Click here to switch to the map view.

The map label for this gene is ndhM [H]

Identifier: 57165213

GI number: 57165213

Start: 1424231

End: 1425235

Strand: Direct

Name: ndhM [H]

Synonym: mlr1704

Alternate gene names: 57165213

Gene position: 1424231-1425235 (Clockwise)

Preceding gene: 57165212

Following gene: 13471664

Centisome position: 20.24

GC content: 65.17

Gene sequence:

>1005_bases
ATGGCGATCCGGCGCGGACGCGGCGTTGCCGCCATCAACTATCCCACCGGCATGAATCTCGGCGGCGACCCGACCCAGGC
GCTGGTGCATTCGACGCCGACCGGCAATTTCATGGTGACGCTGTCATCGGTCGATCTCGGCCAGGGCATGAAGCAGATCA
TGGCGCAGATCTGCGCCGAGACCATCGGCGTGCCCACCGACCGCGTCGTCGTCGACACCGCCGACACCGACACCGGTCCG
CATTGCATGGGCACCTTCGCCTCGCGCGGCACCCACCGCGCCGGCAATGCCGTCATCCAGGCGGCCAGGGAAGCGCGCCA
GGTGATGCTGGAAGTGGCGGCCGAGGAATTGGAAGTGAATGCTTCCGATCTCGAGACCGACGGCCAGGGCAACATTCTGG
TCAAGGGCGCACCGCAAAAGTCGATCTCGATCTTCGATGTCGCGCTGTCCGCCCATTTCAAGCGCGGCCGCTCGATATCG
GGCCGCGGCATGTTCCTGATCCCGCGCTCCTATCCGGAGAAGGAAACCGGCGCGATGAAGCCCTCGACCTGTTACGCCCA
CGCCTGCACCGTGGCCGAGGTCGAGGTCGACGACGAGACCGGTGAGGTCACGGTTTTAACGGTCAAGAACGTCTTCGAGA
TCGGCCGCGCGCTGAATCCGAAAATGGTCGAGCAACAGCTGGTCGGCGGTTCTTGGATGGGCATCAGCCACGCGCTCTAC
GAAACCACCGAGCCCTATTATCCCAACCGCGACCATGGCGGCACCGACTTCAACCAGTATCTTATGCCGGGGCCTGGCGA
TCTCGCGCAGACCGAGATCATCGTCCTGGAACGACCCTCGGCCGATGGGCCTTACGGCGCCAAGGGACCGGGCGAAATGT
GCGCCAACCCGCAGATCCCGGCGGTCGCCAACGCCGTCTTCGACGCCGTCGGCGTGCGCATCGACACGCTGCCGATCACG
CCGGAGCGCATCCTGCGCGCGCTCAAGGCGCAAGCGGCGAACTGA

Upstream 100 bases:

>100_bases
GCGGCACTCATCGAGTGCATGCAGGAAGCCTCGCGCGCCGCCAACTGGCCGGTGGCGGAGAAATATATGGCGATGTCCTC
CTACAGGAAGGGAGCCTGAT

Downstream 100 bases:

>100_bases
GATGCCCGAGGTTAACGCCGAGACTGTCGCGACCTCGGCGGAGGCGGTGGCGCAGCACCTTGCCGCCTCGCGCTATCTGG
CCGACGACAGCCTGGCCACC

Product: dehydrogenase

Products: NA

Alternate protein names: NDH; Nicotinic acid hydroxylase medium molybdopterin subunit; NAH [H]

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MAIRRGRGVAAINYPTGMNLGGDPTQALVHSTPTGNFMVTLSSVDLGQGMKQIMAQICAETIGVPTDRVVVDTADTDTGP
HCMGTFASRGTHRAGNAVIQAAREARQVMLEVAAEELEVNASDLETDGQGNILVKGAPQKSISIFDVALSAHFKRGRSIS
GRGMFLIPRSYPEKETGAMKPSTCYAHACTVAEVEVDDETGEVTVLTVKNVFEIGRALNPKMVEQQLVGGSWMGISHALY
ETTEPYYPNRDHGGTDFNQYLMPGPGDLAQTEIIVLERPSADGPYGAKGPGEMCANPQIPAVANAVFDAVGVRIDTLPIT
PERILRALKAQAAN

Sequences:

>Translated_334_residues
MAIRRGRGVAAINYPTGMNLGGDPTQALVHSTPTGNFMVTLSSVDLGQGMKQIMAQICAETIGVPTDRVVVDTADTDTGP
HCMGTFASRGTHRAGNAVIQAAREARQVMLEVAAEELEVNASDLETDGQGNILVKGAPQKSISIFDVALSAHFKRGRSIS
GRGMFLIPRSYPEKETGAMKPSTCYAHACTVAEVEVDDETGEVTVLTVKNVFEIGRALNPKMVEQQLVGGSWMGISHALY
ETTEPYYPNRDHGGTDFNQYLMPGPGDLAQTEIIVLERPSADGPYGAKGPGEMCANPQIPAVANAVFDAVGVRIDTLPIT
PERILRALKAQAAN
>Mature_333_residues
AIRRGRGVAAINYPTGMNLGGDPTQALVHSTPTGNFMVTLSSVDLGQGMKQIMAQICAETIGVPTDRVVVDTADTDTGPH
CMGTFASRGTHRAGNAVIQAAREARQVMLEVAAEELEVNASDLETDGQGNILVKGAPQKSISIFDVALSAHFKRGRSISG
RGMFLIPRSYPEKETGAMKPSTCYAHACTVAEVEVDDETGEVTVLTVKNVFEIGRALNPKMVEQQLVGGSWMGISHALYE
TTEPYYPNRDHGGTDFNQYLMPGPGDLAQTEIIVLERPSADGPYGAKGPGEMCANPQIPAVANAVFDAVGVRIDTLPITP
ERILRALKAQAAN

Specific function: Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789230, Length=331, Percent_Identity=32.6283987915408, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1789246, Length=327, Percent_Identity=30.2752293577982, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786478, Length=308, Percent_Identity=28.2467532467532, Blast_Score=88, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008274 [H]

Pfam domain/function: PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.5 [H]

Molecular weight: Translated: 35539; Mature: 35408

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIRRGRGVAAINYPTGMNLGGDPTQALVHSTPTGNFMVTLSSVDLGQGMKQIMAQICAE
CCCCCCCCEEEEECCCCCCCCCCHHHHHEECCCCCCEEEEEECCCHHHHHHHHHHHHHHH
TIGVPTDRVVVDTADTDTGPHCMGTFASRGTHRAGNAVIQAAREARQVMLEVAAEELEVN
HHCCCCCEEEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
ASDLETDGQGNILVKGAPQKSISIFDVALSAHFKRGRSISGRGMFLIPRSYPEKETGAMK
HHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHCCCC
PSTCYAHACTVAEVEVDDETGEVTVLTVKNVFEIGRALNPKMVEQQLVGGSWMGISHALY
CCCEEEEEEEEEEEEECCCCCCEEEEEHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHH
ETTEPYYPNRDHGGTDFNQYLMPGPGDLAQTEIIVLERPSADGPYGAKGPGEMCANPQIP
HCCCCCCCCCCCCCCCHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHCCCCCCC
AVANAVFDAVGVRIDTLPITPERILRALKAQAAN
HHHHHHHHHHCCEEEECCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
AIRRGRGVAAINYPTGMNLGGDPTQALVHSTPTGNFMVTLSSVDLGQGMKQIMAQICAE
CCCCCCCEEEEECCCCCCCCCCHHHHHEECCCCCCEEEEEECCCHHHHHHHHHHHHHHH
TIGVPTDRVVVDTADTDTGPHCMGTFASRGTHRAGNAVIQAAREARQVMLEVAAEELEVN
HHCCCCCEEEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
ASDLETDGQGNILVKGAPQKSISIFDVALSAHFKRGRSISGRGMFLIPRSYPEKETGAMK
HHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHCCCC
PSTCYAHACTVAEVEVDDETGEVTVLTVKNVFEIGRALNPKMVEQQLVGGSWMGISHALY
CCCEEEEEEEEEEEEECCCCCCEEEEEHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHH
ETTEPYYPNRDHGGTDFNQYLMPGPGDLAQTEIIVLERPSADGPYGAKGPGEMCANPQIP
HCCCCCCCCCCCCCCCHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHCCCCCCC
AVANAVFDAVGVRIDTLPITPERILRALKAQAAN
HHHHHHHHHHCCEEEECCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA