACCCGGGCCATCCCCCAGCCGGACCGGACGGGCGAGGCCTGGCGGCAGGGCGTCATCGATGGC
GGCTATTGGCTGCGAGCCCCGGCGCGGGGCGCGCGACTGGCGATCGCCTACAGCGGGGCTCTGGCGCCCGAGGCCCTGGC
GGCGTTCGAGGCGCTGGCCGAGGACATGCCCGAGGCGGGCCTCCTGGCCGTGACCTCCGCCGACCTGCTGCACCGCGACT
GGACCGCGTCAGGTCGGGCGCGCTGGACGGGGGAGGGGGCGCGGACCTCGACGATCGAGACCCTGCTAGCGCCGCTGGCG
CAAGGCGCCGGTCTGGTGACCCTGACGGATGGCGCGCCGCTGGCCCTGTCGTGGCTGGGGTCGGTGCGGGGGCAGAGGGT
CCGGGCGCTTGGGCTGGAGACCTTCGGGCAATCGGGCGACCTGCCTGACCTCTACGCCAAGTACCGGCTGGACGCCGACG
CCGTTCTGGACGCCTGCGCGGATCTGCTGGCCTAG

Upstream 100 bases:

>100_bases
GAAGTCGCCGGAGTGGACGGCGCGCCAGATCGAAGCGTATGAAGCCCAGGAAAAGTCGGGTGAGGGGCAAACCTCACCCG
CATAAACCGGGTGAGGAAGC

Downstream 100 bases:

>100_bases
AGCGTTCTCCGATCAGTGTGAAGCGGCGATCGGATCGAAGAACGCGCTAAACTTTTGAAATAGAGCCCTTTTTATCCGAT
CTGATTGGTTCAATCAGATC

Product: transketolase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 784; Mature: 783

Protein sequence:

>784_residues
MPDGALTAKRQEIALLRRLEERILWLAAWTIHNANHLRESRDGLKVGGHQASSASLTTIMTALYMKALRPQDRVAVKPHA
SPVFHAIQHLFGRQSLDNLKRFRALGGAQSYPSRTKDVDDVDFSTGSVGLGVAMTAFASLTQDYLAARGAVKPEKMGRMI
SLLGDAELDEGNIYEALIEACKHDIRNTWWIVDYNRQSLDATTQDRMFTRYGEIFEAAGWAVETLKWSRRQREAFARPGG
DKLQAWIETAPNDLFSALTYQGGAAWRERLTADLADSPEALALIAAYKDVDLAELMTELGGHCLETLLEAFEKASQDDRP
RFFIAYTVKGLRLPFQGHKDNHAGLMTPAQIAELRARLGVVEGEEWDPLSGLSAAERTAIKGLVARAPFAAEVERNHLAP
QIPTPSASELLAAVAGGGDQSTQAAFGKVMFEIAARKDEFAGRVVTTSPDVTVSTNLGGFVNRRGVFQRRAHDDVFKRRR
IPSAQVWSKAETGQHVELGIAENNLFIALAALGLTAPLFGERLFPVGTLYDPFIARGLDALNYACYQDARFLLVATPSGL
TLAPEGGAHQSINAPVIGMAQPGLDTYEPAFADETAVLMAHAFERIQAKDGASTYLRLSTRAIPQPDRTGEAWRQGVIDG
GYWLRAPARGARLAIAYSGALAPEALAAFEALAEDMPEAGLLAVTSADLLHRDWTASGRARWTGEGARTSTIETLLAPLA
QGAGLVTLTDGAPLALSWLGSVRGQRVRALGLETFGQSGDLPDLYAKYRLDADAVLDACADLLA

Sequences:

>Translated_784_residues
MPDGALTAKRQEIALLRRLEERILWLAAWTIHNANHLRESRDGLKVGGHQASSASLTTIMTALYMKALRPQDRVAVKPHA
SPVFHAIQHLFGRQSLDNLKRFRALGGAQSYPSRTKDVDDVDFSTGSVGLGVAMTAFASLTQDYLAARGAVKPEKMGRMI
SLLGDAELDEGNIYEALIEACKHDIRNTWWIVDYNRQSLDATTQDRMFTRYGEIFEAAGWAVETLKWSRRQREAFARPGG
DKLQAWIETAPNDLFSALTYQGGAAWRERLTADLADSPEALALIAAYKDVDLAELMTELGGHCLETLLEAFEKASQDDRP
RFFIAYTVKGLRLPFQGHKDNHAGLMTPAQIAELRARLGVVEGEEWDPLSGLSAAERTAIKGLVARAPFAAEVERNHLAP
QIPTPSASELLAAVAGGGDQSTQAAFGKVMFEIAARKDEFAGRVVTTSPDVTVSTNLGGFVNRRGVFQRRAHDDVFKRRR
IPSAQVWSKAETGQHVELGIAENNLFIALAALGLTAPLFGERLFPVGTLYDPFIARGLDALNYACYQDARFLLVATPSGL
TLAPEGGAHQSINAPVIGMAQPGLDTYEPAFADETAVLMAHAFERIQAKDGASTYLRLSTRAIPQPDRTGEAWRQGVIDG
GYWLRAPARGARLAIAYSGALAPEALAAFEALAEDMPEAGLLAVTSADLLHRDWTASGRARWTGEGARTSTIETLLAPLA
QGAGLVTLTDGAPLALSWLGSVRGQRVRALGLETFGQSGDLPDLYAKYRLDADAVLDACADLLA
>Mature_783_residues
PDGALTAKRQEIALLRRLEERILWLAAWTIHNANHLRESRDGLKVGGHQASSASLTTIMTALYMKALRPQDRVAVKPHAS
PVFHAIQHLFGRQSLDNLKRFRALGGAQSYPSRTKDVDDVDFSTGSVGLGVAMTAFASLTQDYLAARGAVKPEKMGRMIS
LLGDAELDEGNIYEALIEACKHDIRNTWWIVDYNRQSLDATTQDRMFTRYGEIFEAAGWAVETLKWSRRQREAFARPGGD
KLQAWIETAPNDLFSALTYQGGAAWRERLTADLADSPEALALIAAYKDVDLAELMTELGGHCLETLLEAFEKASQDDRPR
FFIAYTVKGLRLPFQGHKDNHAGLMTPAQIAELRARLGVVEGEEWDPLSGLSAAERTAIKGLVARAPFAAEVERNHLAPQ
IPTPSASELLAAVAGGGDQSTQAAFGKVMFEIAARKDEFAGRVVTTSPDVTVSTNLGGFVNRRGVFQRRAHDDVFKRRRI
PSAQVWSKAETGQHVELGIAENNLFIALAALGLTAPLFGERLFPVGTLYDPFIARGLDALNYACYQDARFLLVATPSGLT
LAPEGGAHQSINAPVIGMAQPGLDTYEPAFADETAVLMAHAFERIQAKDGASTYLRLSTRAIPQPDRTGEAWRQGVIDGG
YWLRAPARGARLAIAYSGALAPEALAAFEALAEDMPEAGLLAVTSADLLHRDWTASGRARWTGEGARTSTIETLLAPLAQ
GAGLVTLTDGAPLALSWLGSVRGQRVRALGLETFGQSGDLPDLYAKYRLDADAVLDACADLLA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=815, Percent_Identity=25.0306748466258, Blast_Score=146, Evalue=5e-36,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 84995; Mature: 84864

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDGALTAKRQEIALLRRLEERILWLAAWTIHNANHLRESRDGLKVGGHQASSASLTTIM
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEECCCCCCCHHHHHHH
TALYMKALRPQDRVAVKPHASPVFHAIQHLFGRQSLDNLKRFRALGGAQSYPSRTKDVDD
HHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
VDFSTGSVGLGVAMTAFASLTQDYLAARGAVKPEKMGRMISLLGDAELDEGNIYEALIEA
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHH
CKHDIRNTWWIVDYNRQSLDATTQDRMFTRYGEIFEAAGWAVETLKWSRRQREAFARPGG
HHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCH
DKLQAWIETAPNDLFSALTYQGGAAWRERLTADLADSPEALALIAAYKDVDLAELMTELG
HHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCCCHHEEEEHHHCCCCHHHHHHHHH
GHCLETLLEAFEKASQDDRPRFFIAYTVKGLRLPFQGHKDNHAGLMTPAQIAELRARLGV
HHHHHHHHHHHHHCCCCCCCCEEEEEEEECEECCCCCCCCCCCCCCCHHHHHHHHHHHCC
VEGEEWDPLSGLSAAERTAIKGLVARAPFAAEVERNHLAPQIPTPSASELLAAVAGGGDQ
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCC
STQAAFGKVMFEIAARKDEFAGRVVTTSPDVTVSTNLGGFVNRRGVFQRRAHDDVFKRRR
HHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEECCCCCHHHHCHHHHHHHHHHHHHHHC
IPSAQVWSKAETGQHVELGIAENNLFIALAALGLTAPLFGERLFPVGTLYDPFIARGLDA
CCCHHHHHHCCCCCEEEEEEECCCEEEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
LNYACYQDARFLLVATPSGLTLAPEGGAHQSINAPVIGMAQPGLDTYEPAFADETAVLMA
HHHHHHCCCCEEEEECCCCCEECCCCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHH
HAFERIQAKDGASTYLRLSTRAIPQPDRTGEAWRQGVIDGGYWLRAPARGARLAIAYSGA
HHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHCCCCCCEEEECCCCCCEEEEEECCC
LAPEALAAFEALAEDMPEAGLLAVTSADLLHRDWTASGRARWTGEGARTSTIETLLAPLA
CCHHHHHHHHHHHHHCCCCCEEEEECHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHH
QGAGLVTLTDGAPLALSWLGSVRGQRVRALGLETFGQSGDLPDLYAKYRLDADAVLDACA
CCCCEEEECCCCCHHHHHHHHHCCCCEEEECHHHCCCCCCCHHHHHHHCCCHHHHHHHHH
DLLA
HHHC
>Mature Secondary Structure 
PDGALTAKRQEIALLRRLEERILWLAAWTIHNANHLRESRDGLKVGGHQASSASLTTIM
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEECCCCCCCHHHHHHH
TALYMKALRPQDRVAVKPHASPVFHAIQHLFGRQSLDNLKRFRALGGAQSYPSRTKDVDD
HHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
VDFSTGSVGLGVAMTAFASLTQDYLAARGAVKPEKMGRMISLLGDAELDEGNIYEALIEA
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHH
CKHDIRNTWWIVDYNRQSLDATTQDRMFTRYGEIFEAAGWAVETLKWSRRQREAFARPGG
HHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCH
DKLQAWIETAPNDLFSALTYQGGAAWRERLTADLADSPEALALIAAYKDVDLAELMTELG
HHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCCCHHEEEEHHHCCCCHHHHHHHHH
GHCLETLLEAFEKASQDDRPRFFIAYTVKGLRLPFQGHKDNHAGLMTPAQIAELRARLGV
HHHHHHHHHHHHHCCCCCCCCEEEEEEEECEECCCCCCCCCCCCCCCHHHHHHHHHHHCC
VEGEEWDPLSGLSAAERTAIKGLVARAPFAAEVERNHLAPQIPTPSASELLAAVAGGGDQ
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCC
STQAAFGKVMFEIAARKDEFAGRVVTTSPDVTVSTNLGGFVNRRGVFQRRAHDDVFKRRR
HHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEECCCCCHHHHCHHHHHHHHHHHHHHHC
IPSAQVWSKAETGQHVELGIAENNLFIALAALGLTAPLFGERLFPVGTLYDPFIARGLDA
CCCHHHHHHCCCCCEEEEEEECCCEEEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
LNYACYQDARFLLVATPSGLTLAPEGGAHQSINAPVIGMAQPGLDTYEPAFADETAVLMA
HHHHHHCCCCEEEEECCCCCEECCCCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHH
HAFERIQAKDGASTYLRLSTRAIPQPDRTGEAWRQGVIDGGYWLRAPARGARLAIAYSGA
HHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHCCCCCCEEEECCCCCCEEEEEECCC
LAPEALAAFEALAEDMPEAGLLAVTSADLLHRDWTASGRARWTGEGARTSTIETLLAPLA
CCHHHHHHHHHHHHHCCCCCEEEEECHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHH
QGAGLVTLTDGAPLALSWLGSVRGQRVRALGLETFGQSGDLPDLYAKYRLDADAVLDACA
CCCCEEEECCCCCHHHHHHHHHCCCCEEEECHHHCCCCCCCHHHHHHHCCCHHHHHHHHH
DLLA
HHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA