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The map label for this gene is gcvT [H]

Identifier: 13476081

GI number: 13476081

Start: 6039503

End: 6040648

Strand: Reverse

Name: gcvT [H]

Synonym: mll7302

Alternate gene names: 13476081

Gene position: 6040648-6039503 (Counterclockwise)

Preceding gene: 13476082

Following gene: 13476080

Centisome position: 85.85

GC content: 63.79

Gene sequence:

>1146_bases
ATGACCCGCGAGACATCCTTTCATTCGAGCTTTGCCAAGCACACCCGAAATTTCTCCGAATACAGGGGCTACTGGCTGGC
CAATTCCTTCGCCAAGGAAGGCCCCCTCGCCGAATACTGGGCTTGCCGGCAGGACGCCGTGATCATGGACCTGTCGCCGC
TCAGAAAATTCGAGGTCACCGGACCGGATTCCGAAGCGCTGCTGCAATACACGCTGACCCGCGACGTGAAAAAACTCGGC
GTCGGCCAGGTCGTCTACTCCGCCATGTGCTATGAGCATGGCGGCATGATCGACGACGGCACGCTGCTGCGGCTCGGCAA
GGATAATTTCCGCTGGGTCGGCGGCGACGATCTTTCCGGCGAATGGCTGCGCGAGACCGCCAAGAAGCTTGGGCTCAATG
TGCTGGTGCGCTCGTCGACCGACCAGATGCACAATGTCGCGGTACAGGGGCCGAAGAGCCGCGACATCCTGAGAGAAGTG
GTCTGGACCTCGCCACTGCAGCCGTCGATCGATGAGCTCGAATGGTTCCGCTTCGCGGTTGCCCGCATCGGGGGTGGCAA
CGGCATTCCGGTCGTCGTCTCGCGCACCGGCTATACCGGCGAGCTCGGCTATGAGATTTGGTGCCATCCGCGCGACGCCG
AAAAAGTGTTCGACGCCATCTGGGAAGCCGGCCAGCCGCATGGGCTGAAGCCGATGGGCCTGCAGGCGCTCGACATGGTG
CGCATCGAGGCCGGGCTGATCTTCGCGGGCTACGAGTTCTCCGACCAGACCGATCCGTTCGAGGCCGGTATCGGCTTCAC
CGTGCCGCTGAAAAGCAAGACCGACGACTTCATCGGCCGCGAGGCGCTGATCCGCCGCAAGGAACACCCGCAGACGAAAC
TGGTGGGCCTCGACATCGACAGCAATGTCGCGGTCGGCCATGGCGACTGCGTCCATGTCGGCCGCGCCCAGATCGGCGTG
GTCACCTCGGGCATGCGTTCGCCGGTGCTTGGCAAGAACATCGCGCTGGCAAGGCTCGACGTCACCCATGCGGCCATCGG
CACGGAGGTCGAGATCGGCAAGCTCGACGGCCACGCCAAACGGCTGCCAGCGCGCGTCGTCGCCTTCGCCCATTACGATC
CGCAGAAGACCCGACCGCGCTCCTGA

Upstream 100 bases:

>100_bases
TGGCTGGGACCTGACAGACATCCATGTGCGGACCTATTCCGGCCAGCACAAATTCTCGCGAGCGATCGCCAGACGCATGA
CGCCCGATTCGGAACCGAAA

Downstream 100 bases:

>100_bases
CTGCAGCCGTCCGGACAGGCAGAGCCTCGCGCCGGCAGCGCCGCGAGGCGTATTGTTACGTGCGCGCGCAAGCGTGATGT
GCACGGCGTCACAAAACGCT

Product: aminomethyltransferase

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MTRETSFHSSFAKHTRNFSEYRGYWLANSFAKEGPLAEYWACRQDAVIMDLSPLRKFEVTGPDSEALLQYTLTRDVKKLG
VGQVVYSAMCYEHGGMIDDGTLLRLGKDNFRWVGGDDLSGEWLRETAKKLGLNVLVRSSTDQMHNVAVQGPKSRDILREV
VWTSPLQPSIDELEWFRFAVARIGGGNGIPVVVSRTGYTGELGYEIWCHPRDAEKVFDAIWEAGQPHGLKPMGLQALDMV
RIEAGLIFAGYEFSDQTDPFEAGIGFTVPLKSKTDDFIGREALIRRKEHPQTKLVGLDIDSNVAVGHGDCVHVGRAQIGV
VTSGMRSPVLGKNIALARLDVTHAAIGTEVEIGKLDGHAKRLPARVVAFAHYDPQKTRPRS

Sequences:

>Translated_381_residues
MTRETSFHSSFAKHTRNFSEYRGYWLANSFAKEGPLAEYWACRQDAVIMDLSPLRKFEVTGPDSEALLQYTLTRDVKKLG
VGQVVYSAMCYEHGGMIDDGTLLRLGKDNFRWVGGDDLSGEWLRETAKKLGLNVLVRSSTDQMHNVAVQGPKSRDILREV
VWTSPLQPSIDELEWFRFAVARIGGGNGIPVVVSRTGYTGELGYEIWCHPRDAEKVFDAIWEAGQPHGLKPMGLQALDMV
RIEAGLIFAGYEFSDQTDPFEAGIGFTVPLKSKTDDFIGREALIRRKEHPQTKLVGLDIDSNVAVGHGDCVHVGRAQIGV
VTSGMRSPVLGKNIALARLDVTHAAIGTEVEIGKLDGHAKRLPARVVAFAHYDPQKTRPRS
>Mature_380_residues
TRETSFHSSFAKHTRNFSEYRGYWLANSFAKEGPLAEYWACRQDAVIMDLSPLRKFEVTGPDSEALLQYTLTRDVKKLGV
GQVVYSAMCYEHGGMIDDGTLLRLGKDNFRWVGGDDLSGEWLRETAKKLGLNVLVRSSTDQMHNVAVQGPKSRDILREVV
WTSPLQPSIDELEWFRFAVARIGGGNGIPVVVSRTGYTGELGYEIWCHPRDAEKVFDAIWEAGQPHGLKPMGLQALDMVR
IEAGLIFAGYEFSDQTDPFEAGIGFTVPLKSKTDDFIGREALIRRKEHPQTKLVGLDIDSNVAVGHGDCVHVGRAQIGVV
TSGMRSPVLGKNIALARLDVTHAAIGTEVEIGKLDGHAKRLPARVVAFAHYDPQKTRPRS

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI24797151, Length=351, Percent_Identity=29.3447293447293, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI194306651, Length=311, Percent_Identity=27.9742765273312, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI197927446, Length=267, Percent_Identity=30.3370786516854, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI21361378, Length=267, Percent_Identity=30.3370786516854, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI44662838, Length=361, Percent_Identity=25.207756232687, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI257796258, Length=361, Percent_Identity=25.207756232687, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI257796256, Length=306, Percent_Identity=26.797385620915, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI257796254, Length=348, Percent_Identity=24.1379310344828, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1789272, Length=349, Percent_Identity=31.8051575931232, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17560118, Length=376, Percent_Identity=30.3191489361702, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI71994045, Length=363, Percent_Identity=27.5482093663912, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71994052, Length=363, Percent_Identity=27.5482093663912, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI32563613, Length=344, Percent_Identity=28.1976744186047, Blast_Score=111, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6320222, Length=366, Percent_Identity=24.0437158469945, Blast_Score=89, Evalue=9e-19,
Organism=Drosophila melanogaster, GI20129441, Length=374, Percent_Identity=28.3422459893048, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28571104, Length=258, Percent_Identity=30.2325581395349, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI20130091, Length=317, Percent_Identity=23.6593059936909, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 42208; Mature: 42076

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRETSFHSSFAKHTRNFSEYRGYWLANSFAKEGPLAEYWACRQDAVIMDLSPLRKFEVT
CCCCCCHHHHHHHHHCCHHHHCCEEEECHHHCCCCCHHHHHCCCCCEEEECCCCCEEEEC
GPDSEALLQYTLTRDVKKLGVGQVVYSAMCYEHGGMIDDGTLLRLGKDNFRWVGGDDLSG
CCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEECCCCCCH
EWLRETAKKLGLNVLVRSSTDQMHNVAVQGPKSRDILREVVWTSPLQPSIDELEWFRFAV
HHHHHHHHHCCCEEEEECCCCHHHHEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
ARIGGGNGIPVVVSRTGYTGELGYEIWCHPRDAEKVFDAIWEAGQPHGLKPMGLQALDMV
HHHCCCCCCEEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHE
RIEAGLIFAGYEFSDQTDPFEAGIGFTVPLKSKTDDFIGREALIRRKEHPQTKLVGLDID
EEECCEEEEECCCCCCCCCHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEEECC
SNVAVGHGDCVHVGRAQIGVVTSGMRSPVLGKNIALARLDVTHAAIGTEVEIGKLDGHAK
CCEEECCCCEEEECCCEEEEEECCCCCCCCCCCEEEEEEEEHHHHCCCEEEEECCCCHHH
RLPARVVAFAHYDPQKTRPRS
HCCEEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
TRETSFHSSFAKHTRNFSEYRGYWLANSFAKEGPLAEYWACRQDAVIMDLSPLRKFEVT
CCCCCHHHHHHHHHCCHHHHCCEEEECHHHCCCCCHHHHHCCCCCEEEECCCCCEEEEC
GPDSEALLQYTLTRDVKKLGVGQVVYSAMCYEHGGMIDDGTLLRLGKDNFRWVGGDDLSG
CCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEECCCCCCH
EWLRETAKKLGLNVLVRSSTDQMHNVAVQGPKSRDILREVVWTSPLQPSIDELEWFRFAV
HHHHHHHHHCCCEEEEECCCCHHHHEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
ARIGGGNGIPVVVSRTGYTGELGYEIWCHPRDAEKVFDAIWEAGQPHGLKPMGLQALDMV
HHHCCCCCCEEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHE
RIEAGLIFAGYEFSDQTDPFEAGIGFTVPLKSKTDDFIGREALIRRKEHPQTKLVGLDID
EEECCEEEEECCCCCCCCCHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEEECC
SNVAVGHGDCVHVGRAQIGVVTSGMRSPVLGKNIALARLDVTHAAIGTEVEIGKLDGHAK
CCEEECCCCEEEECCCEEEEEECCCCCCCCCCCEEEEEEEEHHHHCCCEEEEECCCCHHH
RLPARVVAFAHYDPQKTRPRS
HCCEEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA