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The map label for this gene is pyrC [H]

Identifier: 13476463

GI number: 13476463

Start: 6447692

End: 6449161

Strand: Direct

Name: pyrC [H]

Synonym: mlr7790

Alternate gene names: 13476463

Gene position: 6447692-6449161 (Clockwise)

Preceding gene: 13476459

Following gene: 13476468

Centisome position: 91.64

GC content: 65.51

Gene sequence:

>1470_bases
ATGCTCGGCATCCGGGCCGGAGACGGAGATGAGCGCGCGGTCTTTCAGCAGGGCAAAGGGCATGGGGAGGATAAACGCCT
GATCTTGCAAAACGGTTGGCCATTACGTAAGCCGCTGACACTCCCCCCGCAAGAGAGCATGGCCATGACCTACGACCTCA
TCCTGACAGGCGGCACAGTGGTCAACCATGATGGCGAGGGGGCACGTGACATCGGCGTGAAGAATGGACGCATCGCCGCA
ATAGGCGATCTCCGCCAGGCCTCGGCCGACGAGACGATCGACTGCCGCGGCCTGCACATCCTGCCGGGCGTCGTCGACAG
CCAGGTGCATTTCCGCGAGCCGGGACTGGAGCACAAGGAAGATTTGGAAACGGGCTCGCGGGCGGCGGTGCTTGGCGGTG
TCACCGCGGTGTTCGAGATGCCCAACACCAACCCGTTGACCACCAGCGAGGCAACGCTGGCCGACAAGGTGCGGCGCGGC
AGTGGGCGCATGCATTGCGACTTCGCGTTCTGGGTCGGCGGTACCCGCGACAACGCCAGGGATGTCGGCGAGCTTGAACG
GCTGCCAGGCGCCGCGGGCATAAAGGTCTTCATGGGATCGTCCACCGGCGACCTGTTGGTCGAAGACGACGAAGGCGTCG
CGTCGATCCTGCGGAACACCCGCCGCCGTGCCGCCTTTCATTCGGAGGACGAGTTCCGGCTGCGCGAGCGCCTTGGCGAA
CGCATCGAGGGCGACCCGTCATCGCATCCGGTTTGGCGCGACGAGATCGCCGCCTTGCGTTGCACCGAACGGCTGGTGCG
CATTGCGCGCGATGTTCGCGCCCGCATCCACGTCCTGCACATCTCGACCGCCGAGGAGATCCTGTTCCTCGAACAGCACA
AGGACGTCGCGACCTGCGAGGCGACGCCGCACCATCTGACGCTGAGCGCCGACGACTATCTAAGGCTCGGCACGCTGATC
CAGATGAACCCGCCGGTGCGTGCCTCCCGCCACCGCGATGGCGTCTGGCACGGCATCGCGCAAGGTATCGTCGACGTGCT
CGGCTCCGATCACGCGCCGCATACGCTGGCCGAAAAGGCAAAACCCTATCCGGCCTCACCGTCGGGCATGACCGGTGTGC
AGACGCTGGTGCCGATCATGCTCGACCACGTCAACGCCGGCCGGCTGACCTTGCAGCGTTTCGTCGATCTCTCCAGCCAC
GGCCCGCAGCGTATTTTCGGCATGGCCAGAAAAGGCCGCATCGCCGCCGGCTACGATGCCGACTTCACGGTTGTGGATAT
GAAGCGGCGCGAGACCATCACCAATGCGCAGGCCGGCTCCAAGGCCGGCTGGACGCCTTATGACGGCAAGGAAGTCACCG
GCTGGCCGGTCGGCACCGTCATTCGCGGCCGCCGCGTCATGTGGGAAGGCGAAATCGTCACGCCCGGGCAGGGCAGGGCG
GTGGAGTTTTCCGAGGCGTTGCCTGCTTAG

Upstream 100 bases:

>100_bases
AGTCGAACAGGATCTTGCCTTGCGGCGTCAACAGCGCGCCAGGCTTTGTTTCGCCGGCGCCAAGCGTATCGAGATCGGTG
GTCAGGATGTTTTGCAGAAA

Downstream 100 bases:

>100_bases
AGCCTCAAACTCCCCTTGTGAGGTTGGACCGAAAGTTCGGGTGGACGCGGCGCCGCCCCCTTGCTCCGAGGGGCAGGGGT
AAGCCCACTCAGTCTCCGGC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MLGIRAGDGDERAVFQQGKGHGEDKRLILQNGWPLRKPLTLPPQESMAMTYDLILTGGTVVNHDGEGARDIGVKNGRIAA
IGDLRQASADETIDCRGLHILPGVVDSQVHFREPGLEHKEDLETGSRAAVLGGVTAVFEMPNTNPLTTSEATLADKVRRG
SGRMHCDFAFWVGGTRDNARDVGELERLPGAAGIKVFMGSSTGDLLVEDDEGVASILRNTRRRAAFHSEDEFRLRERLGE
RIEGDPSSHPVWRDEIAALRCTERLVRIARDVRARIHVLHISTAEEILFLEQHKDVATCEATPHHLTLSADDYLRLGTLI
QMNPPVRASRHRDGVWHGIAQGIVDVLGSDHAPHTLAEKAKPYPASPSGMTGVQTLVPIMLDHVNAGRLTLQRFVDLSSH
GPQRIFGMARKGRIAAGYDADFTVVDMKRRETITNAQAGSKAGWTPYDGKEVTGWPVGTVIRGRRVMWEGEIVTPGQGRA
VEFSEALPA

Sequences:

>Translated_489_residues
MLGIRAGDGDERAVFQQGKGHGEDKRLILQNGWPLRKPLTLPPQESMAMTYDLILTGGTVVNHDGEGARDIGVKNGRIAA
IGDLRQASADETIDCRGLHILPGVVDSQVHFREPGLEHKEDLETGSRAAVLGGVTAVFEMPNTNPLTTSEATLADKVRRG
SGRMHCDFAFWVGGTRDNARDVGELERLPGAAGIKVFMGSSTGDLLVEDDEGVASILRNTRRRAAFHSEDEFRLRERLGE
RIEGDPSSHPVWRDEIAALRCTERLVRIARDVRARIHVLHISTAEEILFLEQHKDVATCEATPHHLTLSADDYLRLGTLI
QMNPPVRASRHRDGVWHGIAQGIVDVLGSDHAPHTLAEKAKPYPASPSGMTGVQTLVPIMLDHVNAGRLTLQRFVDLSSH
GPQRIFGMARKGRIAAGYDADFTVVDMKRRETITNAQAGSKAGWTPYDGKEVTGWPVGTVIRGRRVMWEGEIVTPGQGRA
VEFSEALPA
>Mature_489_residues
MLGIRAGDGDERAVFQQGKGHGEDKRLILQNGWPLRKPLTLPPQESMAMTYDLILTGGTVVNHDGEGARDIGVKNGRIAA
IGDLRQASADETIDCRGLHILPGVVDSQVHFREPGLEHKEDLETGSRAAVLGGVTAVFEMPNTNPLTTSEATLADKVRRG
SGRMHCDFAFWVGGTRDNARDVGELERLPGAAGIKVFMGSSTGDLLVEDDEGVASILRNTRRRAAFHSEDEFRLRERLGE
RIEGDPSSHPVWRDEIAALRCTERLVRIARDVRARIHVLHISTAEEILFLEQHKDVATCEATPHHLTLSADDYLRLGTLI
QMNPPVRASRHRDGVWHGIAQGIVDVLGSDHAPHTLAEKAKPYPASPSGMTGVQTLVPIMLDHVNAGRLTLQRFVDLSSH
GPQRIFGMARKGRIAAGYDADFTVVDMKRRETITNAQAGSKAGWTPYDGKEVTGWPVGTVIRGRRVMWEGEIVTPGQGRA
VEFSEALPA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=421, Percent_Identity=31.1163895486936, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI19923821, Length=454, Percent_Identity=25.5506607929515, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI4503051, Length=462, Percent_Identity=25.1082251082251, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI62422571, Length=477, Percent_Identity=24.9475890985325, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI4503379, Length=460, Percent_Identity=25.2173913043478, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI190194363, Length=453, Percent_Identity=26.2693156732892, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4503377, Length=460, Percent_Identity=24.3478260869565, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI4503375, Length=466, Percent_Identity=25.1072961373391, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1786722, Length=439, Percent_Identity=33.0296127562642, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI87082175, Length=462, Percent_Identity=26.1904761904762, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI193204318, Length=442, Percent_Identity=29.8642533936652, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17539558, Length=453, Percent_Identity=26.0485651214128, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71989490, Length=465, Percent_Identity=25.3763440860215, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI86575075, Length=438, Percent_Identity=23.972602739726, Blast_Score=82, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6322218, Length=384, Percent_Identity=29.1666666666667, Blast_Score=140, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24642586, Length=396, Percent_Identity=32.3232323232323, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI18859883, Length=417, Percent_Identity=26.6187050359712, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI221377917, Length=487, Percent_Identity=25.0513347022587, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI17137462, Length=472, Percent_Identity=25, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24644287, Length=263, Percent_Identity=26.2357414448669, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24644289, Length=253, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 53471; Mature: 53471

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGIRAGDGDERAVFQQGKGHGEDKRLILQNGWPLRKPLTLPPQESMAMTYDLILTGGTV
CCCCCCCCCCHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHEEEEEEEEECCEE
VNHDGEGARDIGVKNGRIAAIGDLRQASADETIDCRGLHILPGVVDSQVHFREPGLEHKE
EECCCCCCCCCCCCCCEEEEECCHHHCCCCCCCCCCCEEECCCCCCCCEEECCCCCCCHH
DLETGSRAAVLGGVTAVFEMPNTNPLTTSEATLADKVRRGSGRMHCDFAFWVGGTRDNAR
HHCCCCCEEEEECEEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEEECCCCCCCH
DVGELERLPGAAGIKVFMGSSTGDLLVEDDEGVASILRNTRRRAAFHSEDEFRLRERLGE
HHHHHHHCCCCCCEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
RIEGDPSSHPVWRDEIAALRCTERLVRIARDVRARIHVLHISTAEEILFLEQHKDVATCE
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHEECCCCCEEEEC
ATPHHLTLSADDYLRLGTLIQMNPPVRASRHRDGVWHGIAQGIVDVLGSDHAPHTLAEKA
CCCCEEEECCCCCEEECEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHC
KPYPASPSGMTGVQTLVPIMLDHVNAGRLTLQRFVDLSSHGPQRIFGMARKGRIAAGYDA
CCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCEEECCCC
DFTVVDMKRRETITNAQAGSKAGWTPYDGKEVTGWPVGTVIRGRRVMWEGEIVTPGQGRA
CEEEEECHHHHHHHCCCCCCCCCCCCCCCCEECCCCHHHEECCCEEEEECEEECCCCCCE
VEFSEALPA
EEHHHCCCC
>Mature Secondary Structure
MLGIRAGDGDERAVFQQGKGHGEDKRLILQNGWPLRKPLTLPPQESMAMTYDLILTGGTV
CCCCCCCCCCHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHEEEEEEEEECCEE
VNHDGEGARDIGVKNGRIAAIGDLRQASADETIDCRGLHILPGVVDSQVHFREPGLEHKE
EECCCCCCCCCCCCCCEEEEECCHHHCCCCCCCCCCCEEECCCCCCCCEEECCCCCCCHH
DLETGSRAAVLGGVTAVFEMPNTNPLTTSEATLADKVRRGSGRMHCDFAFWVGGTRDNAR
HHCCCCCEEEEECEEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEEECCCCCCCH
DVGELERLPGAAGIKVFMGSSTGDLLVEDDEGVASILRNTRRRAAFHSEDEFRLRERLGE
HHHHHHHCCCCCCEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
RIEGDPSSHPVWRDEIAALRCTERLVRIARDVRARIHVLHISTAEEILFLEQHKDVATCE
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHEECCCCCEEEEC
ATPHHLTLSADDYLRLGTLIQMNPPVRASRHRDGVWHGIAQGIVDVLGSDHAPHTLAEKA
CCCCEEEECCCCCEEECEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHC
KPYPASPSGMTGVQTLVPIMLDHVNAGRLTLQRFVDLSSHGPQRIFGMARKGRIAAGYDA
CCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCEEECCCC
DFTVVDMKRRETITNAQAGSKAGWTPYDGKEVTGWPVGTVIRGRRVMWEGEIVTPGQGRA
CEEEEECHHHHHHHCCCCCCCCCCCCCCCCEECCCCHHHEECCCEEEEECEEECCCCCCE
VEFSEALPA
EEHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]