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The map label for this gene is acdA [H]

Identifier: 13476417

GI number: 13476417

Start: 6404061

End: 6405224

Strand: Reverse

Name: acdA [H]

Synonym: mll7732

Alternate gene names: 13476417

Gene position: 6405224-6404061 (Counterclockwise)

Preceding gene: 13476418

Following gene: 13476416

Centisome position: 91.03

GC content: 63.92

Gene sequence:

>1164_bases
ATGTACACGAACACGCTCAGCTTCGGGCATGACGAGGACATCGAGGCGCTGCGCGACATGGTGCGGCGCTTCGCCCAGGA
CAGGATCGCGCCGATCGCCGGCGATATCGACCGCCAGAACGAATTTCCGGCGCATCTGTGGCGCGAGCTCGGCGCGCTCG
GCCTGCTCGGCATCACCGCCGATCCCGATTTCGGCGGCAGCGGCATGGGTTATCTCGCCCATGTGATTGCGGTGGAAGAA
ATTTCCCGCGCCTCGGCTTCGGTCGGTCTCTCCTATGGCGCCCATTCCAACCTCTGCGTCAACCAGATCAACCGCTGGGC
GACGCCGGCGCAGAAGGAAAAATTCCTGCCGCCGCTGTGTTCGGGCGAGCGTGTCGGCGCGCTGGCGATGTCTGAATCCG
GCGCCGGCTCCGACGTCGTCTCACTTAAGCTGCGTGCTGAAAAGCGCAATGACCGCTATGTGCTCAACGGCACCAAGATG
TGGATCACCAACGGCCCGGACGCCGATACGCTGGTCGTCTATGCCAAGACCGATCCGGAGCGGAAATCGCGCGGCATCAC
CGCCTTCATCGTCGAGAAGGCGATGACGGGGTTTTCCGTGGCGCAGAAACTCGACAAGCTCGGCATGCGCGGCTCCAGCA
CCGGGGAGCTGGTGTTCGAGAATGTCGAGGTGCCATTCGACAATGTGCTGCACGAAGAAGGACGCGGCGTCGAGGTGCTG
ATGTCGGGCCTCGACTATGAACGCACCGTGCTTGCCGGCGGCCCGATCGGCCTGATGGCAGCCTGTCTCGATGTGGCGAT
CCCTTATGTGCACGAACGCAAGCAGTTCGGCCAGCCGATCGGCGAGTTCCAGCTGGTGCAAGGCAAGCTGGCCGACATGT
ATACGGTGATGAACGCCGCGCGCGCTTACGTCTATGCCGTCGCGGCCGGCTGCGATCGCGGCCAGACCACCCGCAAAGAC
GCCGCCGGCTGCGTTTTGTTCGCAGCAGAGAAGGCGACGCAGATGGCGCTGGACGCCATCCAACTTCTGGGCGGCAACGG
CTATATCAACGACTATCCGACCGGTCGGCTGCTGCGCGACGCCAAACTCTACGAGATCGGCGCCGGCACCAGCGAAATCC
GGCGCTGGCTGATCGGCCGCGAGATCATGGCGGAGGGGGTGTGA

Upstream 100 bases:

>100_bases
TCCCTTGGACGTGCAAAGGACGCTGTAGCACTTGAATTTGCGCATGATCCTTTCCGAAAATCGAAGTCGATTTTCGGGGT
CATGCGGCAGGAGGAACGCC

Downstream 100 bases:

>100_bases
GCATGGCCGTCCTAGAGACTCAGATCTCCCCCTCCTCCGACACTTTCCGCGCCAATGCCGAACGCATGCGCGCGCTGGTC
ACCGATATCGCCGACAAGGC

Product: isovaleryl-CoA-dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MYTNTLSFGHDEDIEALRDMVRRFAQDRIAPIAGDIDRQNEFPAHLWRELGALGLLGITADPDFGGSGMGYLAHVIAVEE
ISRASASVGLSYGAHSNLCVNQINRWATPAQKEKFLPPLCSGERVGALAMSESGAGSDVVSLKLRAEKRNDRYVLNGTKM
WITNGPDADTLVVYAKTDPERKSRGITAFIVEKAMTGFSVAQKLDKLGMRGSSTGELVFENVEVPFDNVLHEEGRGVEVL
MSGLDYERTVLAGGPIGLMAACLDVAIPYVHERKQFGQPIGEFQLVQGKLADMYTVMNAARAYVYAVAAGCDRGQTTRKD
AAGCVLFAAEKATQMALDAIQLLGGNGYINDYPTGRLLRDAKLYEIGAGTSEIRRWLIGREIMAEGV

Sequences:

>Translated_387_residues
MYTNTLSFGHDEDIEALRDMVRRFAQDRIAPIAGDIDRQNEFPAHLWRELGALGLLGITADPDFGGSGMGYLAHVIAVEE
ISRASASVGLSYGAHSNLCVNQINRWATPAQKEKFLPPLCSGERVGALAMSESGAGSDVVSLKLRAEKRNDRYVLNGTKM
WITNGPDADTLVVYAKTDPERKSRGITAFIVEKAMTGFSVAQKLDKLGMRGSSTGELVFENVEVPFDNVLHEEGRGVEVL
MSGLDYERTVLAGGPIGLMAACLDVAIPYVHERKQFGQPIGEFQLVQGKLADMYTVMNAARAYVYAVAAGCDRGQTTRKD
AAGCVLFAAEKATQMALDAIQLLGGNGYINDYPTGRLLRDAKLYEIGAGTSEIRRWLIGREIMAEGV
>Mature_387_residues
MYTNTLSFGHDEDIEALRDMVRRFAQDRIAPIAGDIDRQNEFPAHLWRELGALGLLGITADPDFGGSGMGYLAHVIAVEE
ISRASASVGLSYGAHSNLCVNQINRWATPAQKEKFLPPLCSGERVGALAMSESGAGSDVVSLKLRAEKRNDRYVLNGTKM
WITNGPDADTLVVYAKTDPERKSRGITAFIVEKAMTGFSVAQKLDKLGMRGSSTGELVFENVEVPFDNVLHEEGRGVEVL
MSGLDYERTVLAGGPIGLMAACLDVAIPYVHERKQFGQPIGEFQLVQGKLADMYTVMNAARAYVYAVAAGCDRGQTTRKD
AAGCVLFAAEKATQMALDAIQLLGGNGYINDYPTGRLLRDAKLYEIGAGTSEIRRWLIGREIMAEGV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=381, Percent_Identity=63.7795275590551, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI226958414, Length=351, Percent_Identity=65.5270655270655, Blast_Score=468, Evalue=1e-132,
Organism=Homo sapiens, GI4557233, Length=383, Percent_Identity=38.6422976501305, Blast_Score=279, Evalue=3e-75,
Organism=Homo sapiens, GI4501859, Length=375, Percent_Identity=37.6, Blast_Score=261, Evalue=7e-70,
Organism=Homo sapiens, GI4557231, Length=379, Percent_Identity=36.6754617414248, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI187960098, Length=379, Percent_Identity=36.6754617414248, Blast_Score=235, Evalue=4e-62,
Organism=Homo sapiens, GI4501857, Length=382, Percent_Identity=33.5078534031414, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI7656849, Length=383, Percent_Identity=32.1148825065274, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI21361497, Length=353, Percent_Identity=35.9773371104816, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI4557235, Length=385, Percent_Identity=33.5064935064935, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI76496475, Length=385, Percent_Identity=33.5064935064935, Blast_Score=201, Evalue=8e-52,
Organism=Homo sapiens, GI4503943, Length=377, Percent_Identity=31.8302387267904, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI7669494, Length=374, Percent_Identity=32.3529411764706, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI48976061, Length=284, Percent_Identity=28.169014084507, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI211971008, Length=284, Percent_Identity=28.169014084507, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI38505218, Length=282, Percent_Identity=24.113475177305, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI218563752, Length=233, Percent_Identity=25.7510729613734, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI87081958, Length=352, Percent_Identity=30.9659090909091, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1786223, Length=351, Percent_Identity=29.6296296296296, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI87082384, Length=280, Percent_Identity=26.4285714285714, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87081702, Length=336, Percent_Identity=22.9166666666667, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17538396, Length=380, Percent_Identity=62.1052631578947, Blast_Score=492, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17506239, Length=364, Percent_Identity=37.0879120879121, Blast_Score=254, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=35.9580052493438, Blast_Score=237, Evalue=7e-63,
Organism=Caenorhabditis elegans, GI17570075, Length=382, Percent_Identity=35.0785340314136, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17508101, Length=369, Percent_Identity=33.8753387533875, Blast_Score=224, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI17534899, Length=381, Percent_Identity=33.8582677165354, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI71990804, Length=296, Percent_Identity=39.527027027027, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17533517, Length=384, Percent_Identity=31.25, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI71985184, Length=350, Percent_Identity=33.1428571428571, Blast_Score=197, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=40.2597402597403, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI71982178, Length=273, Percent_Identity=34.7985347985348, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17551932, Length=377, Percent_Identity=29.7082228116711, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17534353, Length=373, Percent_Identity=28.4182305630027, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17505929, Length=376, Percent_Identity=30.3191489361702, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71985192, Length=285, Percent_Identity=33.6842105263158, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17531909, Length=244, Percent_Identity=29.9180327868852, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI86563381, Length=268, Percent_Identity=25.3731343283582, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI86563383, Length=268, Percent_Identity=25.3731343283582, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562446, Length=285, Percent_Identity=23.859649122807, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21355753, Length=389, Percent_Identity=64.5244215938303, Blast_Score=509, Evalue=1e-144,
Organism=Drosophila melanogaster, GI21356377, Length=375, Percent_Identity=40.5333333333333, Blast_Score=288, Evalue=6e-78,
Organism=Drosophila melanogaster, GI24646207, Length=375, Percent_Identity=38.9333333333333, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24660351, Length=382, Percent_Identity=37.17277486911, Blast_Score=241, Evalue=8e-64,
Organism=Drosophila melanogaster, GI24666513, Length=377, Percent_Identity=35.0132625994695, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI281363737, Length=392, Percent_Identity=33.1632653061224, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI19920834, Length=375, Percent_Identity=28.8, Blast_Score=154, Evalue=7e-38,
Organism=Drosophila melanogaster, GI24652780, Length=325, Percent_Identity=24.6153846153846, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 41989; Mature: 41989

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTNTLSFGHDEDIEALRDMVRRFAQDRIAPIAGDIDRQNEFPAHLWRELGALGLLGITA
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEC
DPDFGGSGMGYLAHVIAVEEISRASASVGLSYGAHSNLCVNQINRWATPAQKEKFLPPLC
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHCCCCCC
SGERVGALAMSESGAGSDVVSLKLRAEKRNDRYVLNGTKMWITNGPDADTLVVYAKTDPE
CCCCCCEEEECCCCCCCCEEEEEEEECCCCCEEEEECEEEEEECCCCCCEEEEEECCCCH
RKSRGITAFIVEKAMTGFSVAQKLDKLGMRGSSTGELVFENVEVPFDNVLHEEGRGVEVL
HHHCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHCCCCCHHHH
MSGLDYERTVLAGGPIGLMAACLDVAIPYVHERKQFGQPIGEFQLVQGKLADMYTVMNAA
HHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
RAYVYAVAAGCDRGQTTRKDAAGCVLFAAEKATQMALDAIQLLGGNGYINDYPTGRLLRD
HHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHC
AKLYEIGAGTSEIRRWLIGREIMAEGV
CEEEEECCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYTNTLSFGHDEDIEALRDMVRRFAQDRIAPIAGDIDRQNEFPAHLWRELGALGLLGITA
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEC
DPDFGGSGMGYLAHVIAVEEISRASASVGLSYGAHSNLCVNQINRWATPAQKEKFLPPLC
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHCCCCCC
SGERVGALAMSESGAGSDVVSLKLRAEKRNDRYVLNGTKMWITNGPDADTLVVYAKTDPE
CCCCCCEEEECCCCCCCCEEEEEEEECCCCCEEEEECEEEEEECCCCCCEEEEEECCCCH
RKSRGITAFIVEKAMTGFSVAQKLDKLGMRGSSTGELVFENVEVPFDNVLHEEGRGVEVL
HHHCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHCCCCCHHHH
MSGLDYERTVLAGGPIGLMAACLDVAIPYVHERKQFGQPIGEFQLVQGKLADMYTVMNAA
HHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
RAYVYAVAAGCDRGQTTRKDAAGCVLFAAEKATQMALDAIQLLGGNGYINDYPTGRLLRD
HHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHC
AKLYEIGAGTSEIRRWLIGREIMAEGV
CEEEEECCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]