Click here to switch to the map view.

The map label for this gene is lrp [H]

Identifier: 13476067

GI number: 13476067

Start: 6018769

End: 6019329

Strand: Direct

Name: lrp [H]

Synonym: mlr7283

Alternate gene names: 13476067

Gene position: 6018769-6019329 (Clockwise)

Preceding gene: 13476062

Following gene: 13476070

Centisome position: 85.54

GC content: 62.57

Gene sequence:

>561_bases
GTGGCAATCAGGATTGTCGACATGGATGAAGAAACAGATGGCATTCTGCAGAACAGGCCGGCGCCCCGCGATATCGATAC
GATTGACCGAAAAATATTAGGCGTTCTCGTCGACGACGCGACGGTCAGCTACGCGGAACTCGGCGATCGGGTCGGGCTTT
CGCCGCCCGCCGCGCATGAACGGGTCAAGCGCCTTCGGCGCAGCGGCGCCATTCGCGGCACGGCAGCGATCATCGACCCA
AAGGCTGTGAAGAAGCCGCTGCTCGCCTTCGTGCATATCGACACCAGGGGCTGGGGCAAGACCCCGGAGCTGATGGCGGT
TTCGCAATATCCGGAAGTCGAGGAGATCCATACCGTCGCCGGCGATACCTGCATGCTGCTGAAGGTCCGCACCGAAGATA
CGCGGGCGCTGGAAGGCCTGCTTGCTCGCCTCTACGAAACGCCCGGCGTCACCTCGACGCGCAGTTATGTGGTGCTGTCG
ACCTATCTCGAGCGTCCGGTGCAGCCCGGCGTCACCGACAAGTGGCCAACGCCGGGCCACATGAGCAAGCCGCTGTACTA
G

Upstream 100 bases:

>100_bases
ACAGATAGGCGAGGGCCGGGATCGGCGGCCTGGCGTCGGCTGCCAGGGCTGTGGCTTGATTGCTGTTCGACATATCAGCA
TAATGGCCGTATTAAATTCC

Downstream 100 bases:

>100_bases
CTAGCCGGCTTCGGCGCTATGCCCGTTCGGGGAACATCGCCTTCAGGCCCTCGCGCGAGGCCTTGGCGACACCGCGTTCG
GTGATCAGGCCGGTCACCAG

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MAIRIVDMDEETDGILQNRPAPRDIDTIDRKILGVLVDDATVSYAELGDRVGLSPPAAHERVKRLRRSGAIRGTAAIIDP
KAVKKPLLAFVHIDTRGWGKTPELMAVSQYPEVEEIHTVAGDTCMLLKVRTEDTRALEGLLARLYETPGVTSTRSYVVLS
TYLERPVQPGVTDKWPTPGHMSKPLY

Sequences:

>Translated_186_residues
MAIRIVDMDEETDGILQNRPAPRDIDTIDRKILGVLVDDATVSYAELGDRVGLSPPAAHERVKRLRRSGAIRGTAAIIDP
KAVKKPLLAFVHIDTRGWGKTPELMAVSQYPEVEEIHTVAGDTCMLLKVRTEDTRALEGLLARLYETPGVTSTRSYVVLS
TYLERPVQPGVTDKWPTPGHMSKPLY
>Mature_185_residues
AIRIVDMDEETDGILQNRPAPRDIDTIDRKILGVLVDDATVSYAELGDRVGLSPPAAHERVKRLRRSGAIRGTAAIIDPK
AVKKPLLAFVHIDTRGWGKTPELMAVSQYPEVEEIHTVAGDTCMLLKVRTEDTRALEGLLARLYETPGVTSTRSYVVLST
YLERPVQPGVTDKWPTPGHMSKPLY

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=147, Percent_Identity=43.5374149659864, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1790182, Length=147, Percent_Identity=29.2517006802721, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI87081742, Length=136, Percent_Identity=31.6176470588235, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 20585; Mature: 20454

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIRIVDMDEETDGILQNRPAPRDIDTIDRKILGVLVDDATVSYAELGDRVGLSPPAAHE
CEEEEEECCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCHHHH
RVKRLRRSGAIRGTAAIIDPKAVKKPLLAFVHIDTRGWGKTPELMAVSQYPEVEEIHTVA
HHHHHHHCCCCCCEEEEECHHHHHHHEEEEEEEECCCCCCCCCEEEECCCCCHHHHHHHC
GDTCMLLKVRTEDTRALEGLLARLYETPGVTSTRSYVVLSTYLERPVQPGVTDKWPTPGH
CCEEEEEEEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
MSKPLY
CCCCCC
>Mature Secondary Structure 
AIRIVDMDEETDGILQNRPAPRDIDTIDRKILGVLVDDATVSYAELGDRVGLSPPAAHE
EEEEEECCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCHHHH
RVKRLRRSGAIRGTAAIIDPKAVKKPLLAFVHIDTRGWGKTPELMAVSQYPEVEEIHTVA
HHHHHHHCCCCCCEEEEECHHHHHHHEEEEEEEECCCCCCCCCEEEECCCCCHHHHHHHC
GDTCMLLKVRTEDTRALEGLLARLYETPGVTSTRSYVVLSTYLERPVQPGVTDKWPTPGH
CCEEEEEEEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
MSKPLY
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]