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The map label for this gene is cfxB [H]

Identifier: 13476059

GI number: 13476059

Start: 6011548

End: 6012612

Strand: Reverse

Name: cfxB [H]

Synonym: mll7273

Alternate gene names: 13476059

Gene position: 6012612-6011548 (Counterclockwise)

Preceding gene: 13476063

Following gene: 13476044

Centisome position: 85.45

GC content: 62.35

Gene sequence:

>1065_bases
TTGGCTCGCATCACACTGAGACAATTGCTCGATCACGCCGCCGAATACGGCTATGGCGTGCCGGCCTTCAACATGAACAA
CATGGAACAAGGCCTCGCCATCATGGAGGCGGCGGAAGAGACCAAATCGCCTGTCATCCTGCAGGCAAGCCGCGGTGCGC
GTGCCTATGCCAATGACGTGGTGCTGGCCAAGCTGATCGACGCGCTGGTCGAAATCCACCCCGACATCCCGGTCTGCATG
CATCTCGACCATGGCAACAACGAAGCCACCTGCGTCACCGCGATCCAGTACGGCTTCACCTCGGTGATGATGGACGGCTC
GCTCAAGGAAGACGGCAAGTCGCCGGCCGACTACGCCTACAATTCGGGCATCACCAAGCGCGTCGTCGACATGGCGCATT
GGGGCGGCGTGTCTGTCGAAGGCGAGATCGGTGTGCTGGGATCGCTGGAGAGCGGCGGCGGCGAGCAGGAAGACGGTCAC
GGCGTCGAAGGCGCGATCAGCCACGACCAGCTCTTGACCGATCCGGAACAGGCGGTGGAGTTCGTCAAGGACACGCATGT
CGATGCGTTGGCCGTGGCCATGGGCACCAGCCATGGCGCCTACAAATTCTCGCGCAAGCCGGACGGCGCGGTGCTGGCGA
TGAACGTCATCGAGGAGATCCACAGGCGCCTGCCCAACATGCATCTGGTCATGCACGGCTCGTCCTCGGTGCCGGAGGAT
CTGCAGGAGATCATCAACAAATATGGTGGCCAGATGAAGCCGACCTGGGGCGTGCCGGTGGAGGAGATCCAGCGCGGCAT
CAAGCATGGCGTGCGCAAGATCAACATCGACACCGACAACCGCATGGCGCTGACCGGCGCGATCCGCAAAGTGCTGACCG
AGAACCCGAGCGAGTTCGACCCGCGCAAATATCTGACGCCGGCAATGGCTGCGATGCGCAAGCTCTGCAAGGAGCGCTTC
GAGCAATTCGGCACCGCCGGCAACGCACCGAAGATCAAGCCGCTGCCGGTCTCGGAAATGGCCAAGCGCTACAAGTCGGG
CAGCCTCGACCCGAAATTCGGCTGA

Upstream 100 bases:

>100_bases
GGTTGCGGTTGCGCGGAAATCCGGCCAGAAGCATCGGTGGGCTGGACGATACGCGGACAGTCCGCAACCAGGTTTGAAAC
CAGATACGGGAGACTATTCG

Downstream 100 bases:

>100_bases
GTTCCGGCGACTTCACATCAAGAGTTCAACGGGCAGGAGCCGCATCGGCCCCTGCCCGTTTTTTCATTCGGCCTTTAGCA
GAAGATCGGACCTGCCTGTC

Product: fructose-1,6-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase; Fructose-bisphosphate aldolase II [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MARITLRQLLDHAAEYGYGVPAFNMNNMEQGLAIMEAAEETKSPVILQASRGARAYANDVVLAKLIDALVEIHPDIPVCM
HLDHGNNEATCVTAIQYGFTSVMMDGSLKEDGKSPADYAYNSGITKRVVDMAHWGGVSVEGEIGVLGSLESGGGEQEDGH
GVEGAISHDQLLTDPEQAVEFVKDTHVDALAVAMGTSHGAYKFSRKPDGAVLAMNVIEEIHRRLPNMHLVMHGSSSVPED
LQEIINKYGGQMKPTWGVPVEEIQRGIKHGVRKINIDTDNRMALTGAIRKVLTENPSEFDPRKYLTPAMAAMRKLCKERF
EQFGTAGNAPKIKPLPVSEMAKRYKSGSLDPKFG

Sequences:

>Translated_354_residues
MARITLRQLLDHAAEYGYGVPAFNMNNMEQGLAIMEAAEETKSPVILQASRGARAYANDVVLAKLIDALVEIHPDIPVCM
HLDHGNNEATCVTAIQYGFTSVMMDGSLKEDGKSPADYAYNSGITKRVVDMAHWGGVSVEGEIGVLGSLESGGGEQEDGH
GVEGAISHDQLLTDPEQAVEFVKDTHVDALAVAMGTSHGAYKFSRKPDGAVLAMNVIEEIHRRLPNMHLVMHGSSSVPED
LQEIINKYGGQMKPTWGVPVEEIQRGIKHGVRKINIDTDNRMALTGAIRKVLTENPSEFDPRKYLTPAMAAMRKLCKERF
EQFGTAGNAPKIKPLPVSEMAKRYKSGSLDPKFG
>Mature_353_residues
ARITLRQLLDHAAEYGYGVPAFNMNNMEQGLAIMEAAEETKSPVILQASRGARAYANDVVLAKLIDALVEIHPDIPVCMH
LDHGNNEATCVTAIQYGFTSVMMDGSLKEDGKSPADYAYNSGITKRVVDMAHWGGVSVEGEIGVLGSLESGGGEQEDGHG
VEGAISHDQLLTDPEQAVEFVKDTHVDALAVAMGTSHGAYKFSRKPDGAVLAMNVIEEIHRRLPNMHLVMHGSSSVPEDL
QEIINKYGGQMKPTWGVPVEEIQRGIKHGVRKINIDTDNRMALTGAIRKVLTENPSEFDPRKYLTPAMAAMRKLCKERFE
QFGTAGNAPKIKPLPVSEMAKRYKSGSLDPKFG

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI87082041, Length=329, Percent_Identity=33.7386018237082, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1789526, Length=326, Percent_Identity=33.7423312883436, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI1788072, Length=325, Percent_Identity=28.6153846153846, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322790, Length=375, Percent_Identity=27.2, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 38552; Mature: 38421

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARITLRQLLDHAAEYGYGVPAFNMNNMEQGLAIMEAAEETKSPVILQASRGARAYANDV
CCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHH
VLAKLIDALVEIHPDIPVCMHLDHGNNEATCVTAIQYGFTSVMMDGSLKEDGKSPADYAY
HHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHCCCCCHHCCCCCHHHHH
NSGITKRVVDMAHWGGVSVEGEIGVLGSLESGGGEQEDGHGVEGAISHDQLLTDPEQAVE
CCCHHHHHHHHHHCCCEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHH
FVKDTHVDALAVAMGTSHGAYKFSRKPDGAVLAMNVIEEIHRRLPNMHLVMHGSSSVPED
HHHHCCHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCHH
LQEIINKYGGQMKPTWGVPVEEIQRGIKHGVRKINIDTDNRMALTGAIRKVLTENPSEFD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHCCCCCCC
PRKYLTPAMAAMRKLCKERFEQFGTAGNAPKIKPLPVSEMAKRYKSGSLDPKFG
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ARITLRQLLDHAAEYGYGVPAFNMNNMEQGLAIMEAAEETKSPVILQASRGARAYANDV
CCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHH
VLAKLIDALVEIHPDIPVCMHLDHGNNEATCVTAIQYGFTSVMMDGSLKEDGKSPADYAY
HHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHCCCCCHHCCCCCHHHHH
NSGITKRVVDMAHWGGVSVEGEIGVLGSLESGGGEQEDGHGVEGAISHDQLLTDPEQAVE
CCCHHHHHHHHHHCCCEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHH
FVKDTHVDALAVAMGTSHGAYKFSRKPDGAVLAMNVIEEIHRRLPNMHLVMHGSSSVPED
HHHHCCHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCHH
LQEIINKYGGQMKPTWGVPVEEIQRGIKHGVRKINIDTDNRMALTGAIRKVLTENPSEFD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHCCCCCCC
PRKYLTPAMAAMRKLCKERFEQFGTAGNAPKIKPLPVSEMAKRYKSGSLDPKFG
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1939098 [H]