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The map label for this gene is ctaB2

Identifier: 13476227

GI number: 13476227

Start: 6188060

End: 6189004

Strand: Direct

Name: ctaB2

Synonym: mlr7493

Alternate gene names: 13476227

Gene position: 6188060-6189004 (Clockwise)

Preceding gene: 13476226

Following gene: 13476228

Centisome position: 87.95

GC content: 64.66

Gene sequence:

>945_bases
ATGGCCCTAGTCGACGAAACCAGCATTGACGAAGCGGGCTTCCGCATGTCGGAAGCGACGGCGGGCGATTTCTTCGCCCT
GCTGAAGCCGCGCGTCATGTCGCTGGTGGTGTTCACGGCCTTTGTCGGGCTGGTCGCCGCCCCGGTGACCATCAACCCGC
TGCTGGCGGTGATCGCCATCCTGTCGATCGCCATCGGTGCCGGTGCCTCGGGCGCGCTCAACATGTGGTACGACGCCGAC
ATCGATGCGGTGATGACCAGGACCGCAAGCCGTCCGGTGCCGTCCGGCCGCATTCAGCCGCACGAGGCGCTCAGCTTCGG
CCTGGTGCTGTCGGTGCTGTCGGTGATGACGCTTGGCGTGTTGGTCAACTGGCTTTCGGCGACGCTGCTGGCCTTCACCA
TCTTCTTCTATGCCGTCGTCTACACGATGTGGCTGAAGCGCTGGACGCCGCAGAACATCGTCATCGGCGGCGCGGCCGGT
GCCATTCCGCCGGTGATCGGTTGGGCCGCGGTGACCGGATCGGTCAGCCTCGAAAGCATCGTCCTGTTCCTGATCATCTT
CCTGTGGACGCCGCCGCATTTCTGGGCGCTCGCGCTGTTCAAGTCCGGGGACTATGAGCGTGCCGGCATCCCGATGATGC
CCAATGTCGCCGGCCACGCGTCGACCCGCCGTCAGATCTTCGCCTATGCACTGGTGCTGGCCCCGGTCGGCGTGGCGCCG
TGGCTGCTCGGCTATACGACGCCTTTCTATGGCGTGGCCGCCATGCTGCTTGGGCTTGGCTTTGTCTGGTATGCGTGGAA
AGTGCTCGGCATGGCCGATGACGACCGCGCCATGAAGCCGGCCAAGGCGCTGTTCGCCTATTCGCTGCTTTATCTCTTCG
CCATCTTCGCTGCCTACCTGGCCGACAGCGTTGTCGAACGCGCGCTTGCCATGGGTGGGGCATGA

Upstream 100 bases:

>100_bases
GGGAGCAGTTGCCGAAGATCAAGTAAGGCGGCTCCCGCCCGAATACGAAACCGCCGGCCCGCCGGCGGTTTTGGCCAACG
GAATGATGGACTGAGTACGC

Downstream 100 bases:

>100_bases
TCATGGTCGAGGAAAAGCTTGAGACGGTCACCTTGACCGAGCGTCAGAGGAAGGCCCAGCGCAGCCGGTCCATCGCGATC
GGCGTGGCGCTGGCGGTGCT

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase 2; Heme O synthase 2

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MALVDETSIDEAGFRMSEATAGDFFALLKPRVMSLVVFTAFVGLVAAPVTINPLLAVIAILSIAIGAGASGALNMWYDAD
IDAVMTRTASRPVPSGRIQPHEALSFGLVLSVLSVMTLGVLVNWLSATLLAFTIFFYAVVYTMWLKRWTPQNIVIGGAAG
AIPPVIGWAAVTGSVSLESIVLFLIIFLWTPPHFWALALFKSGDYERAGIPMMPNVAGHASTRRQIFAYALVLAPVGVAP
WLLGYTTPFYGVAAMLLGLGFVWYAWKVLGMADDDRAMKPAKALFAYSLLYLFAIFAAYLADSVVERALAMGGA

Sequences:

>Translated_314_residues
MALVDETSIDEAGFRMSEATAGDFFALLKPRVMSLVVFTAFVGLVAAPVTINPLLAVIAILSIAIGAGASGALNMWYDAD
IDAVMTRTASRPVPSGRIQPHEALSFGLVLSVLSVMTLGVLVNWLSATLLAFTIFFYAVVYTMWLKRWTPQNIVIGGAAG
AIPPVIGWAAVTGSVSLESIVLFLIIFLWTPPHFWALALFKSGDYERAGIPMMPNVAGHASTRRQIFAYALVLAPVGVAP
WLLGYTTPFYGVAAMLLGLGFVWYAWKVLGMADDDRAMKPAKALFAYSLLYLFAIFAAYLADSVVERALAMGGA
>Mature_313_residues
ALVDETSIDEAGFRMSEATAGDFFALLKPRVMSLVVFTAFVGLVAAPVTINPLLAVIAILSIAIGAGASGALNMWYDADI
DAVMTRTASRPVPSGRIQPHEALSFGLVLSVLSVMTLGVLVNWLSATLLAFTIFFYAVVYTMWLKRWTPQNIVIGGAAGA
IPPVIGWAAVTGSVSLESIVLFLIIFLWTPPHFWALALFKSGDYERAGIPMMPNVAGHASTRRQIFAYALVLAPVGVAPW
LLGYTTPFYGVAAMLLGLGFVWYAWKVLGMADDDRAMKPAKALFAYSLLYLFAIFAAYLADSVVERALAMGGA

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=187, Percent_Identity=35.8288770053476, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI1786631, Length=255, Percent_Identity=30.9803921568627, Blast_Score=106, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71998235, Length=273, Percent_Identity=30.03663003663, Blast_Score=94, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6325085, Length=250, Percent_Identity=28.8, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19921064, Length=290, Percent_Identity=28.9655172413793, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX2_RHILO (Q985X0)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_107797.1
- GeneID:   1230452
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr7493
- NMPDR:   fig|266835.1.peg.5898
- HOGENOM:   HBG656003
- OMA:   MALTEGW
- ProtClustDB:   PRK04375
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 33653; Mature: 33522

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x17c43308)-; HASH(0x17e369d0)-; HASH(0x1782475c)-; HASH(0x17b538c0)-; HASH(0x177845a0)-; HASH(0x17560c70)-; HASH(0x1796b474)-; HASH(0x17b539b0)-; HASH(0x1638f1ec)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVDETSIDEAGFRMSEATAGDFFALLKPRVMSLVVFTAFVGLVAAPVTINPLLAVIAI
CCCCCCCCCCHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LSIAIGAGASGALNMWYDADIDAVMTRTASRPVPSGRIQPHEALSFGLVLSVLSVMTLGV
HHHHHCCCCCCCEECCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LVNWLSATLLAFTIFFYAVVYTMWLKRWTPQNIVIGGAAGAIPPVIGWAAVTGSVSLESI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCCCCHHHH
VLFLIIFLWTPPHFWALALFKSGDYERAGIPMMPNVAGHASTRRQIFAYALVLAPVGVAP
HHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
WLLGYTTPFYGVAAMLLGLGFVWYAWKVLGMADDDRAMKPAKALFAYSLLYLFAIFAAYL
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ADSVVERALAMGGA
HHHHHHHHHHHCCH
>Mature Secondary Structure 
ALVDETSIDEAGFRMSEATAGDFFALLKPRVMSLVVFTAFVGLVAAPVTINPLLAVIAI
CCCCCCCCCHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LSIAIGAGASGALNMWYDADIDAVMTRTASRPVPSGRIQPHEALSFGLVLSVLSVMTLGV
HHHHHCCCCCCCEECCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LVNWLSATLLAFTIFFYAVVYTMWLKRWTPQNIVIGGAAGAIPPVIGWAAVTGSVSLESI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCCCCHHHH
VLFLIIFLWTPPHFWALALFKSGDYERAGIPMMPNVAGHASTRRQIFAYALVLAPVGVAP
HHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
WLLGYTTPFYGVAAMLLGLGFVWYAWKVLGMADDDRAMKPAKALFAYSLLYLFAIFAAYL
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ADSVVERALAMGGA
HHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11214968