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The map label for this gene is metC [H]

Identifier: 13488085

GI number: 13488085

Start: 120233

End: 121408

Strand: Reverse

Name: metC [H]

Synonym: mll9139

Alternate gene names: 13488085

Gene position: 121408-120233 (Counterclockwise)

Preceding gene: 13488086

Following gene: 13488084

Centisome position: 34.5

GC content: 62.67

Gene sequence:

>1176_bases
ATGCACTGGCGCTCGAAGCTTATTCACCCGACCGCTCAGGCCCCGTCAGGGTTTCGCTCGCTCGTGACGCCGACCTATCG
GGCTTCGACCATTCTGTTCGAGCGGCAGGCCGATGCGGCAGACGATTGGCGTCAGAGCGAGGTCGGTTATACGTACGGCC
TGTATGGAACGCCTACCGTGCTGGAACTTGGAGCGCGTATTGCGGAACTGGAGGGTGCACGCCACAGCTTCGTTGTACCC
GGCGGCCAAGCTGCTATTACCTTGATCTATTTCGCCTTCTGCAAGGCTGGCAGTCACGCGCTCGTACCAGCTTCCGCCTA
TGGGCCCAACCGCGAGCTCGCGGACGGTCTGCTCGCACGGCTCAACATCGAGGTCGAAGCCTATGACCCTCTGATCGGCG
GGGGCATTTCGGCCCTCATCCGTGACAACACGGCGCTGATCTGGACCGAAAGCCCAGGCTCGGTGACGATGGAGATACAA
GACGTGCCAGCCATAGTGGCAGCGGCGCATGCCCGGGGGGTGCCGGTTGCCCTCGACAATACCTACGCAGCCGGTGTGCT
GTTCGACGCCTTCGCCAAGGGCGTAGATGTCAGCATGCAGGCGCTCACGAAGTACGTAGGGGGCCACAGCGACCTTCTGC
TCGGCACGGTGTCAGTCGGGACGCAAGCGGCGTACGACGCGGTCGGACCCGTGCTGAAGCAGCTCGGCGCGGCCGTCTCC
CCGGATGATGCAAGCCTTGCCTTGCGTGGGCTACAGACGCTCGGCGTGCGACTGGAGCGCCTCGAATCATCGACGCTGCA
GGTCGCCAATTGGCTGGTTGCCCAGCCTGGAATCGAAGCCGTCTTTCATCCCGCGCTCCCGTCATGCCCGGGCCACAAGT
TTTGGCAGCGCGACTTCACAGGCTCGGCCAGCGTGTTCTCGATCCTGTTCCGCCGTGAGGTTGACCCTGGGCAGGTCGAA
GCCTTTGTTGACAGTTTGAGGTTGTTCAAAATTGGCTTCAGCTGGGGCGGCACAACCGCACTGGCGATCCTCTATCCAAA
GCTTGACCGACTGGGCAAGGACTATGACGGCCGCCTTGTACGGCTCAATATTGGCCTGGAGGAGCCTTGCGATCTCATTG
CGGATCTCGAGCAGGCTCTCGGGCGCATCAATCAGCCCGGCGCGGCCGCTGCCTGA

Upstream 100 bases:

>100_bases
CGCAAAGGGTGAAGAGGATCGCAGTCGCCGAAAGTATAGACACTGACAAACGTCACACCCAGGCATAGCTATCCGTAGAT
AATCCAGGGAAAAGGCCACC

Downstream 100 bases:

>100_bases
CCTCTCATATACGAACGAGGCGCCGACGTACTCATCGGTGTTGTCATGACGGCGGATTGCTGGCGCGGTGTCGTCACATC
AAGTCCCTGGGGGTCTTTTG

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MHWRSKLIHPTAQAPSGFRSLVTPTYRASTILFERQADAADDWRQSEVGYTYGLYGTPTVLELGARIAELEGARHSFVVP
GGQAAITLIYFAFCKAGSHALVPASAYGPNRELADGLLARLNIEVEAYDPLIGGGISALIRDNTALIWTESPGSVTMEIQ
DVPAIVAAAHARGVPVALDNTYAAGVLFDAFAKGVDVSMQALTKYVGGHSDLLLGTVSVGTQAAYDAVGPVLKQLGAAVS
PDDASLALRGLQTLGVRLERLESSTLQVANWLVAQPGIEAVFHPALPSCPGHKFWQRDFTGSASVFSILFRREVDPGQVE
AFVDSLRLFKIGFSWGGTTALAILYPKLDRLGKDYDGRLVRLNIGLEEPCDLIADLEQALGRINQPGAAAA

Sequences:

>Translated_391_residues
MHWRSKLIHPTAQAPSGFRSLVTPTYRASTILFERQADAADDWRQSEVGYTYGLYGTPTVLELGARIAELEGARHSFVVP
GGQAAITLIYFAFCKAGSHALVPASAYGPNRELADGLLARLNIEVEAYDPLIGGGISALIRDNTALIWTESPGSVTMEIQ
DVPAIVAAAHARGVPVALDNTYAAGVLFDAFAKGVDVSMQALTKYVGGHSDLLLGTVSVGTQAAYDAVGPVLKQLGAAVS
PDDASLALRGLQTLGVRLERLESSTLQVANWLVAQPGIEAVFHPALPSCPGHKFWQRDFTGSASVFSILFRREVDPGQVE
AFVDSLRLFKIGFSWGGTTALAILYPKLDRLGKDYDGRLVRLNIGLEEPCDLIADLEQALGRINQPGAAAA
>Mature_391_residues
MHWRSKLIHPTAQAPSGFRSLVTPTYRASTILFERQADAADDWRQSEVGYTYGLYGTPTVLELGARIAELEGARHSFVVP
GGQAAITLIYFAFCKAGSHALVPASAYGPNRELADGLLARLNIEVEAYDPLIGGGISALIRDNTALIWTESPGSVTMEIQ
DVPAIVAAAHARGVPVALDNTYAAGVLFDAFAKGVDVSMQALTKYVGGHSDLLLGTVSVGTQAAYDAVGPVLKQLGAAVS
PDDASLALRGLQTLGVRLERLESSTLQVANWLVAQPGIEAVFHPALPSCPGHKFWQRDFTGSASVFSILFRREVDPGQVE
AFVDSLRLFKIGFSWGGTTALAILYPKLDRLGKDYDGRLVRLNIGLEEPCDLIADLEQALGRINQPGAAAA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=399, Percent_Identity=29.8245614035088, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI299473759, Length=401, Percent_Identity=29.1770573566085, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI25453487, Length=398, Percent_Identity=27.6381909547739, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1789383, Length=368, Percent_Identity=39.945652173913, Blast_Score=264, Evalue=6e-72,
Organism=Escherichia coli, GI1790375, Length=344, Percent_Identity=28.1976744186047, Blast_Score=132, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI71980708, Length=403, Percent_Identity=29.7766749379653, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17538055, Length=343, Percent_Identity=30.9037900874636, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17560056, Length=354, Percent_Identity=30.225988700565, Blast_Score=142, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6321170, Length=318, Percent_Identity=40.5660377358491, Blast_Score=253, Evalue=4e-68,
Organism=Saccharomyces cerevisiae, GI6319307, Length=346, Percent_Identity=28.3236994219653, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6323333, Length=443, Percent_Identity=25.0564334085779, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321904, Length=249, Percent_Identity=26.9076305220884, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321254, Length=268, Percent_Identity=27.9850746268657, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI19922554, Length=389, Percent_Identity=31.3624678663239, Blast_Score=177, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 41684; Mature: 41684

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHWRSKLIHPTAQAPSGFRSLVTPTYRASTILFERQADAADDWRQSEVGYTYGLYGTPTV
CCCHHCCCCCCCCCCCCHHHHCCCCCCCEEEEEECCCCCCHHHHHHCCCEEEECCCCCHH
LELGARIAELEGARHSFVVPGGQAAITLIYFAFCKAGSHALVPASAYGPNRELADGLLAR
HHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHH
LNIEVEAYDPLIGGGISALIRDNTALIWTESPGSVTMEIQDVPAIVAAAHARGVPVALDN
EEEEEEEECCCCCCCCEEEEECCEEEEEECCCCCEEEEEECCCHHHHHHHCCCCEEEECC
TYAAGVLFDAFAKGVDVSMQALTKYVGGHSDLLLGTVSVGTQAAYDAVGPVLKQLGAAVS
CHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCC
PDDASLALRGLQTLGVRLERLESSTLQVANWLVAQPGIEAVFHPALPSCPGHKFWQRDFT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEECCCCCCCCCCHHHHHCCC
GSASVFSILFRREVDPGQVEAFVDSLRLFKIGFSWGGTTALAILYPKLDRLGKDYDGRLV
CCHHHHHHHHHCCCCHHHHHHHHHHHEEEEEEECCCCCEEEEEEEHHHHHHCCCCCCEEE
RLNIGLEEPCDLIADLEQALGRINQPGAAAA
EEECCCCCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MHWRSKLIHPTAQAPSGFRSLVTPTYRASTILFERQADAADDWRQSEVGYTYGLYGTPTV
CCCHHCCCCCCCCCCCCHHHHCCCCCCCEEEEEECCCCCCHHHHHHCCCEEEECCCCCHH
LELGARIAELEGARHSFVVPGGQAAITLIYFAFCKAGSHALVPASAYGPNRELADGLLAR
HHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHH
LNIEVEAYDPLIGGGISALIRDNTALIWTESPGSVTMEIQDVPAIVAAAHARGVPVALDN
EEEEEEEECCCCCCCCEEEEECCEEEEEECCCCCEEEEEECCCHHHHHHHCCCCEEEECC
TYAAGVLFDAFAKGVDVSMQALTKYVGGHSDLLLGTVSVGTQAAYDAVGPVLKQLGAAVS
CHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCC
PDDASLALRGLQTLGVRLERLESSTLQVANWLVAQPGIEAVFHPALPSCPGHKFWQRDFT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEECCCCCCCCCCHHHHHCCC
GSASVFSILFRREVDPGQVEAFVDSLRLFKIGFSWGGTTALAILYPKLDRLGKDYDGRLV
CCHHHHHHHHHCCCCHHHHHHHHHHHEEEEEEECCCCCEEEEEEEHHHHHHCCCCCCEEE
RLNIGLEEPCDLIADLEQALGRINQPGAAAA
EEECCCCCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]