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The map label for this gene is manX [C]

Identifier: 16124495

GI number: 16124495

Start: 255282

End: 255725

Strand: Direct

Name: manX [C]

Synonym: CC_0240

Alternate gene names: 16124495

Gene position: 255282-255725 (Clockwise)

Preceding gene: 16124494

Following gene: 16124496

Centisome position: 6.36

GC content: 64.64

Gene sequence:

>444_bases
GTGGCGGGAATGGGGATCCCGTTTGAGATACAAGGCATGATCGGGCTCGTGATTGTGACGCACGGGCGTCTGGCGGAAGA
ATTCGTCTCCGCTATGGAGCATGTCGTGGGGCCGCAGGCCGCCGTAAAGGCGATCTGTATCGGTCCGGAAGACGACATGG
AGCGTCGCCGCGCGGACATCCTGAAGGCGTGCGCGGCCGTCGATGAGGGCGGCGACGGCGTCATCCTGCTGACCGACATG
TTCGGCGGGACGCCCAGCAACCTGGCCATCTCGGTGATGGAGCAGACCAAGGCCGAGGTGATCGCGGGCCTCAACCTGCC
CATGCTCATCAAGCTGGCCAGCGTGCGCCAGCGCGAGACGTTGCAGGCCTGTGTCGCTCACGCCCAGGAGGCTGGACGCA
AGTACATCTCCGTGGCCTCCTACGTGCTCGCCGGAGAAAAGTGA

Upstream 100 bases:

>100_bases
AGAACCCGCCGCGCCGGCGAAAATCAGACGCATGATGCAGTCTCTTGGAGTCCAATCCTAACGGGCGTATCAAGACCGCC
CGCGCGACACTCTCCCGGTC

Downstream 100 bases:

>100_bases
CGGGCATGGCTTCAAGAACGGTCGAGATCGTCAACGAGCGGGGATTGCACGCCCGGGCCTCGGCCAAGTTCGTGAAGATG
GCGTCAGGCTTCGACGCCGA

Product: PTS system, IIA component

Products: protein histidine; sugar phosphate

Alternate protein names: PTS System IIA Component; PTS System IIA Component Man Family; PTS System Fructose IIA Component; PTS System Mannose/Fructose/Sorbose Family IIA Subunit; Protein-N P-Phosphohistidine-Sugar Phosphotransferase; IIA Component Of Sugar Transport PTS System; Pts System Fructose Subfamily IIa Component; PTS System Mannose/Fructose-Specific IIA Component; PTS System Mannose-Specific IIAB Component; PTS System Protein; Fructose-Specific IIA Component; PTS System Transporter Subunit IIA; Pts System Mannose-Specific Eiiab Component; PTS Mannose-Specific IIA Component; PTS System Mannose-Specific II AB Component; PTS System Mannose Subfamily IIA Subunit; PTS System Mannose-Specific Transporter Subunit IIAB; PTS System Mannose/Fructose/Sorbose Family IIB Component; Phosphotransferase System IIA Component; PTS System; Phosphotransferase System Fructose Subfamily IIA Component; PTS System Mannose-Type Transporter Subunit IIA; PTS System Fructose-Specific Transporter Subunit IIA; Phosphotransferase Mannose/Fructose-Specific Component IIA; Pts System Mannose/Fructose/Sorbose Family IIa Component; PTS System Mannose/Fructose/Sorbose Family IIAB Subunit; PTS System Fructose Subfamily Transprotein Subunit IIA; PTS System Mannose-Specific IIAB Components; PTS System IIa Component; PTS System Mannose-Specific Transporter Subunit IIA; Pts System Fructose IIA Component; PTS System Sorbose Subfamily IIB Component; Phosphotransferase System Fructose-Specific IIA; PTS System Mannose/Fructose-Specific Component IIA; Pentitol Phosphotransferase IIA Component; PTS System Component IIA

Number of amino acids: Translated: 147; Mature: 146

Protein sequence:

>147_residues
MAGMGIPFEIQGMIGLVIVTHGRLAEEFVSAMEHVVGPQAAVKAICIGPEDDMERRRADILKACAAVDEGGDGVILLTDM
FGGTPSNLAISVMEQTKAEVIAGLNLPMLIKLASVRQRETLQACVAHAQEAGRKYISVASYVLAGEK

Sequences:

>Translated_147_residues
MAGMGIPFEIQGMIGLVIVTHGRLAEEFVSAMEHVVGPQAAVKAICIGPEDDMERRRADILKACAAVDEGGDGVILLTDM
FGGTPSNLAISVMEQTKAEVIAGLNLPMLIKLASVRQRETLQACVAHAQEAGRKYISVASYVLAGEK
>Mature_146_residues
AGMGIPFEIQGMIGLVIVTHGRLAEEFVSAMEHVVGPQAAVKAICIGPEDDMERRRADILKACAAVDEGGDGVILLTDMF
GGTPSNLAISVMEQTKAEVIAGLNLPMLIKLASVRQRETLQACVAHAQEAGRKYISVASYVLAGEK

Specific function: This Is A Component Of The Phosphoenolpyruvate-Dependent Sugar Phosphotransferase System (Pts), A Major Carbohydrate Active -Transport System. The IIcd Domains Contain The Sugar Binding Site And The Transmembrane Channel; The IIa Domain Contains The Prim

COG id: COG2893

COG function: function code G; Phosphotransferase system, mannose/fructose-specific component IIA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.7.1.69

Molecular weight: Translated: 15550; Mature: 15419

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS51096 PTS_EIIA_TYPE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGMGIPFEIQGMIGLVIVTHGRLAEEFVSAMEHVVGPQAAVKAICIGPEDDMERRRADI
CCCCCCCEEECCCEEEEEEECCHHHHHHHHHHHHHHCCHHHHEEEEECCCHHHHHHHHHH
LKACAAVDEGGDGVILLTDMFGGTPSNLAISVMEQTKAEVIAGLNLPMLIKLASVRQRET
HHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LQACVAHAQEAGRKYISVASYVLAGEK
HHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AGMGIPFEIQGMIGLVIVTHGRLAEEFVSAMEHVVGPQAAVKAICIGPEDDMERRRADI
CCCCCCEEECCCEEEEEEECCHHHHHHHHHHHHHHCCHHHHEEEEECCCHHHHHHHHHH
LKACAAVDEGGDGVILLTDMFGGTPSNLAISVMEQTKAEVIAGLNLPMLIKLASVRQRET
HHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LQACVAHAQEAGRKYISVASYVLAGEK
HHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protein N(pi)-phosphohistidine; sugar

Specific reaction: protein N(pi)-phosphohistidine + sugar = protein histidine + sugar phosphate

General reaction: Transferring phosphorus-containing groups; Phosphotransferases with an alcohol group as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA