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The map label for this gene is gdhII [H]

Identifier: 16124655

GI number: 16124655

Start: 421211

End: 422068

Strand: Direct

Name: gdhII [H]

Synonym: CC_0400

Alternate gene names: 16124655

Gene position: 421211-422068 (Clockwise)

Preceding gene: 16124654

Following gene: 16124657

Centisome position: 10.49

GC content: 66.2

Gene sequence:

>858_bases
ATGAGCCTCAAGAACAAGACCCTGTTCGTCACCGGCGCCTCGCGCGGCATCGGTCTGGCCATCGCCGTGCGCGCCGCCCG
CGACGGCGCCAATGTGGTGATCGCGGCCAAGACAGCCGAGGCCCATCCCAAGCTGCCCGGCACCATCTACACCGCCGCCA
AGGAAATCGAGGACGCGGGCGGCAAGGCCCTGCCGCTGGTCGTCGACGTGCGTGAGGAGTCCAGCGTGCAGGAGGCGGTC
GACAAGGCCGTGGCCCAGTTCGGCGGCATCGACATCTGCGTCAACAACGCCTCGGCCATCTCGCTGACCCCGACCCTGAT
GACCGACATGAAGCGATATGACCTGATGCACCAGATCAATACGCGCGGCACGTTCCTGACGTCGAAGGCCTGCATCCCGC
ACCTGAAGAACGCTGAGAACCCGCACGTCCTGATGCTGTCGCCGCCGCTGGACATGTCGCCGCGCTGGTTCGGCTCGCAC
GTGGCCTACACCATGGCCAAGTTCGGCATGTCGATGTGCGTGCTGGGCATGGCCGAGGAGTTCAAGCCCGACGGGATCGC
CTTCAACGCCCTGTGGCCGCGCACCGGCATCGCCACGGCGGCCATCCAGTTCGCCCTGACCGGCGAGGAAGGCCTGCGCC
ATTGCCGCACGCCCGAGATCATGGCCGACGCGGCCTATGGGATCTTCAACAAGCCCTCGCGGGACTTCAGCGGCAACTTC
CTGATCGACGACACCTTCCTCTATGGCGAGGGCGTGCGCGACTTCGATCACTACAAGGTCGACCCGACCGCCAGCCTGAT
GCCGGACTTCTTCGTGCCCGAGAGCAGCGAGCCGCCGCCTGGGGTGAAGATCGGGTGA

Upstream 100 bases:

>100_bases
TGAAGGATCACGGCCCGGTCGCCCACATGGCCAAGATGGCCTTCCTGCTCGGCTTCGCCGTCGTCGGCGTTCAACTGTTT
AAAACCCGTGGAGATCCCGC

Downstream 100 bases:

>100_bases
TTGAGATCCTCTCCCAGAGGGAGAGGAGGGACCCGCCGCGGAGCGGTGGGAGGTGAGGGGTTTCGTCGGCCGACGCCTTA
CCCCCTCTCCCTCCCGCGCT

Product: short chain dehydrogenase

Products: NA

Alternate protein names: GLCDH-II [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MSLKNKTLFVTGASRGIGLAIAVRAARDGANVVIAAKTAEAHPKLPGTIYTAAKEIEDAGGKALPLVVDVREESSVQEAV
DKAVAQFGGIDICVNNASAISLTPTLMTDMKRYDLMHQINTRGTFLTSKACIPHLKNAENPHVLMLSPPLDMSPRWFGSH
VAYTMAKFGMSMCVLGMAEEFKPDGIAFNALWPRTGIATAAIQFALTGEEGLRHCRTPEIMADAAYGIFNKPSRDFSGNF
LIDDTFLYGEGVRDFDHYKVDPTASLMPDFFVPESSEPPPGVKIG

Sequences:

