Click here to switch to the map view.

The map label for this gene is alr3

Identifier: 13488309

GI number: 13488309

Start: 324937

End: 326103

Strand: Direct

Name: alr3

Synonym: mlr9371

Alternate gene names: 13488309

Gene position: 324937-326103 (Clockwise)

Preceding gene: 13488308

Following gene: 13488310

Centisome position: 92.33

GC content: 56.98

Gene sequence:

>1167_bases
ATGTTGACCTCGGTACGACCTGCCGATGTTGTACTCGAAATCGATCTCAGCGCAATTCAGGCGAACTTTCAGACTATATC
GGCTCTCGTTGGGCCACAGGTAAGGGTAGCCGCTGTCGTCAAAAGCGACGCCTACGGGCTTGGCTTGGTTAAGGTTGCAG
GCGCGCTCATTGACGCCGGATGCGATCTGCTCTTCGTCGGCAATCTGCACGAAGCGTTGCTTCTGAGATCTTCCCACATT
AGCGCGGCAGTTGCGGTTTTTTGTGATGAGTTTGCGAGGTATGGCGAACACTATCGATCGAACGGCCTCATACCAGTTGT
GAACAATTCTGTCGAACTGGATGCCATTTGCGGCGCACGGGAGCCGCAAGCATACTTCCTCAACGTGGAGACTGGGCTCT
CTCGCCTTGGGCTCGCTTTCGATGATGTACGGCGCAGGTATCTTGGTGGTATCTTCAAGCGGCGTCCGCCTTCGGTCGTG
CTCAGCCACCTCGCATGCAGCGAACGCGCTGGGGACGCAATGAATCTGCTACAATGGAACCGCTTTCGGGCGACGTCAGA
CCTGCTAAAACCGACACTTCTCAGTCTCGCGGCCTCCGCCGGTGTGTGGCTAGGGAAGCGCTATCACTTCGATATGGTGC
GGGTGGGCTCGGCCCTTTACGGACTTAATAGTGCCGGCATCCGGCCAAATCCTTTAAAGCCCGTTGTCGGCGTCAAGGCA
AAAACACTCGACGCGCGCAACGTAGCAAGGAGTGAGGCAGTTGGCTACGGTGCGACTTTTCGAACGGGCCGAGCCAGCCG
CCTAGCAATCGCCGGGATCGGCTACAAGCATGGCCTTCCATGGGCCTGCGCCAACAAGATATCCGTCCGGTTTGCTGGAT
ATTCCGCTCCATTAGTCGGAAGGGTGTCCATGGAATACATAACAATCGATGTAACGGATGTTCCTGAAGCGCTTTGCGGT
CCGGGTACGAATGTGGAACTGCTGAGTGACGATTTCACCGTCGATGACCTTGCCGCGTCCGCTGGCGTTCATCCACAAGA
AGTGCTCACGCGGCTTGGTGTCGGTTGCGCAAGGCAGTATCTGGATGGTTCTTCTGCATCTGCGGGGTTCCCGGGCAATT
TGACTAATGCGGGCCCTGGCCACGATCCGCGCGCCATCCTTGGCTAG

Upstream 100 bases:

>100_bases
AGGTATTGAGTGCGACTAAGCCTTTGATGTAACGGCTTACATGTCGCCCGACGAATTGCGGTGCTTCGAAGCGCGAACCG
AGGACGGTGGAGAGCAAGGC

Downstream 100 bases:

>100_bases
AGCGAAGAGGCCCGACTGCCTTGTTTCTAGATAGTTATACGAAAGGGCTTCTTTTTGTCACGATCTCTGCAGTCGCGTGG
AGCACCGCAGGGCTGTTCGT

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MLTSVRPADVVLEIDLSAIQANFQTISALVGPQVRVAAVVKSDAYGLGLVKVAGALIDAGCDLLFVGNLHEALLLRSSHI
SAAVAVFCDEFARYGEHYRSNGLIPVVNNSVELDAICGAREPQAYFLNVETGLSRLGLAFDDVRRRYLGGIFKRRPPSVV
LSHLACSERAGDAMNLLQWNRFRATSDLLKPTLLSLAASAGVWLGKRYHFDMVRVGSALYGLNSAGIRPNPLKPVVGVKA
KTLDARNVARSEAVGYGATFRTGRASRLAIAGIGYKHGLPWACANKISVRFAGYSAPLVGRVSMEYITIDVTDVPEALCG
PGTNVELLSDDFTVDDLAASAGVHPQEVLTRLGVGCARQYLDGSSASAGFPGNLTNAGPGHDPRAILG

Sequences:

