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The map label for this gene is argD [H]

Identifier: 13475971

GI number: 13475971

Start: 5920692

End: 5922002

Strand: Direct

Name: argD [H]

Synonym: mlr7169

Alternate gene names: 13475971

Gene position: 5920692-5922002 (Clockwise)

Preceding gene: 13475970

Following gene: 13475972

Centisome position: 84.15

GC content: 65.52

Gene sequence:

>1311_bases
ATGCACGTGTCCCAGTCTTCGCCATATCAAGCAAATGCCGACTCGACGGCATCCGAGCAGGCCCTGCTCGAACGCCGCGC
AAGGCTGCTTGGGCCGACCTATCGCGCCTTCTACCGCAACCCGATCCATCTGGTGCGCGGCAGCGGCGTCTGGCTCTACG
ATGCGACAGGCCGCAAATTTCTCGACGCCTACAACAACGTCGCCTCGGTCGGGCACTGCCATCCGCGCGTCGTCGAGGCG
CTGTCGGGACAGGCCGCTACTCTCAACACCCATACCCGCTATTTGAGCGAGATCATCCTCGATTATGCGGAAAAACTGCT
CGGCACGGTTCCCTCCCATCTCGGCCATGCCATGTTCACCTGCACCGGCAGCGAGGCCAACGACCTCGCCATCCGCATCG
CCCAGCACTCGAGCGGCGGTACCGGCGTCATCATCACCGATTTCGCCTATCACGGCGCCACGATCGCGACCGCGCAGCTG
TCGCCAGCGGCGGTCGGCGCGAAGGGCGTGCCCGTGCACCACCGGACCGTGGCCGCGCCGGACACGTTCCGCGACCACGG
TCGCGCCGCGAAGGACTTCGCCAAGAATGTCGCCGCCGCCATCGAGGACATGCGAGCGCAGAATATCCGCCCGGCGGCGC
TGCTGCTCGACTCGGCCTTTTCCAGCGACGGCATTTTCTTCCCCGACGCGGCTGTCATGCGCGAGGCGGGGGATCACGTT
AGGAAGGCCGGCGGCATCGTCATCGCCGATGAGGTCCAGTCCGGCTTCGGCCGCCTTGGCCAGGGCATGTGGGGTTTTGC
CAACTATGGCCTCGAGCCCGACATCGTCACCATGGGCAAGCCGATCGGCGACGGCCATCCGATGGGTGCGGTACTGGTGC
GGCCGCGGCTTGTCTCGTCCTTCGGCTCCAACACCGGTTATTTCAACACCTTCGGCGGCAATCCGGTCGCGGCCGCCGTC
GGCATCGCGGTGCTGGACGTGATCGAAGGCGAGGGGCTGATCGAGAACGCGCGCAATGTAGGCGCCTATACGGCTGACCT
GCTGCGCGCGCTGCAGGGCCGTCATGGCATGGTCGGTGACGTCAGGCACAACGGTCTCTATTTCGGCGTCGAACTGACAG
CGGACGGCGGCGAAGCGCTGGCGGCCAGCAAGACGTCTTCCGTCGTCGAAGCGATGCGCGAGGACGGCGTGCTGATCTCG
TCCTGCGGTCCGCGCGGCAATGTGTTGAAGATCAGGCCGCCTCTGCCCTTTGCCAGGGACAATGCCGAGCAACTGGCCGA
GACGCTCGATCGTGCTTTGTCGAACTGGTGA

Upstream 100 bases:

>100_bases
GCGCCTCATCGCCGAGGTCTGGACCTCGCTCGAACGGCTCAACGGGCTGTCATCCGATGAGGCCCGCCGTTATTTTCTCG
ATCATTCCAATCCGGAGTAG

Downstream 100 bases:

>100_bases
TCGGGACGCATGCTGAAGCTCGAACATCAAACCCTCAACGATCGCGCCTATGGCGCGCTCAAGCAGGAATTGATTTCAGG
CGGTTTCAACCCAGGCCAGA

Product: aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MHVSQSSPYQANADSTASEQALLERRARLLGPTYRAFYRNPIHLVRGSGVWLYDATGRKFLDAYNNVASVGHCHPRVVEA
LSGQAATLNTHTRYLSEIILDYAEKLLGTVPSHLGHAMFTCTGSEANDLAIRIAQHSSGGTGVIITDFAYHGATIATAQL
SPAAVGAKGVPVHHRTVAAPDTFRDHGRAAKDFAKNVAAAIEDMRAQNIRPAALLLDSAFSSDGIFFPDAAVMREAGDHV
RKAGGIVIADEVQSGFGRLGQGMWGFANYGLEPDIVTMGKPIGDGHPMGAVLVRPRLVSSFGSNTGYFNTFGGNPVAAAV
GIAVLDVIEGEGLIENARNVGAYTADLLRALQGRHGMVGDVRHNGLYFGVELTADGGEALAASKTSSVVEAMREDGVLIS
SCGPRGNVLKIRPPLPFARDNAEQLAETLDRALSNW

Sequences:

>Translated_436_residues
MHVSQSSPYQANADSTASEQALLERRARLLGPTYRAFYRNPIHLVRGSGVWLYDATGRKFLDAYNNVASVGHCHPRVVEA
LSGQAATLNTHTRYLSEIILDYAEKLLGTVPSHLGHAMFTCTGSEANDLAIRIAQHSSGGTGVIITDFAYHGATIATAQL
SPAAVGAKGVPVHHRTVAAPDTFRDHGRAAKDFAKNVAAAIEDMRAQNIRPAALLLDSAFSSDGIFFPDAAVMREAGDHV
RKAGGIVIADEVQSGFGRLGQGMWGFANYGLEPDIVTMGKPIGDGHPMGAVLVRPRLVSSFGSNTGYFNTFGGNPVAAAV
GIAVLDVIEGEGLIENARNVGAYTADLLRALQGRHGMVGDVRHNGLYFGVELTADGGEALAASKTSSVVEAMREDGVLIS
SCGPRGNVLKIRPPLPFARDNAEQLAETLDRALSNW
>Mature_436_residues
MHVSQSSPYQANADSTASEQALLERRARLLGPTYRAFYRNPIHLVRGSGVWLYDATGRKFLDAYNNVASVGHCHPRVVEA
LSGQAATLNTHTRYLSEIILDYAEKLLGTVPSHLGHAMFTCTGSEANDLAIRIAQHSSGGTGVIITDFAYHGATIATAQL
SPAAVGAKGVPVHHRTVAAPDTFRDHGRAAKDFAKNVAAAIEDMRAQNIRPAALLLDSAFSSDGIFFPDAAVMREAGDHV
RKAGGIVIADEVQSGFGRLGQGMWGFANYGLEPDIVTMGKPIGDGHPMGAVLVRPRLVSSFGSNTGYFNTFGGNPVAAAV
GIAVLDVIEGEGLIENARNVGAYTADLLRALQGRHGMVGDVRHNGLYFGVELTADGGEALAASKTSSVVEAMREDGVLIS
SCGPRGNVLKIRPPLPFARDNAEQLAETLDRALSNW

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=430, Percent_Identity=41.1627906976744, Blast_Score=335, Evalue=5e-92,
Organism=Homo sapiens, GI226442705, Length=430, Percent_Identity=39.7674418604651, Blast_Score=312, Evalue=5e-85,
Organism=Homo sapiens, GI24119277, Length=434, Percent_Identity=39.4009216589862, Blast_Score=311, Evalue=1e-84,
Organism=Homo sapiens, GI226442709, Length=377, Percent_Identity=41.9098143236074, Blast_Score=296, Evalue=3e-80,
Organism=Homo sapiens, GI13994255, Length=444, Percent_Identity=32.6576576576577, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI4557809, Length=408, Percent_Identity=26.9607843137255, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI284507298, Length=229, Percent_Identity=26.6375545851528, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1789016, Length=431, Percent_Identity=29.6983758700696, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1788044, Length=401, Percent_Identity=27.930174563591, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1789759, Length=381, Percent_Identity=25.9842519685039, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1787560, Length=399, Percent_Identity=28.3208020050125, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI145693181, Length=407, Percent_Identity=25.5528255528256, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1786349, Length=347, Percent_Identity=25.6484149855908, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71992977, Length=453, Percent_Identity=36.4238410596026, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI32564660, Length=437, Percent_Identity=35.9267734553776, Blast_Score=250, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI25144271, Length=438, Percent_Identity=24.8858447488584, Blast_Score=137, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI71992985, Length=149, Percent_Identity=38.9261744966443, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI25144274, Length=273, Percent_Identity=27.1062271062271, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17541228, Length=438, Percent_Identity=22.1461187214612, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323470, Length=439, Percent_Identity=27.1070615034169, Blast_Score=122, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6324432, Length=416, Percent_Identity=24.2788461538462, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21356575, Length=428, Percent_Identity=37.8504672897196, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI161085790, Length=457, Percent_Identity=37.199124726477, Blast_Score=248, Evalue=6e-66,
Organism=Drosophila melanogaster, GI28574759, Length=454, Percent_Identity=36.5638766519824, Blast_Score=241, Evalue=7e-64,
Organism=Drosophila melanogaster, GI21357415, Length=409, Percent_Identity=25.9168704156479, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 46181; Mature: 46181

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVSQSSPYQANADSTASEQALLERRARLLGPTYRAFYRNPIHLVRGSGVWLYDATGRKF
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHCCCEEEEECCCEEEECCCCHHH
LDAYNNVASVGHCHPRVVEALSGQAATLNTHTRYLSEIILDYAEKLLGTVPSHLGHAMFT
HHHHHHHHHHCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEE
CTGSEANDLAIRIAQHSSGGTGVIITDFAYHGATIATAQLSPAAVGAKGVPVHHRTVAAP
EECCCCCCEEEEEEECCCCCCEEEEECCCCCCCEEEEEECCCHHCCCCCCCCCCEEECCC
DTFRDHGRAAKDFAKNVAAAIEDMRAQNIRPAALLLDSAFSSDGIFFPDAAVMREAGDHV
CHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
RKAGGIVIADEVQSGFGRLGQGMWGFANYGLEPDIVTMGKPIGDGHPMGAVLVRPRLVSS
HHHCCEEEEHHHHHHHHHHCCCCCHHHHCCCCCCEEECCCCCCCCCCCCCEEECHHHHHH
FGSNTGYFNTFGGNPVAAAVGIAVLDVIEGEGLIENARNVGAYTADLLRALQGRHGMVGD
CCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCC
VRHNGLYFGVELTADGGEALAASKTSSVVEAMREDGVLISSCGPRGNVLKIRPPLPFARD
EECCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCEEEECCCCCCCCC
NAEQLAETLDRALSNW
CHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHVSQSSPYQANADSTASEQALLERRARLLGPTYRAFYRNPIHLVRGSGVWLYDATGRKF
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHCCCEEEEECCCEEEECCCCHHH
LDAYNNVASVGHCHPRVVEALSGQAATLNTHTRYLSEIILDYAEKLLGTVPSHLGHAMFT
HHHHHHHHHHCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEE
CTGSEANDLAIRIAQHSSGGTGVIITDFAYHGATIATAQLSPAAVGAKGVPVHHRTVAAP
EECCCCCCEEEEEEECCCCCCEEEEECCCCCCCEEEEEECCCHHCCCCCCCCCCEEECCC
DTFRDHGRAAKDFAKNVAAAIEDMRAQNIRPAALLLDSAFSSDGIFFPDAAVMREAGDHV
CHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
RKAGGIVIADEVQSGFGRLGQGMWGFANYGLEPDIVTMGKPIGDGHPMGAVLVRPRLVSS
HHHCCEEEEHHHHHHHHHHCCCCCHHHHCCCCCCEEECCCCCCCCCCCCCEEECHHHHHH
FGSNTGYFNTFGGNPVAAAVGIAVLDVIEGEGLIENARNVGAYTADLLRALQGRHGMVGD
CCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCC
VRHNGLYFGVELTADGGEALAASKTSSVVEAMREDGVLISSCGPRGNVLKIRPPLPFARD
EECCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCEEEECCCCCCCCC
NAEQLAETLDRALSNW
CHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]