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The map label for this gene is lrp [H]

Identifier: 13475937

GI number: 13475937

Start: 5887003

End: 5887494

Strand: Reverse

Name: lrp [H]

Synonym: mll7129

Alternate gene names: 13475937

Gene position: 5887494-5887003 (Counterclockwise)

Preceding gene: 13475950

Following gene: 13475936

Centisome position: 83.68

GC content: 65.04

Gene sequence:

>492_bases
ATGACTGCCGCGAAACTCGACGCCATCGACCTCAAAATCCTCGACGCCATCCAGCGCGACGGGCGCATCACCAAGCTGGC
ACTGGCCGAGCAGGTGGGGCTGTCTCCGACCCCATGCTGGATGCGGCTGCGTAAGCTGGAGAAGGCCGGCATCGTCTCGG
GCTATCACGCGAGGATCGCCATGCGCGTCGTGGCGCCGGTGGCCACCGTGCTGATGGAAGTGACGCTGGCCAGCCACCGC
CAGGCCGATTTCGACCGCTTCGAGCGCGTCATCCGCGATATCCCCGAGATCGTCGCCTGCTGGTCGGTGGGCGGCGGCGT
CGACTATGTGCTGAAGGTGATGGCGCGCGACATCGACGCCTACCAGCGGCTGGTCGACGGCCTGCTCGACCGCGAGATCG
GTATCGACCGCTACTTCACCTACATCGTCACCAAGACGGTGAAAGAAGAGATCGCACTTCCCATCGCCGAGTTGCTGCCG
GTGTCGCCGTAG

Upstream 100 bases:

>100_bases
GGTTGCCACAATGTCATGACTTATTAGAGATCGAAATCAGTGCAATTGACAATCGAAATAATGCGCCATCATGGTACTGT
GGACGAAAAAGTGAGCCCTG

Downstream 100 bases:

>100_bases
TGCTGGAGAAATCGTCTGCAGAGGCGGCACAATAGAGAGAATCTCTCTACTTCAGGACACCCAAACAGCCTCTCTGTCCG
CCCACGACGGATAGTCTCCC

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 163; Mature: 162

Protein sequence:

>163_residues
MTAAKLDAIDLKILDAIQRDGRITKLALAEQVGLSPTPCWMRLRKLEKAGIVSGYHARIAMRVVAPVATVLMEVTLASHR
QADFDRFERVIRDIPEIVACWSVGGGVDYVLKVMARDIDAYQRLVDGLLDREIGIDRYFTYIVTKTVKEEIALPIAELLP
VSP

Sequences:

>Translated_163_residues
MTAAKLDAIDLKILDAIQRDGRITKLALAEQVGLSPTPCWMRLRKLEKAGIVSGYHARIAMRVVAPVATVLMEVTLASHR
QADFDRFERVIRDIPEIVACWSVGGGVDYVLKVMARDIDAYQRLVDGLLDREIGIDRYFTYIVTKTVKEEIALPIAELLP
VSP
>Mature_162_residues
TAAKLDAIDLKILDAIQRDGRITKLALAEQVGLSPTPCWMRLRKLEKAGIVSGYHARIAMRVVAPVATVLMEVTLASHRQ
ADFDRFERVIRDIPEIVACWSVGGGVDYVLKVMARDIDAYQRLVDGLLDREIGIDRYFTYIVTKTVKEEIALPIAELLPV
SP

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=150, Percent_Identity=38, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=30.6666666666667, Blast_Score=85, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18191; Mature: 18059

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAAKLDAIDLKILDAIQRDGRITKLALAEQVGLSPTPCWMRLRKLEKAGIVSGYHARIA
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHH
MRVVAPVATVLMEVTLASHRQADFDRFERVIRDIPEIVACWSVGGGVDYVLKVMARDIDA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
YQRLVDGLLDREIGIDRYFTYIVTKTVKEEIALPIAELLPVSP
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHCCCCC
>Mature Secondary Structure 
TAAKLDAIDLKILDAIQRDGRITKLALAEQVGLSPTPCWMRLRKLEKAGIVSGYHARIA
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHH
MRVVAPVATVLMEVTLASHRQADFDRFERVIRDIPEIVACWSVGGGVDYVLKVMARDIDA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
YQRLVDGLLDREIGIDRYFTYIVTKTVKEEIALPIAELLPVSP
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]