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The map label for this gene is mutA [H]

Identifier: 13476331

GI number: 13476331

Start: 6311653

End: 6313122

Strand: Reverse

Name: mutA [H]

Synonym: mll7621

Alternate gene names: 13476331

Gene position: 6313122-6311653 (Counterclockwise)

Preceding gene: 13476333

Following gene: 13476330

Centisome position: 89.73

GC content: 65.92

Gene sequence:

>1470_bases
GTGCGGCCATATGAACGAGGAAGATGGATGGGCGCCGGAGCCTTGACCAAGCATGTCGAACCAGTTGGCGCCGAGCGCCA
GCGATGGCTGGCCCTGGCGGAAAAGGCACTGGCTGGTGCATCCTTCGAGGAAAAGCTGGTTTCGCACACCGACGACGCCA
TCCGCATCGAGCCACTCTATGACCGAGTGAGCGGGGCCGAACCACTTGTGCGCGCGAATCCCCGATCGCCCTGGATCGTC
AGCCAGCGCGTCGACGACCCCAATATCGATCGCGCCAAGGCCCAGGTCCTGGACGATATCGCGCAGGGCGCGACGGGACT
GTCGCTCGTCTTCGAAGGCGCGCCGAACGCATTCGGCTACGGTCTGCCGAGAACCGCACAGGCGCTGGAAACGGTGCTGG
AGGGCGTGCCTCTCAACCGGATCCAGATCCGCATCGACACCCACCCGTGGAGCCGCCCCATGGCCGACTGGCTGGTGGCG
TTCCTGAGCAAGCGTCGCTCCGATCCGGCAAAACTCAACCTGTCCTTCGGCATCGATCCGGCGGCGATCCTCGCCGGCAC
CGGCCGGCTGCGCATGTCGATCGAGGCGCTGCAGGAATCGATGCCCCAGTCGCTGGCGCATTTCTTCTCGATGGGCGTTC
CGGGCGTGCTTCTGGAGGCGGACGGTCGCGTCTTCCACAATGCCGGCGCCACGGAAGCGCAGGAACTCGGCATCATGCTG
GCGTCGGCGGTCTCGTATCTGAGAATGTTCGAGAAGGCGCGGCAGCCGCTCGTCTATGCCGCACCCCATATCGGCTTTGC
GCTCAGCGTCGACCAGGACCAGTTCCTCTCCATGGCCAAGGTACGGGCCTTGCGCAGTCTGTGGGCACGCGTGCAGGAGG
CCTGCTCGATCCCCAACTCCACGGCCAACATCCATGCCGAAACGTCATTCCGCATGATGACGGCGCTGGACCCCGAAACC
AACATCCTGCGCACGACGATCAGTTGCTTCGCCGCGGCGGCGGGGGGAGCCGATTCGATCTCCATCCTGCCGCACACGAT
CGCGCACGGCCTGCCGGCGCCGTTTGCCCGCCGCGTCGCGCGCAACGCCCAGCTGATCATGGCCAATGAAAGCCACGTCG
ATCATGTCGCCGATCCCGCCTATGGCTCCGGCGCGGTTGAAGCACTGACGGCGGACCTTTGCGAAGCCGCCTGGGGGGAG
CTGCAGGCGATCGAGGCCGAAGGCGGTGTGCTGTCCAGCCTTCGGGACGGACACATCCAACACCGCGTTCGCGCGGCATC
CGCCCGGCGCGACGCCGCCTTCAAGGCCGGGGAACGGGCCATCATCGGCACCACACTCTATCCTCAGAAGGGCGAAAGCC
CGGTCGAGACGCTGGATGCGGAGCAGCGGCCTGCCTTCACCGAAGGCGTCGTCCTGTGTGAAGCGCTGTTCCCGGCCCGC
ATCGACCAATCGATCGAGGCTGCCTCTTGA

Upstream 100 bases:

>100_bases
TTCGTCCATGCAAGCCGCCCTATATCCGGTGGATCGAATTCAGGCCCGGGATGCGCATTGCGATAACCGACCGGGAACCG
TAGACTGAACCGCCCGGCTG

Downstream 100 bases:

>100_bases
TCCCGGATTTCAGTCAGGTCGGCTGGGCGCCGCCGCGCCGCGCGCCGGTCGAGGTCAAGGGCCAGCGGGTGACGCCGGAA
GGGCTTATCGTCAAGCATCT

Product: methylmalonyl-CoA small subunit

Products: NA

Alternate protein names: MCM-beta [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MRPYERGRWMGAGALTKHVEPVGAERQRWLALAEKALAGASFEEKLVSHTDDAIRIEPLYDRVSGAEPLVRANPRSPWIV
SQRVDDPNIDRAKAQVLDDIAQGATGLSLVFEGAPNAFGYGLPRTAQALETVLEGVPLNRIQIRIDTHPWSRPMADWLVA
FLSKRRSDPAKLNLSFGIDPAAILAGTGRLRMSIEALQESMPQSLAHFFSMGVPGVLLEADGRVFHNAGATEAQELGIML
ASAVSYLRMFEKARQPLVYAAPHIGFALSVDQDQFLSMAKVRALRSLWARVQEACSIPNSTANIHAETSFRMMTALDPET
NILRTTISCFAAAAGGADSISILPHTIAHGLPAPFARRVARNAQLIMANESHVDHVADPAYGSGAVEALTADLCEAAWGE
LQAIEAEGGVLSSLRDGHIQHRVRAASARRDAAFKAGERAIIGTTLYPQKGESPVETLDAEQRPAFTEGVVLCEALFPAR
IDQSIEAAS

Sequences:

>Translated_489_residues
MRPYERGRWMGAGALTKHVEPVGAERQRWLALAEKALAGASFEEKLVSHTDDAIRIEPLYDRVSGAEPLVRANPRSPWIV
SQRVDDPNIDRAKAQVLDDIAQGATGLSLVFEGAPNAFGYGLPRTAQALETVLEGVPLNRIQIRIDTHPWSRPMADWLVA
FLSKRRSDPAKLNLSFGIDPAAILAGTGRLRMSIEALQESMPQSLAHFFSMGVPGVLLEADGRVFHNAGATEAQELGIML
ASAVSYLRMFEKARQPLVYAAPHIGFALSVDQDQFLSMAKVRALRSLWARVQEACSIPNSTANIHAETSFRMMTALDPET
NILRTTISCFAAAAGGADSISILPHTIAHGLPAPFARRVARNAQLIMANESHVDHVADPAYGSGAVEALTADLCEAAWGE
LQAIEAEGGVLSSLRDGHIQHRVRAASARRDAAFKAGERAIIGTTLYPQKGESPVETLDAEQRPAFTEGVVLCEALFPAR
IDQSIEAAS
>Mature_489_residues
MRPYERGRWMGAGALTKHVEPVGAERQRWLALAEKALAGASFEEKLVSHTDDAIRIEPLYDRVSGAEPLVRANPRSPWIV
SQRVDDPNIDRAKAQVLDDIAQGATGLSLVFEGAPNAFGYGLPRTAQALETVLEGVPLNRIQIRIDTHPWSRPMADWLVA
FLSKRRSDPAKLNLSFGIDPAAILAGTGRLRMSIEALQESMPQSLAHFFSMGVPGVLLEADGRVFHNAGATEAQELGIML
ASAVSYLRMFEKARQPLVYAAPHIGFALSVDQDQFLSMAKVRALRSLWARVQEACSIPNSTANIHAETSFRMMTALDPET
NILRTTISCFAAAAGGADSISILPHTIAHGLPAPFARRVARNAQLIMANESHVDHVADPAYGSGAVEALTADLCEAAWGE
LQAIEAEGGVLSSLRDGHIQHRVRAASARRDAAFKAGERAIIGTTLYPQKGESPVETLDAEQRPAFTEGVVLCEALFPAR
IDQSIEAAS

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthes

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=473, Percent_Identity=27.2727272727273, Blast_Score=155, Evalue=1e-37,
Organism=Escherichia coli, GI1789284, Length=503, Percent_Identity=26.441351888668, Blast_Score=141, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI25144500, Length=478, Percent_Identity=26.1506276150628, Blast_Score=142, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 52829; Mature: 52829

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPYERGRWMGAGALTKHVEPVGAERQRWLALAEKALAGASFEEKLVSHTDDAIRIEPLY
CCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEHH
DRVSGAEPLVRANPRSPWIVSQRVDDPNIDRAKAQVLDDIAQGATGLSLVFEGAPNAFGY
HHCCCCCCEEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
GLPRTAQALETVLEGVPLNRIQIRIDTHPWSRPMADWLVAFLSKRRSDPAKLNLSFGIDP
CCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCH
AAILAGTGRLRMSIEALQESMPQSLAHFFSMGVPGVLLEADGRVFHNAGATEAQELGIML
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEECCCCCHHHHHHHHH
ASAVSYLRMFEKARQPLVYAAPHIGFALSVDQDQFLSMAKVRALRSLWARVQEACSIPNS
HHHHHHHHHHHHHCCCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TANIHAETSFRMMTALDPETNILRTTISCFAAAAGGADSISILPHTIAHGLPAPFARRVA
CCEEEECCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHH
RNAQLIMANESHVDHVADPAYGSGAVEALTADLCEAAWGELQAIEAEGGVLSSLRDGHIQ
CCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHH
HRVRAASARRDAAFKAGERAIIGTTLYPQKGESPVETLDAEQRPAFTEGVVLCEALFPAR
HHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHH
IDQSIEAAS
HCCHHHCCC
>Mature Secondary Structure
MRPYERGRWMGAGALTKHVEPVGAERQRWLALAEKALAGASFEEKLVSHTDDAIRIEPLY
CCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEHH
DRVSGAEPLVRANPRSPWIVSQRVDDPNIDRAKAQVLDDIAQGATGLSLVFEGAPNAFGY
HHCCCCCCEEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
GLPRTAQALETVLEGVPLNRIQIRIDTHPWSRPMADWLVAFLSKRRSDPAKLNLSFGIDP
CCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCH
AAILAGTGRLRMSIEALQESMPQSLAHFFSMGVPGVLLEADGRVFHNAGATEAQELGIML
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEECCCCCHHHHHHHHH
ASAVSYLRMFEKARQPLVYAAPHIGFALSVDQDQFLSMAKVRALRSLWARVQEACSIPNS
HHHHHHHHHHHHHCCCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TANIHAETSFRMMTALDPETNILRTTISCFAAAAGGADSISILPHTIAHGLPAPFARRVA
CCEEEECCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHH
RNAQLIMANESHVDHVADPAYGSGAVEALTADLCEAAWGELQAIEAEGGVLSSLRDGHIQ
CCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHH
HRVRAASARRDAAFKAGERAIIGTTLYPQKGESPVETLDAEQRPAFTEGVVLCEALFPAR
HHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHH
IDQSIEAAS
HCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8099072 [H]