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The map label for this gene is coaE

Identifier: 16124260

GI number: 16124260

Start: 2490

End: 3158

Strand: Direct

Name: coaE

Synonym: CC_0004

Alternate gene names: 16124260

Gene position: 2490-3158 (Clockwise)

Preceding gene: 16124259

Following gene: 16124261

Centisome position: 0.06

GC content: 66.97

Gene sequence:

>669_bases
ATGGCCAGGCCCCCTCCCCCAAGATCGACGTTCGGGTCCTGGCGCTCAAGCTCCTGGGCGAGGTCTGAAATGTTGATCCT
TGGGCTGACCGGTTCCATCGGCATGGGCAAGTCGACGACCTCCAAGATGTTCCAGGACGAAGGCGTGCCCGTCTATGACG
CCGACGCGGCTGTCCACGCTCTCTACGCTTCGGGTGGCGCGGCGGTAGCGCCTGTCGAGACGGCCTTTCCCGGCGTCGTT
GTGGACGGGGCGATCGACCGGGCCAAGCTCAGCGCCCAGGTCGTTGGAAACTCCGAGGCCCTCGCCAAGCTGGAGGCGAT
CGTCCATCCGCTGGTCGGCGCCCACCGCATCGGTTTCTTCGAGCAGGCCAAGGCCGAGGGGCATGAAATTGTCGTGCTCG
ACATCCCGCTGCTGTTCGAAACAGGTGGCGAAAAGCGGGTCGACAAGGTGGTGGTGGTGTCGGCCCCCGCCGAGGTGCAG
CGCGAGCGGGTCCTGGCCCGCCCGGAGATGACCCCGGAGAAGTTCGAGGCCATCCTGGCCCGGCAGACGCCGGACGCCGA
CAAGCGCGCCCGCGCCGATTTCGTGATCGATACCGGCCAAGGCCTAGACCACGCGCGCCGCCAGGTCCGCGACCTTCTGA
CTCTGTTGAGAACCGCCCGCTCGGCTTGA

Upstream 100 bases:

>100_bases
CGGACAGAGTTCCTGCGCCGGGCCGAGGCCGCCGGTCGCCGTACGGTGGACGGGCTGGAGATGCTGCTGCGTCAGGCGAT
CCCCACCTTCGAGACCATTT

Downstream 100 bases:

>100_bases
AGCCGACCGCGAACGGCTTCATGGAAGGGCCATGGCCCGCGAGATCATCCTCGATACCGAAACCACCGGCTTTGACCCAA
AGACCGGTGACCGCCTGGTC

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase [H]

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MARPPPPRSTFGSWRSSSWARSEMLILGLTGSIGMGKSTTSKMFQDEGVPVYDADAAVHALYASGGAAVAPVETAFPGVV
VDGAIDRAKLSAQVVGNSEALAKLEAIVHPLVGAHRIGFFEQAKAEGHEIVVLDIPLLFETGGEKRVDKVVVVSAPAEVQ
RERVLARPEMTPEKFEAILARQTPDADKRARADFVIDTGQGLDHARRQVRDLLTLLRTARSA

Sequences:

>Translated_222_residues
MARPPPPRSTFGSWRSSSWARSEMLILGLTGSIGMGKSTTSKMFQDEGVPVYDADAAVHALYASGGAAVAPVETAFPGVV
VDGAIDRAKLSAQVVGNSEALAKLEAIVHPLVGAHRIGFFEQAKAEGHEIVVLDIPLLFETGGEKRVDKVVVVSAPAEVQ
RERVLARPEMTPEKFEAILARQTPDADKRARADFVIDTGQGLDHARRQVRDLLTLLRTARSA
>Mature_221_residues
ARPPPPRSTFGSWRSSSWARSEMLILGLTGSIGMGKSTTSKMFQDEGVPVYDADAAVHALYASGGAAVAPVETAFPGVVV
DGAIDRAKLSAQVVGNSEALAKLEAIVHPLVGAHRIGFFEQAKAEGHEIVVLDIPLLFETGGEKRVDKVVVVSAPAEVQR
ERVLARPEMTPEKFEAILARQTPDADKRARADFVIDTGQGLDHARRQVRDLLTLLRTARSA

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A [H]

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain [H]

Homologues:

Organism=Homo sapiens, GI191252797, Length=189, Percent_Identity=30.6878306878307, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI191252795, Length=189, Percent_Identity=30.6878306878307, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI110227607, Length=196, Percent_Identity=29.0816326530612, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI205277394, Length=196, Percent_Identity=29.0816326530612, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI110227605, Length=196, Percent_Identity=29.0816326530612, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI110227603, Length=196, Percent_Identity=29.0816326530612, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI110227601, Length=196, Percent_Identity=29.0816326530612, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1786292, Length=176, Percent_Identity=33.5227272727273, Blast_Score=84, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17554944, Length=198, Percent_Identity=30.3030303030303, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6320402, Length=196, Percent_Identity=30.6122448979592, Blast_Score=90, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24644728, Length=202, Percent_Identity=32.6732673267327, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24658602, Length=187, Percent_Identity=26.2032085561497, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001977 [H]

Pfam domain/function: PF01121 CoaE [H]

EC number: =2.7.1.24 [H]

Molecular weight: Translated: 23804; Mature: 23673

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARPPPPRSTFGSWRSSSWARSEMLILGLTGSIGMGKSTTSKMFQDEGVPVYDADAAVHA
CCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCEEECCHHHHH
LYASGGAAVAPVETAFPGVVVDGAIDRAKLSAQVVGNSEALAKLEAIVHPLVGAHRIGFF
HHHCCCCEECCHHHCCCCEEEECCCCHHHHHEEECCCHHHHHHHHHHHHHHHHHHHCCHH
EQAKAEGHEIVVLDIPLLFETGGEKRVDKVVVVSAPAEVQRERVLARPEMTPEKFEAILA
HHHHCCCCEEEEEEECEEEECCCCCCCCEEEEEECCHHHHHHHHHCCCCCCHHHHHHHHH
RQTPDADKRARADFVIDTGQGLDHARRQVRDLLTLLRTARSA
CCCCCHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ARPPPPRSTFGSWRSSSWARSEMLILGLTGSIGMGKSTTSKMFQDEGVPVYDADAAVHA
CCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCEEECCHHHHH
LYASGGAAVAPVETAFPGVVVDGAIDRAKLSAQVVGNSEALAKLEAIVHPLVGAHRIGFF
HHHCCCCEECCHHHCCCCEEEECCCCHHHHHEEECCCHHHHHHHHHHHHHHHHHHHCCHH
EQAKAEGHEIVVLDIPLLFETGGEKRVDKVVVVSAPAEVQRERVLARPEMTPEKFEAILA
HHHHCCCCEEEEEEECEEEECCCCCCCCEEEEEECCHHHHHHHHHCCCCCCHHHHHHHHH
RQTPDADKRARADFVIDTGQGLDHARRQVRDLLTLLRTARSA
CCCCCHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]