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The map label for this gene is purH

Identifier: 16124341

GI number: 16124341

Start: 89053

End: 90642

Strand: Direct

Name: purH

Synonym: CC_0086

Alternate gene names: 16124341

Gene position: 89053-90642 (Clockwise)

Preceding gene: 16124337

Following gene: 16124342

Centisome position: 2.22

GC content: 68.81

Gene sequence:

>1590_bases
GTGCCCGCCGCCCCCGACTATCCGTCCGCCCCCGATCTCGTCGCCCCCAAGCGCGCCCTGCTGTCGGTCTCCGACAAGAC
CGGCCTCGTCGACGCCGCCAAGATCCTGCACGCCGCCGGCGTTGAGCTGGTCTCGACCGGCGGCACCAAGGCCGCCATCG
CCGCTGCGGGCGTTCCCGTGAAGGACGTCTCGGACCTGACGGGCTTCCCCGAGATGATGGACGGCCGCGTGAAGACCCTG
CACCCGGTGGTGCATGGCGGGCTTCTGGGCGTGCGCGACGCGGCCGATCACGCCAAGGCCATGGCCGACCACGGCATCGG
CGGCATCGATATCCTGTACGTAAACCTCTATCCGTTCGAGGCGACCGTCGCGAAGGGCGGGTCCTATGCCGAGTGCGTCG
AGAACATCGACATCGGCGGCCCGGCCATGATCCGCTCGGCGGCCAAGAACCACGGCTATGTCGCCGTCTGCACCGATCCA
TCGGACCTCGCCGAGGTGCTGGAAGCCCTGAAGGCCGGCGGGACGACGCTGGCTTTGCGCCAGCAGCTCGCGGCCCGCGC
CTATGCCCGCACGGCCGCCTATGACGCGGCGATCTCGGCCTGGTTCGCGGAAGCCCTTGGCCAGGACTTCCCGGCCCGCA
AGAGCATCGCCGGGACCCTGCGCCAGACCATGCGCTACGGCGAGAACCCGCACCAGAAGGCGGCCTTCTACACCTTCCCG
AACCCGCGTCCGGGCGTGGCCACGGCCACCCAGCTGCAGGGCAAGGAACTCAGCTACAACAACATCAACGACACCGACGC
GGCCTTCGAGCTGATCGCCGAGTTCGACCCGGCGGCCGGTCCGGCCGTGGCGATCATCAAGCACGCCAATCCGTGCGGCG
TGGCCGTGGGCGCCACCCAGCGTGAGGCCTATGAGCGGGCGCTGGCCTGCGATCCGACCTCGGCCTTCGGCGGCATCGTG
GCGGTCAATTCGCGCCTGACCCGTGAGGCGGCCGAAGCGATGGTCGAGATCTTCACCGAGGTGGTCATCGCCCCCGAGGC
CGACGAAGACGCCATCGCTGTCTTCGCCGCCAAGAAGAACCTGCGCCTCTTGGTCACCGGCGGTCTGCCCGATGCGCTAT
CCACCGGCGACACCTTCAAGAGCGTGGCCGGCGGCTTCCTGGTGCAGTCGCGCGATGACGCGCGGATCAAGGCTTCGGAC
CTGAAGATCGTCACCCAGCGCCAGCCGACCGAGGAAGAGGTGCGCGACATGCTGTTCGCCTTCACGGTGGGCAAGCACGT
CAAGTCGAACGCCATCGTCTACGCCCGCGCCGGCCAGACCCTGGGCGTCGGCGCCGGCCAGATGAACCGCAAGGACAGCG
CCCGGATCGCGGCCCTGCGCGCCGCCGATTTCGGCTTGGACCTCAAGGGTTGCGCCTGCGCCTCGGAAGCCTTCTTCCCG
TTCGCGGATGGTCTCATCCAGGCGGCGGAAGCGGGGGCCACGGCGATCATCCAGCCGGGTGGCTCGATGCGGGATCCGGA
AGTGATCGAGGCGGCCGACAAGCTTGGCCTTACAATGGCCTTCACGGGTGTGCGAGTGTTCCGTCACTAG

Upstream 100 bases:

>100_bases
TCGCGTGACTGGCGCTAGTGATGGGGAACCATCGGGGAGCGTGGACATCATAAGCCGCGCGCCTGGGCTCCCTTTCTGAA
ACACACCAGAGGAGTCCGCC

Downstream 100 bases:

>100_bases
CTCTGCTTTGAGGTGAAGATGGACAGCGCCGCCTGGGGTGAAAAGGTCGCCAAGCACTCGCGGGTGTTCAAACCTGCGGG
GCCCGGCCCTTTCCCGGTGG

Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase

Number of amino acids: Translated: 529; Mature: 528

Protein sequence:

>529_residues
MPAAPDYPSAPDLVAPKRALLSVSDKTGLVDAAKILHAAGVELVSTGGTKAAIAAAGVPVKDVSDLTGFPEMMDGRVKTL
HPVVHGGLLGVRDAADHAKAMADHGIGGIDILYVNLYPFEATVAKGGSYAECVENIDIGGPAMIRSAAKNHGYVAVCTDP
SDLAEVLEALKAGGTTLALRQQLAARAYARTAAYDAAISAWFAEALGQDFPARKSIAGTLRQTMRYGENPHQKAAFYTFP
NPRPGVATATQLQGKELSYNNINDTDAAFELIAEFDPAAGPAVAIIKHANPCGVAVGATQREAYERALACDPTSAFGGIV
AVNSRLTREAAEAMVEIFTEVVIAPEADEDAIAVFAAKKNLRLLVTGGLPDALSTGDTFKSVAGGFLVQSRDDARIKASD
LKIVTQRQPTEEEVRDMLFAFTVGKHVKSNAIVYARAGQTLGVGAGQMNRKDSARIAALRAADFGLDLKGCACASEAFFP
FADGLIQAAEAGATAIIQPGGSMRDPEVIEAADKLGLTMAFTGVRVFRH

Sequences:

>Translated_529_residues
MPAAPDYPSAPDLVAPKRALLSVSDKTGLVDAAKILHAAGVELVSTGGTKAAIAAAGVPVKDVSDLTGFPEMMDGRVKTL
HPVVHGGLLGVRDAADHAKAMADHGIGGIDILYVNLYPFEATVAKGGSYAECVENIDIGGPAMIRSAAKNHGYVAVCTDP
SDLAEVLEALKAGGTTLALRQQLAARAYARTAAYDAAISAWFAEALGQDFPARKSIAGTLRQTMRYGENPHQKAAFYTFP
NPRPGVATATQLQGKELSYNNINDTDAAFELIAEFDPAAGPAVAIIKHANPCGVAVGATQREAYERALACDPTSAFGGIV
AVNSRLTREAAEAMVEIFTEVVIAPEADEDAIAVFAAKKNLRLLVTGGLPDALSTGDTFKSVAGGFLVQSRDDARIKASD
LKIVTQRQPTEEEVRDMLFAFTVGKHVKSNAIVYARAGQTLGVGAGQMNRKDSARIAALRAADFGLDLKGCACASEAFFP
FADGLIQAAEAGATAIIQPGGSMRDPEVIEAADKLGLTMAFTGVRVFRH
>Mature_528_residues
PAAPDYPSAPDLVAPKRALLSVSDKTGLVDAAKILHAAGVELVSTGGTKAAIAAAGVPVKDVSDLTGFPEMMDGRVKTLH
PVVHGGLLGVRDAADHAKAMADHGIGGIDILYVNLYPFEATVAKGGSYAECVENIDIGGPAMIRSAAKNHGYVAVCTDPS
DLAEVLEALKAGGTTLALRQQLAARAYARTAAYDAAISAWFAEALGQDFPARKSIAGTLRQTMRYGENPHQKAAFYTFPN
PRPGVATATQLQGKELSYNNINDTDAAFELIAEFDPAAGPAVAIIKHANPCGVAVGATQREAYERALACDPTSAFGGIVA
VNSRLTREAAEAMVEIFTEVVIAPEADEDAIAVFAAKKNLRLLVTGGLPDALSTGDTFKSVAGGFLVQSRDDARIKASDL
KIVTQRQPTEEEVRDMLFAFTVGKHVKSNAIVYARAGQTLGVGAGQMNRKDSARIAALRAADFGLDLKGCACASEAFFPF
ADGLIQAAEAGATAIIQPGGSMRDPEVIEAADKLGLTMAFTGVRVFRH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family

Homologues:

Organism=Homo sapiens, GI20127454, Length=476, Percent_Identity=36.7647058823529, Blast_Score=255, Evalue=8e-68,
Organism=Escherichia coli, GI1790439, Length=529, Percent_Identity=54.0642722117202, Blast_Score=520, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI71985564, Length=480, Percent_Identity=35.625, Blast_Score=259, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI71985574, Length=346, Percent_Identity=25.4335260115607, Blast_Score=99, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6323768, Length=478, Percent_Identity=36.6108786610879, Blast_Score=257, Evalue=3e-69,
Organism=Saccharomyces cerevisiae, GI6323056, Length=530, Percent_Identity=34.1509433962264, Blast_Score=252, Evalue=9e-68,
Organism=Drosophila melanogaster, GI24649832, Length=488, Percent_Identity=37.5, Blast_Score=259, Evalue=4e-69,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR9_CAUCR (Q9ABY4)

Other databases:

- EMBL:   AE005673
- PIR:   E87259
- RefSeq:   NP_418905.1
- ProteinModelPortal:   Q9ABY4
- SMR:   Q9ABY4
- GeneID:   944147
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_0086
- NMPDR:   fig|190650.1.peg.85
- TIGR:   CC_0086
- HOGENOM:   HBG498048
- OMA:   ASDGFFP
- ProtClustDB:   PRK00881
- BRENDA:   2.1.2.3
- BRENDA:   3.5.4.10
- HAMAP:   MF_00139
- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607
- Gene3D:   G3DSA:3.40.50.1380
- PANTHER:   PTHR11692
- PIRSF:   PIRSF000414
- SMART:   SM00798
- SMART:   SM00851
- TIGRFAMs:   TIGR00355

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS; SSF53927 Cytidine_deaminase-like; SSF52335 MGS-like_dom

EC number: =2.1.2.3; =3.5.4.10

Molecular weight: Translated: 55238; Mature: 55107

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAAPDYPSAPDLVAPKRALLSVSDKTGLVDAAKILHAAGVELVSTGGTKAAIAAAGVPV
CCCCCCCCCCCCCCCCCHHHEEECCCCCHHHHHHHHHHCCCEEEECCCCCEEHEECCCCH
KDVSDLTGFPEMMDGRVKTLHPVVHGGLLGVRDAADHAKAMADHGIGGIDILYVNLYPFE
HHHHHHCCCHHHHCCCHHHHHHHHHCCCEECCHHHHHHHHHHHCCCCCEEEEEEEEEECE
ATVAKGGSYAECVENIDIGGPAMIRSAAKNHGYVAVCTDPSDLAEVLEALKAGGTTLALR
EHECCCCCHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCHHHHH
QQLAARAYARTAAYDAAISAWFAEALGQDFPARKSIAGTLRQTMRYGENPHQKAAFYTFP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECC
NPRPGVATATQLQGKELSYNNINDTDAAFELIAEFDPAAGPAVAIIKHANPCGVAVGATQ
CCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEECCHH
REAYERALACDPTSAFGGIVAVNSRLTREAAEAMVEIFTEVVIAPEADEDAIAVFAAKKN
HHHHHHHHCCCCCHHCCCEEEECHHHHHHHHHHHHHHHHHHEECCCCCCCCEEEEEECCC
LRLLVTGGLPDALSTGDTFKSVAGGFLVQSRDDARIKASDLKIVTQRQPTEEEVRDMLFA
CEEEEECCCCCCCCCCCHHHHHHCCEEEECCCCCEEEECCEEEEECCCCCHHHHHHHHHH
FTVGKHVKSNAIVYARAGQTLGVGAGQMNRKDSARIAALRAADFGLDLKGCACASEAFFP
HHHHHHCCCCEEEEEECCCEEECCCCCCCCCCCHHEEEEEHHCCCCCCCCCHHCCCCCCH
FADGLIQAAEAGATAIIQPGGSMRDPEVIEAADKLGLTMAFTGVRVFRH
HHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHCCEEEEECCCHHHCC
>Mature Secondary Structure 
PAAPDYPSAPDLVAPKRALLSVSDKTGLVDAAKILHAAGVELVSTGGTKAAIAAAGVPV
CCCCCCCCCCCCCCCCHHHEEECCCCCHHHHHHHHHHCCCEEEECCCCCEEHEECCCCH
KDVSDLTGFPEMMDGRVKTLHPVVHGGLLGVRDAADHAKAMADHGIGGIDILYVNLYPFE
HHHHHHCCCHHHHCCCHHHHHHHHHCCCEECCHHHHHHHHHHHCCCCCEEEEEEEEEECE
ATVAKGGSYAECVENIDIGGPAMIRSAAKNHGYVAVCTDPSDLAEVLEALKAGGTTLALR
EHECCCCCHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCHHHHH
QQLAARAYARTAAYDAAISAWFAEALGQDFPARKSIAGTLRQTMRYGENPHQKAAFYTFP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECC
NPRPGVATATQLQGKELSYNNINDTDAAFELIAEFDPAAGPAVAIIKHANPCGVAVGATQ
CCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEECCHH
REAYERALACDPTSAFGGIVAVNSRLTREAAEAMVEIFTEVVIAPEADEDAIAVFAAKKN
HHHHHHHHCCCCCHHCCCEEEECHHHHHHHHHHHHHHHHHHEECCCCCCCCEEEEEECCC
LRLLVTGGLPDALSTGDTFKSVAGGFLVQSRDDARIKASDLKIVTQRQPTEEEVRDMLFA
CEEEEECCCCCCCCCCCHHHHHHCCEEEECCCCCEEEECCEEEEECCCCCHHHHHHHHHH
FTVGKHVKSNAIVYARAGQTLGVGAGQMNRKDSARIAALRAADFGLDLKGCACASEAFFP
HHHHHHCCCCEEEEEECCCEEECCCCCCCCCCCHHEEEEEHHCCCCCCCCCHHCCCCCCH
FADGLIQAAEAGATAIIQPGGSMRDPEVIEAADKLGLTMAFTGVRVFRH
HHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHCCEEEEECCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647