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The map label for this gene is moaB [H]

Identifier: 13476170

GI number: 13476170

Start: 6132974

End: 6133519

Strand: Reverse

Name: moaB [H]

Synonym: mll7421

Alternate gene names: 13476170

Gene position: 6133519-6132974 (Counterclockwise)

Preceding gene: 13476171

Following gene: 13476168

Centisome position: 87.17

GC content: 64.29

Gene sequence:

>546_bases
ATGGCTGGGATTAACGAGGGCCGTTCGTTCGTTCCGGTCCGTATCGCGGTGCTGACGGTTTCGGACACGCGCAGCCTTGC
CGACGACAAATCCGGCCAGACGCTGGCCGACCGCATCACCGAGGCCGGTCACATACTGGCAGCCCGCGATATCGTCACCG
ACGACCGCGACAAGATCCGCGACACGGTCCTGGCGTGGTCGCGCGACAAGGCCATCGATGTCGTCATCACCACCGGCGGC
ACCGGCTTCACCGGGCGCGACGTGACACCAGAGGCGCTGGAGCCGATCTTTGAAAAGCGCATGGATGGCTTTTCGGAAGT
GTTCCACCGCATCTCCTACGACAAGATCGGTACGTCGACGATCCAGAGCCGGGCGACCGGCGGCGTCGTCAACGCCACTT
TCGTCTTCGTGCTGCCGGGCTCGCCCGGCGCCTGCAAGGACGCCTGGGACGGTATCCTCAAGGCGCAGCTCGACTATCGC
CACATGCCCTGCAACTTCGTCGAGATCATGCCGCGCCTGGACGAGCATCTGCGGCGCGGAAAGTAA

Upstream 100 bases:

>100_bases
ACCGGCAATGTCGCCAAGCGCGCGGCGGCCGAAATCCGCAGCCGCCAGCCCGACTGGTTCGTCGCGGCGACGCGCAGCAT
GTCATCAGAGGCTGAGTGAA

Downstream 100 bases:

>100_bases
CACGCAGAACTGCGCTTCCAACAGTCCGCCTTCAGCGGATCACCGGTTCGCCATGAAAGCGCCGGCGCGAGGGGCGCGAA
ACGCCGAAGCCGACTTCCAT

Product: molybdopterin biosynthesis, protein B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 181; Mature: 180

Protein sequence:

>181_residues
MAGINEGRSFVPVRIAVLTVSDTRSLADDKSGQTLADRITEAGHILAARDIVTDDRDKIRDTVLAWSRDKAIDVVITTGG
TGFTGRDVTPEALEPIFEKRMDGFSEVFHRISYDKIGTSTIQSRATGGVVNATFVFVLPGSPGACKDAWDGILKAQLDYR
HMPCNFVEIMPRLDEHLRRGK

Sequences:

>Translated_181_residues
MAGINEGRSFVPVRIAVLTVSDTRSLADDKSGQTLADRITEAGHILAARDIVTDDRDKIRDTVLAWSRDKAIDVVITTGG
TGFTGRDVTPEALEPIFEKRMDGFSEVFHRISYDKIGTSTIQSRATGGVVNATFVFVLPGSPGACKDAWDGILKAQLDYR
HMPCNFVEIMPRLDEHLRRGK
>Mature_180_residues
AGINEGRSFVPVRIAVLTVSDTRSLADDKSGQTLADRITEAGHILAARDIVTDDRDKIRDTVLAWSRDKAIDVVITTGGT
GFTGRDVTPEALEPIFEKRMDGFSEVFHRISYDKIGTSTIQSRATGGVVNATFVFVLPGSPGACKDAWDGILKAQLDYRH
MPCNFVEIMPRLDEHLRRGK

Specific function: Maybe involved in the biosynthesis of molybdopterin. Can bind GTP and has low GTPase activity. Can bind MPT, but has no MPT adenylyl transferase activity [H]

COG id: COG0521

COG function: function code H; Molybdopterin biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaB/mog family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=148, Percent_Identity=35.1351351351351, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI66932975, Length=148, Percent_Identity=35.1351351351351, Blast_Score=91, Evalue=6e-19,
Organism=Escherichia coli, GI1787000, Length=157, Percent_Identity=50.3184713375796, Blast_Score=166, Evalue=7e-43,
Organism=Escherichia coli, GI1786190, Length=149, Percent_Identity=30.8724832214765, Blast_Score=65, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17564954, Length=145, Percent_Identity=37.2413793103448, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17136978, Length=143, Percent_Identity=33.5664335664336, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24638841, Length=143, Percent_Identity=33.5664335664336, Blast_Score=71, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR012245
- InterPro:   IPR013484
- InterPro:   IPR008284
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth [H]

EC number: NA

Molecular weight: Translated: 19892; Mature: 19761

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01078 MOCF_BIOSYNTHESIS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGINEGRSFVPVRIAVLTVSDTRSLADDKSGQTLADRITEAGHILAARDIVTDDRDKIR
CCCCCCCCCEEEEEEEEEEECCCHHHCCCCCCCHHHHHHHHCCCEEEHHHHCCCCHHHHH
DTVLAWSRDKAIDVVITTGGTGFTGRDVTPEALEPIFEKRMDGFSEVFHRISYDKIGTST
HHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHH
IQSRATGGVVNATFVFVLPGSPGACKDAWDGILKAQLDYRHMPCNFVEIMPRLDEHLRRG
HHHHCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCC
K
C
>Mature Secondary Structure 
AGINEGRSFVPVRIAVLTVSDTRSLADDKSGQTLADRITEAGHILAARDIVTDDRDKIR
CCCCCCCCEEEEEEEEEEECCCHHHCCCCCCCHHHHHHHHCCCEEEHHHHCCCCHHHHH
DTVLAWSRDKAIDVVITTGGTGFTGRDVTPEALEPIFEKRMDGFSEVFHRISYDKIGTST
HHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHH
IQSRATGGVVNATFVFVLPGSPGACKDAWDGILKAQLDYRHMPCNFVEIMPRLDEHLRRG
HHHHCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin precursor biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]