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The map label for this gene is pdxH

Identifier: 13476197

GI number: 13476197

Start: 6159758

End: 6160375

Strand: Reverse

Name: pdxH

Synonym: mll7454

Alternate gene names: 13476197

Gene position: 6160375-6159758 (Counterclockwise)

Preceding gene: 13476202

Following gene: 13476194

Centisome position: 87.55

GC content: 62.46

Gene sequence:

>618_bases
ATGAGTGACACAGAGTTAACAACCAGTGACTTTACCGAAGCGGCCGAGCCGTTTCGCCTCTTTGCCGCATGGCTGGACGA
CGCCACCAAGAGCGAAATCAACGATGCCAATGGCGTGGCGCTGGCGACCGTCGACGCCGAAGGCATGCCGGATGTGCGGA
TGGTGCTGCTGAAGGGGTTCGATGAAGGCGGCTTTGTCTTCTACACGAATTTCGAAAGCGCGAAGGGCCAGGAGATTCTT
GGCAGCATGAAGGCGGCGATGTGTTTCCACTGGAAATCGCTACGCCGGCAGGTGCGCATTCGCGGCCCGGTGGAGATCGT
CAGCGATGCCGAGGCCGACGCCTATTACGCGACGCGCCCACGCGGCAGCCGCATCGGCGCCTGGGCGTCGAAGCAGTCAC
GGCCGCTGGAAAGCCGCTTCGCGCTGGAGAAAGCTGTCGCCGAATACACGGCGCGCTACGCCATCGGCGAGATTCCGCGC
CCGAAGCACTGGTCTGGGTTCCGCATCGTGCCGAAGACGATCGAGTTCTGGCACGACCGCCCATTCCGGCTGCATGACCG
GGTGGTTTTTTCCCGCAACGCGAAAGGCGATTGGGACAAGGCGCGGCTCTATCCCTGA

Upstream 100 bases:

>100_bases
GCTGGCCGAAGCGATAACGCCCCATTGCCTGCTGTCAAAAGCTTGCGCGATACGCGACAATCGGCAACCTCCCTGATTTC
GTGACAATTTGAGAAAAACT

Downstream 100 bases:

>100_bases
AAGGGCAAGGCCTCAGCCCTTCTTCCTGGTCATGAACGCGGTGAGCGCCGCGCGGGCCTCATCCGACTTCAGCCGCTCGC
GAAAATGTTCGCTTTCCTCG

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 205; Mature: 204

Protein sequence:

>205_residues
MSDTELTTSDFTEAAEPFRLFAAWLDDATKSEINDANGVALATVDAEGMPDVRMVLLKGFDEGGFVFYTNFESAKGQEIL
GSMKAAMCFHWKSLRRQVRIRGPVEIVSDAEADAYYATRPRGSRIGAWASKQSRPLESRFALEKAVAEYTARYAIGEIPR
PKHWSGFRIVPKTIEFWHDRPFRLHDRVVFSRNAKGDWDKARLYP

Sequences:

>Translated_205_residues
MSDTELTTSDFTEAAEPFRLFAAWLDDATKSEINDANGVALATVDAEGMPDVRMVLLKGFDEGGFVFYTNFESAKGQEIL
GSMKAAMCFHWKSLRRQVRIRGPVEIVSDAEADAYYATRPRGSRIGAWASKQSRPLESRFALEKAVAEYTARYAIGEIPR
PKHWSGFRIVPKTIEFWHDRPFRLHDRVVFSRNAKGDWDKARLYP
>Mature_204_residues
SDTELTTSDFTEAAEPFRLFAAWLDDATKSEINDANGVALATVDAEGMPDVRMVLLKGFDEGGFVFYTNFESAKGQEILG
SMKAAMCFHWKSLRRQVRIRGPVEIVSDAEADAYYATRPRGSRIGAWASKQSRPLESRFALEKAVAEYTARYAIGEIPRP
KHWSGFRIVPKTIEFWHDRPFRLHDRVVFSRNAKGDWDKARLYP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=192, Percent_Identity=42.7083333333333, Blast_Score=165, Evalue=2e-41,
Organism=Escherichia coli, GI1787926, Length=191, Percent_Identity=41.3612565445026, Blast_Score=158, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17553712, Length=198, Percent_Identity=39.3939393939394, Blast_Score=143, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6319509, Length=196, Percent_Identity=41.3265306122449, Blast_Score=142, Evalue=3e-35,
Organism=Drosophila melanogaster, GI45551845, Length=187, Percent_Identity=41.7112299465241, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24644901, Length=187, Percent_Identity=41.7112299465241, Blast_Score=132, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_RHILO (Q986A0)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_107767.1
- ProteinModelPortal:   Q986A0
- SMR:   Q986A0
- GeneID:   1230422
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll7454
- NMPDR:   fig|266835.1.peg.5868
- HOGENOM:   HBG327559
- OMA:   HWSGFRI
- ProtClustDB:   PRK05679
- BRENDA:   1.4.3.5
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 23301; Mature: 23169

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 53-53 BINDING 56-56 BINDING 58-58 BINDING 75-75 BINDING 115-115 BINDING 119-119 BINDING 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTELTTSDFTEAAEPFRLFAAWLDDATKSEINDANGVALATVDAEGMPDVRMVLLKGF
CCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEEEECCCCCCHHHHHEECCC
DEGGFVFYTNFESAKGQEILGSMKAAMCFHWKSLRRQVRIRGPVEIVSDAEADAYYATRP
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCCCCCEEEECC
RGSRIGAWASKQSRPLESRFALEKAVAEYTARYAIGEIPRPKHWSGFRIVPKTIEFWHDR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECHHHHHHHCCC
PFRLHDRVVFSRNAKGDWDKARLYP
CCEEECEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SDTELTTSDFTEAAEPFRLFAAWLDDATKSEINDANGVALATVDAEGMPDVRMVLLKGF
CCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEEEECCCCCCHHHHHEECCC
DEGGFVFYTNFESAKGQEILGSMKAAMCFHWKSLRRQVRIRGPVEIVSDAEADAYYATRP
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCCCCCEEEECC
RGSRIGAWASKQSRPLESRFALEKAVAEYTARYAIGEIPRPKHWSGFRIVPKTIEFWHDR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECHHHHHHHCCC
PFRLHDRVVFSRNAKGDWDKARLYP
CCEEECEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968