Click here to switch to the map view.

The map label for this gene is cusR [H]

Identifier: 13476389

GI number: 13476389

Start: 6369134

End: 6369853

Strand: Direct

Name: cusR [H]

Synonym: mlr7695

Alternate gene names: 13476389

Gene position: 6369134-6369853 (Clockwise)

Preceding gene: 13476388

Following gene: 13476390

Centisome position: 90.52

GC content: 61.39

Gene sequence:

>720_bases
ATGCCGACTACTCAACCTTCCAGCGAAATCGCGTATAACGGCCCTATGAAGATTCTCGTCATAGAAGACGATCGCGAGGC
TGCCGATTATCTGCAGAAAGCCTTTACCGAGGCTGGCCATACCGCCCATGTAGCCGGTGACGGCGAGACCGGTTTCGCGC
TTGCCGACGCCGGCGACTATGACGTAATGGTCATCGACCGGATGATGCCCCGCCGCGACGGTCTGTCGGTCATTGCCGGT
CTTCGCTCCAGGGGCAACACCACACCCGTGCTGATCCTGTCGGCGCTGGGGGAGGTCGATGACCGGGTCACCGGCCTGCG
CGCCGGCGGCGACGATTATCTGACCAAGCCCTATGCGTTTTCCGAACTTCTGGCCCGCGTCGAGGTGTTGAACCGCCGTG
CCAGCGCCAAGGAAGCCGAAACCGTCTACCGGGTTGGCGACCTTGAACTCGACAGGCTGTCGCATTCGGTGCGCCGGGCA
GCGCGCGAGATCACGCTGCAGCCGCGCGAATTCCGCTTGCTCGAATATCTGATGCGCCATGCCGGCCAGGTGGTAACGCG
CACCATGCTGCTCGAAAATGTCTGGGATTATCATTTCGACCCGCAGACCAATGTCATTGACGTCCACGTGTCGCGGCTGC
GCGGCAAGATCGAAAAGGGCTTCGATAAGCCGATCCTGCATACGGTTCGCGGCGCCGGTTACATGCTGAAGGGCGGCTAG

Upstream 100 bases:

>100_bases
CAGGCATGTTCGGGATGAAGACAACCAGAGAACAAGATTTTATCGCGTGCGGCCTCGATCATCTTGATCGAGGCGCGCTT
TGGCAAAGGCTAAAATGCAG

Downstream 100 bases:

>100_bases
GCGACAGCATGGCTCTTTCCGTGCCGGCCATCATGAAGACGACGGCAGCGCGGCTTTCGGCGCTCTACCTTCTGCTCTTC
GCGCTCTGCGCCGTGCTGCT

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MPTTQPSSEIAYNGPMKILVIEDDREAADYLQKAFTEAGHTAHVAGDGETGFALADAGDYDVMVIDRMMPRRDGLSVIAG
LRSRGNTTPVLILSALGEVDDRVTGLRAGGDDYLTKPYAFSELLARVEVLNRRASAKEAETVYRVGDLELDRLSHSVRRA
AREITLQPREFRLLEYLMRHAGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRGKIEKGFDKPILHTVRGAGYMLKGG

Sequences:

>Translated_239_residues
MPTTQPSSEIAYNGPMKILVIEDDREAADYLQKAFTEAGHTAHVAGDGETGFALADAGDYDVMVIDRMMPRRDGLSVIAG
LRSRGNTTPVLILSALGEVDDRVTGLRAGGDDYLTKPYAFSELLARVEVLNRRASAKEAETVYRVGDLELDRLSHSVRRA
AREITLQPREFRLLEYLMRHAGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRGKIEKGFDKPILHTVRGAGYMLKGG
>Mature_238_residues
PTTQPSSEIAYNGPMKILVIEDDREAADYLQKAFTEAGHTAHVAGDGETGFALADAGDYDVMVIDRMMPRRDGLSVIAGL
RSRGNTTPVLILSALGEVDDRVTGLRAGGDDYLTKPYAFSELLARVEVLNRRASAKEAETVYRVGDLELDRLSHSVRRAA
REITLQPREFRLLEYLMRHAGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRGKIEKGFDKPILHTVRGAGYMLKGG

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=46.8468468468468, Blast_Score=221, Evalue=3e-59,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=40.1826484018265, Blast_Score=174, Evalue=5e-45,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=36.6515837104072, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=38.2222222222222, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=34.5454545454545, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=32.15859030837, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=31.5315315315315, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=32.5892857142857, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=35.9649122807018, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=31.390134529148, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=29.5154185022026, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=28.3842794759825, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=28.2608695652174, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=27.2727272727273, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=34.5794392523364, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=36.6336633663366, Blast_Score=72, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26614; Mature: 26482

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTTQPSSEIAYNGPMKILVIEDDREAADYLQKAFTEAGHTAHVAGDGETGFALADAGDY
CCCCCCCCCEEECCCEEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEECCCCC
DVMVIDRMMPRRDGLSVIAGLRSRGNTTPVLILSALGEVDDRVTGLRAGGDDYLTKPYAF
EEEEECHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
SELLARVEVLNRRASAKEAETVYRVGDLELDRLSHSVRRAAREITLQPREFRLLEYLMRH
HHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
AGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRGKIEKGFDKPILHTVRGAGYMLKGG
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHCCCCHHHHHHCCCCEEECCC
>Mature Secondary Structure 
PTTQPSSEIAYNGPMKILVIEDDREAADYLQKAFTEAGHTAHVAGDGETGFALADAGDY
CCCCCCCCEEECCCEEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEECCCCC
DVMVIDRMMPRRDGLSVIAGLRSRGNTTPVLILSALGEVDDRVTGLRAGGDDYLTKPYAF
EEEEECHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
SELLARVEVLNRRASAKEAETVYRVGDLELDRLSHSVRRAAREITLQPREFRLLEYLMRH
HHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
AGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRGKIEKGFDKPILHTVRGAGYMLKGG
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHCCCCHHHHHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]