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The map label for this gene is lysR [H]

Identifier: 13475849

GI number: 13475849

Start: 5787814

End: 5788719

Strand: Direct

Name: lysR [H]

Synonym: mlr7023

Alternate gene names: 13475849

Gene position: 5787814-5788719 (Clockwise)

Preceding gene: 13475837

Following gene: 13475850

Centisome position: 82.26

GC content: 67.88

Gene sequence:

>906_bases
ATGCGGGCCCGTCAGCTCGAAGTGTTCATCGCCGTCATGCGCGCGGGTACCGTGACCGCCGCGGCGCGGATGCTGAACAT
CTCCCAACCCGCACTCAGCCAGATCCTGCTCCACACCGAGGACGAACTCGGCTTCACGTTGTTCGAGCGCATCAAGGGCC
GGCTGCGGCCAACCCCGGAGGCGCTCGAGATATTCGCCGATGCCGAGCGTCTATCGGCGGGGTTGGAGGGCTTGCGCCGC
AAGACCACTGATCTGCGTCTGGGTCGGACGGGGCTGGTCCGGGTCGCGGCCTCGCCGCCGCCAGCCCTGGCGATCTTGCC
GCGCGCTTTCACCAGCTTCCGGGCGCGGCATCCCGATATTTTGCTGCGCTCCCACATGGCGCCGATCGCAGCGATCGTCG
ACATGCTGCGCGCCGGCGATGCCAGCCTTGGCGTGGCCTTGGACGACCGCCTGCCTCCCGACATCGAGGCGGAGGTGCTC
GGTAGCGTCGGCTTCGCCTGCCTGCTGCCCACCGGGCATGCGTTGGCCGTGAAAACCGAGCTCACGCTCGCCGATCTCGC
CGGCGAGGAATTGATATCCTATCGCGGAAACACCCGCCCCGCCGACGAACTGGCCCATGCCGCGCGCGCGCAAGGTGTGG
CGCTTTCGCCGTCGCTCGAGATCGATGTCTCCATCTCGGCGGTCGGCTTCGTCCAGGCCGGTCTGGGTATCGCCCTCGTC
GATGCGCTGCTGCCCTGGCACCAGTTTGCCGGGCTTGCCGTCCGGCCTCTCGCGAATGGGCCGGAATTCCCGATCGCGCT
GCTCACCTCGCGCACACGGGCTCTTTCGCGGGCCGATGAAATGATGCGCGACCAGATCCGCGCGGCCTGTTCAGTCGTGC
TGGGCAGTGACGGGACAGGGGCATAA

Upstream 100 bases:

>100_bases
CGGAGCGAATGATCCTGAAGTCGCCGATCTTGTCGGCTCCGCAGGATTGCGTCAAAGATGGGTTTGGACAACAGCCATAA
GCTTGACCTATGGAGTGGCA

Downstream 100 bases:

>100_bases
GCAAGACTTATATTGTTCCTCGTCATACGTCTTGGACCCCGGCCATCCTGTCGTGTCAGCTTTGGTTGGCAGACAGGAAG
GGACGTATCATGGATGGTGC

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MRARQLEVFIAVMRAGTVTAAARMLNISQPALSQILLHTEDELGFTLFERIKGRLRPTPEALEIFADAERLSAGLEGLRR
KTTDLRLGRTGLVRVAASPPPALAILPRAFTSFRARHPDILLRSHMAPIAAIVDMLRAGDASLGVALDDRLPPDIEAEVL
GSVGFACLLPTGHALAVKTELTLADLAGEELISYRGNTRPADELAHAARAQGVALSPSLEIDVSISAVGFVQAGLGIALV
DALLPWHQFAGLAVRPLANGPEFPIALLTSRTRALSRADEMMRDQIRAACSVVLGSDGTGA

Sequences:

>Translated_301_residues
MRARQLEVFIAVMRAGTVTAAARMLNISQPALSQILLHTEDELGFTLFERIKGRLRPTPEALEIFADAERLSAGLEGLRR
KTTDLRLGRTGLVRVAASPPPALAILPRAFTSFRARHPDILLRSHMAPIAAIVDMLRAGDASLGVALDDRLPPDIEAEVL
GSVGFACLLPTGHALAVKTELTLADLAGEELISYRGNTRPADELAHAARAQGVALSPSLEIDVSISAVGFVQAGLGIALV
DALLPWHQFAGLAVRPLANGPEFPIALLTSRTRALSRADEMMRDQIRAACSVVLGSDGTGA
>Mature_301_residues
MRARQLEVFIAVMRAGTVTAAARMLNISQPALSQILLHTEDELGFTLFERIKGRLRPTPEALEIFADAERLSAGLEGLRR
KTTDLRLGRTGLVRVAASPPPALAILPRAFTSFRARHPDILLRSHMAPIAAIVDMLRAGDASLGVALDDRLPPDIEAEVL
GSVGFACLLPTGHALAVKTELTLADLAGEELISYRGNTRPADELAHAARAQGVALSPSLEIDVSISAVGFVQAGLGIALV
DALLPWHQFAGLAVRPLANGPEFPIALLTSRTRALSRADEMMRDQIRAACSVVLGSDGTGA

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=266, Percent_Identity=33.0827067669173, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1788748, Length=288, Percent_Identity=28.4722222222222, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI157672245, Length=230, Percent_Identity=30.8695652173913, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787879, Length=258, Percent_Identity=25.1937984496124, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI145693105, Length=233, Percent_Identity=22.3175965665236, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788887, Length=286, Percent_Identity=28.3216783216783, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1787530, Length=264, Percent_Identity=25.3787878787879, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87081904, Length=302, Percent_Identity=26.158940397351, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787601, Length=179, Percent_Identity=26.2569832402235, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788296, Length=248, Percent_Identity=29.0322580645161, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31964; Mature: 31964

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRARQLEVFIAVMRAGTVTAAARMLNISQPALSQILLHTEDELGFTLFERIKGRLRPTPE
CCCHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHH
ALEIFADAERLSAGLEGLRRKTTDLRLGRTGLVRVAASPPPALAILPRAFTSFRARHPDI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEHHHHHHHHHCCCCHH
LLRSHMAPIAAIVDMLRAGDASLGVALDDRLPPDIEAEVLGSVGFACLLPTGHALAVKTE
HHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHCCEEEEECCCCEEEEEEE
LTLADLAGEELISYRGNTRPADELAHAARAQGVALSPSLEIDVSISAVGFVQAGLGIALV
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEECCCCEEEEEEHHHHHHHHHHHHHHH
DALLPWHQFAGLAVRPLANGPEFPIALLTSRTRALSRADEMMRDQIRAACSVVLGSDGTG
HHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCC
A
C
>Mature Secondary Structure
MRARQLEVFIAVMRAGTVTAAARMLNISQPALSQILLHTEDELGFTLFERIKGRLRPTPE
CCCHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHH
ALEIFADAERLSAGLEGLRRKTTDLRLGRTGLVRVAASPPPALAILPRAFTSFRARHPDI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEHHHHHHHHHCCCCHH
LLRSHMAPIAAIVDMLRAGDASLGVALDDRLPPDIEAEVLGSVGFACLLPTGHALAVKTE
HHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHCCEEEEECCCCEEEEEEE
LTLADLAGEELISYRGNTRPADELAHAARAQGVALSPSLEIDVSISAVGFVQAGLGIALV
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEECCCCEEEEEEHHHHHHHHHHHHHHH
DALLPWHQFAGLAVRPLANGPEFPIALLTSRTRALSRADEMMRDQIRAACSVVLGSDGTG
HHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]