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The map label for this gene is hisD3

Identifier: 13475921

GI number: 13475921

Start: 5865050

End: 5866372

Strand: Direct

Name: hisD3

Synonym: mlr7107

Alternate gene names: 13475921

Gene position: 5865050-5866372 (Clockwise)

Preceding gene: 13475920

Following gene: 13475922

Centisome position: 83.36

GC content: 64.78

Gene sequence:

>1323_bases
ATGTCCGACGTCAGCTTCCACGATCTGTCATCGCTCGACGCCACCCAGCGGTCCAGCCTGCTGAAGCGCGCCGAGGCCGA
TCTGTCGGTCTTCGTCGAAAAGGTCCGCCCGATCATCCAGGCCGTCAAGGACGAGGGTGACGCCGCGCTGATCCGCTTCG
CCAGGGAGCTCGACAAGGCCAATGTCGCCGAAGGCGGACTACAGGTGTCGGAAGCCGAGTTCGACGCGGCCTTCGACAAG
GTCGAGAAGGATGTCGTGGAAAGCATCGGCTTCGGCATAGACAATATCAGGCGTTTCCATGAGGAGCAGAAGCCGGAAAC
GATGTGGCTCAAGGAAGTCCGGCCGGGCGCCTATGCCGGCGACCGCTATACGCCGATCGCGTCCGTCGCGCTCTACGTGC
CGCGCGGCAAGGGCGCCTTTCCGTCGGTGACGATGATGACCTCGGTTCCGGCAGTCATTGCCGGCGTGCCGCAGATCGCC
ATCGTGACGCCGCCGACATCGGACGGTTCGGTGGATGCGGCGACCCTTGTCGCCGCCCGCCTCGCTGGCGTGCACACCGT
TTACAAATGCGGTGGCGCCCAGGCCGTCGCCGCCGTCGCCTACGGCACTGAAACGGTGAAGCCCGCGCTCAAGATCGTCG
GCCCCGGCAGCCCATGGGTGGTTGCGGCAAAAAGCGAGCTGTCGTCGATCATCAACACGGGTCTTCCGGCCGGCCCGTCG
GAAGCCATCATCTTTGCCGATGACAGCGTCGACGGCGGCCTTGCCGCGCTCGATCTACTGATCGAGGCCGAGCACGGACC
GGATTCTTCGGCCTATCTGGTGACGCACAGCCGCAAGGTCGCCGAGGCCGCACTTGCCGCACTCCCGCAACACTGGTCGC
GGATGACCGAACAGCGTGTGGAGTTCTCGCGCGCGGTGCTGACCGGCAAGCGTGGCGGCATCGTGCTGACCGCGTCGCTG
GAAGACAGCTATCGCTTCATCAACGACTATGCGCCCGAACATCTGGAAATCCTGTCGAAGGAGCCGTTCGCGCACCTCGG
GCATATCACCGAGGCAGCCGAAATCCTCATGGGCCCGCACACGCCGGTGACCCTTGCCAACTTCGTCCTTGGGCCTAATG
CCGTGCTGCCGACCAGCCGCTGGGCGCGCACCTATGGGCCGCTCTCGGTGACCGATTTCGTCAAGCGCTCATCTGTCGGC
TACGTCACCTCCGCCGCTTATCCGGAATTGGCGAAGCATGCCCGCAGGCTTGCCCGCTACGAGGGCTTCAGCTCACACGA
AAACGCGGTCTCGGAAATCCGCGACCGCTACCTCGCCGGCTGA

Upstream 100 bases:

>100_bases
GCTTCCTGGCATCGATTTGAGGCAGCGCTAAAGGTTCGAAATCAACGTCTTGCGCAACGTAACCGGCCGGCGCGTTGCGT
TCCAACAAAGAGGAACATCC

Downstream 100 bases:

>100_bases
ACGGAGACGATCGCGATGAAGGCCGCACGGCTTTATGGACCCGGCGATCTGCGGGTGGAGGACGTTGCCCCGCCAGGCAT
TCCGGATCCCGGCTGGGTGA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH 3

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MSDVSFHDLSSLDATQRSSLLKRAEADLSVFVEKVRPIIQAVKDEGDAALIRFARELDKANVAEGGLQVSEAEFDAAFDK
VEKDVVESIGFGIDNIRRFHEEQKPETMWLKEVRPGAYAGDRYTPIASVALYVPRGKGAFPSVTMMTSVPAVIAGVPQIA
IVTPPTSDGSVDAATLVAARLAGVHTVYKCGGAQAVAAVAYGTETVKPALKIVGPGSPWVVAAKSELSSIINTGLPAGPS
EAIIFADDSVDGGLAALDLLIEAEHGPDSSAYLVTHSRKVAEAALAALPQHWSRMTEQRVEFSRAVLTGKRGGIVLTASL
EDSYRFINDYAPEHLEILSKEPFAHLGHITEAAEILMGPHTPVTLANFVLGPNAVLPTSRWARTYGPLSVTDFVKRSSVG
YVTSAAYPELAKHARRLARYEGFSSHENAVSEIRDRYLAG

Sequences:

