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The map label for this gene is ndhL [H]

Identifier: 57165212

GI number: 57165212

Start: 1422859

End: 1424229

Strand: Direct

Name: ndhL [H]

Synonym: mlr1703

Alternate gene names: 57165212

Gene position: 1422859-1424229 (Clockwise)

Preceding gene: 13471661

Following gene: 57165213

Centisome position: 20.22

GC content: 64.19

Gene sequence:

>1371_bases
ATGATGGAACTGCGCAAGAACTACTTCGCCGATGTCCGCAAGGACGATCTGCACGAGATCGGCCAGCCCCGGCCCCGTTC
GGATTCACCCGGCCACGTCACCGGCAAGACCGCCTTTTTCGCCGACCGCAGCTTTCCCGGCATGCTGCACCTGAAGATGG
TGCGCAGCCCGCACCACCACGCCCGCATCCGCTCGATCGACACCTCGGAGGCCGAAAAGCACCCTGGCGTGGTCAAGGTG
CTGACCGCCAAGGACGTGCCGCACAATGTCTACACCATCCTGATCCTGATCCAGATCGGCCCGGAGGACGAGACGGTGCT
GGCCGACGGCAAGGTGCGCTGGAAAGGCGAGGCCGTGGTGGCGGTGCTGGCCGAGACCGAGCGCGCCGCGCAAGAGGCCG
CCGCCAAGGTCAAGATCGACTACGAAGTGCTGCCGGCCGTCTTCGACATGGAGGAAGCGCTGAAGCCCGGCGCGCCGCTG
GTCAACGAATATCACGGCCAGAACTATTACCTTTATGACAGCGGCGAGTGCCGCAAGGTGCGTTTCGGCGATGTCGAGGC
GGGCTTCGCCGGCGCCGATCACATACTGGAGCAGAGCTACCAATCCTCGCCGATCGAGCATGCGCCGACCGAGACCACCG
GCTGCGTGGTGGCGCCCGAGGGCAATGACCGCTTCACCTGCTACACCAACACGCAGGCGATGTTCTTCACCCTCGACAAC
ACCTCGATCATCCTGCAGATGCCGGGCTCGAAGCTGCATTTCGTCGGCGGCACCGTCGGCGGCGGTTTTGGCGGCAAGGT
CGACGTCATCGTCGAGCCCATCGCCATTCTCGGCGCCAAGCTAACAGGACGACCGGTCTGTTTTATCTACAGCCGCGAGG
AGGAGATGCAGATCTCCTCGCCTCGCGCCGCCGAGAAGGTCGTCATCAAGGACGGCGTCATGAAGGACGGCCGCATCGTC
GCGCGAAAGGTCACCGGCTACACCGATGCCGGCGCCTATTCGCGCCACTCGCCCTATGGCGCGCAGAAGGGTGCCGGGCA
CTATCCCGGCCCTTACACCATTCCCAATGTCTGGATCGACACTTATTGCGTCTACACCAACCGCACGCCGTCCTCGGCCA
TGCGCGGCTTCGGCGTCACCATCGGCGACTTCGCACTGGAGGTGCAGATGGACAAGCTGGCGCGGTTGATCGGCATGGAC
CCGCTCGAATTCCGCTTCATCAACGCCTATCGCGACGGCGACATGAAGGCGCACCGCCAGCCGACCGAGGGGGCGGCACT
CATCGAGTGCATGCAGGAAGCCTCGCGCGCCGCCAACTGGCCGGTGGCGGAGAAATATATGGCGATGTCCTCCTACAGGA
AGGGAGCCTGA

Upstream 100 bases:

>100_bases
TCGACCTGAAATCTGAATCCGGCTCTAAATCAAAGAGATAGAGCATGATGTCGTCCGAAAACCGCTTCACACTTTTCGAC
ATCATGCTCTGAGGGAAGCA

Downstream 100 bases:

>100_bases
TATGGCGATCCGGCGCGGACGCGGCGTTGCCGCCATCAACTATCCCACCGGCATGAATCTCGGCGGCGACCCGACCCAGG
CGCTGGTGCATTCGACGCCG

Product: dehydrogenase

Products: NA

Alternate protein names: NDH; Nicotinic acid hydroxylase large molybdopterin subunit; NAH [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MMELRKNYFADVRKDDLHEIGQPRPRSDSPGHVTGKTAFFADRSFPGMLHLKMVRSPHHHARIRSIDTSEAEKHPGVVKV
LTAKDVPHNVYTILILIQIGPEDETVLADGKVRWKGEAVVAVLAETERAAQEAAAKVKIDYEVLPAVFDMEEALKPGAPL
VNEYHGQNYYLYDSGECRKVRFGDVEAGFAGADHILEQSYQSSPIEHAPTETTGCVVAPEGNDRFTCYTNTQAMFFTLDN
TSIILQMPGSKLHFVGGTVGGGFGGKVDVIVEPIAILGAKLTGRPVCFIYSREEEMQISSPRAAEKVVIKDGVMKDGRIV
ARKVTGYTDAGAYSRHSPYGAQKGAGHYPGPYTIPNVWIDTYCVYTNRTPSSAMRGFGVTIGDFALEVQMDKLARLIGMD
PLEFRFINAYRDGDMKAHRQPTEGAALIECMQEASRAANWPVAEKYMAMSSYRKGA

Sequences:

>Translated_456_residues
MMELRKNYFADVRKDDLHEIGQPRPRSDSPGHVTGKTAFFADRSFPGMLHLKMVRSPHHHARIRSIDTSEAEKHPGVVKV
LTAKDVPHNVYTILILIQIGPEDETVLADGKVRWKGEAVVAVLAETERAAQEAAAKVKIDYEVLPAVFDMEEALKPGAPL
VNEYHGQNYYLYDSGECRKVRFGDVEAGFAGADHILEQSYQSSPIEHAPTETTGCVVAPEGNDRFTCYTNTQAMFFTLDN
TSIILQMPGSKLHFVGGTVGGGFGGKVDVIVEPIAILGAKLTGRPVCFIYSREEEMQISSPRAAEKVVIKDGVMKDGRIV
ARKVTGYTDAGAYSRHSPYGAQKGAGHYPGPYTIPNVWIDTYCVYTNRTPSSAMRGFGVTIGDFALEVQMDKLARLIGMD
PLEFRFINAYRDGDMKAHRQPTEGAALIECMQEASRAANWPVAEKYMAMSSYRKGA
>Mature_456_residues
MMELRKNYFADVRKDDLHEIGQPRPRSDSPGHVTGKTAFFADRSFPGMLHLKMVRSPHHHARIRSIDTSEAEKHPGVVKV
LTAKDVPHNVYTILILIQIGPEDETVLADGKVRWKGEAVVAVLAETERAAQEAAAKVKIDYEVLPAVFDMEEALKPGAPL
VNEYHGQNYYLYDSGECRKVRFGDVEAGFAGADHILEQSYQSSPIEHAPTETTGCVVAPEGNDRFTCYTNTQAMFFTLDN
TSIILQMPGSKLHFVGGTVGGGFGGKVDVIVEPIAILGAKLTGRPVCFIYSREEEMQISSPRAAEKVVIKDGVMKDGRIV
ARKVTGYTDAGAYSRHSPYGAQKGAGHYPGPYTIPNVWIDTYCVYTNRTPSSAMRGFGVTIGDFALEVQMDKLARLIGMD
PLEFRFINAYRDGDMKAHRQPTEGAALIECMQEASRAANWPVAEKYMAMSSYRKGA

Specific function: Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=438, Percent_Identity=31.5068493150685, Blast_Score=182, Evalue=8e-46,
Organism=Homo sapiens, GI71773480, Length=445, Percent_Identity=30.561797752809, Blast_Score=176, Evalue=4e-44,
Organism=Escherichia coli, GI1789246, Length=472, Percent_Identity=30.7203389830508, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1789230, Length=442, Percent_Identity=30.5429864253394, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1786478, Length=433, Percent_Identity=24.4803695150115, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17540638, Length=398, Percent_Identity=26.6331658291457, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17539860, Length=466, Percent_Identity=24.4635193133047, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI32566215, Length=468, Percent_Identity=23.5042735042735, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17737937, Length=428, Percent_Identity=28.5046728971963, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24647201, Length=372, Percent_Identity=26.6129032258064, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24647199, Length=390, Percent_Identity=24.8717948717949, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.5 [H]

Molecular weight: Translated: 50245; Mature: 50245

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMELRKNYFADVRKDDLHEIGQPRPRSDSPGHVTGKTAFFADRSFPGMLHLKMVRSPHHH
CCCHHHHHHHCCCHHHHHHCCCCCCCCCCCCEEECCEEEEECCCCCCEEEEEECCCCCCH
ARIRSIDTSEAEKHPGVVKVLTAKDVPHNVYTILILIQIGPEDETVLADGKVRWKGEAVV
HEEEECCCCHHHCCCCEEEEEEECCCCCCEEEEEEEEEECCCCCEEEECCEEEECCCEEE
AVLAETERAAQEAAAKVKIDYEVLPAVFDMEEALKPGAPLVNEYHGQNYYLYDSGECRKV
EEEEHHHHHHHHHHHEEEECHHHHHHHHCHHHHHCCCCCCHHHHCCCEEEEEECCCEEEE
RFGDVEAGFAGADHILEQSYQSSPIEHAPTETTGCVVAPEGNDRFTCYTNTQAMFFTLDN
EECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCEEEEEECCEEEEEEECC
TSIILQMPGSKLHFVGGTVGGGFGGKVDVIVEPIAILGAKLTGRPVCFIYSREEEMQISS
CEEEEECCCCEEEEEECCCCCCCCCEEEEEECCHHHHCCCCCCCEEEEEEECCCCCCCCC
PRAAEKVVIKDGVMKDGRIVARKVTGYTDAGAYSRHSPYGAQKGAGHYPGPYTIPNVWID
CCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
TYCVYTNRTPSSAMRGFGVTIGDFALEVQMDKLARLIGMDPLEFRFINAYRDGDMKAHRQ
EEEEEECCCHHHHHHCCCCEEEEEEEEEEHHHHHHHHCCCCHHEEEEEEECCCCCCCCCC
PTEGAALIECMQEASRAANWPVAEKYMAMSSYRKGA
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMELRKNYFADVRKDDLHEIGQPRPRSDSPGHVTGKTAFFADRSFPGMLHLKMVRSPHHH
CCCHHHHHHHCCCHHHHHHCCCCCCCCCCCCEEECCEEEEECCCCCCEEEEEECCCCCCH
ARIRSIDTSEAEKHPGVVKVLTAKDVPHNVYTILILIQIGPEDETVLADGKVRWKGEAVV
HEEEECCCCHHHCCCCEEEEEEECCCCCCEEEEEEEEEECCCCCEEEECCEEEECCCEEE
AVLAETERAAQEAAAKVKIDYEVLPAVFDMEEALKPGAPLVNEYHGQNYYLYDSGECRKV
EEEEHHHHHHHHHHHEEEECHHHHHHHHCHHHHHCCCCCCHHHHCCCEEEEEECCCEEEE
RFGDVEAGFAGADHILEQSYQSSPIEHAPTETTGCVVAPEGNDRFTCYTNTQAMFFTLDN
EECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCEEEEEECCEEEEEEECC
TSIILQMPGSKLHFVGGTVGGGFGGKVDVIVEPIAILGAKLTGRPVCFIYSREEEMQISS
CEEEEECCCCEEEEEECCCCCCCCCEEEEEECCHHHHCCCCCCCEEEEEEECCCCCCCCC
PRAAEKVVIKDGVMKDGRIVARKVTGYTDAGAYSRHSPYGAQKGAGHYPGPYTIPNVWID
CCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
TYCVYTNRTPSSAMRGFGVTIGDFALEVQMDKLARLIGMDPLEFRFINAYRDGDMKAHRQ
EEEEEECCCHHHHHHCCCCEEEEEEEEEEHHHHHHHHCCCCHHEEEEEEECCCCCCCCCC
PTEGAALIECMQEASRAANWPVAEKYMAMSSYRKGA
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA