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The map label for this gene is hutC [H]

Identifier: 13475923

GI number: 13475923

Start: 5867445

End: 5868176

Strand: Direct

Name: hutC [H]

Synonym: mlr7110

Alternate gene names: 13475923

Gene position: 5867445-5868176 (Clockwise)

Preceding gene: 13475922

Following gene: 13475924

Centisome position: 83.39

GC content: 59.84

Gene sequence:

>732_bases
ATGATCGATTTGCCCGATACGGCGAGCCCTCTTTACGAGAAGGTGAAGGACTACATCCTGGCCAACATCGGAACGGGCCG
GTGGGGCAAGGATCGCAAGCTGCCGTCCGAGAATGAGCTGGTGGCTTCGCTTGGTGTCTCGCGCATGACGGTCCACCGGG
CCTTGCGGGAACTGACCGCGGCGGGGTTCCTGATCCGGCTGCAAGGCGTCGGCACCTTCATCGCGCCACCCCGGCCGCAA
TCGACGCTGATCGAGATCAACAACATCGCGGCCGAGATCGTCGAGCGCGGCAACAGGCATCGTTCCGAAGTCCTCGTGCT
TGAAACCATCATGCCGACCAAGGAACTTGCGCTGTCCTTCGAGTTCCCAAAGCGCGTCGCGATCTATCACTCGGTCGTCG
TCAATTTCGAGAACGATTTGCCGGTGCAGCTCGAAGAGCGCTTCGTCAATCCGAGCCTGATCCCCGACTACGACAAGCAG
GATTTTTCGAAGACGGCGACCTACGATTACCTTATGCAGAAGACCCCGGTGACCGAGGTCGAGCATATTATCTCGGCGAT
CCCGGCCGACGCCGAGACTGCGCGGCATCTCAATATCGATGTCGGTAGCTGCTGTCTGTTTCTGCACCGTCGCACATGGA
CGGGTGCGATCGTCGCCACCATCAGCAAGCTAACTTATGCCGGCAGCCGCTACTCGCTCGGCAGCCGCTATTCCCCCTCC
AAGACCAACTGA

Upstream 100 bases:

>100_bases
CTGTTGGCGGGGCAAAGCGACGGCTTGAAAACAATCATTCGCATGCGGCAACCTGTTGAGCCGGCGTGACTTCCGATAAA
TTGCCGGAAAGGATTTTGAA

Downstream 100 bases:

>100_bases
CGCCGAAAGCCAATGCAGGTCACGGAATCTTCGACGCAGATGTATGTACATGTACTGATAAGAGCAGTTTCGCGCCTTGC
AGACGGATTGGCTGGAAGGG

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MIDLPDTASPLYEKVKDYILANIGTGRWGKDRKLPSENELVASLGVSRMTVHRALRELTAAGFLIRLQGVGTFIAPPRPQ
STLIEINNIAAEIVERGNRHRSEVLVLETIMPTKELALSFEFPKRVAIYHSVVVNFENDLPVQLEERFVNPSLIPDYDKQ
DFSKTATYDYLMQKTPVTEVEHIISAIPADAETARHLNIDVGSCCLFLHRRTWTGAIVATISKLTYAGSRYSLGSRYSPS
KTN

Sequences:

>Translated_243_residues
MIDLPDTASPLYEKVKDYILANIGTGRWGKDRKLPSENELVASLGVSRMTVHRALRELTAAGFLIRLQGVGTFIAPPRPQ
STLIEINNIAAEIVERGNRHRSEVLVLETIMPTKELALSFEFPKRVAIYHSVVVNFENDLPVQLEERFVNPSLIPDYDKQ
DFSKTATYDYLMQKTPVTEVEHIISAIPADAETARHLNIDVGSCCLFLHRRTWTGAIVATISKLTYAGSRYSLGSRYSPS
KTN
>Mature_243_residues
MIDLPDTASPLYEKVKDYILANIGTGRWGKDRKLPSENELVASLGVSRMTVHRALRELTAAGFLIRLQGVGTFIAPPRPQ
STLIEINNIAAEIVERGNRHRSEVLVLETIMPTKELALSFEFPKRVAIYHSVVVNFENDLPVQLEERFVNPSLIPDYDKQ
DFSKTATYDYLMQKTPVTEVEHIISAIPADAETARHLNIDVGSCCLFLHRRTWTGAIVATISKLTYAGSRYSLGSRYSPS
KTN

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082252, Length=194, Percent_Identity=25.2577319587629, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1786950, Length=193, Percent_Identity=27.979274611399, Blast_Score=78, Evalue=4e-16,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 27218; Mature: 27218

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDLPDTASPLYEKVKDYILANIGTGRWGKDRKLPSENELVASLGVSRMTVHRALRELTA
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHH
AGFLIRLQGVGTFIAPPRPQSTLIEINNIAAEIVERGNRHRSEVLVLETIMPTKELALSF
HCEEEEEECCCEECCCCCCCCCEEEHHHHHHHHHHCCCCCHHHEEEEEHHCCHHHHEEEE
EFPKRVAIYHSVVVNFENDLPVQLEERFVNPSLIPDYDKQDFSKTATYDYLMQKTPVTEV
CCCHHHHEEHHEEEECCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHH
EHIISAIPADAETARHLNIDVGSCCLFLHRRTWTGAIVATISKLTYAGSRYSLGSRYSPS
HHHHHHCCCCCHHHEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
KTN
CCC
>Mature Secondary Structure
MIDLPDTASPLYEKVKDYILANIGTGRWGKDRKLPSENELVASLGVSRMTVHRALRELTA
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHH
AGFLIRLQGVGTFIAPPRPQSTLIEINNIAAEIVERGNRHRSEVLVLETIMPTKELALSF
HCEEEEEECCCEECCCCCCCCCEEEHHHHHHHHHHCCCCCHHHEEEEEHHCCHHHHEEEE
EFPKRVAIYHSVVVNFENDLPVQLEERFVNPSLIPDYDKQDFSKTATYDYLMQKTPVTEV
CCCHHHHEEHHEEEECCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHH
EHIISAIPADAETARHLNIDVGSCCLFLHRRTWTGAIVATISKLTYAGSRYSLGSRYSPS
HHHHHHCCCCCHHHEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
KTN
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]