>Translated_285_residues
MSLKNKTLFVTGASRGIGLAIAVRAARDGANVVIAAKTAEAHPKLPGTIYTAAKEIEDAGGKALPLVVDVREESSVQEAV
DKAVAQFGGIDICVNNASAISLTPTLMTDMKRYDLMHQINTRGTFLTSKACIPHLKNAENPHVLMLSPPLDMSPRWFGSH
VAYTMAKFGMSMCVLGMAEEFKPDGIAFNALWPRTGIATAAIQFALTGEEGLRHCRTPEIMADAAYGIFNKPSRDFSGNF
LIDDTFLYGEGVRDFDHYKVDPTASLMPDFFVPESSEPPPGVKIG
>Mature_284_residues
SLKNKTLFVTGASRGIGLAIAVRAARDGANVVIAAKTAEAHPKLPGTIYTAAKEIEDAGGKALPLVVDVREESSVQEAVD
KAVAQFGGIDICVNNASAISLTPTLMTDMKRYDLMHQINTRGTFLTSKACIPHLKNAENPHVLMLSPPLDMSPRWFGSHV
AYTMAKFGMSMCVLGMAEEFKPDGIAFNALWPRTGIATAAIQFALTGEEGLRHCRTPEIMADAAYGIFNKPSRDFSGNFL
IDDTFLYGEGVRDFDHYKVDPTASLMPDFFVPESSEPPPGVKIG

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254986, Length=272, Percent_Identity=61.3970588235294, Blast_Score=335, Evalue=3e-92,
Organism=Homo sapiens, GI10190704, Length=218, Percent_Identity=29.8165137614679, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI4504505, Length=198, Percent_Identity=27.7777777777778, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI209862901, Length=222, Percent_Identity=27.027027027027, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI19923983, Length=222, Percent_Identity=27.027027027027, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI32483357, Length=193, Percent_Identity=28.4974093264249, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI87082100, Length=193, Percent_Identity=32.6424870466321, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789208, Length=234, Percent_Identity=27.3504273504274, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787335, Length=198, Percent_Identity=30.3030303030303, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71982365, Length=268, Percent_Identity=65.2985074626866, Blast_Score=369, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17558628, Length=274, Percent_Identity=64.5985401459854, Blast_Score=352, Evalue=1e-97,
Organism=Caenorhabditis elegans, GI71994604, Length=185, Percent_Identity=28.6486486486486, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=196, Percent_Identity=27.0408163265306, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=195, Percent_Identity=28.2051282051282, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21357673, Length=278, Percent_Identity=63.6690647482014, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI23397609, Length=197, Percent_Identity=31.9796954314721, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28571526, Length=193, Percent_Identity=31.0880829015544, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI21357041, Length=193, Percent_Identity=30.5699481865285, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21355319, Length=192, Percent_Identity=26.5625, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24644339, Length=194, Percent_Identity=26.8041237113402, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.47 [H]

Molecular weight: Translated: 30740; Mature: 30608

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKNKTLFVTGASRGIGLAIAVRAARDGANVVIAAKTAEAHPKLPGTIYTAAKEIEDAG
CCCCCCEEEEEECCCCCEEEEEEEECCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCC
GKALPLVVDVREESSVQEAVDKAVAQFGGIDICVNNASAISLTPTLMTDMKRYDLMHQIN
CCEEEEEEECCCCHHHHHHHHHHHHHHCCEEEEECCCCEEEECHHHHHHHHHHHHHHHHC
TRGTFLTSKACIPHLKNAENPHVLMLSPPLDMSPRWFGSHVAYTMAKFGMSMCVLGMAEE
CCCEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FKPDGIAFNALWPRTGIATAAIQFALTGEEGLRHCRTPEIMADAAYGIFNKPSRDFSGNF
CCCCCEEEEEECCCCCCEEEEEEEEEECHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCE
LIDDTFLYGEGVRDFDHYKVDPTASLMPDFFVPESSEPPPGVKIG
EEEEEEEECCCCCCCCCEECCCCHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SLKNKTLFVTGASRGIGLAIAVRAARDGANVVIAAKTAEAHPKLPGTIYTAAKEIEDAG
CCCCCEEEEEECCCCCEEEEEEEECCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCC
GKALPLVVDVREESSVQEAVDKAVAQFGGIDICVNNASAISLTPTLMTDMKRYDLMHQIN
CCEEEEEEECCCCHHHHHHHHHHHHHHCCEEEEECCCCEEEECHHHHHHHHHHHHHHHHC
TRGTFLTSKACIPHLKNAENPHVLMLSPPLDMSPRWFGSHVAYTMAKFGMSMCVLGMAEE
CCCEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FKPDGIAFNALWPRTGIATAAIQFALTGEEGLRHCRTPEIMADAAYGIFNKPSRDFSGNF
CCCCCEEEEEECCCCCCEEEEEEEEEECHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCE
LIDDTFLYGEGVRDFDHYKVDPTASLMPDFFVPESSEPPPGVKIG
EEEEEEEECCCCCCCCCEECCCCHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA