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The map label for this gene is argM [C]

Identifier: 13475935

GI number: 13475935

Start: 5883967

End: 5885346

Strand: Reverse

Name: argM [C]

Synonym: mll7127

Alternate gene names: 13475935

Gene position: 5885346-5883967 (Counterclockwise)

Preceding gene: 13475936

Following gene: 13475934

Centisome position: 83.65

GC content: 62.61

Gene sequence:

>1380_bases
ATGCTCAACCAGTCCAACGAACTCAACGCCTGGGATCGCGACCACTTCTTCCATCCCTCGACGCATATGGGCACGCACGC
ACGCGGTGAGAGCCCGACCCGCATCATGGCCGGTGGTGAAGGCGTCACCGTCTGGGATAACAATGGCAGGAAGAGCATCG
ACGCCTTCGCTGGCCTCTATTGCGTCAATGTCGGCTATGGCCGCCAGAAGATCGCTGATGCCATCGCCACACAGGCGAAG
AACCTCGCCTACTATCATGCCTATGTCGGACACGGCACCGAGGCCTCGATCACGTTGGCCAAGATGATCATCGACCGCGC
GCCGAAGGGGATGTCGAGGGTCTATTTCGGCCTCTCCGGCTCGGACGCCAACGAAACCAACATCAAGCTGATCTGGTACT
ACAACAATGTGCTGGGCCGGCCGGAGAAGAAGAAGATCATCTCGCGTTGGCGCGGCTATCACGGCTCGGGCGTGATGACC
GGATCGCTGACCGGGCTCGACCTGTTCCATAACGCCTTCGACCTCCCGCGCGCGCCGGTGCTGCACACCGAGGCGCCGTA
CTATTTCCGCCGCACCGACCGCTCGATGAGCGAGGAACAGTTCTCGCAGCACTGCGCCGACAAGCTCGAGGAGATGATCT
TGGCCGAAGGTCCCGAAACCATCGCCGCCTTCATTGGCGAGCCGATTCTCGGCACCGGTGGCATCGTGCCGCCGCCTGCC
GGTTACTGGGAAAAGATCCAGGCGGTGCTGAAGAAATATGACGTGCTTCTGGTCGCCGACGAAGTGGTTACCGGCTTCGG
CCGGCTGGGCACCATGTTCGGCTCCGATCATTACGGCATCAAGCCGGATCTGATCACCATCGCCAAGGGCCTGACCTCGG
CCTATGCGCCGCTGTCGGGCGTCATCGTCGCCGACAGGGTGTGGCAGGTGCTGGTGCAGGGTTCCGACAAACTCGGCTCG
CTCGGCCATGGCTGGACCTATTCGGCGCATCCGATCTGCGTTGCCGCCGGAGTCGCCAATCTCGAACTGATCGACGAGAT
GGATCTGGTGACGAATGCCGGCGAAACCGGCGCCTATTTCCGTGCCGAACTCGCCAAGGCCGTCGGTGGCCATAAAAATG
TCGGCGAGGTGCGCGGCGACGGCATGCTGGCAGCGGTCGAGTTCGTCGCCGACAAGGACGACCGGGTATTCTTCGACGCT
TCGCAGAAGATCGGGCCGCAAGTGGCGACAGCGCTGGCCGCCAGCGGCGTCATCGGCCGCGCCATGCCGCAGGGCGACAT
TCTGGGCTTCGCACCGCCGCTCTGCCTGACCCGCGAGCAAGCCGACATCGTCGTCTCGAAGACTGCGGATGCGGTGAAGA
GTGTGTTTGCCAATCTCTGA

Upstream 100 bases:

>100_bases
GCGAGGGCTCGCGCCACGGGCTCGAAGCGTTCACCGATCTCAAGTATCTCTGCCTGGACGTCGCATAAGTCCGCCCGGCC
ACATCTCAAGGAGACCAAAA

Downstream 100 bases:

>100_bases
GATCGACGATGACTGCCATGACCACAACCGTCCCTGCCACCATGGCCGCCGTGCTGCTCACCGGGCACGGCGGACCGGAA
AAACTCGTCTACCGCACCGA

Product: hypothetical protein

Products: L-glutamate; N2-succinylglutamic-semialdehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MLNQSNELNAWDRDHFFHPSTHMGTHARGESPTRIMAGGEGVTVWDNNGRKSIDAFAGLYCVNVGYGRQKIADAIATQAK
NLAYYHAYVGHGTEASITLAKMIIDRAPKGMSRVYFGLSGSDANETNIKLIWYYNNVLGRPEKKKIISRWRGYHGSGVMT
GSLTGLDLFHNAFDLPRAPVLHTEAPYYFRRTDRSMSEEQFSQHCADKLEEMILAEGPETIAAFIGEPILGTGGIVPPPA
GYWEKIQAVLKKYDVLLVADEVVTGFGRLGTMFGSDHYGIKPDLITIAKGLTSAYAPLSGVIVADRVWQVLVQGSDKLGS
LGHGWTYSAHPICVAAGVANLELIDEMDLVTNAGETGAYFRAELAKAVGGHKNVGEVRGDGMLAAVEFVADKDDRVFFDA
SQKIGPQVATALAASGVIGRAMPQGDILGFAPPLCLTREQADIVVSKTADAVKSVFANL

Sequences:

>Translated_459_residues
MLNQSNELNAWDRDHFFHPSTHMGTHARGESPTRIMAGGEGVTVWDNNGRKSIDAFAGLYCVNVGYGRQKIADAIATQAK
NLAYYHAYVGHGTEASITLAKMIIDRAPKGMSRVYFGLSGSDANETNIKLIWYYNNVLGRPEKKKIISRWRGYHGSGVMT
GSLTGLDLFHNAFDLPRAPVLHTEAPYYFRRTDRSMSEEQFSQHCADKLEEMILAEGPETIAAFIGEPILGTGGIVPPPA
GYWEKIQAVLKKYDVLLVADEVVTGFGRLGTMFGSDHYGIKPDLITIAKGLTSAYAPLSGVIVADRVWQVLVQGSDKLGS
LGHGWTYSAHPICVAAGVANLELIDEMDLVTNAGETGAYFRAELAKAVGGHKNVGEVRGDGMLAAVEFVADKDDRVFFDA
SQKIGPQVATALAASGVIGRAMPQGDILGFAPPLCLTREQADIVVSKTADAVKSVFANL
>Mature_459_residues
MLNQSNELNAWDRDHFFHPSTHMGTHARGESPTRIMAGGEGVTVWDNNGRKSIDAFAGLYCVNVGYGRQKIADAIATQAK
NLAYYHAYVGHGTEASITLAKMIIDRAPKGMSRVYFGLSGSDANETNIKLIWYYNNVLGRPEKKKIISRWRGYHGSGVMT
GSLTGLDLFHNAFDLPRAPVLHTEAPYYFRRTDRSMSEEQFSQHCADKLEEMILAEGPETIAAFIGEPILGTGGIVPPPA
GYWEKIQAVLKKYDVLLVADEVVTGFGRLGTMFGSDHYGIKPDLITIAKGLTSAYAPLSGVIVADRVWQVLVQGSDKLGS
LGHGWTYSAHPICVAAGVANLELIDEMDLVTNAGETGAYFRAELAKAVGGHKNVGEVRGDGMLAAVEFVADKDDRVFFDA
SQKIGPQVATALAASGVIGRAMPQGDILGFAPPLCLTREQADIVVSKTADAVKSVFANL

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=428, Percent_Identity=27.1028037383178, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI4557809, Length=449, Percent_Identity=27.1714922048998, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI37574042, Length=418, Percent_Identity=26.3157894736842, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI226442705, Length=420, Percent_Identity=26.9047619047619, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI226442709, Length=365, Percent_Identity=27.6712328767123, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI284507298, Length=221, Percent_Identity=31.6742081447964, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI24119277, Length=431, Percent_Identity=23.6658932714617, Blast_Score=107, Evalue=3e-23,
Organism=Escherichia coli, GI1788044, Length=416, Percent_Identity=26.9230769230769, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI145693181, Length=415, Percent_Identity=26.5060240963855, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1789759, Length=419, Percent_Identity=25.2983293556086, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1787560, Length=416, Percent_Identity=29.0865384615385, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1789016, Length=359, Percent_Identity=26.4623955431755, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786991, Length=449, Percent_Identity=26.0579064587973, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI32564660, Length=449, Percent_Identity=29.1759465478842, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI25144271, Length=449, Percent_Identity=27.6169265033408, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI25144274, Length=240, Percent_Identity=32.5, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71992977, Length=415, Percent_Identity=24.8192771084337, Blast_Score=114, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323470, Length=430, Percent_Identity=28.8372093023256, Blast_Score=133, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6324432, Length=378, Percent_Identity=24.6031746031746, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6324386, Length=365, Percent_Identity=25.2054794520548, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6321456, Length=281, Percent_Identity=27.4021352313167, Blast_Score=86, Evalue=9e-18,
Organism=Drosophila melanogaster, GI161085790, Length=440, Percent_Identity=27.9545454545455, Blast_Score=151, Evalue=9e-37,
Organism=Drosophila melanogaster, GI28574759, Length=434, Percent_Identity=28.110599078341, Blast_Score=148, Evalue=6e-36,
Organism=Drosophila melanogaster, GI21357415, Length=420, Percent_Identity=29.0476190476191, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI21356575, Length=423, Percent_Identity=23.8770685579196, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI281366494, Length=282, Percent_Identity=24.822695035461, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24667139, Length=282, Percent_Identity=24.822695035461, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24667143, Length=282, Percent_Identity=24.822695035461, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.- [C]

Molecular weight: Translated: 49554; Mature: 49554

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNQSNELNAWDRDHFFHPSTHMGTHARGESPTRIMAGGEGVTVWDNNGRKSIDAFAGLY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEECCCCCHHHHHHHCEE
CVNVGYGRQKIADAIATQAKNLAYYHAYVGHGTEASITLAKMIIDRAPKGMSRVYFGLSG
EEECCCCHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECC
SDANETNIKLIWYYNNVLGRPEKKKIISRWRGYHGSGVMTGSLTGLDLFHNAFDLPRAPV
CCCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHCCCCCCE
LHTEAPYYFRRTDRSMSEEQFSQHCADKLEEMILAEGPETIAAFIGEPILGTGGIVPPPA
EECCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCC
GYWEKIQAVLKKYDVLLVADEVVTGFGRLGTMFGSDHYGIKPDLITIAKGLTSAYAPLSG
CHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCC
VIVADRVWQVLVQGSDKLGSLGHGWTYSAHPICVAAGVANLELIDEMDLVTNAGETGAYF
CHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCHHH
RAELAKAVGGHKNVGEVRGDGMLAAVEFVADKDDRVFFDASQKIGPQVATALAASGVIGR
HHHHHHHHCCCCCCCHHCCCCEEEEEEECCCCCCEEEEECCHHCCHHHHHHHHHCCHHHC
AMPQGDILGFAPPLCLTREQADIVVSKTADAVKSVFANL
CCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHCC
>Mature Secondary Structure
MLNQSNELNAWDRDHFFHPSTHMGTHARGESPTRIMAGGEGVTVWDNNGRKSIDAFAGLY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEECCCCCHHHHHHHCEE
CVNVGYGRQKIADAIATQAKNLAYYHAYVGHGTEASITLAKMIIDRAPKGMSRVYFGLSG
EEECCCCHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECC
SDANETNIKLIWYYNNVLGRPEKKKIISRWRGYHGSGVMTGSLTGLDLFHNAFDLPRAPV
CCCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHCCCCCCE
LHTEAPYYFRRTDRSMSEEQFSQHCADKLEEMILAEGPETIAAFIGEPILGTGGIVPPPA
EECCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCC
GYWEKIQAVLKKYDVLLVADEVVTGFGRLGTMFGSDHYGIKPDLITIAKGLTSAYAPLSG
CHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCC
VIVADRVWQVLVQGSDKLGSLGHGWTYSAHPICVAAGVANLELIDEMDLVTNAGETGAYF
CHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCHHH
RAELAKAVGGHKNVGEVRGDGMLAAVEFVADKDDRVFFDASQKIGPQVATALAASGVIGR
HHHHHHHHCCCCCCCHHCCCCEEEEEEECCCCCCEEEEECCHHCCHHHHHHHHHCCHHHC
AMPQGDILGFAPPLCLTREQADIVVSKTADAVKSVFANL
CCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-alpha-acetylornithine; 2-oxoglutarate [C]

Specific reaction: N-alpha-acetylornithine + 2-oxoglutarate = N-acetylglutamate semialdehyde + L-glutamate N2-succinylornithine + 2-oxoglutarate = N2-succinylglutamic-semialdehyde + L-glutamate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8796346; 9163424 [H]