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The map label for this gene is rcsC [C]

Identifier: 13476354

GI number: 13476354

Start: 6333830

End: 6335455

Strand: Direct

Name: rcsC [C]

Synonym: mlr7649

Alternate gene names: 13476354

Gene position: 6333830-6335455 (Clockwise)

Preceding gene: 13476351

Following gene: 13476355

Centisome position: 90.02

GC content: 65.5

Gene sequence:

>1626_bases
ATGGCCGCCATCTTCGCCGCCTTCGGCCTGTGCTGGTTCGTCGCCTTGCTGGTGGCGGCTACCGGCAAGATGGCCGCGGC
GGCACCGGTTGCCCTTGCAATGGCGGCTGTTGCCCTTGGCGGTCTGATCGCCGCTGCCGGCGGGTTGAGCTCTCCCGTCG
CCGTGCTTGCCGTGGCGCTGCCCTTCGAAGCCTGGTGGATCGGCGCTTCGCGGCGCGCGGCCCTGTGGGGAGCGGTCTCG
GCCATTGCCGCCATTGCCCTTCAGCCTCTGGCCGCGGCCTTCTTGCCCTTCGCGGGCGCGCAGATCGCGGCCTGGCATTG
GCTGGTGCCGCTGGCCTGGGCGCTGACGCTGATCCCGCGCCTGTCGGCGGTTGGCGATAGCGCCGGCGCCACCGATACGC
TGGATGCCGGCGGTCGGCTGGAAGACATCATCGATGCGGTAATCCTGCGCGTCGCCCGCCATGGCGAGGTGCTCGATGCG
TCCGACAAGGCACGCACGCTTTTGAAATTGCCGCCGGAACTCCTTTCCGGAACCGGCTTCTTCGACCGTGTCCATCTGTC
GGACCGTGTCTCCTATCTCAGCGCGCTGGCCGATATGCGCGATGGTGCTGCCTCGCGCCGCCTCGAATTGCGCGTCAGGC
TGCCCCAGAACGGCAACGGCCAGAATGATACGCGCCAAAGTGACAGTCGCTTGATGGCCGACAATTACCGGCCGTTCCTG
CTCGAACTGCTGCGTGGCGAGGAGCAGAGCGACGTCTTCACGCTGGTGCTGCGCGAGAATGACGAGACTGCCCGGCTGCG
TGAGGAACTGGCGCAGGCCAATGAGACGGCGGCAGCCGCGGAAGTGGCCAAGGGCCGGTTCCTGGCGGTGGTCAGCCATG
AGCTGCGCACGCCGCTGAACGCCATCATCGGCTTCTCGGACATGCTGCTGCACGAGATGTTCGGCGCCTTCAAGGACCCG
CGCCAGAAGGAATATGTCACCCTGGTGCGTGATTCAGGGCAGCATCTTCTGGCGGTCGTGACATCCATACTCGACGTATC
GAGGATCGAATCGGGCGCCTACACGGCGGACCCGGAGCCGTTCCGGTTCATGGAAGCCGTCGACATGTGCCAGTCGATGA
TGCGGCTGCAGGCGCAGGCCAAGAACATCGACCTGCAGACGCAGATCGCTCCCGACGCCGGCGACATCAATGCCGATCGC
CGCGCCGTGCAGCAGATGCTGATCAATCTCGTCTCCAATGCGATCAAGTTCACGCCCGACGGCGGCGATGTCGTCGTTGG
CGCCAAGCGGATCGGTTCGCGCCTGCATTTCTGGGTCAGGGACACCGGCATCGGCATTGCCGAGGAGGATTTCGCCAATC
TCGGCAAGCCCTTCACGCAGATCCAGAACGACTATACGCGCCGTTTCGAGGGGACCGGTCTTGGCCTGTCACTGGTGAAG
GGGCTGGTGGCGCTGCATGAAGGCACCATGTCGATCGAAAGCATGCCGGGCGAGGGCACCACGGTGACCATCAGCCTGCC
GGTCAACGGGCCGAAGGGGCGCCCGGCGAACGAGGCAGGGGTGCTGACGATGCCGGTGACGAGGGCGAAAGGGGACAGAA
ATGGCTCGCTCCGCAAAACAGCCTAA

Upstream 100 bases:

>100_bases
GCGCCAACGCCGTTTCATCGGCGTCATGCTGGCAGCGCCATTCTTCGCCGCCGGTGCCGCGGTCACGCTGGTCACATCGG
GCATGGGCGCCGCTGTGACC

Downstream 100 bases:

>100_bases
GGCGGTCAAACGCCGCAGCAACGCCTTCCAGGATGGCGCCATGGCCGTCGGCGGGATGATTTCGCGCAACCCCGTGCTGG
TAGGCGGATCGACGGCATTC

Product: two component histidine sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MAAIFAAFGLCWFVALLVAATGKMAAAAPVALAMAAVALGGLIAAAGGLSSPVAVLAVALPFEAWWIGASRRAALWGAVS
AIAAIALQPLAAAFLPFAGAQIAAWHWLVPLAWALTLIPRLSAVGDSAGATDTLDAGGRLEDIIDAVILRVARHGEVLDA
SDKARTLLKLPPELLSGTGFFDRVHLSDRVSYLSALADMRDGAASRRLELRVRLPQNGNGQNDTRQSDSRLMADNYRPFL
LELLRGEEQSDVFTLVLRENDETARLREELAQANETAAAAEVAKGRFLAVVSHELRTPLNAIIGFSDMLLHEMFGAFKDP
RQKEYVTLVRDSGQHLLAVVTSILDVSRIESGAYTADPEPFRFMEAVDMCQSMMRLQAQAKNIDLQTQIAPDAGDINADR
RAVQQMLINLVSNAIKFTPDGGDVVVGAKRIGSRLHFWVRDTGIGIAEEDFANLGKPFTQIQNDYTRRFEGTGLGLSLVK
GLVALHEGTMSIESMPGEGTTVTISLPVNGPKGRPANEAGVLTMPVTRAKGDRNGSLRKTA

Sequences:

>Translated_541_residues
MAAIFAAFGLCWFVALLVAATGKMAAAAPVALAMAAVALGGLIAAAGGLSSPVAVLAVALPFEAWWIGASRRAALWGAVS
AIAAIALQPLAAAFLPFAGAQIAAWHWLVPLAWALTLIPRLSAVGDSAGATDTLDAGGRLEDIIDAVILRVARHGEVLDA
SDKARTLLKLPPELLSGTGFFDRVHLSDRVSYLSALADMRDGAASRRLELRVRLPQNGNGQNDTRQSDSRLMADNYRPFL
LELLRGEEQSDVFTLVLRENDETARLREELAQANETAAAAEVAKGRFLAVVSHELRTPLNAIIGFSDMLLHEMFGAFKDP
RQKEYVTLVRDSGQHLLAVVTSILDVSRIESGAYTADPEPFRFMEAVDMCQSMMRLQAQAKNIDLQTQIAPDAGDINADR
RAVQQMLINLVSNAIKFTPDGGDVVVGAKRIGSRLHFWVRDTGIGIAEEDFANLGKPFTQIQNDYTRRFEGTGLGLSLVK
GLVALHEGTMSIESMPGEGTTVTISLPVNGPKGRPANEAGVLTMPVTRAKGDRNGSLRKTA
>Mature_540_residues
AAIFAAFGLCWFVALLVAATGKMAAAAPVALAMAAVALGGLIAAAGGLSSPVAVLAVALPFEAWWIGASRRAALWGAVSA
IAAIALQPLAAAFLPFAGAQIAAWHWLVPLAWALTLIPRLSAVGDSAGATDTLDAGGRLEDIIDAVILRVARHGEVLDAS
DKARTLLKLPPELLSGTGFFDRVHLSDRVSYLSALADMRDGAASRRLELRVRLPQNGNGQNDTRQSDSRLMADNYRPFLL
ELLRGEEQSDVFTLVLRENDETARLREELAQANETAAAAEVAKGRFLAVVSHELRTPLNAIIGFSDMLLHEMFGAFKDPR
QKEYVTLVRDSGQHLLAVVTSILDVSRIESGAYTADPEPFRFMEAVDMCQSMMRLQAQAKNIDLQTQIAPDAGDINADRR
AVQQMLINLVSNAIKFTPDGGDVVVGAKRIGSRLHFWVRDTGIGIAEEDFANLGKPFTQIQNDYTRRFEGTGLGLSLVKG
LVALHEGTMSIESMPGEGTTVTISLPVNGPKGRPANEAGVLTMPVTRAKGDRNGSLRKTA

Specific function: Member Of The Two-Component Regulatory System rcsC/rcsB Involved In The Regulation Of The Expression Of Genes Involved In Colanic Acid Capsule Synthesis. rcsC Probably Functions As A Membrane-Associated Protein Kinase That Phosphorylates rcsB In Response

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAC (PAS-associated C-terminal) domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=261, Percent_Identity=35.632183908046, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI1789149, Length=251, Percent_Identity=35.0597609561753, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1788713, Length=253, Percent_Identity=35.9683794466403, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI87081816, Length=302, Percent_Identity=32.1192052980132, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI48994928, Length=225, Percent_Identity=30.6666666666667, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI1786600, Length=233, Percent_Identity=31.3304721030043, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1788549, Length=257, Percent_Identity=28.4046692607004, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI87082128, Length=227, Percent_Identity=26.8722466960352, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790436, Length=237, Percent_Identity=29.1139240506329, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788393, Length=251, Percent_Identity=23.9043824701195, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1786783, Length=227, Percent_Identity=24.6696035242291, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786912, Length=271, Percent_Identity=25.4612546125461, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1789808, Length=247, Percent_Identity=26.3157894736842, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1790300, Length=265, Percent_Identity=24.9056603773585, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790346, Length=241, Percent_Identity=24.4813278008299, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001610
- InterPro:   IPR000700
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 57879; Mature: 57748

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAIFAAFGLCWFVALLVAATGKMAAAAPVALAMAAVALGGLIAAAGGLSSPVAVLAVAL
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
PFEAWWIGASRRAALWGAVSAIAAIALQPLAAAFLPFAGAQIAAWHWLVPLAWALTLIPR
CHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LSAVGDSAGATDTLDAGGRLEDIIDAVILRVARHGEVLDASDKARTLLKLPPELLSGTGF
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHCCCCC
FDRVHLSDRVSYLSALADMRDGAASRRLELRVRLPQNGNGQNDTRQSDSRLMADNYRPFL
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHCCCHHHCCCCHHH
LELLRGEEQSDVFTLVLRENDETARLREELAQANETAAAAEVAKGRFLAVVSHELRTPLN
HHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHCHHHHHHHHHCCCEEEEHHHHHHCHHH
AIIGFSDMLLHEMFGAFKDPRQKEYVTLVRDSGQHLLAVVTSILDVSRIESGAYTADPEP
HHHHHHHHHHHHHHHHHCCCCCHHEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCH
FRFMEAVDMCQSMMRLQAQAKNIDLQTQIAPDAGDINADRRAVQQMLINLVSNAIKFTPD
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHEEECCC
GGDVVVGAKRIGSRLHFWVRDTGIGIAEEDFANLGKPFTQIQNDYTRRFEGTGLGLSLVK
CCCEEEEHHHHCCCEEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHH
GLVALHEGTMSIESMPGEGTTVTISLPVNGPKGRPANEAGVLTMPVTRAKGDRNGSLRKT
HHHHHHCCCCEEECCCCCCCEEEEEEECCCCCCCCCCCCCEEEECCHHCCCCCCCCCCCC
A
C
>Mature Secondary Structure 
AAIFAAFGLCWFVALLVAATGKMAAAAPVALAMAAVALGGLIAAAGGLSSPVAVLAVAL
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
PFEAWWIGASRRAALWGAVSAIAAIALQPLAAAFLPFAGAQIAAWHWLVPLAWALTLIPR
CHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LSAVGDSAGATDTLDAGGRLEDIIDAVILRVARHGEVLDASDKARTLLKLPPELLSGTGF
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHCCCCC
FDRVHLSDRVSYLSALADMRDGAASRRLELRVRLPQNGNGQNDTRQSDSRLMADNYRPFL
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHCCCHHHCCCCHHH
LELLRGEEQSDVFTLVLRENDETARLREELAQANETAAAAEVAKGRFLAVVSHELRTPLN
HHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHCHHHHHHHHHCCCEEEEHHHHHHCHHH
AIIGFSDMLLHEMFGAFKDPRQKEYVTLVRDSGQHLLAVVTSILDVSRIESGAYTADPEP
HHHHHHHHHHHHHHHHHCCCCCHHEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCH
FRFMEAVDMCQSMMRLQAQAKNIDLQTQIAPDAGDINADRRAVQQMLINLVSNAIKFTPD
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHEEECCC
GGDVVVGAKRIGSRLHFWVRDTGIGIAEEDFANLGKPFTQIQNDYTRRFEGTGLGLSLVK
CCCEEEEHHHHCCCEEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHH
GLVALHEGTMSIESMPGEGTTVTISLPVNGPKGRPANEAGVLTMPVTRAKGDRNGSLRKT
HHHHHHCCCCEEECCCCCCCEEEEEEECCCCCCCCCCCCCEEEECCHHCCCCCCCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430; 7756693 [H]