>Translated_440_residues
MSDVSFHDLSSLDATQRSSLLKRAEADLSVFVEKVRPIIQAVKDEGDAALIRFARELDKANVAEGGLQVSEAEFDAAFDK
VEKDVVESIGFGIDNIRRFHEEQKPETMWLKEVRPGAYAGDRYTPIASVALYVPRGKGAFPSVTMMTSVPAVIAGVPQIA
IVTPPTSDGSVDAATLVAARLAGVHTVYKCGGAQAVAAVAYGTETVKPALKIVGPGSPWVVAAKSELSSIINTGLPAGPS
EAIIFADDSVDGGLAALDLLIEAEHGPDSSAYLVTHSRKVAEAALAALPQHWSRMTEQRVEFSRAVLTGKRGGIVLTASL
EDSYRFINDYAPEHLEILSKEPFAHLGHITEAAEILMGPHTPVTLANFVLGPNAVLPTSRWARTYGPLSVTDFVKRSSVG
YVTSAAYPELAKHARRLARYEGFSSHENAVSEIRDRYLAG
>Mature_439_residues
SDVSFHDLSSLDATQRSSLLKRAEADLSVFVEKVRPIIQAVKDEGDAALIRFARELDKANVAEGGLQVSEAEFDAAFDKV
EKDVVESIGFGIDNIRRFHEEQKPETMWLKEVRPGAYAGDRYTPIASVALYVPRGKGAFPSVTMMTSVPAVIAGVPQIAI
VTPPTSDGSVDAATLVAARLAGVHTVYKCGGAQAVAAVAYGTETVKPALKIVGPGSPWVVAAKSELSSIINTGLPAGPSE
AIIFADDSVDGGLAALDLLIEAEHGPDSSAYLVTHSRKVAEAALAALPQHWSRMTEQRVEFSRAVLTGKRGGIVLTASLE
DSYRFINDYAPEHLEILSKEPFAHLGHITEAAEILMGPHTPVTLANFVLGPNAVLPTSRWARTYGPLSVTDFVKRSSVGY
VTSAAYPELAKHARRLARYEGFSSHENAVSEIRDRYLAG

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=442, Percent_Identity=34.3891402714932, Blast_Score=226, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6319819, Length=423, Percent_Identity=31.9148936170213, Blast_Score=213, Evalue=4e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX3_RHILO (Q987C6)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_107491.1
- ProteinModelPortal:   Q987C6
- SMR:   Q987C6
- GeneID:   1230146
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr7107
- NMPDR:   fig|266835.1.peg.5592
- HOGENOM:   HBG329596
- OMA:   KIVGPGS
- ProtClustDB:   PRK12447
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 47090; Mature: 46959

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 333-333 ACT_SITE 334-334

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDVSFHDLSSLDATQRSSLLKRAEADLSVFVEKVRPIIQAVKDEGDAALIRFARELDKA
CCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
NVAEGGLQVSEAEFDAAFDKVEKDVVESIGFGIDNIRRFHEEQKPETMWLKEVRPGAYAG
HHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCC
DRYTPIASVALYVPRGKGAFPSVTMMTSVPAVIAGVPQIAIVTPPTSDGSVDAATLVAAR
CCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHH
LAGVHTVYKCGGAQAVAAVAYGTETVKPALKIVGPGSPWVVAAKSELSSIINTGLPAGPS
HHHHHHHHHCCCHHHHHHHHHCCHHHCCHHEEECCCCCEEEEEHHHHHHHHHCCCCCCCC
EAIIFADDSVDGGLAALDLLIEAEHGPDSSAYLVTHSRKVAEAALAALPQHWSRMTEQRV
CEEEEECCCCCCCHHHHHHHEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
EFSRAVLTGKRGGIVLTASLEDSYRFINDYAPEHLEILSKEPFAHLGHITEAAEILMGPH
HHHHHHHCCCCCCEEEEEECCHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
TPVTLANFVLGPNAVLPTSRWARTYGPLSVTDFVKRSSVGYVTSAAYPELAKHARRLARY
CCHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHCCCCCEEHHCCHHHHHHHHHHHHH
EGFSSHENAVSEIRDRYLAG
CCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDVSFHDLSSLDATQRSSLLKRAEADLSVFVEKVRPIIQAVKDEGDAALIRFARELDKA
CCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
NVAEGGLQVSEAEFDAAFDKVEKDVVESIGFGIDNIRRFHEEQKPETMWLKEVRPGAYAG
HHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCC
DRYTPIASVALYVPRGKGAFPSVTMMTSVPAVIAGVPQIAIVTPPTSDGSVDAATLVAAR
CCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHH
LAGVHTVYKCGGAQAVAAVAYGTETVKPALKIVGPGSPWVVAAKSELSSIINTGLPAGPS
HHHHHHHHHCCCHHHHHHHHHCCHHHCCHHEEECCCCCEEEEEHHHHHHHHHCCCCCCCC
EAIIFADDSVDGGLAALDLLIEAEHGPDSSAYLVTHSRKVAEAALAALPQHWSRMTEQRV
CEEEEECCCCCCCHHHHHHHEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
EFSRAVLTGKRGGIVLTASLEDSYRFINDYAPEHLEILSKEPFAHLGHITEAAEILMGPH
HHHHHHHCCCCCCEEEEEECCHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
TPVTLANFVLGPNAVLPTSRWARTYGPLSVTDFVKRSSVGYVTSAAYPELAKHARRLARY
CCHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHCCCCCEEHHCCHHHHHHHHHHHHH
EGFSSHENAVSEIRDRYLAG
CCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968