>Translated_388_residues
MLTSVRPADVVLEIDLSAIQANFQTISALVGPQVRVAAVVKSDAYGLGLVKVAGALIDAGCDLLFVGNLHEALLLRSSHI
SAAVAVFCDEFARYGEHYRSNGLIPVVNNSVELDAICGAREPQAYFLNVETGLSRLGLAFDDVRRRYLGGIFKRRPPSVV
LSHLACSERAGDAMNLLQWNRFRATSDLLKPTLLSLAASAGVWLGKRYHFDMVRVGSALYGLNSAGIRPNPLKPVVGVKA
KTLDARNVARSEAVGYGATFRTGRASRLAIAGIGYKHGLPWACANKISVRFAGYSAPLVGRVSMEYITIDVTDVPEALCG
PGTNVELLSDDFTVDDLAASAGVHPQEVLTRLGVGCARQYLDGSSASAGFPGNLTNAGPGHDPRAILG
>Mature_388_residues
MLTSVRPADVVLEIDLSAIQANFQTISALVGPQVRVAAVVKSDAYGLGLVKVAGALIDAGCDLLFVGNLHEALLLRSSHI
SAAVAVFCDEFARYGEHYRSNGLIPVVNNSVELDAICGAREPQAYFLNVETGLSRLGLAFDDVRRRYLGGIFKRRPPSVV
LSHLACSERAGDAMNLLQWNRFRATSDLLKPTLLSLAASAGVWLGKRYHFDMVRVGSALYGLNSAGIRPNPLKPVVGVKA
KTLDARNVARSEAVGYGATFRTGRASRLAIAGIGYKHGLPWACANKISVRFAGYSAPLVGRVSMEYITIDVTDVPEALCG
PGTNVELLSDDFTVDDLAASAGVHPQEVLTRLGVGCARQYLDGSSASAGFPGNLTNAGPGHDPRAILG

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1790487, Length=358, Percent_Identity=31.5642458100559, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1787439, Length=353, Percent_Identity=28.8951841359773, Blast_Score=114, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR3_RHILO (Q981H7)

Other databases:

- EMBL:   BA000013
- RefSeq:   NP_085891.1
- ProteinModelPortal:   Q981H7
- GeneID:   1231478
- GenomeReviews:   BA000013_GR
- KEGG:   mlo:mlr9371
- NMPDR:   fig|266835.1.peg.7045
- HOGENOM:   HBG712172
- OMA:   SETIEHE
- ProtClustDB:   CLSK250252
- BRENDA:   5.1.1.1
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 41131; Mature: 41131

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 41-41 ACT_SITE 256-256

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTSVRPADVVLEIDLSAIQANFQTISALVGPQVRVAAVVKSDAYGLGLVKVAGALIDAG
CCCCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHCC
CDLLFVGNLHEALLLRSSHISAAVAVFCDEFARYGEHYRSNGLIPVVNNSVELDAICGAR
CCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEECCCC
EPQAYFLNVETGLSRLGLAFDDVRRRYLGGIFKRRPPSVVLSHLACSERAGDAMNLLQWN
CCCEEEEEHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHH
RFRATSDLLKPTLLSLAASAGVWLGKRYHFDMVRVGSALYGLNSAGIRPNPLKPVVGVKA
HHHHHHHHHHHHHHHHHHHCCHHCCCEECHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
KTLDARNVARSEAVGYGATFRTGRASRLAIAGIGYKHGLPWACANKISVRFAGYSAPLVG
ECCCHHHHHHHHHCCCCCEECCCCCCEEEEEECCHHCCCCHHHCCCEEEEEECCCCCEEE
RVSMEYITIDVTDVPEALCGPGTNVELLSDDFTVDDLAASAGVHPQEVLTRLGVGCARQY
EEEEEEEEEEECCCCHHHHCCCCCEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHH
LDGSSASAGFPGNLTNAGPGHDPRAILG
CCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLTSVRPADVVLEIDLSAIQANFQTISALVGPQVRVAAVVKSDAYGLGLVKVAGALIDAG
CCCCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHCC
CDLLFVGNLHEALLLRSSHISAAVAVFCDEFARYGEHYRSNGLIPVVNNSVELDAICGAR
CCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEECCCC
EPQAYFLNVETGLSRLGLAFDDVRRRYLGGIFKRRPPSVVLSHLACSERAGDAMNLLQWN
CCCEEEEEHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHH
RFRATSDLLKPTLLSLAASAGVWLGKRYHFDMVRVGSALYGLNSAGIRPNPLKPVVGVKA
HHHHHHHHHHHHHHHHHHHCCHHCCCEECHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
KTLDARNVARSEAVGYGATFRTGRASRLAIAGIGYKHGLPWACANKISVRFAGYSAPLVG
ECCCHHHHHHHHHCCCCCEECCCCCCEEEEEECCHHCCCCHHHCCCEEEEEECCCCCEEE
RVSMEYITIDVTDVPEALCGPGTNVELLSDDFTVDDLAASAGVHPQEVLTRLGVGCARQY
EEEEEEEEEEECCCCHHHHCCCCCEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHH
LDGSSASAGFPGNLTNAGPGHDPRAILG
CCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968