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The map label for this gene is ybiC [H]

Identifier: 13488218

GI number: 13488218

Start: 94298

End: 95449

Strand: Direct

Name: ybiC [H]

Synonym: mlr9117

Alternate gene names: 13488218

Gene position: 94298-95449 (Clockwise)

Preceding gene: 13488217

Following gene: 13488219

Centisome position: 26.8

GC content: 60.42

Gene sequence:

>1152_bases
ATGATCCGGAAAAGTGAGCATCGGTGCTTCGACGGTCACGCTCAAGCGGAGAGAGGACAAGCGACCATGGTTATCATCAA
GGTTGAAAATCTCATCGATTTCATCGCAGAAGTCTTCGGTCACGCCGACTCCTCGCCGGAAGAGGCACGTCGCATAGCAA
CCTATCTGACGACAGCCAATCTCACCGGCCATGACAGTCATGGCGTGATCCGGGTGCCGGGCTATATTCGCTGGAAAAAA
ATAGGTTCGGTGGTGCCAAACCAGACGGTCGAGGTCTTGGTCGACACGCCCTCGCTCGCAGTGCTCGACGGCAAGTTCGG
CTACGGTCAGACGGTGGCGCCAGTTGCAGTGAAGCTCGGCATCGAGAAGTGCAAGAAGGCGGGCTTGGCGGCGGTGGCGC
TGCGCAATGCCGGCCATATTGGCCGCATCGGCGACTGGGCGGAGATGGCGGCGGCCGATGGCCTCGTCTCCGTGCACTTT
GTCAATGCCACCGATTCGCTTTTGGTCGCACCTTTCGGCGGTGTCGAGAGGCGCATGTCGACCGCGCCCTATTGCGTGGG
AATCCCGCGGCAAGGCCATGATCCAATCGTGCTCGATTTCGCAACCTCTGTTGTCGCGGAGGGTAAGTGCCTGGTCGCAA
GCCTGGGCGGCAAGAAATTGCCCAAGGGCGCGCTGATCGATTCCGACGGCACCCTTAGCGACGATCCGCGGTTGCTCTAC
GGTCCATACACCTCCGATAGCACGCGCGATCATACCCAGGGTATAGGAGCCATCCGCGCCTTTGGCGAGCACAAGGGCTC
TGGCCTTGCCCTGATCTGCGAGCTGATGGGCGGAGCGCTGACGGGTACGGGTGCGACCGCCGCTAATCAACGGTTCGCCA
ACGGCATGCTGGCGTTCTATATCGATCCAAAGGTGGTCGATCCCGCCAATTTTTTCGACGGTGAAGTCACCCGCTATACC
GATTTCATCCGCGCCACGAAGCCGGTCCCCGGCATCGAGCAGGTGCAGCTCCCGGGCGATCCAGAACGCAGGATCCGCGC
CGAACGAACCAAGGATGGCATCCCGTTGCTCGATGATACCTGGGCCGCAATAGTGAACACCGCGCGTGAAATGGGCGTGA
GTGAGACAGATATCCGGCAGGCCACAAGCTAG

Upstream 100 bases:

>100_bases
GTTCCACAAGACTTGCTGGAGCTGGGACTGAAACGCGTCGTCGAGACCCTAAACAGCCTGAAGACTAGGCAGCCTTCAAA
AGGTCGGGTGACCAAGGCGC

Downstream 100 bases:

>100_bases
AAAAGAGAGAGGTGCCTTGGTCGATTCGCTACGAGCCGTGGCTTCTGGTCACCTCTTCCCACAAGGCGCGGGTCGGAGCA
TCGGAAGACAGACCCGGAGG

Product: malate dehydrogenase-like protein

Products: oxaloacetate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MIRKSEHRCFDGHAQAERGQATMVIIKVENLIDFIAEVFGHADSSPEEARRIATYLTTANLTGHDSHGVIRVPGYIRWKK
IGSVVPNQTVEVLVDTPSLAVLDGKFGYGQTVAPVAVKLGIEKCKKAGLAAVALRNAGHIGRIGDWAEMAAADGLVSVHF
VNATDSLLVAPFGGVERRMSTAPYCVGIPRQGHDPIVLDFATSVVAEGKCLVASLGGKKLPKGALIDSDGTLSDDPRLLY
GPYTSDSTRDHTQGIGAIRAFGEHKGSGLALICELMGGALTGTGATAANQRFANGMLAFYIDPKVVDPANFFDGEVTRYT
DFIRATKPVPGIEQVQLPGDPERRIRAERTKDGIPLLDDTWAAIVNTAREMGVSETDIRQATS

Sequences:

>Translated_383_residues
MIRKSEHRCFDGHAQAERGQATMVIIKVENLIDFIAEVFGHADSSPEEARRIATYLTTANLTGHDSHGVIRVPGYIRWKK
IGSVVPNQTVEVLVDTPSLAVLDGKFGYGQTVAPVAVKLGIEKCKKAGLAAVALRNAGHIGRIGDWAEMAAADGLVSVHF
VNATDSLLVAPFGGVERRMSTAPYCVGIPRQGHDPIVLDFATSVVAEGKCLVASLGGKKLPKGALIDSDGTLSDDPRLLY
GPYTSDSTRDHTQGIGAIRAFGEHKGSGLALICELMGGALTGTGATAANQRFANGMLAFYIDPKVVDPANFFDGEVTRYT
DFIRATKPVPGIEQVQLPGDPERRIRAERTKDGIPLLDDTWAAIVNTAREMGVSETDIRQATS
>Mature_383_residues
MIRKSEHRCFDGHAQAERGQATMVIIKVENLIDFIAEVFGHADSSPEEARRIATYLTTANLTGHDSHGVIRVPGYIRWKK
IGSVVPNQTVEVLVDTPSLAVLDGKFGYGQTVAPVAVKLGIEKCKKAGLAAVALRNAGHIGRIGDWAEMAAADGLVSVHF
VNATDSLLVAPFGGVERRMSTAPYCVGIPRQGHDPIVLDFATSVVAEGKCLVASLGGKKLPKGALIDSDGTLSDDPRLLY
GPYTSDSTRDHTQGIGAIRAFGEHKGSGLALICELMGGALTGTGATAANQRFANGMLAFYIDPKVVDPANFFDGEVTRYT
DFIRATKPVPGIEQVQLPGDPERRIRAERTKDGIPLLDDTWAAIVNTAREMGVSETDIRQATS

Specific function: Unknown

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787020, Length=358, Percent_Identity=37.1508379888268, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI1786727, Length=351, Percent_Identity=24.5014245014245, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790000, Length=327, Percent_Identity=25.6880733944954, Blast_Score=101, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17507179, Length=336, Percent_Identity=28.2738095238095, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17536633, Length=369, Percent_Identity=24.390243902439, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI45553211, Length=346, Percent_Identity=26.0115606936416, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24667912, Length=346, Percent_Identity=26.0115606936416, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24667908, Length=346, Percent_Identity=26.0115606936416, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24667904, Length=350, Percent_Identity=25.7142857142857, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24648360, Length=365, Percent_Identity=23.2876712328767, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24658010, Length=346, Percent_Identity=23.4104046242775, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: 1.1.1.37

Molecular weight: Translated: 40889; Mature: 40889

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRKSEHRCFDGHAQAERGQATMVIIKVENLIDFIAEVFGHADSSPEEARRIATYLTTAN
CCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEECC
LTGHDSHGVIRVPGYIRWKKIGSVVPNQTVEVLVDTPSLAVLDGKFGYGQTVAPVAVKLG
CCCCCCCCEEECCCEEEEHHHCCCCCCCEEEEEEECCCEEEEECCCCCCCCHHHHHHHHH
IEKCKKAGLAAVALRNAGHIGRIGDWAEMAAADGLVSVHFVNATDSLLVAPFGGVERRMS
HHHHHHCCEEEEEECCCCCCCCCCCHHHHHHCCCEEEEEEECCCCCEEEECCCCHHHHHC
TAPYCVGIPRQGHDPIVLDFATSVVAEGKCLVASLGGKKLPKGALIDSDGTLSDDPRLLY
CCCEEEECCCCCCCCEEEEEHHHHHHCCCEEEEECCCCCCCCCCEECCCCCCCCCCEEEE
GPYTSDSTRDHTQGIGAIRAFGEHKGSGLALICELMGGALTGTGATAANQRFANGMLAFY
CCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHCCEEEEE
IDPKVVDPANFFDGEVTRYTDFIRATKPVPGIEQVQLPGDPERRIRAERTKDGIPLLDDT
ECCEEECCCCCCCCCHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHCCCCCCCCHHH
WAAIVNTAREMGVSETDIRQATS
HHHHHHHHHHCCCCHHHHHHCCC
>Mature Secondary Structure
MIRKSEHRCFDGHAQAERGQATMVIIKVENLIDFIAEVFGHADSSPEEARRIATYLTTAN
CCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEECC
LTGHDSHGVIRVPGYIRWKKIGSVVPNQTVEVLVDTPSLAVLDGKFGYGQTVAPVAVKLG
CCCCCCCCEEECCCEEEEHHHCCCCCCCEEEEEEECCCEEEEECCCCCCCCHHHHHHHHH
IEKCKKAGLAAVALRNAGHIGRIGDWAEMAAADGLVSVHFVNATDSLLVAPFGGVERRMS
HHHHHHCCEEEEEECCCCCCCCCCCHHHHHHCCCEEEEEEECCCCCEEEECCCCHHHHHC
TAPYCVGIPRQGHDPIVLDFATSVVAEGKCLVASLGGKKLPKGALIDSDGTLSDDPRLLY
CCCEEEECCCCCCCCEEEEEHHHHHHCCCEEEEECCCCCCCCCCEECCCCCCCCCCEEEE
GPYTSDSTRDHTQGIGAIRAFGEHKGSGLALICELMGGALTGTGATAANQRFANGMLAFY
CCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHCCEEEEE
IDPKVVDPANFFDGEVTRYTDFIRATKPVPGIEQVQLPGDPERRIRAERTKDGIPLLDDT
ECCEEECCCCCCCCCHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHCCCCCCCCHHH
WAAIVNTAREMGVSETDIRQATS
HHHHHHHHHHCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-malate; NAD+

Specific reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]