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The map label for this gene is pcoS [H]

Identifier: 13476390

GI number: 13476390

Start: 6369886

End: 6371343

Strand: Direct

Name: pcoS [H]

Synonym: mlr7697

Alternate gene names: 13476390

Gene position: 6369886-6371343 (Clockwise)

Preceding gene: 13476389

Following gene: 13476391

Centisome position: 90.53

GC content: 63.85

Gene sequence:

>1458_bases
ATGAAGACGACGGCAGCGCGGCTTTCGGCGCTCTACCTTCTGCTCTTCGCGCTCTGCGCCGTGCTGCTCGTCTTCTACAT
GACCTCGCTGTCGGCGCGTATGCTGACGGCGCAGACGCAGGAGACCATCAACGACGAAGTGCTGGGCCTCGCCCGCGCCT
ATCAGCGCGGTGGCTTGCCCGTGCTGGTGCGCGTCGTCGAAAACCGCTCCCGCCAGCCCGGTGCCAACCTCTATCTCATC
GCCGATGCCAATGGCCAGATTCTAACCGGCAATGTGCAGAGCCTCGAACCGGGCGTGATTGACACGGAGGGCTGGACGAC
CGAGCCGTTCTCCTACAAGCGCTTCGGAGAAGGCGAGCTTGACCGCCTGCGCAGCGGAACGTCCGACCAGACGACAGCTC
CTGCAACTGGCGACAACGCGGCGCAGCAAGCCGAAGGCGAGCAGGGCCACAACGCCATTGCGCTGGTGCTGCGGCTGCCT
AACCAGATGATCATGCTGGTCGGCCGCGATCTTGGCGAACCGGAGCGCTTTCGTGCCGTCATCCGCCGTGCGCTGACGCT
GGCGCTCGGCATGATGGGGCTCGGCGGACTGCTAATCTGGTTCTTTGTCGGCCGTGCCGCGCTGAAGCGCATAGACAGCG
TTTCGGAGGCCAGCCGCCGCATCATGGGCGGTGATCTCTCGGGCCGGCTGCCGGTGACCGGCGCCGGCGACGAATTCGAC
CGGCTGTCGGAAAACCTCAATTCCATGCTGGCCAGGATCGCCACGCTCAACGAAGGCCTGAAGCAGGTTTCCGACAACAT
CGCGCATGATCTGAAGACGCCGCTGACCCGGCTGCGCAATCGCGCCGAAGCGACACTTTCCGGCAAGCACAGGCCCGCCG
ACTACCGCCAGGCGCTGGAAAGCACCATCGCCGAGTCCGACCAGCTGATAAAGACCTTCAACGCTATCCTGATGATCTCC
CGGCTCGAGGCCGGATATTCATCAGAGCACACCAATCGCGTCGACCTGGCGGCGGCCGTGCGTGATGTCGCCGAGCTCTA
CGAGCCGGTGGCGGAAGAGGCCGGCGTTTCGCTCGAAGCCGAAGTGAATGGCGCTTTTCTCGTCGACGGCAACCGCGAGC
TGATCGGCCAGGCGCTGTCCAACATCGTCGACAATGCGATCAAATATTCGACGGACTCCACGTCCAAGCCGGCCGTTCGC
GTGACGCTCGAGCGGACACATGGCGAGATCTGGCTTTGTGTCGCCGACAACGGCCAGGGCATTCCCGACGATGCCGATCG
GGCCCGCGCGACCGAACGCTTCGTGCGGCTGGAGAAGAGCCGTTCTCAACCGGGCTCCGGCCTTGGCCTCAGCCTCGCCA
AGGCGGTCATGACTTTCCACTATGGACGGCTTGATCTCTTGCCTGGCAATCCGGGACTATCCGTGGTCATGAGTTTCCCT
GTACGGGAGGATCACTGA

Upstream 100 bases:

>100_bases
AAAAGGGCTTCGATAAGCCGATCCTGCATACGGTTCGCGGCGCCGGTTACATGCTGAAGGGCGGCTAGGCGACAGCATGG
CTCTTTCCGTGCCGGCCATC

Downstream 100 bases:

>100_bases
TGGCTGCGGTTGCGAAGCGGACGGTCACGGACTGGCAGTTGAAGCCCGCCCTTGGGCTCGCCCCTCTCGACCAAGGCCGG
GCGCGGCAGGAACTGGCCGA

Product: two-component, sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MKTTAARLSALYLLLFALCAVLLVFYMTSLSARMLTAQTQETINDEVLGLARAYQRGGLPVLVRVVENRSRQPGANLYLI
ADANGQILTGNVQSLEPGVIDTEGWTTEPFSYKRFGEGELDRLRSGTSDQTTAPATGDNAAQQAEGEQGHNAIALVLRLP
NQMIMLVGRDLGEPERFRAVIRRALTLALGMMGLGGLLIWFFVGRAALKRIDSVSEASRRIMGGDLSGRLPVTGAGDEFD
RLSENLNSMLARIATLNEGLKQVSDNIAHDLKTPLTRLRNRAEATLSGKHRPADYRQALESTIAESDQLIKTFNAILMIS
RLEAGYSSEHTNRVDLAAAVRDVAELYEPVAEEAGVSLEAEVNGAFLVDGNRELIGQALSNIVDNAIKYSTDSTSKPAVR
VTLERTHGEIWLCVADNGQGIPDDADRARATERFVRLEKSRSQPGSGLGLSLAKAVMTFHYGRLDLLPGNPGLSVVMSFP
VREDH

Sequences:

>Translated_485_residues
MKTTAARLSALYLLLFALCAVLLVFYMTSLSARMLTAQTQETINDEVLGLARAYQRGGLPVLVRVVENRSRQPGANLYLI
ADANGQILTGNVQSLEPGVIDTEGWTTEPFSYKRFGEGELDRLRSGTSDQTTAPATGDNAAQQAEGEQGHNAIALVLRLP
NQMIMLVGRDLGEPERFRAVIRRALTLALGMMGLGGLLIWFFVGRAALKRIDSVSEASRRIMGGDLSGRLPVTGAGDEFD
RLSENLNSMLARIATLNEGLKQVSDNIAHDLKTPLTRLRNRAEATLSGKHRPADYRQALESTIAESDQLIKTFNAILMIS
RLEAGYSSEHTNRVDLAAAVRDVAELYEPVAEEAGVSLEAEVNGAFLVDGNRELIGQALSNIVDNAIKYSTDSTSKPAVR
VTLERTHGEIWLCVADNGQGIPDDADRARATERFVRLEKSRSQPGSGLGLSLAKAVMTFHYGRLDLLPGNPGLSVVMSFP
VREDH
>Mature_485_residues
MKTTAARLSALYLLLFALCAVLLVFYMTSLSARMLTAQTQETINDEVLGLARAYQRGGLPVLVRVVENRSRQPGANLYLI
ADANGQILTGNVQSLEPGVIDTEGWTTEPFSYKRFGEGELDRLRSGTSDQTTAPATGDNAAQQAEGEQGHNAIALVLRLP
NQMIMLVGRDLGEPERFRAVIRRALTLALGMMGLGGLLIWFFVGRAALKRIDSVSEASRRIMGGDLSGRLPVTGAGDEFD
RLSENLNSMLARIATLNEGLKQVSDNIAHDLKTPLTRLRNRAEATLSGKHRPADYRQALESTIAESDQLIKTFNAILMIS
RLEAGYSSEHTNRVDLAAAVRDVAELYEPVAEEAGVSLEAEVNGAFLVDGNRELIGQALSNIVDNAIKYSTDSTSKPAVR
VTLERTHGEIWLCVADNGQGIPDDADRARATERFVRLEKSRSQPGSGLGLSLAKAVMTFHYGRLDLLPGNPGLSVVMSFP
VREDH

Specific function: Probable member of a two-component regulatory system pcoS/pcoR. May activate pcoR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=290, Percent_Identity=26.8965517241379, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788279, Length=259, Percent_Identity=27.027027027027, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788393, Length=286, Percent_Identity=25.1748251748252, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1786600, Length=203, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1787894, Length=262, Percent_Identity=29.3893129770992, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1790861, Length=294, Percent_Identity=27.891156462585, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1789808, Length=300, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788713, Length=226, Percent_Identity=24.3362831858407, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789403, Length=243, Percent_Identity=27.1604938271605, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790551, Length=271, Percent_Identity=24.3542435424354, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790346, Length=255, Percent_Identity=26.2745098039216, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52715; Mature: 52715

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTAARLSALYLLLFALCAVLLVFYMTSLSARMLTAQTQETINDEVLGLARAYQRGGLP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VLVRVVENRSRQPGANLYLIADANGQILTGNVQSLEPGVIDTEGWTTEPFSYKRFGEGEL
EEHHHHHCCCCCCCCCEEEEECCCCCEEECCHHHCCCCEECCCCCCCCCCCCCCCCCCHH
DRLRSGTSDQTTAPATGDNAAQQAEGEQGHNAIALVLRLPNQMIMLVGRDLGEPERFRAV
HHHHCCCCCCCCCCCCCCCHHHHCCCCCCCCCEEEEECCCCHHHHHHCCCCCCHHHHHHH
IRRALTLALGMMGLGGLLIWFFVGRAALKRIDSVSEASRRIMGGDLSGRLPVTGAGDEFD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
RLSENLNSMLARIATLNEGLKQVSDNIAHDLKTPLTRLRNRAEATLSGKHRPADYRQALE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
STIAESDQLIKTFNAILMISRLEAGYSSEHTNRVDLAAAVRDVAELYEPVAEEAGVSLEA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEE
EVNGAFLVDGNRELIGQALSNIVDNAIKYSTDSTSKPAVRVTLERTHGEIWLCVADNGQG
ECCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCEEEEEECCCCCC
IPDDADRARATERFVRLEKSRSQPGSGLGLSLAKAVMTFHYGRLDLLPGNPGLSVVMSFP
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCEEEEECC
VREDH
CCCCC
>Mature Secondary Structure
MKTTAARLSALYLLLFALCAVLLVFYMTSLSARMLTAQTQETINDEVLGLARAYQRGGLP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VLVRVVENRSRQPGANLYLIADANGQILTGNVQSLEPGVIDTEGWTTEPFSYKRFGEGEL
EEHHHHHCCCCCCCCCEEEEECCCCCEEECCHHHCCCCEECCCCCCCCCCCCCCCCCCHH
DRLRSGTSDQTTAPATGDNAAQQAEGEQGHNAIALVLRLPNQMIMLVGRDLGEPERFRAV
HHHHCCCCCCCCCCCCCCCHHHHCCCCCCCCCEEEEECCCCHHHHHHCCCCCCHHHHHHH
IRRALTLALGMMGLGGLLIWFFVGRAALKRIDSVSEASRRIMGGDLSGRLPVTGAGDEFD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
RLSENLNSMLARIATLNEGLKQVSDNIAHDLKTPLTRLRNRAEATLSGKHRPADYRQALE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
STIAESDQLIKTFNAILMISRLEAGYSSEHTNRVDLAAAVRDVAELYEPVAEEAGVSLEA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEE
EVNGAFLVDGNRELIGQALSNIVDNAIKYSTDSTSKPAVRVTLERTHGEIWLCVADNGQG
ECCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCEEEEEECCCCCC
IPDDADRARATERFVRLEKSRSQPGSGLGLSLAKAVMTFHYGRLDLLPGNPGLSVVMSFP
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCEEEEECC
VREDH
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]