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The map label for this gene is aroE

Identifier: 16124259

GI number: 16124259

Start: 1700

End: 2557

Strand: Direct

Name: aroE

Synonym: CC_0003

Alternate gene names: 16124259

Gene position: 1700-2557 (Clockwise)

Preceding gene: 16124258

Following gene: 16124260

Centisome position: 0.04

GC content: 68.65

Gene sequence:

>858_bases
ATGACCAACGCCATCACGGGCGCGGCCATTGTCGGCGGTGTCTGCGGTCAACCGATCAAGCATTCGATGAGCCCGGTGAT
CCACAACGCCTGGATCGCAGCGGCCGGCCTTGACGCGGCTTATGTGCCATTCGCCCCGGCGGCTGATCGGTTCGAGACCT
TTGTCGACGGTTTGCGTGGCGGCGCGGTGCGCGGGCTCAACGTCACCATTCCGTTCAAGGAGCGGGCGCTGGCCGTCGCC
GACACCGCCAGCGATCTGGCGCGGATGGCCGGGGCGGCCAATCTGTTGGTGTTCAATGAGGACGGCAGCGTCCATGCCGA
CAATACCGACGGCCCGGGCCTGCTGGGCGCCATCGCGATCCAGGCGCCTGGCTTCGACGTCACGGCCGCACCTGTGGTCA
TTCTCGGCGCGGGTGGCGCGGCCCGGGGAGCGGTCGCGGCCCTGCTGCTGGCCGGCGCGCCGCGCATAGCTGTCGTCAAC
CGCACTGTCGCGCGCGCCCAGGACCTGGCCGACACGTTCGGGGAGAAGGTCGTAGCCAAGGGCGAAGACGCCCTCCCCGC
TCTGCTGCCAGAAGCGGGATTGATCATCAACGCGACCTCGCTAGGTCTGGGCGGCGGCGCTGGGCCGTCAGCCGACTTGA
CCCTGACCCCCAAGACCGCCGTCGTGATGGACATGGTCTACAAGCCGCTGCGGACAGAGTTCCTGCGCCGGGCCGAGGCC
GCCGGTCGCCGTACGGTGGACGGGCTGGAGATGCTGCTGCGTCAGGCGATCCCCACCTTCGAGACCATTTATGGCCAGGC
CCCCTCCCCCAAGATCGACGTTCGGGTCCTGGCGCTCAAGCTCCTGGGCGAGGTCTGA

Upstream 100 bases:

>100_bases
TCCAGCTGTTCGACAAGATCGAGGGCGACTATTTCACCATCCTGGGCCTGCCTCTGGTCGGGCTGCTGGATTTCCTGCGT
CTTCATGGAGCCCTGACCGT

Downstream 100 bases:

>100_bases
AATGTTGATCCTTGGGCTGACCGGTTCCATCGGCATGGGCAAGTCGACGACCTCCAAGATGTTCCAGGACGAAGGCGTGC
CCGTCTATGACGCCGACGCG

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MTNAITGAAIVGGVCGQPIKHSMSPVIHNAWIAAAGLDAAYVPFAPAADRFETFVDGLRGGAVRGLNVTIPFKERALAVA
DTASDLARMAGAANLLVFNEDGSVHADNTDGPGLLGAIAIQAPGFDVTAAPVVILGAGGAARGAVAALLLAGAPRIAVVN
RTVARAQDLADTFGEKVVAKGEDALPALLPEAGLIINATSLGLGGGAGPSADLTLTPKTAVVMDMVYKPLRTEFLRRAEA
AGRRTVDGLEMLLRQAIPTFETIYGQAPSPKIDVRVLALKLLGEV

Sequences:

>Translated_285_residues
MTNAITGAAIVGGVCGQPIKHSMSPVIHNAWIAAAGLDAAYVPFAPAADRFETFVDGLRGGAVRGLNVTIPFKERALAVA
DTASDLARMAGAANLLVFNEDGSVHADNTDGPGLLGAIAIQAPGFDVTAAPVVILGAGGAARGAVAALLLAGAPRIAVVN
RTVARAQDLADTFGEKVVAKGEDALPALLPEAGLIINATSLGLGGGAGPSADLTLTPKTAVVMDMVYKPLRTEFLRRAEA
AGRRTVDGLEMLLRQAIPTFETIYGQAPSPKIDVRVLALKLLGEV
>Mature_284_residues
TNAITGAAIVGGVCGQPIKHSMSPVIHNAWIAAAGLDAAYVPFAPAADRFETFVDGLRGGAVRGLNVTIPFKERALAVAD
TASDLARMAGAANLLVFNEDGSVHADNTDGPGLLGAIAIQAPGFDVTAAPVVILGAGGAARGAVAALLLAGAPRIAVVNR
TVARAQDLADTFGEKVVAKGEDALPALLPEAGLIINATSLGLGGGAGPSADLTLTPKTAVVMDMVYKPLRTEFLRRAEAA
GRRTVDGLEMLLRQAIPTFETIYGQAPSPKIDVRVLALKLLGEV

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1789675, Length=272, Percent_Identity=36.7647058823529, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1787983, Length=276, Percent_Identity=32.2463768115942, Blast_Score=120, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320332, Length=164, Percent_Identity=31.0975609756098, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_CAUCN (B8GWW0)

Other databases:

- EMBL:   CP001340
- RefSeq:   YP_002515378.1
- ProteinModelPortal:   B8GWW0
- SMR:   B8GWW0
- GeneID:   7333144
- GenomeReviews:   CP001340_GR
- KEGG:   ccs:CCNA_00003
- OMA:   ESVPPEG
- ProtClustDB:   CLSK889644
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 29015; Mature: 28884

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: ACT_SITE 73-73

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNAITGAAIVGGVCGQPIKHSMSPVIHNAWIAAAGLDAAYVPFAPAADRFETFVDGLRG
CCCCCCHHHHHHHHCCCCHHHHCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCC
GAVRGLNVTIPFKERALAVADTASDLARMAGAANLLVFNEDGSVHADNTDGPGLLGAIAI
CCEECEEEEECHHHCEEEEHHHHHHHHHHCCCCEEEEECCCCCEECCCCCCCCEEEEEEE
QAPGFDVTAAPVVILGAGGAARGAVAALLLAGAPRIAVVNRTVARAQDLADTFGEKVVAK
ECCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHEECC
GEDALPALLPEAGLIINATSLGLGGGAGPSADLTLTPKTAVVMDMVYKPLRTEFLRRAEA
CCCCCHHHCCCCCEEEEEEECCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHH
AGRRTVDGLEMLLRQAIPTFETIYGQAPSPKIDVRVLALKLLGEV
CCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TNAITGAAIVGGVCGQPIKHSMSPVIHNAWIAAAGLDAAYVPFAPAADRFETFVDGLRG
CCCCCHHHHHHHHCCCCHHHHCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCC
GAVRGLNVTIPFKERALAVADTASDLARMAGAANLLVFNEDGSVHADNTDGPGLLGAIAI
CCEECEEEEECHHHCEEEEHHHHHHHHHHCCCCEEEEECCCCCEECCCCCCCCEEEEEEE
QAPGFDVTAAPVVILGAGGAARGAVAALLLAGAPRIAVVNRTVARAQDLADTFGEKVVAK
ECCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHEECC
GEDALPALLPEAGLIINATSLGLGGGAGPSADLTLTPKTAVVMDMVYKPLRTEFLRRAEA
CCCCCHHHCCCCCEEEEEEECCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHH
AGRRTVDGLEMLLRQAIPTFETIYGQAPSPKIDVRVLALKLLGEV
CCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA