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The map label for this gene is yxbG [H]

Identifier: 16124379

GI number: 16124379

Start: 133900

End: 134682

Strand: Direct

Name: yxbG [H]

Synonym: CC_0124

Alternate gene names: 16124379

Gene position: 133900-134682 (Clockwise)

Preceding gene: 16124376

Following gene: 16124383

Centisome position: 3.33

GC content: 68.2

Gene sequence:

>783_bases
ATGAAACTCGACAACACCGTCGCCGCCGTCGTCACCGGGGGCGCTTCGGGCCTCGGCGAAGCCACCGCCCGCGCGCTCGC
CGCCCAAGGCGTCAAGGTCGCCCTCTTCGACATGAACGAAGAGCGCGGCCTGCAGGTCGCCAAGGAAATCGGCGGCGTGT
TCTGTAAGGTCAATGTGACCAGCGACGCCGATGTCGACGCCGGTTTCGAAAAGGCCCGCGCCGCCCACGGCCAGGAGCGC
ATCCTGGTCAACTGCGCCGGCACCGGCAACGCGGCCAAGACCGCCAGCCGCGACAAGGCCACCGGCGAGACCAAGCACTT
CCCGCTCGACGCCTTCGACCGCATCATCCAGATCAACCTCGTCGGCACGTTCCGCTGCATCGCCAAGTCGGCCAAGGGCA
TGCTGGATCTGGAGCCGCTGGAAGACGGCGAGCGCGGCGCCATCGTCAACACCGCCAGCGTCGCGGCCGAGGACGGTCAG
ATGGGCCAGGCGGCCTATTCGGCCTCGAAGGGCGGCGTTGTGGGCATGACCCTGCCGATCGCCCGCGACCTGATGGGCGA
GGGCATCCGCGTCAACACTATCCTGCCGGGCATCTTCAACACCCCGCTGATGAACAATGCGCCCGAAGCGGTGAAGGCGG
GCCTGGCCGCCAGCGTGCCGTTCCCCAAGCGCCTGGGTCACCCCGAAGAATACGCCCAGCTGGCGCTCACCATGATCACC
TGCGGCTACTTCAACGGCGAGGACGTGCGCCTGGACGGCGGCATCCGCATGGCGCCGCGGTAG

Upstream 100 bases:

>100_bases
CGGGGGACGGTTTGGCGTCGCCGCTCATCGGGATAAACCTCTGTTCAAATTCGATCCTAACCGCGAACGCTTCAAACGCG
AACTAGCAGGGAAACGTCCA

Downstream 100 bases:

>100_bases
TCTGCGCATAAAAATCCTCCCCTAGCGGGGGAGGTGATCGCGAAGCGATCGGAGGGGGAAGCGATGCGGAGGCCCCGCAG
ACACTTCCCTCTCCGTCGCT

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MKLDNTVAAVVTGGASGLGEATARALAAQGVKVALFDMNEERGLQVAKEIGGVFCKVNVTSDADVDAGFEKARAAHGQER
ILVNCAGTGNAAKTASRDKATGETKHFPLDAFDRIIQINLVGTFRCIAKSAKGMLDLEPLEDGERGAIVNTASVAAEDGQ
MGQAAYSASKGGVVGMTLPIARDLMGEGIRVNTILPGIFNTPLMNNAPEAVKAGLAASVPFPKRLGHPEEYAQLALTMIT
CGYFNGEDVRLDGGIRMAPR

Sequences:

>Translated_260_residues
MKLDNTVAAVVTGGASGLGEATARALAAQGVKVALFDMNEERGLQVAKEIGGVFCKVNVTSDADVDAGFEKARAAHGQER
ILVNCAGTGNAAKTASRDKATGETKHFPLDAFDRIIQINLVGTFRCIAKSAKGMLDLEPLEDGERGAIVNTASVAAEDGQ
MGQAAYSASKGGVVGMTLPIARDLMGEGIRVNTILPGIFNTPLMNNAPEAVKAGLAASVPFPKRLGHPEEYAQLALTMIT
CGYFNGEDVRLDGGIRMAPR
>Mature_260_residues
MKLDNTVAAVVTGGASGLGEATARALAAQGVKVALFDMNEERGLQVAKEIGGVFCKVNVTSDADVDAGFEKARAAHGQER
ILVNCAGTGNAAKTASRDKATGETKHFPLDAFDRIIQINLVGTFRCIAKSAKGMLDLEPLEDGERGAIVNTASVAAEDGQ
MGQAAYSASKGGVVGMTLPIARDLMGEGIRVNTILPGIFNTPLMNNAPEAVKAGLAASVPFPKRLGHPEEYAQLALTMIT
CGYFNGEDVRLDGGIRMAPR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=255, Percent_Identity=50.9803921568627, Blast_Score=230, Evalue=8e-61,
Organism=Homo sapiens, GI83715985, Length=256, Percent_Identity=48.4375, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI15277342, Length=264, Percent_Identity=30.6818181818182, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI40254992, Length=251, Percent_Identity=29.0836653386454, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI31542939, Length=209, Percent_Identity=32.5358851674641, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI59889578, Length=249, Percent_Identity=27.3092369477912, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI5031737, Length=261, Percent_Identity=26.0536398467433, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI224922801, Length=180, Percent_Identity=31.6666666666667, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI33667109, Length=205, Percent_Identity=28.2926829268293, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4503817, Length=203, Percent_Identity=27.5862068965517, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787335, Length=254, Percent_Identity=32.2834645669291, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789057, Length=206, Percent_Identity=31.0679611650485, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI2367175, Length=260, Percent_Identity=29.2307692307692, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87082100, Length=265, Percent_Identity=29.0566037735849, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788459, Length=258, Percent_Identity=27.906976744186, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790717, Length=258, Percent_Identity=28.6821705426357, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787905, Length=263, Percent_Identity=27.3764258555133, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082160, Length=261, Percent_Identity=28.3524904214559, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1789208, Length=255, Percent_Identity=28.2352941176471, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=251, Percent_Identity=49.402390438247, Blast_Score=241, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI25147288, Length=257, Percent_Identity=30.7392996108949, Blast_Score=114, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17555706, Length=254, Percent_Identity=28.740157480315, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI72000259, Length=271, Percent_Identity=26.1992619926199, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17563726, Length=277, Percent_Identity=25.6317689530686, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17538480, Length=203, Percent_Identity=30.0492610837438, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=267, Percent_Identity=26.5917602996255, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=266, Percent_Identity=27.8195488721804, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560332, Length=203, Percent_Identity=29.5566502463054, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320089, Length=239, Percent_Identity=27.1966527196653, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322861, Length=252, Percent_Identity=26.1904761904762, Blast_Score=62, Evalue=1e-10,
Organism=Drosophila melanogaster, GI17737361, Length=253, Percent_Identity=53.7549407114625, Blast_Score=250, Evalue=8e-67,
Organism=Drosophila melanogaster, GI24639444, Length=254, Percent_Identity=34.251968503937, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI21355319, Length=259, Percent_Identity=30.1158301158301, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28571526, Length=265, Percent_Identity=27.1698113207547, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI21357041, Length=271, Percent_Identity=26.9372693726937, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 27075; Mature: 27075

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDNTVAAVVTGGASGLGEATARALAAQGVKVALFDMNEERGLQVAKEIGGVFCKVNVT
CCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCEEEEEEEC
SDADVDAGFEKARAAHGQERILVNCAGTGNAAKTASRDKATGETKHFPLDAFDRIIQINL
CCCCCCCCHHHHHHCCCCCEEEEEECCCCCCHHCCCCCCCCCCCCCCCHHHHCCEEEEEE
VGTFRCIAKSAKGMLDLEPLEDGERGAIVNTASVAAEDGQMGQAAYSASKGGVVGMTLPI
EHHHHHHHHHCCCCEECCCCCCCCCCCEEEHHHHCCCCCCCCHHHHHCCCCCEEEEEHHH
ARDLMGEGIRVNTILPGIFNTPLMNNAPEAVKAGLAASVPFPKRLGHPEEYAQLALTMIT
HHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHH
CGYFNGEDVRLDGGIRMAPR
HCCCCCCEEEECCCEEECCC
>Mature Secondary Structure
MKLDNTVAAVVTGGASGLGEATARALAAQGVKVALFDMNEERGLQVAKEIGGVFCKVNVT
CCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCEEEEEEEC
SDADVDAGFEKARAAHGQERILVNCAGTGNAAKTASRDKATGETKHFPLDAFDRIIQINL
CCCCCCCCHHHHHHCCCCCEEEEEECCCCCCHHCCCCCCCCCCCCCCCHHHHCCEEEEEE
VGTFRCIAKSAKGMLDLEPLEDGERGAIVNTASVAAEDGQMGQAAYSASKGGVVGMTLPI
EHHHHHHHHHCCCCEECCCCCCCCCCCEEEHHHHCCCCCCCCHHHHHCCCCCEEEEEHHH
ARDLMGEGIRVNTILPGIFNTPLMNNAPEAVKAGLAASVPFPKRLGHPEEYAQLALTMIT
HHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHH
CGYFNGEDVRLDGGIRMAPR
HCCCCCCEEEECCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377 [H]