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The map label for this gene is lysX [H]

Identifier: 13476451

GI number: 13476451

Start: 6438434

End: 6439897

Strand: Direct

Name: lysX [H]

Synonym: mlr7777

Alternate gene names: 13476451

Gene position: 6438434-6439897 (Clockwise)

Preceding gene: 13476450

Following gene: 13476452

Centisome position: 91.51

GC content: 61.41

Gene sequence:

>1464_bases
ATGACCTGGGTCATCCTTACCGGCCGGCAGAGCGATCTCGACCAGGTGGCGACACCACACAAGATCATCACCAATCGCGA
CTATCTCGCGCATCCGTCGCTGTTTCGCGGCCAGCGGCCTAAGGTCATCAACCTGTCGAACAATTACGGCTACCAGAGCC
GTGGCTACTATGCCTCGCTGCTGGCGAGTTCACGCGGCCACAAGGTCATTCCGACGGTCGAGACGATGATCGACCTGTCC
GAACGCAAGCTCTACGAACATGCGCTGCCGGAACTGGAGCTGGCACTCAACAAATGCCGCAAGGATCTCGGCGGTGTCTT
TCCTGCCAAGGTGTGCATCTTCTTTGGCATCGGCCCCTCCAAGGTCTGGGACCGCTTCGCCAAGCTGTTGTTCGACTGGT
TCCGGGCGCCGGCGCTCGAGGTCCACATCAAGGACAGCGCGGAATGGGCTTCAATCCGCAAGATCGGTTTCCATCCGCTG
GCGCGCATGACCGAGGACGAGGAAAAAAGCTTCATCCAGTGCCTGGAGACCTACACCAACCGTGAATGGCGCGACACCAA
GGGGCGCACGCCGGCGCGCTACACCTTCGCCACGCTGGTCGATCCGCACGAGGAACTGCCGCCGTCGGAAATCTCCTCGC
TGCGCTACTGGGCCAAGATCGCCGAAAAGATGGGCGTCGAAATCGAGCCCATCACCAGGAAGGACCTCGCCAAGCTCGCG
AACTACGATGCGCTGTTCATCCGCGAGACCACCTCGATCTCCAACCATACCTATCGTTTCGCCCGCCGCGCCCAACAGGA
AGGCATGCCCGTCATCGACGATCCGCTGTCGATGATCCGCTGCACCAACAAGGTCTATCTCAACGAGCTGATGGCCTACA
ACAAGGTGCCGGTGCCGCCGACCGTGATGATCGCCGGCACCTCCGACTTCGAACTGGCCGCGCAGACGCTGGGCTTTCCG
CTGGTGCTGAAGATCCCGGATTCGTCCTTCTCGCGCGGCGTCAAGAAATGCGAGAATATAGAGGAACTGACACGGCTCGC
GACCGAGTGGCTGGAGGATTCCGACCTTCTCATCGCGCAGAAATTCATCCCGACCGAATATGACTGGCGCGTCGGCGTGC
TCGGCGGCCAGCCGCTGTTTGCCGTGCACTACCTGATGGCCAAGAAGCATTGGCAGATCGTCAACCACAAGGCCAATGGC
AAGCCCGACCAAGGTGGCATCAAGACCTTCACGCTGAAGGAGACGCCGGCCCATGTCGTCGAGACGGCGGTCAAGGCGGC
GCGCTGCATCGGCGACGGCCTCTACGGCGTCGACCTCAAGGAGACCAAGGACGGCGTCTTCGTCATCGAGGTCAACGACA
ACCCAAATCTCGACCATGGCTGGGAGGATTCCGGCGAGAAGGACGAGGTCTGGGTGCGGCTGACGCAGTGGTTCCTGGAG
CGCCTCGACCGGCCGGGGCGGTAA

Upstream 100 bases:

>100_bases
CCGCCAACATTCCCGTGCCCTACGGCATCTTCATGAACATGGCGCAGTTCGGCCGCGACGGACTGCGTGCCGCCATCACT
CTAGGGAAGCGCGACACACA

Downstream 100 bases:

>100_bases
CGGTTCAACTCTATCTCTTTGTTTTAAAGCAATTCCGGACGGAAAACCGCTTCACGCTTTTCCAAGAATTACACTGGGGG
GAAAACATGCAGTTCATCGT

Product: ribosomal protein S6-glutamic acid ligase

Products: NA

Alternate protein names: AAA--lysW ligase lysX [H]

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MTWVILTGRQSDLDQVATPHKIITNRDYLAHPSLFRGQRPKVINLSNNYGYQSRGYYASLLASSRGHKVIPTVETMIDLS
ERKLYEHALPELELALNKCRKDLGGVFPAKVCIFFGIGPSKVWDRFAKLLFDWFRAPALEVHIKDSAEWASIRKIGFHPL
ARMTEDEEKSFIQCLETYTNREWRDTKGRTPARYTFATLVDPHEELPPSEISSLRYWAKIAEKMGVEIEPITRKDLAKLA
NYDALFIRETTSISNHTYRFARRAQQEGMPVIDDPLSMIRCTNKVYLNELMAYNKVPVPPTVMIAGTSDFELAAQTLGFP
LVLKIPDSSFSRGVKKCENIEELTRLATEWLEDSDLLIAQKFIPTEYDWRVGVLGGQPLFAVHYLMAKKHWQIVNHKANG
KPDQGGIKTFTLKETPAHVVETAVKAARCIGDGLYGVDLKETKDGVFVIEVNDNPNLDHGWEDSGEKDEVWVRLTQWFLE
RLDRPGR

Sequences:

>Translated_487_residues
MTWVILTGRQSDLDQVATPHKIITNRDYLAHPSLFRGQRPKVINLSNNYGYQSRGYYASLLASSRGHKVIPTVETMIDLS
ERKLYEHALPELELALNKCRKDLGGVFPAKVCIFFGIGPSKVWDRFAKLLFDWFRAPALEVHIKDSAEWASIRKIGFHPL
ARMTEDEEKSFIQCLETYTNREWRDTKGRTPARYTFATLVDPHEELPPSEISSLRYWAKIAEKMGVEIEPITRKDLAKLA
NYDALFIRETTSISNHTYRFARRAQQEGMPVIDDPLSMIRCTNKVYLNELMAYNKVPVPPTVMIAGTSDFELAAQTLGFP
LVLKIPDSSFSRGVKKCENIEELTRLATEWLEDSDLLIAQKFIPTEYDWRVGVLGGQPLFAVHYLMAKKHWQIVNHKANG
KPDQGGIKTFTLKETPAHVVETAVKAARCIGDGLYGVDLKETKDGVFVIEVNDNPNLDHGWEDSGEKDEVWVRLTQWFLE
RLDRPGR
>Mature_486_residues
TWVILTGRQSDLDQVATPHKIITNRDYLAHPSLFRGQRPKVINLSNNYGYQSRGYYASLLASSRGHKVIPTVETMIDLSE
RKLYEHALPELELALNKCRKDLGGVFPAKVCIFFGIGPSKVWDRFAKLLFDWFRAPALEVHIKDSAEWASIRKIGFHPLA
RMTEDEEKSFIQCLETYTNREWRDTKGRTPARYTFATLVDPHEELPPSEISSLRYWAKIAEKMGVEIEPITRKDLAKLAN
YDALFIRETTSISNHTYRFARRAQQEGMPVIDDPLSMIRCTNKVYLNELMAYNKVPVPPTVMIAGTSDFELAAQTLGFPL
VLKIPDSSFSRGVKKCENIEELTRLATEWLEDSDLLIAQKFIPTEYDWRVGVLGGQPLFAVHYLMAKKHWQIVNHKANGK
PDQGGIKTFTLKETPAHVVETAVKAARCIGDGLYGVDLKETKDGVFVIEVNDNPNLDHGWEDSGEKDEVWVRLTQWFLER
LDRPGR

Specific function: Catalyzes the ATP-dependent binding between the amino group of alpha-aminoadipate (AAA) and the gamma-carboxyl group of the C-terminal glutamate residue of lysW (Probable) [H]

COG id: COG0189

COG function: function code HJ; Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013651
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011870
- InterPro:   IPR016185
- InterPro:   IPR004666 [H]

Pfam domain/function: PF08443 RimK [H]

EC number: NA

Molecular weight: Translated: 55613; Mature: 55482

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWVILTGRQSDLDQVATPHKIITNRDYLAHPSLFRGQRPKVINLSNNYGYQSRGYYASL
CEEEEEECCCCCHHHHCCCCHHHCCCCCCCCCHHHCCCCCCEEEECCCCCCCCCCHHHHH
LASSRGHKVIPTVETMIDLSERKLYEHALPELELALNKCRKDLGGVFPAKVCIFFGIGPS
HHCCCCCEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEEECCCHH
KVWDRFAKLLFDWFRAPALEVHIKDSAEWASIRKIGFHPLARMTEDEEKSFIQCLETYTN
HHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHCC
REWRDTKGRTPARYTFATLVDPHEELPPSEISSLRYWAKIAEKMGVEIEPITRKDLAKLA
CCCCCCCCCCCCEEEEEEECCCHHCCCHHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHH
NYDALFIRETTSISNHTYRFARRAQQEGMPVIDDPLSMIRCTNKVYLNELMAYNKVPVPP
CCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
TVMIAGTSDFELAAQTLGFPLVLKIPDSSFSRGVKKCENIEELTRLATEWLEDSDLLIAQ
EEEEECCCCHHHHHHHCCCEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEH
KFIPTEYDWRVGVLGGQPLFAVHYLMAKKHWQIVNHKANGKPDQGGIKTFTLKETPAHVV
HCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHEEECCCCCCCCCCCEEEEEECCCHHHHH
ETAVKAARCIGDGLYGVDLKETKDGVFVIEVNDNPNLDHGWEDSGEKDEVWVRLTQWFLE
HHHHHHHHHHCCCCCCCCCEECCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
RLDRPGR
HHCCCCC
>Mature Secondary Structure 
TWVILTGRQSDLDQVATPHKIITNRDYLAHPSLFRGQRPKVINLSNNYGYQSRGYYASL
EEEEEECCCCCHHHHCCCCHHHCCCCCCCCCHHHCCCCCCEEEECCCCCCCCCCHHHHH
LASSRGHKVIPTVETMIDLSERKLYEHALPELELALNKCRKDLGGVFPAKVCIFFGIGPS
HHCCCCCEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEEECCCHH
KVWDRFAKLLFDWFRAPALEVHIKDSAEWASIRKIGFHPLARMTEDEEKSFIQCLETYTN
HHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHCC
REWRDTKGRTPARYTFATLVDPHEELPPSEISSLRYWAKIAEKMGVEIEPITRKDLAKLA
CCCCCCCCCCCCEEEEEEECCCHHCCCHHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHH
NYDALFIRETTSISNHTYRFARRAQQEGMPVIDDPLSMIRCTNKVYLNELMAYNKVPVPP
CCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
TVMIAGTSDFELAAQTLGFPLVLKIPDSSFSRGVKKCENIEELTRLATEWLEDSDLLIAQ
EEEEECCCCHHHHHHHCCCEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEH
KFIPTEYDWRVGVLGGQPLFAVHYLMAKKHWQIVNHKANGKPDQGGIKTFTLKETPAHVV
HCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHEEECCCCCCCCCCCEEEEEECCCHHHHH
ETAVKAARCIGDGLYGVDLKETKDGVFVIEVNDNPNLDHGWEDSGEKDEVWVRLTQWFLE
HHHHHHHHHHCCCCCCCCCEECCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
RLDRPGR
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Glu; Ribosomal protein S6 [C]

Specific reaction: Catalyzes the addition of glutamic acids to the carboxyl end of ribosomal protein S6 [C]

General reaction: Ligases; Forming Carbon-Nitrogen Bonds; Acid-D-Amino-Acid Ligases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11427726; 12042311 [H]