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The map label for this gene is dxs

Identifier: 13476214

GI number: 13476214

Start: 6173606

End: 6175519

Strand: Direct

Name: dxs

Synonym: mlr7474

Alternate gene names: 13476214

Gene position: 6173606-6175519 (Clockwise)

Preceding gene: 13476213

Following gene: 13476215

Centisome position: 87.74

GC content: 66.04

Gene sequence:

>1914_bases
GTGAACGCAACGCCGCATACGCCGCTTCTCGACAAGGTCCGCATCCCGGCGGATCTGCGCGCGCTTGACGAGAGCGAGCT
GCCGCAACTGGCGTCCGAGCTTCGCCTCGAACTGGTCGACGCGGTGTCCCGCACCGGCGGCCATCTCGGCGCCGGCCTCG
GCGTGGTCGAACTGACGGTGGCGCTGCACTACGTCTTCAACACGCCGGACGACCGGCTGATCTGGGATGTCGGCCACCAG
GCCTATCCGCACAAGATCCTGACCGGCCGCCGCGACCGCATCCGCACATTGCGCCAGGAGGGCGGCCTGTCCGGCTTCAC
CCGCCGCGCCGAGAGTGAATACGATCCCTTCGGCGCCGCCCATTCCTCGACGTCGATATCGGCTGGCCTCGGCATGGCCG
CCGCTCGCGACCTCTCCGGCGGCCGCAACAATGTCATCGCCGTCATCGGCGACGGCGCCATGTCGGCCGGCATGGCCTAT
GAGGCGATGAACAATGCCGGTGCGCTCGATGCCCGGCTCATCGTCATCCTCAACGATAACGACATGTCGATCGCGCCGCC
CACCGGCGCCATGAGCGCCTATCTGGCGCGCCTCGCCTCGGGCAAGGCCTATGCCGGCCTGCGCGATTTCGGCAAGAAGC
TGACATCCTATCTCGGCAAGCGCGCCGATCGTGCGATCACAAGAGCGGTCGAGCATGCGCGCGGCTATGTCACCGGCGGC
ACGCTGTTCGAGGAGCTCGGTTTCTACCACATCGGCCCGATCGACGGCCACAATCTCGAGCATCTGATCCCGGTGCTGAA
GAATGTCCGCGACAATGGCGAAGGCCCGGTGCTGATCCATGTCGTCACCCAGAAGGGCAAGGGCTATGCGCCGGCGGAGG
CTGCGGCCGACAAATACCACGGCGTCAACAAATTCGACGTCATCACCGGCGCGCAGGCCAAGGCGCCGGCCAACGCACCG
GCCTACACCAAGGTGTTCGCCGAAAGCCTGATTAGAGAAGCCCGCGAGGACGACCGGATCGTCGCCGTCACCGCCGCCAT
GCCGAGTGGGACGGGGCTGGATCTGTTCGGCGAAGTGTTCCCGTCACGGACCTTCGACGTCGGCATTGCCGAACAGCATG
CGGTGACCTTTGCTGCCGGTCTCGCGACCGAAGGCTACAAGCCGTTTGCGGCAATCTATTCGACCTTCCTGCAGCGCGCC
TATGACCAGGTCGTCCATGATGTCGCCATCCAGAAACTGCCGGTGCGTTTCCCGATCGACCGCGCCGGCTTCGTCGGTGC
CGATGGCGCCACCCATTGCGGTGCTTTCGACACAACTTTCCTGGCAAGCCTGCCGGGCTTTGTCGTGATGGCGGCCGCCG
ACGAAGCGGAGTTGCGCCACATGGTGCGCACGGCGGCAGCCTATGATGACGGCCCGATCGCCTTCCGCTATCCGCGCGGC
AATGGCGTCGGCGTCGACATGCCGGAGCGCGGCGAGGTTCTCGAACTCGGCAAGGGCCGCGTCGTTCGGGAAGGCAGCAA
GGTGGCGCTGCTGTCCTTCGGCACGCGCTTACAGGATTGCCTGATCGCTGCTGAGGAACTCGGCGCGGCGGGGCTTTCCA
CCACCGTTGCCGATGCCCGCTTTGCCAAGCCGCTCGACGAGGATCTGATCCGGCGGCTCGCCCGCTCGCACGAGGTTCTG
GTGACGGTGGAAGAGGGCGCCATTGGCGGCTTCGCCAGCCATGTGCTGCAGTTCCTCGCCCATGAAGGACTGCTGGAAAG
CGGCTTGAAGGTGCGCCCGCTGGTGCTGCCTGACGTGTTCACCGATCACGCCAAGCCGGAAAAAATGTATGCCGATGCCG
GGCTCGATGCCGCCGGCATCGTGCGCACCGTTTTCACCGCGCTCGATCATACGGCCCGCGCCCAGCGCGCCTGA

Upstream 100 bases:

>100_bases
GAAGTCGGCGAGGGGACCTGATTGATCCGCGTCATCGACACGCATTTACTTTCGCCGGCCGGCGGCCTATCTCGCCGTTG
AACAGAAAGCCTGAGCTCCC

Downstream 100 bases:

>100_bases
CTCAAAACCTCTAGCGCTTGAATCAGTTTGCCGGCTTGATTTCGTAACGCATTGTTAACACTGCTGTTTGGCGTTTTGCT
TACCGTGTCCCTTGGCCGTT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 637; Mature: 637

Protein sequence:

>637_residues
MNATPHTPLLDKVRIPADLRALDESELPQLASELRLELVDAVSRTGGHLGAGLGVVELTVALHYVFNTPDDRLIWDVGHQ
AYPHKILTGRRDRIRTLRQEGGLSGFTRRAESEYDPFGAAHSSTSISAGLGMAAARDLSGGRNNVIAVIGDGAMSAGMAY
EAMNNAGALDARLIVILNDNDMSIAPPTGAMSAYLARLASGKAYAGLRDFGKKLTSYLGKRADRAITRAVEHARGYVTGG
TLFEELGFYHIGPIDGHNLEHLIPVLKNVRDNGEGPVLIHVVTQKGKGYAPAEAAADKYHGVNKFDVITGAQAKAPANAP
AYTKVFAESLIREAREDDRIVAVTAAMPSGTGLDLFGEVFPSRTFDVGIAEQHAVTFAAGLATEGYKPFAAIYSTFLQRA
YDQVVHDVAIQKLPVRFPIDRAGFVGADGATHCGAFDTTFLASLPGFVVMAAADEAELRHMVRTAAAYDDGPIAFRYPRG
NGVGVDMPERGEVLELGKGRVVREGSKVALLSFGTRLQDCLIAAEELGAAGLSTTVADARFAKPLDEDLIRRLARSHEVL
VTVEEGAIGGFASHVLQFLAHEGLLESGLKVRPLVLPDVFTDHAKPEKMYADAGLDAAGIVRTVFTALDHTARAQRA

Sequences:

>Translated_637_residues
MNATPHTPLLDKVRIPADLRALDESELPQLASELRLELVDAVSRTGGHLGAGLGVVELTVALHYVFNTPDDRLIWDVGHQ
AYPHKILTGRRDRIRTLRQEGGLSGFTRRAESEYDPFGAAHSSTSISAGLGMAAARDLSGGRNNVIAVIGDGAMSAGMAY
EAMNNAGALDARLIVILNDNDMSIAPPTGAMSAYLARLASGKAYAGLRDFGKKLTSYLGKRADRAITRAVEHARGYVTGG
TLFEELGFYHIGPIDGHNLEHLIPVLKNVRDNGEGPVLIHVVTQKGKGYAPAEAAADKYHGVNKFDVITGAQAKAPANAP
AYTKVFAESLIREAREDDRIVAVTAAMPSGTGLDLFGEVFPSRTFDVGIAEQHAVTFAAGLATEGYKPFAAIYSTFLQRA
YDQVVHDVAIQKLPVRFPIDRAGFVGADGATHCGAFDTTFLASLPGFVVMAAADEAELRHMVRTAAAYDDGPIAFRYPRG
NGVGVDMPERGEVLELGKGRVVREGSKVALLSFGTRLQDCLIAAEELGAAGLSTTVADARFAKPLDEDLIRRLARSHEVL
VTVEEGAIGGFASHVLQFLAHEGLLESGLKVRPLVLPDVFTDHAKPEKMYADAGLDAAGIVRTVFTALDHTARAQRA
>Mature_637_residues
MNATPHTPLLDKVRIPADLRALDESELPQLASELRLELVDAVSRTGGHLGAGLGVVELTVALHYVFNTPDDRLIWDVGHQ
AYPHKILTGRRDRIRTLRQEGGLSGFTRRAESEYDPFGAAHSSTSISAGLGMAAARDLSGGRNNVIAVIGDGAMSAGMAY
EAMNNAGALDARLIVILNDNDMSIAPPTGAMSAYLARLASGKAYAGLRDFGKKLTSYLGKRADRAITRAVEHARGYVTGG
TLFEELGFYHIGPIDGHNLEHLIPVLKNVRDNGEGPVLIHVVTQKGKGYAPAEAAADKYHGVNKFDVITGAQAKAPANAP
AYTKVFAESLIREAREDDRIVAVTAAMPSGTGLDLFGEVFPSRTFDVGIAEQHAVTFAAGLATEGYKPFAAIYSTFLQRA
YDQVVHDVAIQKLPVRFPIDRAGFVGADGATHCGAFDTTFLASLPGFVVMAAADEAELRHMVRTAAAYDDGPIAFRYPRG
NGVGVDMPERGEVLELGKGRVVREGSKVALLSFGTRLQDCLIAAEELGAAGLSTTVADARFAKPLDEDLIRRLARSHEVL
VTVEEGAIGGFASHVLQFLAHEGLLESGLKVRPLVLPDVFTDHAKPEKMYADAGLDAAGIVRTVFTALDHTARAQRA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=531, Percent_Identity=25.2354048964218, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI4507521, Length=531, Percent_Identity=25.2354048964218, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI133778974, Length=364, Percent_Identity=25, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI225637463, Length=242, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI225637461, Length=242, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI225637459, Length=242, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1786622, Length=615, Percent_Identity=54.1463414634146, Blast_Score=623, Evalue=1e-179,
Organism=Caenorhabditis elegans, GI17539652, Length=423, Percent_Identity=25.531914893617, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45551847, Length=639, Percent_Identity=24.7261345852895, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI45550715, Length=639, Percent_Identity=24.7261345852895, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24645119, Length=522, Percent_Identity=25.8620689655172, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24666278, Length=264, Percent_Identity=29.5454545454545, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_RHILO (Q985Y3)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_107784.1
- ProteinModelPortal:   Q985Y3
- SMR:   Q985Y3
- GeneID:   1230439
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr7474
- NMPDR:   fig|266835.1.peg.5885
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- ProtClustDB:   PRK05444
- BRENDA:   2.2.1.7
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 67948; Mature: 67948

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNATPHTPLLDKVRIPADLRALDESELPQLASELRLELVDAVSRTGGHLGAGLGVVELTV
CCCCCCCCCHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
ALHYVFNTPDDRLIWDVGHQAYPHKILTGRRDRIRTLRQEGGLSGFTRRAESEYDPFGAA
HHHHEECCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCCC
HSSTSISAGLGMAAARDLSGGRNNVIAVIGDGAMSAGMAYEAMNNAGALDARLIVILNDN
CCCCCHHHCCCHHHHHHCCCCCCCEEEEEECCCHHCCHHHHHHCCCCCCCEEEEEEECCC
DMSIAPPTGAMSAYLARLASGKAYAGLRDFGKKLTSYLGKRADRAITRAVEHARGYVTGG
CCEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECH
TLFEELGFYHIGPIDGHNLEHLIPVLKNVRDNGEGPVLIHVVTQKGKGYAPAEAAADKYH
HHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHC
GVNKFDVITGAQAKAPANAPAYTKVFAESLIREAREDDRIVAVTAAMPSGTGLDLFGEVF
CCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHC
PSRTFDVGIAEQHAVTFAAGLATEGYKPFAAIYSTFLQRAYDQVVHDVAIQKLPVRFPID
CCCCEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RAGFVGADGATHCGAFDTTFLASLPGFVVMAAADEAELRHMVRTAAAYDDGPIAFRYPRG
CCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCC
NGVGVDMPERGEVLELGKGRVVREGSKVALLSFGTRLQDCLIAAEELGAAGLSTTVADAR
CCCCCCCCCCCCEEECCCCCEEECCCCEEEEECCHHHHHHHHHHHHHCCCCCHHHHHHHH
FAKPLDEDLIRRLARSHEVLVTVEEGAIGGFASHVLQFLAHEGLLESGLKVRPLVLPDVF
HCCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCHHH
TDHAKPEKMYADAGLDAAGIVRTVFTALDHTARAQRA
CCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNATPHTPLLDKVRIPADLRALDESELPQLASELRLELVDAVSRTGGHLGAGLGVVELTV
CCCCCCCCCHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
ALHYVFNTPDDRLIWDVGHQAYPHKILTGRRDRIRTLRQEGGLSGFTRRAESEYDPFGAA
HHHHEECCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCCC
HSSTSISAGLGMAAARDLSGGRNNVIAVIGDGAMSAGMAYEAMNNAGALDARLIVILNDN
CCCCCHHHCCCHHHHHHCCCCCCCEEEEEECCCHHCCHHHHHHCCCCCCCEEEEEEECCC
DMSIAPPTGAMSAYLARLASGKAYAGLRDFGKKLTSYLGKRADRAITRAVEHARGYVTGG
CCEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECH
TLFEELGFYHIGPIDGHNLEHLIPVLKNVRDNGEGPVLIHVVTQKGKGYAPAEAAADKYH
HHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHC
GVNKFDVITGAQAKAPANAPAYTKVFAESLIREAREDDRIVAVTAAMPSGTGLDLFGEVF
CCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHC
PSRTFDVGIAEQHAVTFAAGLATEGYKPFAAIYSTFLQRAYDQVVHDVAIQKLPVRFPID
CCCCEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RAGFVGADGATHCGAFDTTFLASLPGFVVMAAADEAELRHMVRTAAAYDDGPIAFRYPRG
CCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCC
NGVGVDMPERGEVLELGKGRVVREGSKVALLSFGTRLQDCLIAAEELGAAGLSTTVADAR
CCCCCCCCCCCCEEECCCCCEEECCCCEEEEECCHHHHHHHHHHHHHCCCCCHHHHHHHH
FAKPLDEDLIRRLARSHEVLVTVEEGAIGGFASHVLQFLAHEGLLESGLKVRPLVLPDVF
HCCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCHHH
TDHAKPEKMYADAGLDAAGIVRTVFTALDHTARAQRA
CCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968