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The map label for this gene is tdh [H]

Identifier: 13475922

GI number: 13475922

Start: 5866388

End: 5867413

Strand: Direct

Name: tdh [H]

Synonym: mlr7108

Alternate gene names: 13475922

Gene position: 5866388-5867413 (Clockwise)

Preceding gene: 13475921

Following gene: 13475923

Centisome position: 83.38

GC content: 67.06

Gene sequence:

>1026_bases
ATGAAGGCCGCACGGCTTTATGGACCCGGCGATCTGCGGGTGGAGGACGTTGCCCCGCCAGGCATTCCGGATCCCGGCTG
GGTGAAGCTCAGGGTCGATGCCGCCGGCATTTGCGGTTCGGACCTGCACAATTTCCGCACCGGCCAATGGATAAGCCGCT
CGCCTTCGACGGCCGGCCATGAGCTGACCGGCACGGTGACCGCGCTCGGCGAGGGCGTCGACACCGTCGCCGTCGGCGAC
AGGGTGGTTGCCGATTCCCGCTTCTGGTGCGAGGAATGCGTGCAATGCCGTGCCGGCAGGCGCCATCTCTGCGCTTCGCT
GGGCTTCGTCGGCGAAGTCTGCGACGGCGGCTTCGCCGAACAGGTCGTTCTACCCGCGCGGCTGCTGCATGTTGTCGATG
CAGCACTGGACGAGCGGGTCGCCGCGATGGCCGAGCCGCTCGCTGTGGCGCTGCACGCGGTGCGGCGTCTGCCGAAGACG
GCAGGCTCCGTGCTTGTCGTCGGCTGCGGGCCGATCGGCGGTCTCGCCGCACTGCTGCTTTCGCGGAGCTTTGCCGGCAC
GGTGCTTGTCGCCGACCGCAACCAAGCCCGCTGCGCCCGCGTGGCGCGGGTGACCGGCGCAACAATCGTCGACCTTGACC
GTGATGCGATTGCCGCAGCGACTGGCTACGCCCCCTTGCTGGCGGCCGTCGAGGCGACCGGCAGCATCGCCGCATTCAAC
CAGTTGCTCGGCGTTCTCGATTCCGGCAGCGCTGTGGCGATGGTCGGCATCTTCCATGGCCGTCTCGACATCGACCCCAA
CCTTCTGGTCGAACGCGAGATCGCGCTGCTGGGGTGCCATGCCTTCGCCGACGAGTTGCCCGACGCCGTGCGGATGCTGG
GTGAATTGAGCGAACCTTTGCTCGCCCTGATCGATCGCGAGATCGGTCTCGACGATATTCCGGCCGCCTATGAGCGGCTG
TTGGCGGGGCAAAGCGACGGCTTGAAAACAATCATTCGCATGCGGCAACCTGTTGAGCCGGCGTGA

Upstream 100 bases:

>100_bases
TGCCCGCAGGCTTGCCCGCTACGAGGGCTTCAGCTCACACGAAAACGCGGTCTCGGAAATCCGCGACCGCTACCTCGCCG
GCTGAACGGAGACGATCGCG

Downstream 100 bases:

>100_bases
CTTCCGATAAATTGCCGGAAAGGATTTTGAAATGATCGATTTGCCCGATACGGCGAGCCCTCTTTACGAGAAGGTGAAGG
ACTACATCCTGGCCAACATC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKAARLYGPGDLRVEDVAPPGIPDPGWVKLRVDAAGICGSDLHNFRTGQWISRSPSTAGHELTGTVTALGEGVDTVAVGD
RVVADSRFWCEECVQCRAGRRHLCASLGFVGEVCDGGFAEQVVLPARLLHVVDAALDERVAAMAEPLAVALHAVRRLPKT
AGSVLVVGCGPIGGLAALLLSRSFAGTVLVADRNQARCARVARVTGATIVDLDRDAIAAATGYAPLLAAVEATGSIAAFN
QLLGVLDSGSAVAMVGIFHGRLDIDPNLLVEREIALLGCHAFADELPDAVRMLGELSEPLLALIDREIGLDDIPAAYERL
LAGQSDGLKTIIRMRQPVEPA

Sequences:

>Translated_341_residues
MKAARLYGPGDLRVEDVAPPGIPDPGWVKLRVDAAGICGSDLHNFRTGQWISRSPSTAGHELTGTVTALGEGVDTVAVGD
RVVADSRFWCEECVQCRAGRRHLCASLGFVGEVCDGGFAEQVVLPARLLHVVDAALDERVAAMAEPLAVALHAVRRLPKT
AGSVLVVGCGPIGGLAALLLSRSFAGTVLVADRNQARCARVARVTGATIVDLDRDAIAAATGYAPLLAAVEATGSIAAFN
QLLGVLDSGSAVAMVGIFHGRLDIDPNLLVEREIALLGCHAFADELPDAVRMLGELSEPLLALIDREIGLDDIPAAYERL
LAGQSDGLKTIIRMRQPVEPA
>Mature_341_residues
MKAARLYGPGDLRVEDVAPPGIPDPGWVKLRVDAAGICGSDLHNFRTGQWISRSPSTAGHELTGTVTALGEGVDTVAVGD
RVVADSRFWCEECVQCRAGRRHLCASLGFVGEVCDGGFAEQVVLPARLLHVVDAALDERVAAMAEPLAVALHAVRRLPKT
AGSVLVVGCGPIGGLAALLLSRSFAGTVLVADRNQARCARVARVTGATIVDLDRDAIAAATGYAPLLAAVEATGSIAAFN
QLLGVLDSGSAVAMVGIFHGRLDIDPNLLVEREIALLGCHAFADELPDAVRMLGELSEPLLALIDREIGLDDIPAAYERL
LAGQSDGLKTIIRMRQPVEPA

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=340, Percent_Identity=28.5294117647059, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI262073058, Length=367, Percent_Identity=25.8855585831063, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI71743840, Length=367, Percent_Identity=25.8855585831063, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI226510992, Length=319, Percent_Identity=29.153605015674, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI1790045, Length=306, Percent_Identity=27.7777777777778, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1787863, Length=209, Percent_Identity=34.9282296650718, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788073, Length=349, Percent_Identity=25.7879656160458, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790718, Length=300, Percent_Identity=27.3333333333333, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788407, Length=169, Percent_Identity=33.7278106508876, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788075, Length=344, Percent_Identity=25.8720930232558, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786825, Length=267, Percent_Identity=28.4644194756554, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI87082125, Length=253, Percent_Identity=28.8537549407115, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1786518, Length=320, Percent_Identity=26.25, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=343, Percent_Identity=29.7376093294461, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17562878, Length=345, Percent_Identity=31.5942028985507, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322619, Length=341, Percent_Identity=27.8592375366569, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6319955, Length=341, Percent_Identity=27.5659824046921, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323099, Length=340, Percent_Identity=26.4705882352941, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6319257, Length=324, Percent_Identity=29.0123456790123, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319258, Length=240, Percent_Identity=33.3333333333333, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17737897, Length=225, Percent_Identity=37.7777777777778, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17137530, Length=225, Percent_Identity=36, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI45551930, Length=214, Percent_Identity=28.0373831775701, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45550770, Length=214, Percent_Identity=28.0373831775701, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221457811, Length=214, Percent_Identity=28.0373831775701, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 35683; Mature: 35683

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAARLYGPGDLRVEDVAPPGIPDPGWVKLRVDAAGICGSDLHNFRTGQWISRSPSTAGH
CCCCEECCCCCCEEECCCCCCCCCCCEEEEEEECCCCCCHHHHHCCCCCCCCCCCCCCCC
ELTGTVTALGEGVDTVAVGDRVVADSRFWCEECVQCRAGRRHLCASLGFVGEVCDGGFAE
EEEEHHHHHCCCCCEEEECCEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHH
QVVLPARLLHVVDAALDERVAAMAEPLAVALHAVRRLPKTAGSVLVVGCGPIGGLAALLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHH
SRSFAGTVLVADRNQARCARVARVTGATIVDLDRDAIAAATGYAPLLAAVEATGSIAAFN
HCCCCCEEEEECCCHHHHHHHHHHCCCEEEECCCHHHHHHCCHHHHHHHHHCCCHHHHHH
QLLGVLDSGSAVAMVGIFHGRLDIDPNLLVEREIALLGCHAFADELPDAVRMLGELSEPL
HHHHHHCCCCEEEEEEEEECEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LALIDREIGLDDIPAAYERLLAGQSDGLKTIIRMRQPVEPA
HHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure
MKAARLYGPGDLRVEDVAPPGIPDPGWVKLRVDAAGICGSDLHNFRTGQWISRSPSTAGH
CCCCEECCCCCCEEECCCCCCCCCCCEEEEEEECCCCCCHHHHHCCCCCCCCCCCCCCCC
ELTGTVTALGEGVDTVAVGDRVVADSRFWCEECVQCRAGRRHLCASLGFVGEVCDGGFAE
EEEEHHHHHCCCCCEEEECCEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHH
QVVLPARLLHVVDAALDERVAAMAEPLAVALHAVRRLPKTAGSVLVVGCGPIGGLAALLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHH
SRSFAGTVLVADRNQARCARVARVTGATIVDLDRDAIAAATGYAPLLAAVEATGSIAAFN
HCCCCCEEEEECCCHHHHHHHHHHCCCEEEECCCHHHHHHCCHHHHHHHHHCCCHHHHHH
QLLGVLDSGSAVAMVGIFHGRLDIDPNLLVEREIALLGCHAFADELPDAVRMLGELSEPL
HHHHHHCCCCEEEEEEEEECEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LALIDREIGLDDIPAAYERLLAGQSDGLKTIIRMRQPVEPA
HHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA