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The map label for this gene is ywrD [H]

Identifier: 13475814

GI number: 13475814

Start: 5745476

End: 5747062

Strand: Reverse

Name: ywrD [H]

Synonym: mll6984

Alternate gene names: 13475814

Gene position: 5747062-5745476 (Counterclockwise)

Preceding gene: 13475816

Following gene: 13475813

Centisome position: 81.68

GC content: 66.73

Gene sequence:

>1587_bases
ATGCGTGATTTCCAGTTTCCCGGCCGCTCGCCGGTTCGTGCCACGCAAGCGGTCGCGGCGACATCGCACCCGCTGTCGAC
GCTGGCGGCGATCGAGATGCTGCGTGCCGGCGGCAACGCCATGGACGCCGCCGTCTGCGCCGCCGCCGTGCAGGGCGTCG
TCGAGCCGCAGTCGACCGGCATTGGTGGCGATTGCTTTGTCCTCTACTGCCCGAAGGGACAAGGCGACGTGCTGGCCTTC
AACGGCTCGGGCCGAGCGCCGGCGGCAGCGACCGTGGACTGGTATCTGGACAGGGGTTTCAGCGAGCTTCCGAAACAGGG
GCCGCACGCGGTGACCGTGCCGGGCGCCATCGACGCATGGTGCCGGCTGCTTCAGGACCATGGCAGCAAGGACCTTGCCG
AGGTTCTGGCGCCGGCCATCCACTACGCCGAGAACGGCTATGTCGTGCATGACCGCGTCGCCTTCGACTGGGCGGACCCG
GAGATCGACCTGTCGGCCGACGAACATGCCGCGCGCATCTTCCTGCCGGCCGGCCAGGCGCCGAAGGCCGGCGACATCCA
CCGCCAGCCGGAACTCGCCGCCACCTTGCGGATAATCGCAAAGCATGGCCGCGCCGGTTTTTACGAAGGCGCCGTTGCCG
ACGACATGGTGCGCCGGCTCAATGAACTGGGCGGGCTGCATAGCCAAGAGGATTTCGCCGCGACCAAAGGCGACTATGTG
GCGCCGGTCAGCACCACCTATGGCGGCTATGACATCCACCAGATGCCGCCGAACAATCAGGGGCTGACGGCGTTGCTGAT
GCTGAACGTTCTTTCAGGCTTCAAGCTCGGCGGCCTCGACCCCAATGGCGCCGAGCGCCTGCACCTGGAGATCGAGGCCG
GACGCCTGGCCTATCAGGATCGCGACCGCTACGTCGGCGACCAGGACCAGGTTCATGTGCCGATAAAACAGCTTCTGTCC
GGCGCCTATGCCGACAGGCTGCGCGCCGAGATCCACCGCGACCGCGCCATGATGCATCTGCCGCGCCTGGAGCTGCCCGG
CAGCGACACGGTCTATATCTCGATCGTCGACCGCGACCGCAACGCGGTCTCCTTCATCAACTCGACCTATTATTCCTTCG
GCAGCGGCGTCGTCGGCCCGAAGAGCGGCGTCGTGCTGCAGAATCGCGGATCGAGCTTCCGCCTCGACCCGGCGCACCCG
AACGCGATCGCTCCCGGCAAGCGGCCGATGCACACGATCATGCCCGGCATGGCGACGAAAAACGGCCGCGTGGTGATGCC
GTTCGGCGTCATGGGCGGCGGCTACCAGCCTTTCGGCCATGTCCATCTCCTGACCAACATGATCGACTTCGGCATGGATC
CGCAGCTGGCGCTGGATGCGCCGCGCGTGTTCTACAATGACGATACCGTGGAGGCCGAGCGCAACGTTCCCGCCGAGGCG
ATCGAAGGCCTGCGCAAGCGCGGCCATCGCGTCGTCGAGCCGCAGCATCCGCTTGGCGGCGGGCAGGCGGTGCTGATCGA
CTGGGAGAAAGGCACGCTCACCGGCGCCTCCGACCCGCGCAAAGATGGGATGGCGCTGGGGTATTGA

Upstream 100 bases:

>100_bases
GGCATGCGCCGCTGTCGAAAAGCCGAGCGACGCGCTGCCGTGTCGTGTCAAGCGATGGCGGTAACGTCGCATCCAGCAGA
CCAAGGGATTGAAAAACAGA

Downstream 100 bases:

>100_bases
GGTGATTCGGGGATTGGAGAACCGGCTTCCGGTTGTGGACAATTGTCCGGGGTCGGAACCATTCCCAGGGCTTTCTAGAA
GCAGCCGTTTAAAACATAGT

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MRDFQFPGRSPVRATQAVAATSHPLSTLAAIEMLRAGGNAMDAAVCAAAVQGVVEPQSTGIGGDCFVLYCPKGQGDVLAF
NGSGRAPAAATVDWYLDRGFSELPKQGPHAVTVPGAIDAWCRLLQDHGSKDLAEVLAPAIHYAENGYVVHDRVAFDWADP
EIDLSADEHAARIFLPAGQAPKAGDIHRQPELAATLRIIAKHGRAGFYEGAVADDMVRRLNELGGLHSQEDFAATKGDYV
APVSTTYGGYDIHQMPPNNQGLTALLMLNVLSGFKLGGLDPNGAERLHLEIEAGRLAYQDRDRYVGDQDQVHVPIKQLLS
GAYADRLRAEIHRDRAMMHLPRLELPGSDTVYISIVDRDRNAVSFINSTYYSFGSGVVGPKSGVVLQNRGSSFRLDPAHP
NAIAPGKRPMHTIMPGMATKNGRVVMPFGVMGGGYQPFGHVHLLTNMIDFGMDPQLALDAPRVFYNDDTVEAERNVPAEA
IEGLRKRGHRVVEPQHPLGGGQAVLIDWEKGTLTGASDPRKDGMALGY

Sequences:

>Translated_528_residues
MRDFQFPGRSPVRATQAVAATSHPLSTLAAIEMLRAGGNAMDAAVCAAAVQGVVEPQSTGIGGDCFVLYCPKGQGDVLAF
NGSGRAPAAATVDWYLDRGFSELPKQGPHAVTVPGAIDAWCRLLQDHGSKDLAEVLAPAIHYAENGYVVHDRVAFDWADP
EIDLSADEHAARIFLPAGQAPKAGDIHRQPELAATLRIIAKHGRAGFYEGAVADDMVRRLNELGGLHSQEDFAATKGDYV
APVSTTYGGYDIHQMPPNNQGLTALLMLNVLSGFKLGGLDPNGAERLHLEIEAGRLAYQDRDRYVGDQDQVHVPIKQLLS
GAYADRLRAEIHRDRAMMHLPRLELPGSDTVYISIVDRDRNAVSFINSTYYSFGSGVVGPKSGVVLQNRGSSFRLDPAHP
NAIAPGKRPMHTIMPGMATKNGRVVMPFGVMGGGYQPFGHVHLLTNMIDFGMDPQLALDAPRVFYNDDTVEAERNVPAEA
IEGLRKRGHRVVEPQHPLGGGQAVLIDWEKGTLTGASDPRKDGMALGY
>Mature_528_residues
MRDFQFPGRSPVRATQAVAATSHPLSTLAAIEMLRAGGNAMDAAVCAAAVQGVVEPQSTGIGGDCFVLYCPKGQGDVLAF
NGSGRAPAAATVDWYLDRGFSELPKQGPHAVTVPGAIDAWCRLLQDHGSKDLAEVLAPAIHYAENGYVVHDRVAFDWADP
EIDLSADEHAARIFLPAGQAPKAGDIHRQPELAATLRIIAKHGRAGFYEGAVADDMVRRLNELGGLHSQEDFAATKGDYV
APVSTTYGGYDIHQMPPNNQGLTALLMLNVLSGFKLGGLDPNGAERLHLEIEAGRLAYQDRDRYVGDQDQVHVPIKQLLS
GAYADRLRAEIHRDRAMMHLPRLELPGSDTVYISIVDRDRNAVSFINSTYYSFGSGVVGPKSGVVLQNRGSSFRLDPAHP
NAIAPGKRPMHTIMPGMATKNGRVVMPFGVMGGGYQPFGHVHLLTNMIDFGMDPQLALDAPRVFYNDDTVEAERNVPAEA
IEGLRKRGHRVVEPQHPLGGGQAVLIDWEKGTLTGASDPRKDGMALGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=536, Percent_Identity=26.6791044776119, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI73915090, Length=536, Percent_Identity=26.6791044776119, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI73915096, Length=536, Percent_Identity=26.6791044776119, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI73915094, Length=536, Percent_Identity=26.6791044776119, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI113429324, Length=521, Percent_Identity=26.1036468330134, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI113429326, Length=530, Percent_Identity=25.8490566037736, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI109148539, Length=498, Percent_Identity=27.710843373494, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI153266885, Length=531, Percent_Identity=24.8587570621469, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI153266901, Length=532, Percent_Identity=25.187969924812, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI153266907, Length=531, Percent_Identity=23.728813559322, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI30581157, Length=228, Percent_Identity=28.5087719298246, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI30581155, Length=228, Percent_Identity=28.5087719298246, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1789856, Length=545, Percent_Identity=31.743119266055, Blast_Score=253, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI193208245, Length=549, Percent_Identity=26.0473588342441, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI193208247, Length=549, Percent_Identity=26.0473588342441, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI212646519, Length=475, Percent_Identity=26.9473684210526, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI72000294, Length=475, Percent_Identity=26.9473684210526, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17542894, Length=511, Percent_Identity=25.6360078277886, Blast_Score=125, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17506189, Length=525, Percent_Identity=25.7142857142857, Blast_Score=122, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6323330, Length=445, Percent_Identity=25.8426966292135, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45551474, Length=493, Percent_Identity=27.9918864097363, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24642670, Length=493, Percent_Identity=27.9918864097363, Blast_Score=153, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24642666, Length=493, Percent_Identity=27.9918864097363, Blast_Score=153, Evalue=4e-37,
Organism=Drosophila melanogaster, GI161077880, Length=493, Percent_Identity=27.9918864097363, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI161077878, Length=493, Percent_Identity=27.9918864097363, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI18859741, Length=554, Percent_Identity=23.826714801444, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI18859893, Length=432, Percent_Identity=25.6944444444444, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI161077496, Length=487, Percent_Identity=24.2299794661191, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 56857; Mature: 56857

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDFQFPGRSPVRATQAVAATSHPLSTLAAIEMLRAGGNAMDAAVCAAAVQGVVEPQSTG
CCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCC
IGGDCFVLYCPKGQGDVLAFNGSGRAPAAATVDWYLDRGFSELPKQGPHAVTVPGAIDAW
CCCCEEEEECCCCCCCEEEECCCCCCCCEEEHHHHHHCCHHHCCCCCCCEEECCCHHHHH
CRLLQDHGSKDLAEVLAPAIHYAENGYVVHDRVAFDWADPEIDLSADEHAARIFLPAGQA
HHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCEECCCCCCCEEEEEECCCC
PKAGDIHRQPELAATLRIIAKHGRAGFYEGAVADDMVRRLNELGGLHSQEDFAATKGDYV
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHCCCCCEE
APVSTTYGGYDIHQMPPNNQGLTALLMLNVLSGFKLGGLDPNGAERLHLEIEAGRLAYQD
CCCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCEECCCCCCCCCEEEEEEECCCEEECC
RDRYVGDQDQVHVPIKQLLSGAYADRLRAEIHRDRAMMHLPRLELPGSDTVYISIVDRDR
CCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCC
NAVSFINSTYYSFGSGVVGPKSGVVLQNRGSSFRLDPAHPNAIAPGKRPMHTIMPGMATK
CHHHHHHHHHHHHCCCCCCCCCCEEEECCCCEEEECCCCCCCCCCCCCCHHHHCCCCCCC
NGRVVMPFGVMGGGYQPFGHVHLLTNMIDFGMDPQLALDAPRVFYNDDTVEAERNVPAEA
CCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCEEEECCCCCCCCCCCCHHH
IEGLRKRGHRVVEPQHPLGGGQAVLIDWEKGTLTGASDPRKDGMALGY
HHHHHHCCCEECCCCCCCCCCCEEEEECCCCEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MRDFQFPGRSPVRATQAVAATSHPLSTLAAIEMLRAGGNAMDAAVCAAAVQGVVEPQSTG
CCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCC
IGGDCFVLYCPKGQGDVLAFNGSGRAPAAATVDWYLDRGFSELPKQGPHAVTVPGAIDAW
CCCCEEEEECCCCCCCEEEECCCCCCCCEEEHHHHHHCCHHHCCCCCCCEEECCCHHHHH
CRLLQDHGSKDLAEVLAPAIHYAENGYVVHDRVAFDWADPEIDLSADEHAARIFLPAGQA
HHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCEECCCCCCCEEEEEECCCC
PKAGDIHRQPELAATLRIIAKHGRAGFYEGAVADDMVRRLNELGGLHSQEDFAATKGDYV
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHCCCCCEE
APVSTTYGGYDIHQMPPNNQGLTALLMLNVLSGFKLGGLDPNGAERLHLEIEAGRLAYQD
CCCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCEECCCCCCCCCEEEEEEECCCEEECC
RDRYVGDQDQVHVPIKQLLSGAYADRLRAEIHRDRAMMHLPRLELPGSDTVYISIVDRDR
CCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCC
NAVSFINSTYYSFGSGVVGPKSGVVLQNRGSSFRLDPAHPNAIAPGKRPMHTIMPGMATK
CHHHHHHHHHHHHCCCCCCCCCCEEEECCCCEEEECCCCCCCCCCCCCCHHHHCCCCCCC
NGRVVMPFGVMGGGYQPFGHVHLLTNMIDFGMDPQLALDAPRVFYNDDTVEAERNVPAEA
CCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCEEEECCCCCCCCCCCCHHH
IEGLRKRGHRVVEPQHPLGGGQAVLIDWEKGTLTGASDPRKDGMALGY
HHHHHHCCCEECCCCCCCCCCCEEEEECCCCEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]