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The map label for this gene is ycsA [H]

Identifier: 13475867

GI number: 13475867

Start: 5808810

End: 5809853

Strand: Reverse

Name: ycsA [H]

Synonym: mll7044

Alternate gene names: 13475867

Gene position: 5809853-5808810 (Counterclockwise)

Preceding gene: 13475868

Following gene: 13475866

Centisome position: 82.57

GC content: 64.85

Gene sequence:

>1044_bases
ATGAAGTCTTATTCGATCGCTATGATCCCCGGTGACGGCATTGGCCGGGACGTGACCGCCGCCGCATGGACGGTGCTGGA
GGCCGCGGCAAAACACGCGGGCTTTGCCTTGACCGGAACCGAGTTCCCCTGGTCCTGCAAATTCTACAAGGATACCGGCC
GCATGATGCCCGAGGACGGCATAGAGACCTTGCGCGGCTTCGACGCCATCCTTCTCGGCGCAGTCGGCTGGCCGGCGGAG
GTGCCGGATTCCGTTTCGCTGCACGGCCTGCTGCTGCCGATCCGCAAGGCATTCGTGCAGTACGCCAACATCCGGCCGCA
CCGCCTGCTGCCGGGCGTGACAGGGCCGCTGCGGGCGGAAGGTTTCGACATATTGTGCATCCGCGAGAACACCGAAGGCG
AATATTCGGGCGCCGGCGGTCGCGTGCATCAGGGCACGCTGGACGAGGTTGCGGTTGAGACCTCGATCTTCACCCGTGCC
GGCGTCGAGCGCATCCTGCGCTTCGGCTTCGAGCAGGCGCGGACACGGAACGGCAAGCTGGCTTCCGTCACCAAGTCCAA
CGCGCAGAAATACTCGATGGTGTTCTGGGACGAGATCACCCGCAAGCTGGCCGCGGAGTATTCCGACGTCGCTGTGACCA
GCTATCATGTCGATGCGCTCGCCGCGCGCATGATCATGGCGCCGGAGAGCCTCGACGTGGTCGTCGCCTCCAACCTGTTC
GGCGATATCCTCACCGACATCGGCGCGGCAATCCAGGGCGGGCTCGGCTACGCTGCCTCAGCCAACATCAATCCCGACCA
CTCGGCGCCGTCCATGTTCGAGCCGGTGCACGGCTCGGCACCCGACATCGCACATCTGGGCATCGCCAATCCGATCGCCA
CCATCTGGTCCGGCGCCATGATGCTCGATCATCTCGGCGAAAAGCCTGCTGCCGACCGCGTCATGAAGGCGGTCGAGGTC
GCAACCGCCAGAGGCATAGGCACCATTCCCGCCAAGGATCGCACAGAGGCCATCACCGCCGCCGTCGTCGCGGCGCTCAC
CTAA

Upstream 100 bases:

>100_bases
GGCTACAAGCGCTCCGGCATCGGCAAGGACCTCGGCCGCGAGGCCTATCTCGCCAACCGCAGGAGCAAGAGCGTCCTGAT
CAGCCTCTAGAGAGATGCCG

Downstream 100 bases:

>100_bases
TTGCAAGGTCATTTTCGATGAAAACCCTGAAAGACAAAAATCTCTTCCGCGAAGCCGGCCTGATCGGCGGTGAGTGGGTC
GCTGCCGGCTCCGGCAAGAC

Product: 3-isopropylmalate dehydrogenase

Products: NA

Alternate protein names: TDH; D-malate dehydrogenase [decarboxylating] [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MKSYSIAMIPGDGIGRDVTAAAWTVLEAAAKHAGFALTGTEFPWSCKFYKDTGRMMPEDGIETLRGFDAILLGAVGWPAE
VPDSVSLHGLLLPIRKAFVQYANIRPHRLLPGVTGPLRAEGFDILCIRENTEGEYSGAGGRVHQGTLDEVAVETSIFTRA
GVERILRFGFEQARTRNGKLASVTKSNAQKYSMVFWDEITRKLAAEYSDVAVTSYHVDALAARMIMAPESLDVVVASNLF
GDILTDIGAAIQGGLGYAASANINPDHSAPSMFEPVHGSAPDIAHLGIANPIATIWSGAMMLDHLGEKPAADRVMKAVEV
ATARGIGTIPAKDRTEAITAAVVAALT

Sequences:

>Translated_347_residues
MKSYSIAMIPGDGIGRDVTAAAWTVLEAAAKHAGFALTGTEFPWSCKFYKDTGRMMPEDGIETLRGFDAILLGAVGWPAE
VPDSVSLHGLLLPIRKAFVQYANIRPHRLLPGVTGPLRAEGFDILCIRENTEGEYSGAGGRVHQGTLDEVAVETSIFTRA
GVERILRFGFEQARTRNGKLASVTKSNAQKYSMVFWDEITRKLAAEYSDVAVTSYHVDALAARMIMAPESLDVVVASNLF
GDILTDIGAAIQGGLGYAASANINPDHSAPSMFEPVHGSAPDIAHLGIANPIATIWSGAMMLDHLGEKPAADRVMKAVEV
ATARGIGTIPAKDRTEAITAAVVAALT
>Mature_347_residues
MKSYSIAMIPGDGIGRDVTAAAWTVLEAAAKHAGFALTGTEFPWSCKFYKDTGRMMPEDGIETLRGFDAILLGAVGWPAE
VPDSVSLHGLLLPIRKAFVQYANIRPHRLLPGVTGPLRAEGFDILCIRENTEGEYSGAGGRVHQGTLDEVAVETSIFTRA
GVERILRFGFEQARTRNGKLASVTKSNAQKYSMVFWDEITRKLAAEYSDVAVTSYHVDALAARMIMAPESLDVVVASNLF
GDILTDIGAAIQGGLGYAASANINPDHSAPSMFEPVHGSAPDIAHLGIANPIATIWSGAMMLDHLGEKPAADRVMKAVEV
ATARGIGTIPAKDRTEAITAAVVAALT

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=321, Percent_Identity=33.3333333333333, Blast_Score=158, Evalue=6e-39,
Organism=Homo sapiens, GI28178838, Length=317, Percent_Identity=30.2839116719243, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI4758582, Length=317, Percent_Identity=30.2839116719243, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI28178816, Length=354, Percent_Identity=26.5536723163842, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI28178821, Length=311, Percent_Identity=27.0096463022508, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI28178819, Length=154, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1788101, Length=338, Percent_Identity=52.6627218934911, Blast_Score=342, Evalue=2e-95,
Organism=Escherichia coli, GI87081683, Length=338, Percent_Identity=39.3491124260355, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI1787381, Length=360, Percent_Identity=26.9444444444444, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71986051, Length=323, Percent_Identity=35.6037151702786, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI25144293, Length=314, Percent_Identity=28.6624203821656, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17505779, Length=306, Percent_Identity=28.1045751633987, Blast_Score=111, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17550882, Length=307, Percent_Identity=28.0130293159609, Blast_Score=111, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6322097, Length=362, Percent_Identity=33.1491712707182, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6324709, Length=355, Percent_Identity=31.5492957746479, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324291, Length=328, Percent_Identity=33.8414634146341, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6319830, Length=314, Percent_Identity=32.484076433121, Blast_Score=129, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24643268, Length=325, Percent_Identity=32, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24643270, Length=325, Percent_Identity=32, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24661184, Length=322, Percent_Identity=33.5403726708075, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI161078635, Length=317, Percent_Identity=25.5520504731861, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI161078633, Length=317, Percent_Identity=25.5520504731861, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24650122, Length=317, Percent_Identity=25.5520504731861, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI161078637, Length=317, Percent_Identity=25.5520504731861, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI161078639, Length=227, Percent_Identity=29.5154185022026, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI281362242, Length=348, Percent_Identity=26.1494252873563, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24648872, Length=348, Percent_Identity=26.1494252873563, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI20130355, Length=325, Percent_Identity=26.1538461538462, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR011829 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.93; =4.1.1.73; =1.1.1.83 [H]

Molecular weight: Translated: 36907; Mature: 36907

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSYSIAMIPGDGIGRDVTAAAWTVLEAAAKHAGFALTGTEFPWSCKFYKDTGRMMPEDG
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCCEEEEECCCCCCCCHHH
IETLRGFDAILLGAVGWPAEVPDSVSLHGLLLPIRKAFVQYANIRPHRLLPGVTGPLRAE
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GFDILCIRENTEGEYSGAGGRVHQGTLDEVAVETSIFTRAGVERILRFGFEQARTRNGKL
CEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCE
ASVTKSNAQKYSMVFWDEITRKLAAEYSDVAVTSYHVDALAARMIMAPESLDVVVASNLF
EEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCCCEEEHHHHH
GDILTDIGAAIQGGLGYAASANINPDHSAPSMFEPVHGSAPDIAHLGIANPIATIWSGAM
HHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHH
MLDHLGEKPAADRVMKAVEVATARGIGTIPAKDRTEAITAAVVAALT
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKSYSIAMIPGDGIGRDVTAAAWTVLEAAAKHAGFALTGTEFPWSCKFYKDTGRMMPEDG
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCCEEEEECCCCCCCCHHH
IETLRGFDAILLGAVGWPAEVPDSVSLHGLLLPIRKAFVQYANIRPHRLLPGVTGPLRAE
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GFDILCIRENTEGEYSGAGGRVHQGTLDEVAVETSIFTRAGVERILRFGFEQARTRNGKL
CEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCE
ASVTKSNAQKYSMVFWDEITRKLAAEYSDVAVTSYHVDALAARMIMAPESLDVVVASNLF
EEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCCCEEEHHHHH
GDILTDIGAAIQGGLGYAASANINPDHSAPSMFEPVHGSAPDIAHLGIANPIATIWSGAM
HHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHH
MLDHLGEKPAADRVMKAVEVATARGIGTIPAKDRTEAITAAVVAALT
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 10568751 [H]